GO:0006469

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Name negative regulation of protein kinase activity
Categary Process
Go Slim No
Go Link GO:0006469
Unique Molecular Interactions 2364
Total Molecular Interactions 3232
Total Single Events 25101
Pain Genes Associated 71

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
6 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
7 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
8 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
9 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
10 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
11 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
12 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
13 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
14 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
15 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
16 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
17 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
18 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
19 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
20 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
21 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
22 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
23 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
24 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
25 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
26 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
27 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
28 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
29 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
30 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
31 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
32 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
33 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
34 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
35 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
36 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
37 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
38 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
39 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
40 INT112514 Binding of Prkaca and Trib3 1 0.03 1.18 1.9
41 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
42 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
43 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
44 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
45 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
46 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
47 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
48 INT186433 Trib3 Regulation of Phosphorylation of Creb1 1 0.03 0.32 1.71
49 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
50 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
51 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
52 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
53 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
54 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
55 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
56 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
57 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
58 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
59 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
60 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
61 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
62 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
63 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
64 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
65 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
66 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
67 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
68 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
69 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
70 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
71 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
72 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
73 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
74 INT50706 Phax Positive_regulation of Localization of Trib3 1 0.04 0.28 1.38
75 INT161185 NMS Regulation of Gene_expression of Trib3 1 0.03 2 1.38
76 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
77 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
78 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
79 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
80 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
81 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
82 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
83 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
84 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
85 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
86 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
87 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
88 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
89 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
90 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
91 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
92 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
93 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
94 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
95 INT228681 Fkbp4 Negative_regulation of Trib3 1 0.00 0.57 1.2
96 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
97 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
98 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
99 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
100 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
101 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
102 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
103 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
104 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
105 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
106 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
107 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
108 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
109 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
110 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
111 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
112 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
113 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
114 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
115 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
116 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
117 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
118 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
119 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
120 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
121 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
122 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
123 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
124 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
125 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
126 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
127 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
128 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
129 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
130 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
131 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
132 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
133 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
134 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
135 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
136 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
137 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
138 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
139 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
140 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
141 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
142 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
143 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
144 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
145 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
146 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
147 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
148 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
149 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
150 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
151 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
152 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
153 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
154 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
155 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
156 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
157 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
158 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
159 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
160 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
161 INT186431 Trib3 Regulation of Creb1 1 0.03 0.23 0.92
162 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
163 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
164 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
165 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
166 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
167 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
168 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
169 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
170 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
171 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
172 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
173 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
174 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
175 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
176 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
177 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
178 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
179 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
180 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
181 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
182 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
183 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
184 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
185 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
186 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
187 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
188 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
189 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
190 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
191 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
192 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
193 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
194 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
195 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
196 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
197 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
198 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
199 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
200 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
8 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
9 INT12082 Localization of IL6 365 0.81 241.78 105.78
10 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
11 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
12 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48
13 INT19511 Localization of Il6 212 0.81 118.17 67.67
14 INT11937 Localization of Il6 228 0.81 139.83 64.39
15 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
16 INT10706 Regulation of Il6 150 0.62 93.23 62.34
17 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
18 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
19 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
20 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
21 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
22 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
23 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
24 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
25 INT9210 Regulation of IL6 166 0.62 125.61 49.95
26 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
27 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
28 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
29 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
30 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
31 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
32 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
33 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
34 INT9655 Regulation of Il6 98 0.62 70.92 31.95
35 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
36 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
37 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
38 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
39 INT86437 Binding of IL6 154 0.48 121.22 29.3
40 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
41 INT12681 Regulation of Trib3 76 0.53 23.92 26.58
42 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
43 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
44 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
45 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
46 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
47 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27
48 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58
49 INT117527 Binding of Prkca 25 0.48 6.43 21.05
50 INT51474 Binding of Il6 55 0.48 44.99 20.52
51 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
52 INT49985 Transcription of Il6 62 0.72 40.13 20.29
53 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
54 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
55 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
56 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
57 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
58 INT61626 Transcription of IL6 73 0.72 42.04 17.86
59 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
60 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
61 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
62 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
63 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
64 INT79458 Localization of Prkca 30 0.81 11.13 15.78
65 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
66 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
67 INT38253 Localization of Trib3 35 0.63 10.28 15.42
68 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
69 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
70 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
71 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
72 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
73 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
74 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
75 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
76 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
77 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
78 INT54763 Binding of Il6 82 0.48 63.27 12.89
79 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
80 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
81 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
82 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
83 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
84 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
85 INT50933 Transcription of Il6 38 0.72 24.31 11.58
86 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
87 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
88 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
89 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
90 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
91 INT33127 Positive_regulation of Phosphorylation of Trib3 26 0.17 14.04 10
92 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
93 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
94 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
95 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
96 INT10533 Positive_regulation of Positive_regulation of Trib3 24 0.42 6.59 9.2
97 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
98 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
99 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
100 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
101 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
102 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
103 INT104013 Negative_regulation of Gene_expression of Pdpk1 4 0.31 2.36 7.89
104 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
105 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
106 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
107 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
108 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
109 INT73181 Gene_expression of Hspb1 24 0.78 15.84 7.31
110 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
111 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
112 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99
113 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
114 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86
115 INT71824 Phosphorylation of Pdpk1 14 0.38 4.9 6.86
116 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
117 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
118 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
119 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
120 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
121 INT55077 Positive_regulation of Positive_regulation of Pdpk1 6 0.26 1.77 5.78
122 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
123 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
124 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
125 INT68465 Positive_regulation of Gene_expression of Pdpk1 7 0.19 2.35 5.49
126 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
127 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
128 INT50704 Binding of Trib3 13 0.31 6.33 5.46
129 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
130 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
131 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
132 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23
133 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
134 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
135 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
136 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97
137 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
138 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
139 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
140 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
141 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
142 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
143 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
144 INT134657 Localization of Akt1 37 0.68 11.58 4.62
145 INT49652 Gene_expression of Fabp4 7 0.67 6.23 4.61
146 INT68216 Binding of NF1 40 0.48 51.24 4.59
147 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
148 INT24813 Negative_regulation of Positive_regulation of Trib3 10 0.16 1.3 4.48
149 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
150 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
151 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
152 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
153 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
154 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
155 INT75136 Binding of Akt1 27 0.27 8.81 4.15
156 INT1231 Negative_regulation of Positive_regulation of Pdpk1 6 0.35 1.88 4.13
157 INT32205 Regulation of Positive_regulation of Trib3 9 0.11 2.82 4.1
158 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
159 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
160 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
161 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
162 INT351271 Binding of Fabp4 1 0.48 3.92 3.79
163 INT10535 Positive_regulation of Gene_expression of Trib3 13 0.59 4.93 3.74
164 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
165 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
166 INT136692 Localization of Akt1 12 0.78 2.14 3.65
167 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
168 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
169 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
170 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
171 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45
172 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
173 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
174 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
175 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
176 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
177 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
178 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
179 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
180 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
181 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
182 INT179489 Positive_regulation of Fabp4 3 0.60 3.62 3.15
183 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
184 INT29929 Gene_expression of Rb1 20 0.69 5.81 3.1
185 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
186 INT271442 Positive_regulation of Thy1 10 0.40 6.64 3.05
187 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
188 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
189 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
190 INT15327 Negative_regulation of Phosphorylation of Trib3 7 0.30 4.95 2.99
191 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
192 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
193 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
194 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85
195 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
196 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
197 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
198 INT24068 Localization of Hspb1 6 0.78 6.11 2.75
199 INT86592 Positive_regulation of PKIB 3 0.09 0.54 2.75
200 INT47846 Negative_regulation of Localization of Pdpk1 2 0.33 1.12 2.75
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