GO:0006508

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Name proteolysis
Categary Process
Go Slim No
Go Link GO:0006508
Unique Molecular Interactions 3822
Total Molecular Interactions 5116
Total Single Events 48914
Pain Genes Associated 374

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
3 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
4 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
5 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
6 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
7 INT17300 Prss12 Positive_regulation of Localization of Acot1 4 0.11 0 3.28
8 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
9 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
10 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
11 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
12 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
13 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
14 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
15 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
16 INT150455 Binding of Prss12 and Nts 3 0.24 1.42 2.66
17 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
18 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
19 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
20 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
21 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
22 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
23 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
24 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
25 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
26 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
27 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
28 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
29 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
30 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
31 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
32 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
33 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
34 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
35 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
36 INT17299 Prss12 Regulation of Localization of Acot1 3 0.05 0 2.07
37 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
38 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
39 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
40 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
41 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
42 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
43 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
44 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
45 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
46 INT82867 Cck Regulation of Localization of Pgc 1 0.05 0 1.83
47 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
48 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
49 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
50 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
51 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
52 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
53 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
54 INT54484 Npepo Positive_regulation of Gene_expression of Fos 1 0.43 0 1.63
55 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
56 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
57 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
58 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
59 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
60 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
61 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
62 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
63 INT237286 Dlat Regulation of Prep 1 0.01 0 1.57
64 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
65 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
66 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
67 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
68 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
69 INT351366 LPA Positive_regulation of Rab38 1 0.00 0.95 1.53
70 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
71 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
72 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
73 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
74 INT104975 MITF Regulation of Transcription of PRSS1 1 0.68 0.35 1.46
75 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
76 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
77 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
78 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
79 INT31391 Binding of PRCP and Abpa 1 0.03 0.16 1.42
80 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
81 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
82 INT202910 Uchl1 Positive_regulation of Gene_expression of Tacr1 1 0.05 1.65 1.42
83 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
84 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
85 INT140314 PCSK7 Positive_regulation of LDHA 1 0.07 1.6 1.4
86 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
87 INT54490 Npepo Positive_regulation of Gene_expression of Pdyn 1 0.06 0 1.35
88 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33
89 INT777 Prss12 Positive_regulation of Prl 1 0.19 0 1.33
90 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
91 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3
92 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
93 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
94 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
95 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
96 INT139722 PROC Positive_regulation of CDCP1 1 0.00 1.61 1.29
97 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
98 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
99 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
100 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
101 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
102 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
103 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
104 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
105 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
106 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
107 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
108 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
109 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
110 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
111 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
112 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24
113 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
114 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24
115 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
116 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
117 INT20530 Nts Regulation of Prss12 5 0.24 0.74 1.23
118 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
119 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
120 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
121 INT187174 RPS3AP9 Negative_regulation of MMP2 1 0.00 0.9 1.22
122 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
123 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
124 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
125 INT187172 RPS3AP9 Negative_regulation of MMP9 1 0.00 0.89 1.2
126 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
127 INT264333 IL-17 Positive_regulation of Gene_expression of Mmp1a 1 0.05 2.88 1.18
128 INT182159 Binding of HGF and DCPS 1 0.01 2.5 1.17
129 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
130 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
131 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
132 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
133 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
134 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
135 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
136 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
137 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
138 INT34422 Cck Positive_regulation of Negative_regulation of Npepo 1 0.31 0 1.14
139 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
140 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14
141 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
142 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
143 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
144 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
145 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
146 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
147 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
148 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
149 INT59035 Binding of CPB1 and POMC 1 0.00 0 1.12
150 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
151 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
152 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
153 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
154 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
155 INT54486 Npepo Positive_regulation of Gene_expression of Rabep2 1 0.14 0 1.08
156 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
157 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08
158 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
159 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
160 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
161 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
162 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
163 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
164 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
165 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
166 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
167 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
168 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
169 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
170 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
171 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
172 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1 0.43 1.35 1.03
173 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
174 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
175 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
176 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
177 INT30135 S100A9 Positive_regulation of REN 1 0.32 0.32 1
178 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
179 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
180 INT344973 Negative_regulation of Mmp23 Regulation of Negative_regulation of Mag 1 0.01 1.14 0.99
181 INT314037 THL Negative_regulation of Localization of Plau 1 0.17 1.64 0.99
182 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
183 INT238091 Binding of GRIP1 and Mmp24 1 0.00 0 0.98
184 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
185 INT238092 Binding of SHBG and Mmp24 1 0.04 0 0.98
186 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
187 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
188 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97
189 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
190 INT219279 Ctss Positive_regulation of Gene_expression of Fam64a 1 0.06 1.39 0.96
191 INT195219 Binding of CPB2 and CSRP1 1 0.03 0.99 0.96
192 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96
193 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
194 INT219273 Fam64a Positive_regulation of Gene_expression of Ctss 1 0.06 1.39 0.96
195 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
196 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
197 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
198 INT351311 Has1 Regulation of Gene_expression of MMP3 1 0.11 1.15 0.95
199 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
200 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94

Single Events

The table below shows the top 100 pain related interactions that have been reported for proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
3 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
4 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
5 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
6 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
7 INT46 Localization of Ren 233 0.81 46.15 62.44
8 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
9 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72
10 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
11 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
12 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56
13 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
14 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
15 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15
16 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
17 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
18 INT117598 Regulation of ACR 118 0.26 41.25 48.01
19 INT654 Localization of REN 250 0.81 75.12 47.86
20 INT375 Positive_regulation of REN 293 0.70 152.46 47.55
21 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9
22 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12
23 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
24 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
25 INT5214 Localization of Cpe 49 0.73 13.3 44.36
26 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
27 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
28 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78
29 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
30 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
31 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48
32 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
33 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
34 INT223416 Gene_expression of Trhde 2 0.48 64.16 34.21
35 INT2699 Binding of Cpe 40 0.48 7.07 33.64
36 INT1116 Regulation of Ren 103 0.62 27.66 33.26
37 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
38 INT99610 Localization of MMP9 126 0.79 48.46 32.67
39 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
40 INT124860 Gene_expression of Bace1 330 0.78 157.11 31.65
41 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
42 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
43 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
44 INT660 Negative_regulation of REN 194 0.59 82.06 29.46
45 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
46 INT9650 Gene_expression of LPA 141 0.75 104.57 29
47 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
48 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
49 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71
50 INT8362 Localization of Prss12 53 0.78 5.09 27
51 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
52 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
53 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75
54 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7
55 INT2609 Localization of ELANE 111 0.81 50.22 26.63
56 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42
57 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14
58 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4
59 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39
60 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03
61 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89
62 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
63 INT2140 Regulation of REN 104 0.62 28.24 24.49
64 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
65 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
66 INT16431 Localization of Lnpep 62 0.70 6.28 23.94
67 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
68 INT34487 Localization of MMP2 56 0.81 31.41 23.61
69 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
70 INT310853 Positive_regulation of Gene_expression of Trhde 1 0.43 42.95 22.75
71 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57
72 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
73 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
74 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
75 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72
76 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36
77 INT4535 Localization of PROC 106 0.73 76.24 21.1
78 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
79 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4
80 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18
81 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86
82 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
83 INT12243 Positive_regulation of PRSS1 91 0.70 52.87 19.48
84 INT9490 Regulation of Mme 44 0.56 6.69 19.21
85 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
86 INT48 Positive_regulation of Localization of Ren 69 0.70 12.47 18.03
87 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95
88 INT132997 Localization of Mmp9 59 0.80 45.9 17.61
89 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
90 INT95767 Negative_regulation of Mmp9 72 0.57 49.14 17.1
91 INT1767 Positive_regulation of PROC 83 0.67 54.14 17
92 INT49379 Localization of MMP12 26 0.77 13.07 16.93
93 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
94 INT110767 Localization of Mcpt1 43 0.68 24.3 16.74
95 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7
96 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
97 INT99898 Gene_expression of Mmp14 37 0.56 28.54 16.39
98 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
99 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
100 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17
101 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
102 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86
103 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
104 INT131296 Positive_regulation of Bace1 208 0.70 170.1 15.79
105 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7
106 INT36554 Gene_expression of PRSS1 70 0.78 50.25 15.33
107 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25
108 INT81486 Localization of MMP3 31 0.81 12.94 15.21
109 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16
110 INT103210 Localization of MMP1 43 0.78 12.15 15.13
111 INT113606 Positive_regulation of Gene_expression of Mmp9 46 0.64 44 15.07
112 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06
113 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91
114 INT1284 Negative_regulation of Mmp13 20 0.57 36.21 14.91
115 INT14453 Localization of Mme 44 0.80 2.46 14.75
116 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31
117 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
118 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89
119 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85
120 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69
121 INT17938 Binding of Cpe 28 0.48 11.17 13.62
122 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56
123 INT24684 Localization of PLAT 30 0.78 26.21 13.56
124 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
125 INT95427 Positive_regulation of Mmp3 39 0.70 15.28 13.36
126 INT101147 Gene_expression of Uchl1 31 0.76 14.73 13.22
127 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
128 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79
129 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63
130 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62
131 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
132 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
133 INT11359 Gene_expression of PLAU 84 0.76 49.54 12.31
134 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
135 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99
136 INT13287 Gene_expression of Cpb2 27 0.56 7.84 11.95
137 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73
138 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64
139 INT481 Regulation of Localization of Ren 37 0.62 5.95 11.61
140 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54
141 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
142 INT661 Gene_expression of REN 100 0.78 48.21 11.36
143 INT68976 Positive_regulation of Gene_expression of Mmp9 34 0.42 28.21 11.28
144 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28
145 INT18334 Positive_regulation of Cpb2 24 0.69 2.98 11.22
146 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
147 INT96271 Positive_regulation of Gene_expression of Mcpt1 30 0.53 21.34 11.06
148 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03
149 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01
150 INT273123 Binding of Hp 1 0.25 3.56 10.9
151 INT4498 Gene_expression of F2 83 0.65 57.4 10.8
152 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77
153 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
154 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
155 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
156 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
157 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52
158 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51
159 INT34485 Negative_regulation of Localization of MMP2 17 0.50 9.96 10.49
160 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
161 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
162 INT89282 Regulation of MMP9 39 0.60 25.45 10.34
163 INT11205 Gene_expression of Prep 65 0.77 8.11 10.12
164 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11
165 INT119777 Negative_regulation of Naalad2 9 0.40 5.93 10.11
166 INT32344 Localization of LTF 30 0.80 15.28 10.09
167 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
168 INT27937 Gene_expression of Klkb1 35 0.55 1.86 10.08
169 INT10546 Positive_regulation of Prss12 12 0.44 4.57 10.05
170 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01
171 INT64054 Positive_regulation of Tmprss11d 19 0.67 9.33 9.99
172 INT113605 Negative_regulation of Gene_expression of Mmp9 25 0.41 22.92 9.98
173 INT95632 Positive_regulation of MMP8 26 0.70 10.06 9.96
174 INT113603 Negative_regulation of Gene_expression of Mcpt1 26 0.41 22.82 9.91
175 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81
176 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79
177 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71
178 INT140191 Positive_regulation of Gene_expression of Mmp13 25 0.67 13.47 9.71
179 INT102987 Regulation of MMP3 23 0.60 9.35 9.54
180 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
181 INT72789 Gene_expression of Cpa1 29 0.50 12.36 9.47
182 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42
183 INT18941 Regulation of Enpep 17 0.55 2.56 9.38
184 INT8360 Positive_regulation of Localization of Prss12 14 0.26 1.72 9.38
185 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
186 INT125247 Negative_regulation of Mmp9 42 0.43 23.68 9.37
187 INT13593 Binding of Prss12 13 0.36 4.35 9.37
188 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
189 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31
190 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
191 INT20664 Binding of ACE 60 0.48 35.27 9.16
192 INT20425 Localization of Cpe 23 0.81 5.18 9.14
193 INT48233 Negative_regulation of Gene_expression of MMP1 34 0.58 12.94 9.08
194 INT1168 Binding of PROC 62 0.38 44.15 9.04
195 INT4534 Regulation of PROC 38 0.33 19.81 8.99
196 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93
197 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
198 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
199 INT13432 Positive_regulation of Klkb1 23 0.57 5.36 8.65
200 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61
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