GO:0006471

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Name protein ADP-ribosylation
Categary Process
Go Slim No
Go Link GO:0006471
Unique Molecular Interactions 84
Total Molecular Interactions 119
Total Single Events 1352
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein ADP-ribosylation. They are ordered first by their pain relevance and then by number of times they were reported for protein ADP-ribosylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
2 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
3 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
4 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
5 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
6 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
7 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
8 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
9 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
10 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
11 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
12 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
13 INT355687 Art2b Positive_regulation of Gene_expression of Mc3r 1 0.02 1.01 0.48
14 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
15 INT337047 Art2b Positive_regulation of Gene_expression of S100a8 1 0.00 1.03 0.42
16 INT173356 Gnaq Positive_regulation of CDK20 1 0.06 0 0.37
17 INT118852 Positive_regulation of GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
18 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
19 INT118846 GNA14 Positive_regulation of CAMK2G 1 0.01 0.09 0.27
20 INT118848 GNA14 Positive_regulation of RAC1 1 0.01 0.14 0.26
21 INT118856 Positive_regulation of GNA14 Positive_regulation of STAT3 1 0.01 0.14 0.26
22 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
23 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
24 INT118849 GNA14 Positive_regulation of MAPK1 1 0.00 0.14 0.26
25 INT118851 GNA14 Positive_regulation of RAF1 1 0.00 0.14 0.26
26 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
27 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
28 INT341378 Positive_regulation of Ros1 Positive_regulation of Parp1 1 0.01 1.08 0.22
29 INT173357 Gnaq Positive_regulation of PRKCA 1 0.01 0 0.22
30 INT81159 Binding of PARP1 and IgG-2a 1 0.00 1.02 0.21
31 INT72019 Binding of Gnaq and Ptprg 1 0.01 0 0.21
32 INT287693 Parp1 Positive_regulation of Positive_regulation of Nfkb1 1 0.07 0.54 0.2
33 INT336503 Parp1 Positive_regulation of Tubgcp2 1 0.11 0.52 0.13
34 INT336504 Parp1 Positive_regulation of Mcpt3 1 0.11 0.52 0.13
35 INT336506 Parp1 Positive_regulation of Cxcl2 1 0.16 0.52 0.13
36 INT336505 Parp1 Positive_regulation of Mcpt1 1 0.14 0.52 0.13
37 INT64188 ART3 Negative_regulation of HSD17B2 1 0.00 0 0.09
38 INT227593 Gnaq Negative_regulation of GLUL 1 0.01 0 0.06
39 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
40 INT253193 Ros1 Regulation of Parp1 1 0.01 0.57 0.05
41 INT322358 Binding of Parp1 and Casp3 1 0.05 1.08 0.04
42 INT261962 Binding of Parp1 and El4 1 0.19 1.33 0.03
43 INT250796 Tlr4 Positive_regulation of Parp1 1 0.14 1 0.03
44 INT225479 Binding of Parp1 and Acsl1 1 0.00 0 0
45 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
46 INT66344 ANTXR1 Positive_regulation of ART1 1 0.00 0.69 0
47 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
48 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
49 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
50 INT155920 PARP1 Regulation of Gene_expression of IL6 1 0.19 0.08 0
51 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0
52 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
53 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
54 INT155926 PARP1 Regulation of Binding of NFKB1 1 0.24 0.16 0
55 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
56 INT325375 Binding of Tp53 and Positive_regulation of Positive_regulation of PARP1 1 0.05 0.59 0
57 INT155916 PARP1 Positive_regulation of Gene_expression of TNF 1 0.42 0 0
58 INT155923 Negative_regulation of PARP1 Negative_regulation of Gene_expression of TNF 1 0.36 0.07 0
59 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
60 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
61 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
62 INT225614 Binding of XRCC5 and Parp1 1 0.09 0 0
63 INT341377 Gene_expression of Ros1 Positive_regulation of Parp1 1 0.01 1.03 0
64 INT233020 SFTPA1 Negative_regulation of Parp1 1 0.00 0.58 0
65 INT155919 Gene_expression of PARP1 Positive_regulation of Gene_expression of IL6 1 0.33 0 0
66 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
67 INT322363 TNF Positive_regulation of Positive_regulation of Parp1 1 0.02 1.54 0
68 INT155922 PARP1 Positive_regulation of Binding of NFKB1 1 0.42 0.06 0
69 INT155924 Binding of PARP1 and NFKB1 1 0.34 0.23 0
70 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
71 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
72 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
73 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
74 INT233117 Binding of SIRT2 and PAMR1 1 0.00 0 0
75 INT155925 PARP1 Positive_regulation of NFKB1 1 0.42 0.06 0
76 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
77 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
78 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein ADP-ribosylation. They are ordered first by their pain relevance and then by number of times they were reported in protein ADP-ribosylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84
2 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77
3 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56
4 INT126583 Positive_regulation of PARP1 50 0.68 41.44 7.78
5 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
6 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74
7 INT99348 Negative_regulation of PARP1 38 0.58 30.96 3.36
8 INT155091 Localization of PARP1 15 0.63 13.34 3.15
9 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02
10 INT107677 Positive_regulation of Parp1 7 0.45 9.77 3
11 INT107674 Negative_regulation of Parp1 7 0.27 8.91 2.88
12 INT163833 Positive_regulation of Localization of PARP1 7 0.28 7.54 2.14
13 INT155928 Positive_regulation of Gene_expression of PARP1 13 0.68 6.54 2.1
14 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95
15 INT153800 Positive_regulation of Protein_catabolism of PARP1 18 0.49 16.16 1.89
16 INT10993 Regulation of PARP1 4 0.26 2.04 1.89
17 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
18 INT131818 Binding of Parp1 14 0.46 8.74 1.76
19 INT63586 Regulation of Parp1 5 0.43 3.28 1.68
20 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63
21 INT71999 Negative_regulation of Gene_expression of Gnaq 3 0.41 0.08 1.56
22 INT97053 Transcription of Parp1 3 0.66 2.04 1.43
23 INT110188 Regulation of Gene_expression of Gnaq 2 0.25 0.85 1.22
24 INT175508 Protein_catabolism of Parp1 30 0.85 30 1.09
25 INT123816 Positive_regulation of Gene_expression of Parp1 9 0.50 6.64 1.04
26 INT72002 Negative_regulation of Gnaq 7 0.35 0.2 1.02
27 INT153125 Negative_regulation of Protein_catabolism of PARP1 8 0.32 6.57 0.98
28 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
29 INT147616 Negative_regulation of Positive_regulation of Parp1 3 0.43 2.53 0.84
30 INT110187 Regulation of Regulation of Gnaq 1 0.00 0.07 0.82
31 INT157610 Gene_expression of Parp1 4 0.58 2.16 0.77
32 INT141915 Positive_regulation of Gene_expression of Gnaq 3 0.19 1.31 0.76
33 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
34 INT123814 Positive_regulation of Positive_regulation of Parp1 9 0.50 9.32 0.57
35 INT126585 Positive_regulation of Positive_regulation of PARP1 3 0.55 2.84 0.56
36 INT112881 Positive_regulation of Positive_regulation of Gnaq 2 0.49 0.86 0.54
37 INT126586 Binding of PARP1 15 0.43 4.96 0.53
38 INT109867 Negative_regulation of Negative_regulation of Parp1 2 0.42 3.37 0.49
39 INT141919 Positive_regulation of Transcription of Gnaq 1 0.21 1.05 0.49
40 INT126584 Regulation of Positive_regulation of PARP1 1 0.24 0.78 0.49
41 INT141912 Negative_regulation of Transcription of Gnaq 1 0.18 1.07 0.49
42 INT141917 Transcription of Gnaq 1 0.29 1.05 0.49
43 INT107676 Positive_regulation of Protein_catabolism of Parp1 1 0.10 0.91 0.48
44 INT233013 Positive_regulation of Positive_regulation of Parp1 1 0.23 1.78 0.47
45 INT107675 Negative_regulation of Protein_catabolism of Parp1 1 0.08 0.91 0.47
46 INT107678 Protein_catabolism of Parp1 1 0.19 0.9 0.47
47 INT157609 Regulation of Parp1 2 0.26 1.4 0.43
48 INT180142 Negative_regulation of SIRT2 10 0.07 0.19 0.41
49 INT180138 Negative_regulation of Gene_expression of SIRT2 2 0.07 0.19 0.41
50 INT291905 Localization of ART1 1 0.01 0.27 0.38
51 INT10994 Regulation of Gene_expression of PARP1 1 0.01 0.2 0.38
52 INT186468 Positive_regulation of Protein_catabolism of Parp1 2 0.33 5.05 0.34
53 INT154804 Negative_regulation of Positive_regulation of PARP1 2 0.34 3.88 0.33
54 INT352918 Transcription of PARP1 1 0.25 0.85 0.33
55 INT287690 Negative_regulation of Positive_regulation of Parp1 1 0.20 0.65 0.33
56 INT278102 Binding of GNA15 1 0.01 0.16 0.32
57 INT36626 Negative_regulation of ART1 1 0.14 0.32 0.32
58 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
59 INT153126 Negative_regulation of Gene_expression of PARP1 3 0.19 2.09 0.29
60 INT180144 Binding of SIRT2 57 0.06 1.29 0.27
61 INT118873 Binding of GNA14 1 0.01 0.13 0.27
62 INT149315 Binding of Gnaq 2 0.04 0 0.26
63 INT169195 Negative_regulation of Localization of PARP1 1 0.27 0.99 0.26
64 INT287683 Regulation of Gene_expression of Parp1 1 0.21 0.64 0.26
65 INT118875 Gene_expression of GNA14 1 0.02 0.09 0.26
66 INT124366 Gene_expression of GNA15 1 0.11 0 0.25
67 INT118869 Phosphorylation of GNA14 1 0.02 0.15 0.23
68 INT207809 Positive_regulation of Negative_regulation of Parp1 2 0.50 1.01 0.2
69 INT175663 Positive_regulation of SIRT2 56 0.14 3.58 0.17
70 INT175532 Localization of Parp1 9 0.74 5.73 0.17
71 INT250795 Negative_regulation of Gene_expression of Parp1 4 0.41 5.01 0.15
72 INT199856 Negative_regulation of Protein_catabolism of Parp1 2 0.41 1.46 0.15
73 INT325373 Negative_regulation of Binding of PARP1 1 0.31 0.98 0.15
74 INT233124 Positive_regulation of Gene_expression of SIRT2 17 0.04 0.16 0.14
75 INT118872 Positive_regulation of GNA14 1 0.02 0.1 0.14
76 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
77 INT272710 Phosphorylation of Gnaq 1 0.09 0.12 0.12
78 INT253175 Regulation of Positive_regulation of Parp1 2 0.52 0.97 0.08
79 INT175513 Positive_regulation of Localization of Parp1 2 0.23 2.23 0.07
80 INT256156 Positive_regulation of ART1 1 0.01 0.21 0.07
81 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
82 INT253176 Regulation of Gene_expression of Parp1 2 0.23 0.61 0.05
83 INT257999 Phosphorylation of PARP1 1 0.12 0.28 0.05
84 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
85 INT155929 Positive_regulation of Negative_regulation of PARP1 2 0.49 1.02 0.04
86 INT227570 Localization of Gnaq 1 0.07 0 0.04
87 INT227569 Negative_regulation of Positive_regulation of Gnaq 1 0.04 0.08 0.04
88 INT236481 Negative_regulation of Negative_regulation of PARP1 1 0.15 0.95 0.04
89 INT256109 Positive_regulation of Gene_expression of Sirt6 1 0.21 0.52 0.03
90 INT256123 Gene_expression of Sirt6 1 0.27 0.98 0.03
91 INT220796 Positive_regulation of Art2b 1 0.04 0.84 0.03
92 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
93 INT204349 Regulation of SIRT1 8 0.61 1.99 0
94 INT233125 Positive_regulation of Positive_regulation of SIRT2 4 0.04 0 0
95 INT204353 Transcription of SIRT1 3 0.68 0.67 0
96 INT180140 Regulation of SIRT2 3 0.04 0 0
97 INT220795 Gene_expression of Art2b 3 0.07 0 0
98 INT233126 Regulation of Gene_expression of SIRT2 2 0.03 0 0
99 INT180146 Positive_regulation of Binding of SIRT2 2 0.08 0 0
100 INT220794 Regulation of Art2b 2 0.06 0.08 0
101 INT220778 Negative_regulation of Art2b 2 0.04 0 0
102 INT155927 Positive_regulation of Binding of PARP1 2 0.49 0.32 0
103 INT271494 Binding of ART1 1 0.01 0.66 0
104 INT256128 Localization of Sirt6 1 0.32 0.58 0
105 INT233120 Regulation of Binding of SIRT2 1 0.03 0 0
106 INT175530 Regulation of Protein_catabolism of Parp1 1 0.09 1.36 0
107 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
108 INT330573 Gene_expression of ART1 1 0.01 0.5 0
109 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
110 INT301188 Regulation of Positive_regulation of SIRT2 1 0.03 1.05 0
111 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
112 INT207802 Regulation of Localization of Parp1 1 0.45 0.35 0
113 INT180143 Phosphorylation of SIRT2 1 0.13 0 0
114 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
115 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
116 INT256117 Regulation of Sirt6 1 0.12 0.59 0
117 INT276275 Positive_regulation of Localization of SIRT2 1 0.04 0 0
118 INT276271 Transcription of SIRT2 1 0.05 0 0
119 INT220788 Regulation of Gene_expression of Art2b 1 0.03 0 0
120 INT276273 Positive_regulation of Protein_catabolism of SIRT2 1 0.04 0.06 0
121 INT204331 Binding of SIRT1 1 0.47 0.39 0
122 INT233121 Negative_regulation of Positive_regulation of SIRT2 1 0.03 0.26 0
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