GO:0006461

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Name protein complex assembly
Categary Process
Go Slim Yes
Go Link GO:0006461
Unique Molecular Interactions 862
Total Molecular Interactions 1179
Total Single Events 7599
Pain Genes Associated 90

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein complex assembly. They are ordered first by their pain relevance and then by number of times they were reported for protein complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
3 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
4 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
5 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
6 INT85042 Binding of CCT6A and MAX 1 0.00 0 3.13
7 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
8 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
9 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
10 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
11 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
12 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
13 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
14 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46
15 INT104972 MITF Regulation of Transcription of TYR 1 0.20 0.35 1.45
16 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
17 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
18 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
19 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
20 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
21 INT105918 Binding of FUT1 and SLC9A3R2 1 0.00 0.14 1.2
22 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
23 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
24 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16
25 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16
26 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
27 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
28 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
29 INT85040 Positive_regulation of Binding of CCT6A and MAX 1 0.00 0 1.06
30 INT329959 Binding of TRAF1 and HEPACAM 1 0.03 2.25 1.06
31 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
32 INT85039 Binding of GPM6A and MAX 1 0.00 0 1.05
33 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
34 INT143177 Apcs Negative_regulation of Gene_expression of Fos 1 0.02 0.36 1.01
35 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
36 INT156380 Regulation of Binding of Grin1 and Dlg4 1 0.29 0.32 0.97
37 INT296179 Pla2g2a Positive_regulation of Apcs 1 0.17 7.13 0.96
38 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
39 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
40 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91
41 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91
42 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91
43 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
44 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
45 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
46 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
47 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
48 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
49 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
50 INT120820 Binding of ASIC3 and Dlg4 3 0.02 0.11 0.84
51 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
52 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
53 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
54 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
55 INT152945 Dlg4 Regulation of Cap1 1 0.11 0.18 0.76
56 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
57 INT152944 Dlg4 Regulation of Gpr88 1 0.12 0.18 0.75
58 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
59 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
60 INT228499 Binding of FAS and Fasl 1 0.15 2.75 0.73
61 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
62 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
63 INT16048 MAX Positive_regulation of SLC25A4 1 0.50 0 0.71
64 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
65 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
66 INT168205 Binding of Dlg4 and Pik3cd 1 0.11 0.37 0.65
67 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
68 INT121713 WAS Positive_regulation of Gene_expression of SELP 1 0.30 0.49 0.63
69 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
70 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
71 INT92998 Positive_regulation of SFTPA1 Positive_regulation of Localization of CD40 1 0.15 0.34 0.61
72 INT223158 Mapk3 Regulation of Gene_expression of Mapk14 1 0.48 1.33 0.59
73 INT92999 Binding of CD40 and VCAM1 1 0.39 0.33 0.57
74 INT80030 Binding of FAS and TNF 3 0.27 2.54 0.56
75 INT96089 Binding of F2 and Pf4 1 0.00 1.31 0.56
76 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
77 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
78 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55
79 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
80 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
81 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
82 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
83 INT168256 Binding of MLL and TNFRSF1B 1 0.00 1.2 0.53
84 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
85 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
86 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
87 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
88 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
89 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49
90 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
91 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
92 INT263746 Binding of Dlg4 and Neto1 1 0.27 0 0.48
93 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
94 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
95 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
96 INT109780 WAS Regulation of Localization of Acot1 1 0.01 0.26 0.46
97 INT60935 Negative_regulation of Maoa Negative_regulation of Apcs 1 0.33 0.17 0.46
98 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
99 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46
100 INT96095 Binding of Selp and Pf4 1 0.01 1.2 0.45
101 INT96097 Binding of SELP and Pf4 1 0.13 1.2 0.45
102 INT159755 HP Regulation of OXA1L 1 0.01 0 0.44
103 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
104 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
105 INT142171 Positive_regulation of Adarb1 Positive_regulation of Apcs 1 0.01 0.19 0.43
106 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
107 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
108 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
109 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
110 INT225738 Binding of RANBP9 and Entpd1 1 0.13 0.3 0.42
111 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
112 INT329955 Binding of STAT4 and TRAF1 1 0.38 0.93 0.4
113 INT96833 Binding of WAS and Positive_regulation of Cnr1 1 0.02 0.69 0.39
114 INT96834 Binding of WAS and Positive_regulation of Cnr2 1 0.03 0.69 0.39
115 INT96836 WAS Positive_regulation of Cnr1 1 0.02 0.69 0.39
116 INT96835 WAS Positive_regulation of Cnr2 1 0.03 0.69 0.39
117 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
118 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
119 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
120 INT355018 Binding of FAS and Faslg 1 0.12 1.34 0.37
121 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
122 INT120821 Dlg4 Positive_regulation of ASIC3 1 0.02 0 0.36
123 INT164890 Binding of IL1RAP and IL33 1 0.09 0.2 0.36
124 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
125 INT272602 Binding of Dlg4 and Gria2 3 0.09 0.19 0.34
126 INT120817 Binding of Dlg4 and Lin7b 1 0.00 0 0.34
127 INT296465 Binding of Dlg4 and Rbm39 1 0.00 0.05 0.34
128 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
129 INT324224 Binding of OTX2 and H9 1 0.11 0.17 0.33
130 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
131 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
132 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
133 INT214987 Binding of FANCC and Sigmar1 1 0.06 0.34 0.32
134 INT100028 TNF Positive_regulation of Mapk3 1 0.22 0.79 0.32
135 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
136 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
137 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
138 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
139 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
140 INT198779 Binding of Dlg4 and Psd 10 0.25 0.09 0.31
141 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
142 INT90263 Binding of PPBP and Pf4 1 0.03 3.71 0.31
143 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
144 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
145 INT80029 Binding of FAS and Positive_regulation of NFKB1 1 0.34 0.92 0.3
146 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
147 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
148 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
149 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
150 INT255292 Regulation of Binding of Napb and Vamp2 1 0.07 0 0.3
151 INT80031 FAS Positive_regulation of Positive_regulation of NFKB1 1 0.50 0.93 0.3
152 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
153 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
154 INT255286 Binding of Napb and Vamp2 1 0.09 0 0.29
155 INT326438 Binding of HFE and TAPVR1 1 0.01 0.48 0.29
156 INT255284 Binding of Vamp2 and Vti1b 1 0.16 0 0.29
157 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
158 INT228500 Fadd Positive_regulation of FAS 1 0.14 1.12 0.28
159 INT135425 Binding of Dlg4 and Dlg3 1 0.29 0.07 0.28
160 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
161 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
162 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
163 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
164 INT166156 Ccr9 Positive_regulation of Mapk3 1 0.49 1.47 0.28
165 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
166 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
167 INT238632 Binding of EPB41 and Cask 1 0.44 0.78 0.27
168 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
169 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
170 INT32147 LLGL1 Positive_regulation of Gene_expression of IFNA1 1 0.13 0 0.27
171 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
172 INT134645 Binding of ORM1 and OXA1L 1 0.17 0.1 0.27
173 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
174 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
175 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
176 INT32149 Binding of ENG and LLGL1 1 0.11 0 0.26
177 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
178 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
179 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
180 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
181 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
182 INT274939 Binding of Dlg4 and Ephb6 1 0.12 0 0.25
183 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
184 INT191876 Pbsn Positive_regulation of Mapk3 1 0.01 0.33 0.25
185 INT191894 Prkca Positive_regulation of Mapk3 1 0.05 0.33 0.25
186 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
187 INT314045 THL Negative_regulation of Phosphorylation of Mapk3 1 0.13 0.7 0.25
188 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
189 INT213804 Binding of Mitf and Tfeb 1 0.24 0.81 0.24
190 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
191 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
192 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
193 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
194 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
195 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
196 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
197 INT263787 Binding of GRIN1 and Dlg4 3 0.18 0.05 0.23
198 INT191887 Pbsn Regulation of Phosphorylation of Mapk3 1 0.00 0.24 0.23
199 INT191879 Positive_regulation of Pbsn Negative_regulation of Positive_regulation of Mapk3 1 0.01 0.25 0.23
200 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein complex assembly. They are ordered first by their pain relevance and then by number of times they were reported in protein complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
2 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
3 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
4 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
5 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
6 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
7 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
8 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86
9 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
10 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
11 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
12 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
13 INT1850 Binding of OXA1L 77 0.48 7.61 15.22
14 INT97100 Negative_regulation of Dlg4 16 0.58 6.18 14.36
15 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96
16 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
17 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
18 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74
19 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
20 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83
21 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88
22 INT238920 Positive_regulation of SLC9A3R2 44 0.50 27.86 10.51
23 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
24 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
25 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
26 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
27 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
28 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
29 INT34268 Binding of WAS 14 0.47 4.41 8.67
30 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58
31 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
32 INT45914 Gene_expression of Apcs 22 0.65 24.25 8.48
33 INT24141 Negative_regulation of Apcs 24 0.59 16.82 8.29
34 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
35 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03
36 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
37 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
38 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
39 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
40 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
41 INT152347 Binding of GCH1 8 0.37 6.13 7.36
42 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
43 INT33105 Regulation of WAS 11 0.60 3.61 7.18
44 INT93003 Binding of CD40 28 0.47 20.25 7.13
45 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
46 INT97099 Positive_regulation of Dlg4 13 0.60 3.04 6.98
47 INT104979 Gene_expression of MITF 51 0.62 54.83 6.91
48 INT88786 Binding of Dlg4 11 0.46 2.73 6.58
49 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
50 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
51 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
52 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
53 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
54 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97
55 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
56 INT80033 Binding of FAS 37 0.48 41.19 5.67
57 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
58 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
59 INT60585 Regulation of TP53 59 0.59 54.55 5.21
60 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09
61 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
62 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
63 INT88790 Negative_regulation of Gene_expression of Dlg4 6 0.59 1.53 4.66
64 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
65 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
66 INT145532 Localization of Dlg4 25 0.79 1.97 4.36
67 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
68 INT88787 Transcription of Dlg4 4 0.69 0.83 4.09
69 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
70 INT120810 Binding of Dlg4 38 0.41 3.55 4.03
71 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
72 INT48456 Localization of WAS 6 0.56 1.63 3.95
73 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
74 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
75 INT63121 Binding of APC 29 0.41 23.02 3.8
76 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
77 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
78 INT60933 Positive_regulation of Apcs 16 0.67 11.69 3.68
79 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
80 INT187168 Binding of Cd74 13 0.27 11.2 3.44
81 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35
82 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
83 INT135815 Transcription of Gch1 1 0.60 0 3.32
84 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
85 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18
86 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1
87 INT105297 Negative_regulation of Regulation of WAS 3 0.28 0.98 3.07
88 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
89 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
90 INT8103 Binding of TP53 46 0.44 40.2 2.96
91 INT41358 Localization of Pf4 11 0.79 6.06 2.89
92 INT32394 Regulation of Pf4 12 0.23 6.07 2.85
93 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
94 INT36489 Regulation of Apcs 12 0.58 10.6 2.78
95 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
96 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
97 INT243350 Binding of CD74 2 0.11 4.86 2.72
98 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
99 INT63869 Positive_regulation of IL1RAP 8 0.45 3.84 2.63
100 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
101 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
102 INT346375 Protein_catabolism of Vamp2 1 0.33 1.56 2.46
103 INT249378 Negative_regulation of Vamp2 3 0.20 0.27 2.4
104 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
105 INT55952 Transcription of TP53 16 0.61 12.14 2.36
106 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
107 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
108 INT93753 Positive_regulation of Tap2 1 0.57 1.31 2.21
109 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
110 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12
111 INT92415 Positive_regulation of Max 4 0.67 1.13 2.1
112 INT98132 Regulation of FAS 16 0.42 20.57 2.06
113 INT102176 Transcription of FAS 3 0.60 3.22 2.05
114 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
115 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
116 INT121781 Regulation of Mapk3 5 0.44 1.96 1.98
117 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
118 INT248374 Binding of IKBKAP 10 0.42 10.45 1.9
119 INT238608 Gene_expression of Cask 1 0.73 2.74 1.9
120 INT65855 Localization of TP53 18 0.76 17.08 1.89
121 INT253975 Binding of Cd74 4 0.27 4.57 1.88
122 INT135820 Regulation of Gch1 1 0.59 0 1.88
123 INT198748 Regulation of Gene_expression of Dlg4 10 0.44 2.16 1.85
124 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
125 INT8787 Negative_regulation of WAS 4 0.42 2.42 1.81
126 INT293158 Gene_expression of TRAF1 2 0.63 3.62 1.81
127 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
128 INT97750 Positive_regulation of Positive_regulation of FAS 4 0.49 4.9 1.8
129 INT139459 Negative_regulation of MAX 6 0.57 0.32 1.79
130 INT82760 Negative_regulation of Positive_regulation of Mapk3 7 0.57 3.18 1.78
131 INT105920 Binding of SLC9A3R2 5 0.36 1.99 1.75
132 INT14961 Positive_regulation of Gene_expression of Pf4 4 0.30 3.42 1.7
133 INT3818 Regulation of Apc 13 0.39 12.52 1.68
134 INT97062 Binding of PML 10 0.41 11.63 1.65
135 INT58456 Gene_expression of HFE 10 0.58 7.68 1.65
136 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
137 INT337100 Gene_expression of Mgp 3 0.71 45.04 1.64
138 INT149994 Gene_expression of Mapk3 16 0.65 3.45 1.62
139 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
140 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
141 INT48412 Gene_expression of Apcs 26 0.54 7.16 1.53
142 INT82761 Regulation of Positive_regulation of Mapk3 3 0.40 1.34 1.52
143 INT119219 Localization of Dlg4 3 0.64 0.16 1.5
144 INT152939 Regulation of Dlg4 9 0.60 1.09 1.49
145 INT132886 Negative_regulation of Positive_regulation of Mapk3 2 0.30 1.27 1.49
146 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
147 INT217825 Regulation of Gene_expression of MITF 3 0.00 5.2 1.47
148 INT58032 Positive_regulation of Localization of Pf4 3 0.67 1.72 1.46
149 INT93001 Localization of CD40 4 0.78 1.97 1.45
150 INT1851 Regulation of OXA1L 7 0.40 0.59 1.42
151 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
152 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
153 INT134873 Phosphorylation of Dlg4 3 0.80 0.5 1.42
154 INT172953 Binding of Trp53 33 0.37 20.76 1.41
155 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
156 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
157 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
158 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
159 INT220177 Binding of Apc 21 0.37 15.34 1.37
160 INT145221 Binding of Tp53 10 0.37 8.59 1.37
161 INT54020 Regulation of Binding of OXA1L 4 0.51 0.27 1.37
162 INT329968 Binding of TRAF1 1 0.45 3.42 1.37
163 INT35271 Negative_regulation of Apcs 12 0.59 8.05 1.36
164 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
165 INT130773 Regulation of Gene_expression of FAS 5 0.37 6.87 1.32
166 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
167 INT181526 Positive_regulation of Apcs 13 0.49 4.09 1.3
168 INT97098 Regulation of Negative_regulation of Dlg4 3 0.45 0.97 1.3
169 INT214983 Positive_regulation of FANCC 11 0.15 1.81 1.29
170 INT74287 Regulation of IL1RAP 1 0.05 0.8 1.29
171 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
172 INT190067 Binding of Traf2 5 0.20 3.28 1.27
173 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26
174 INT22067 Positive_regulation of IL2RB 11 0.70 5.74 1.23
175 INT115108 Negative_regulation of Gene_expression of FAS 9 0.57 9.16 1.23
176 INT153757 Positive_regulation of Mitf 10 0.46 8.38 1.22
177 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
178 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21
179 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
180 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
181 INT174156 Localization of Trp53 16 0.72 13.52 1.18
182 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
183 INT48338 Gene_expression of Ahsg 2 0.52 0.25 1.16
184 INT128413 Positive_regulation of Shank1 2 0.70 0.61 1.16
185 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
186 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
187 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
188 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
189 INT238919 Regulation of Gene_expression of MAPK3 3 0.16 1.6 1.13
190 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
191 INT283972 Localization of GCH1 1 0.67 0.99 1.13
192 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
193 INT47079 Localization of Apcs 4 0.75 7.28 1.11
194 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
195 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09
196 INT6630 Binding of IL1RAP 4 0.17 1.07 1.08
197 INT286596 Positive_regulation of Positive_regulation of SLC9A3R2 2 0.50 3.37 1.07
198 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
199 INT286597 Localization of SLC9A3R2 3 0.54 6.71 1.05
200 INT105922 Gene_expression of SLC9A3R2 6 0.48 2.09 1.04
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