GO:0006476

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Name protein deacetylation
Categary Process
Go Slim No
Go Link GO:0006476
Unique Molecular Interactions 161
Total Molecular Interactions 208
Total Single Events 1272
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein deacetylation. They are ordered first by their pain relevance and then by number of times they were reported for protein deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
4 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
5 INT227495 Regulation of Binding of TCEA1 and SIRT2 1 0.01 0.45 0.45
6 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
7 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
8 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
9 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
10 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
11 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
12 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
13 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
14 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
15 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
16 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
17 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
18 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
19 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
20 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
21 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
22 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
23 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
24 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
25 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
26 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
27 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
28 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
29 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
30 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
31 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
32 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
33 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
34 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
35 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
36 INT277615 Positive_regulation of Binding of ZNF238 and Hdac3 1 0.38 0.06 0.07
37 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
38 INT277614 Binding of ZNF238 and Hdac3 1 0.29 0.06 0.07
39 INT298806 Binding of Hdac3 and Rb1 1 0.02 0.77 0.05
40 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
41 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
42 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
43 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
44 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
45 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
46 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
47 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
48 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
49 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
50 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
51 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
52 INT332881 Negative_regulation of Binding of Hdac3 and Ncor1 1 0.28 0.18 0
53 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
54 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
55 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
56 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
57 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
58 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
59 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
60 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
61 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
62 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
63 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
64 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
65 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
66 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
67 INT339977 Positive_regulation of Binding of HDAC3 and HDAC7 1 0.23 0.52 0
68 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
69 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
70 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
71 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
72 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0
73 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
74 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
75 INT332894 Binding of Ahrr and Hdac3 1 0.01 0.08 0
76 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
77 INT332896 Binding of Hdac3 and Ncor1 1 0.31 1.38 0
78 INT339978 Binding of HDAC3 and HDAC7 1 0.17 1.04 0
79 INT332878 Hdac3 Negative_regulation of Gene_expression of Arntl 1 0.42 0.17 0
80 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
81 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
82 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
83 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
84 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
85 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
86 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
87 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
88 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
89 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0
90 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
91 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
92 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
93 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
94 INT332892 Ncor1 Positive_regulation of Hdac3 1 0.45 0.18 0
95 INT332879 Negative_regulation of Ncor1 Positive_regulation of Hdac3 1 0.28 0.18 0
96 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
97 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
98 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
99 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
100 INT233117 Binding of SIRT2 and PAMR1 1 0.00 0 0
101 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0
102 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
103 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
104 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
105 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein deacetylation. They are ordered first by their pain relevance and then by number of times they were reported in protein deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
2 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
3 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
4 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
5 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
6 INT180134 Gene_expression of SIRT2 70 0.11 6.95 1.84
7 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
8 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
9 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
10 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
11 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
12 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
13 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
14 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
15 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
16 INT180136 Localization of SIRT2 15 0.12 1.42 0.88
17 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
18 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
19 INT70423 Binding of HDAC3 1 0.01 0.36 0.75
20 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
21 INT180139 Protein_catabolism of SIRT2 11 0.14 1.1 0.72
22 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
23 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
24 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
25 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
26 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
27 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
28 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
29 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
30 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
31 INT180142 Negative_regulation of SIRT2 10 0.07 0.19 0.41
32 INT180138 Negative_regulation of Gene_expression of SIRT2 2 0.07 0.19 0.41
33 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
34 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
35 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
36 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
37 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
38 INT312879 Regulation of Hdac6 1 0.55 0.76 0.29
39 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
40 INT180144 Binding of SIRT2 57 0.06 1.29 0.27
41 INT312887 Gene_expression of Hdac6 1 0.60 1.28 0.25
42 INT312883 Regulation of Regulation of Hdac6 1 0.40 0.38 0.24
43 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
44 INT175663 Positive_regulation of SIRT2 56 0.14 3.58 0.17
45 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
46 INT298778 Phosphorylation of Hdac3 1 0.44 0.67 0.17
47 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
48 INT312881 Positive_regulation of Hdac6 1 0.45 0.67 0.15
49 INT233124 Positive_regulation of Gene_expression of SIRT2 17 0.04 0.16 0.14
50 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
51 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
52 INT265376 Gene_expression of Hdac3 4 0.51 1.8 0.13
53 INT337484 Gene_expression of HDAC3 2 0.37 0.15 0.13
54 INT341562 Negative_regulation of Gene_expression of HDAC3 1 0.23 0.05 0.13
55 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
56 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
57 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
58 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
59 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
60 INT331785 Negative_regulation of Gene_expression of Hdac3 1 0.04 0.86 0.1
61 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
62 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
63 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
64 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
65 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
66 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
67 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
68 INT312877 Positive_regulation of Negative_regulation of Hdac6 1 0.45 0 0.05
69 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
70 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
71 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
72 INT265372 Localization of Hdac3 3 0.55 0.6 0.04
73 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
74 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
75 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
76 INT265373 Regulation of Hdac3 2 0.17 1.1 0.03
77 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
78 INT256109 Positive_regulation of Gene_expression of Sirt6 1 0.21 0.52 0.03
79 INT312888 Phosphorylation of Hdac6 1 0.73 0 0.03
80 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
81 INT256123 Gene_expression of Sirt6 1 0.27 0.98 0.03
82 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
83 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
84 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
85 INT204349 Regulation of SIRT1 8 0.61 1.99 0
86 INT256134 Localization of Sirt1 5 0.50 2.99 0
87 INT233125 Positive_regulation of Positive_regulation of SIRT2 4 0.04 0 0
88 INT277595 Localization of Hdac1 4 0.73 0.81 0
89 INT204353 Transcription of SIRT1 3 0.68 0.67 0
90 INT180140 Regulation of SIRT2 3 0.04 0 0
91 INT233126 Regulation of Gene_expression of SIRT2 2 0.03 0 0
92 INT180146 Positive_regulation of Binding of SIRT2 2 0.08 0 0
93 INT265371 Binding of Hdac3 2 0.27 0.94 0
94 INT261751 Regulation of Hdac1 2 0.41 0 0
95 INT312873 Negative_regulation of Gene_expression of Hdac6 1 0.38 0 0
96 INT256128 Localization of Sirt6 1 0.32 0.58 0
97 INT233120 Regulation of Binding of SIRT2 1 0.03 0 0
98 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
99 INT265375 Negative_regulation of Hdac3 1 0.36 0.78 0
100 INT312885 Binding of Hdac6 1 0.43 0 0
101 INT319154 Transcription of Hdac1 1 0.66 0 0
102 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
103 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
104 INT289569 Transcription of Sirt1 1 0.71 0.25 0
105 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
106 INT312874 Regulation of Phosphorylation of Hdac6 1 0.40 0 0
107 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
108 INT300287 Localization of Sirt1 1 0.66 1.46 0
109 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
110 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
111 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
112 INT312876 Negative_regulation of Transcription of Hdac6 1 0.38 0 0
113 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
114 INT301188 Regulation of Positive_regulation of SIRT2 1 0.03 1.05 0
115 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
116 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
117 INT180143 Phosphorylation of SIRT2 1 0.13 0 0
118 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
119 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
120 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
121 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
122 INT256117 Regulation of Sirt6 1 0.12 0.59 0
123 INT312875 Transcription of Hdac6 1 0.61 0 0
124 INT276275 Positive_regulation of Localization of SIRT2 1 0.04 0 0
125 INT276271 Transcription of SIRT2 1 0.05 0 0
126 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
127 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
128 INT337460 Positive_regulation of Gene_expression of HDAC3 1 0.17 0.1 0
129 INT276273 Positive_regulation of Protein_catabolism of SIRT2 1 0.04 0.06 0
130 INT204331 Binding of SIRT1 1 0.47 0.39 0
131 INT312878 Protein_catabolism of Hdac6 1 0.88 0 0
132 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
133 INT233121 Negative_regulation of Positive_regulation of SIRT2 1 0.03 0.26 0
134 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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