GO:0006509

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Name membrane protein ectodomain proteolysis
Categary Process
Go Slim No
Go Link GO:0006509
Unique Molecular Interactions 212
Total Molecular Interactions 271
Total Single Events 2793
Pain Genes Associated 26

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for membrane protein ectodomain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for membrane protein ectodomain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
3 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
4 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
5 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
6 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
7 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
8 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
9 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
10 INT355815 BACE1 Regulation of Positive_regulation of NAV1 1 0.32 0.26 0.72
11 INT163946 Binding of ERAP1 and Il23r 1 0.23 0.56 0.72
12 INT355814 BACE1 Regulation of Gene_expression of NAV1 1 0.37 0.24 0.72
13 INT160711 Binding of KIR3DL1 and ERAP1 1 0.15 0.71 0.71
14 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
15 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
16 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
17 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
18 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
19 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
20 INT156557 TRPV6 Positive_regulation of BACE2 1 0.00 0.23 0.58
21 INT156558 TRPV6 Negative_regulation of BACE2 1 0.00 0.23 0.58
22 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
23 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
24 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
25 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
26 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
27 INT355817 BACE1 Regulation of NAV1 1 0.37 0.7 0.45
28 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
29 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
30 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
31 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
32 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
33 INT329954 Binding of PRKCQ and SNRNP70 1 0.07 0.65 0.33
34 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
35 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
36 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
37 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
38 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
39 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
40 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
41 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
42 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
43 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
44 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
45 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
46 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
47 INT189670 CHKB Negative_regulation of Gene_expression of DAG1 1 0.11 0 0.24
48 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
49 INT335464 Binding of DAG1 and PRKCA 1 0.03 0 0.22
50 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
51 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
52 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
53 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
54 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
55 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
56 INT139848 Binding of Bace1 and Bace2 2 0.28 0.31 0.18
57 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
58 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
59 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
60 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
61 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
62 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
63 INT352763 Sms Regulation of Gene_expression of DAG1 1 0.08 0.64 0.11
64 INT243996 Binding of Dag1 and Dmd 1 0.04 0.08 0.11
65 INT139851 Binding of MBTPS1 and Bace2 1 0.00 0.16 0.1
66 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
67 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
68 INT54095 ERAP1 Regulation of Protein_catabolism of Fgg 1 0.00 0 0.09
69 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
70 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
71 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
72 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
73 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
74 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
75 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
76 INT244027 Binding of Dag1 and Helt 1 0.00 0.05 0.08
77 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
78 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
79 INT283126 Dag1 Positive_regulation of Localization of Aqp4 1 0.47 0.2 0.07
80 INT352766 DAG1 Positive_regulation of Prkd1 1 0.15 0.38 0.07
81 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
82 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
83 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
84 INT220638 Gene_expression of Bace2 Positive_regulation of Localization of Il1r2 1 0.13 0.19 0.07
85 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
86 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
87 INT345245 Adam9 Regulation of Adam10 1 0.09 0.18 0.05
88 INT352762 DAG1 Regulation of Sms 1 0.03 0.37 0.05
89 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
90 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
91 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
92 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
93 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
94 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
95 INT352764 DAG1 Positive_regulation of Sms 1 0.06 0.11 0.03
96 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
97 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
98 INT230134 Binding of SORL1 and BACE1 1 0.19 0.09 0
99 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
100 INT130531 BACE1 Regulation of Gene_expression of BACE2 1 0.40 0.18 0
101 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
102 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
103 INT342358 Binding of Irs1 and Erap1 1 0.37 0 0
104 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0
105 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
106 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
107 INT217399 Binding of Bace1 and Ncstn 1 0.05 0.72 0
108 INT342367 Binding of Erap1 and OSBPL1A 1 0.39 0 0
109 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
110 INT230762 Binding of DAG1 and Tbx15 1 0.00 0.21 0
111 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
112 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
113 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
114 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
115 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
116 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
117 INT283122 Binding of Dag1 and Sptbn1 1 0.00 0.07 0
118 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
119 INT285396 Binding of Adam17 and R3hcc1 1 0.15 0.93 0
120 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
121 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
122 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
123 INT130533 BACE1 Regulation of SNAP25 1 0.27 0.18 0
124 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
125 INT159710 Binding of Tap1 and ERAP1 1 0.04 0.11 0
126 INT152402 Binding of Il1a and ERAP1 1 0.00 0.06 0
127 INT130532 BACE2 Regulation of SNAP25 1 0.12 0.18 0
128 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
129 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
130 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
131 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
132 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
133 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
134 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
135 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
136 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
137 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
138 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
139 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
140 INT352765 DAG1 Regulation of Localization of Prkd1 1 0.09 0.09 0
141 INT356107 Binding of Ncstn and Aph1a 1 0.05 0.06 0
142 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
143 INT262707 Bace2 Positive_regulation of Bace1 1 0.33 0.15 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for membrane protein ectodomain proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in membrane protein ectodomain proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
5 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
6 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
7 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
8 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
9 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
10 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
11 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
12 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
13 INT107070 Gene_expression of BACE1 11 0.68 8.63 6.16
14 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
15 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
16 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
17 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
18 INT111068 Regulation of Psenen 6 0.35 4.17 4.33
19 INT137795 Positive_regulation of BACE1 3 0.68 4.74 4.31
20 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
21 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
22 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
23 INT103489 Positive_regulation of Bace2 5 0.03 3.3 3.47
24 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
25 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
26 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
27 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
28 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
29 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
30 INT159709 Binding of ERAP1 12 0.47 3.42 2.91
31 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
32 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
33 INT63846 Gene_expression of Prkcq 1 0.73 1.11 2.58
34 INT163544 Binding of Psen1 40 0.36 15.28 2.42
35 INT107068 Negative_regulation of BACE1 5 0.42 1.81 2.2
36 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
37 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
38 INT60723 Localization of Psen2 5 0.68 2.11 2.02
39 INT161121 Binding of Erap1 2 0.48 1.99 1.99
40 INT137797 Positive_regulation of Gene_expression of BACE1 2 0.59 2.15 1.99
41 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
42 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
43 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
44 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
45 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
46 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
47 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
48 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
49 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
50 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
51 INT139982 Positive_regulation of BACE2 6 0.42 4.33 1.48
52 INT114203 Positive_regulation of Bace2 6 0.52 4.89 1.46
53 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
54 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
55 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
56 INT220578 Gene_expression of Bace2 12 0.60 4.32 1.36
57 INT173328 Positive_regulation of DAG1 6 0.31 1.74 1.36
58 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
59 INT156564 Negative_regulation of Gene_expression of BACE1 2 0.36 0.36 1.32
60 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
61 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
62 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
63 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
64 INT63849 Regulation of Gene_expression of Prkcq 1 0.58 0.62 1.24
65 INT63847 Regulation of Prkcq 1 0.42 0.5 1.23
66 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
67 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
68 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
69 INT142957 Binding of BACE1 3 0.37 0.83 1.17
70 INT107071 Localization of BACE1 3 0.64 0.19 1.16
71 INT63856 Positive_regulation of Gene_expression of Prkcq 1 0.47 0.53 1.16
72 INT189771 Gene_expression of DAG1 5 0.27 4.14 1.12
73 INT211095 Negative_regulation of Dag1 14 0.57 7.18 1.07
74 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
75 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
76 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
77 INT91767 Gene_expression of BACE2 5 0.69 2.48 0.96
78 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
79 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
80 INT64044 Localization of DAG1 3 0.59 0.27 0.87
81 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87
82 INT29981 Binding of PSENEN 2 0.17 0.24 0.86
83 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
84 INT89668 Positive_regulation of Prkcq 1 0.09 0.22 0.86
85 INT180100 Positive_regulation of Adam10 6 0.33 2 0.84
86 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
87 INT114086 Regulation of Bace2 1 0.02 0.94 0.82
88 INT115441 Positive_regulation of Aph1a 1 0.02 0.46 0.82
89 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
90 INT144730 Negative_regulation of Psenen 3 0.31 1.07 0.78
91 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
92 INT134789 Negative_regulation of Gene_expression of Adam10 1 0.30 1.22 0.78
93 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
94 INT45645 Negative_regulation of Erap1 2 0.11 0.07 0.77
95 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
96 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
97 INT145747 Regulation of ERAP1 1 0.25 0.19 0.76
98 INT8146 Gene_expression of PSENEN 2 0.14 0.89 0.75
99 INT355827 Protein_catabolism of BACE1 1 0.76 0.24 0.74
100 INT78649 Binding of Psen2 7 0.36 5.9 0.73
101 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
102 INT99822 Negative_regulation of Gene_expression of BACE2 1 0.01 0.59 0.7
103 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
104 INT193863 Gene_expression of Ncstn 7 0.29 3.88 0.66
105 INT144731 Binding of Psenen 3 0.26 1.02 0.66
106 INT283119 Regulation of Dag1 4 0.44 1.98 0.65
107 INT355820 Positive_regulation of Positive_regulation of BACE1 1 0.49 0.26 0.64
108 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
109 INT355826 Positive_regulation of Localization of BACE1 1 0.43 0 0.62
110 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
111 INT283110 Localization of Dag1 5 0.73 3.14 0.61
112 INT154643 Negative_regulation of ERAP1 1 0.11 0.69 0.58
113 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
114 INT161505 Negative_regulation of Bace2 2 0.01 1.93 0.55
115 INT327666 Regulation of Adam10 1 0.20 0 0.55
116 INT156568 Regulation of Positive_regulation of Bace2 1 0.00 0.22 0.55
117 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
118 INT228248 Gene_expression of Adam9 4 0.45 1.63 0.51
119 INT167612 Binding of Bace2 1 0.17 0.86 0.51
120 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
121 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
122 INT167609 Localization of Bace2 1 0.34 0.85 0.5
123 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
124 INT114206 Negative_regulation of Bace2 3 0.30 1.98 0.48
125 INT237402 Positive_regulation of Gene_expression of Ncstn 3 0.26 2.78 0.48
126 INT63850 Negative_regulation of Prkcq 1 0.40 0 0.46
127 INT147427 Gene_expression of Psenen 1 0.17 0.75 0.45
128 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
129 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
130 INT121118 Regulation of Protein_catabolism of Aph1a 1 0.06 0.35 0.45
131 INT121119 Protein_catabolism of Aph1a 1 0.13 0.35 0.45
132 INT147431 Regulation of Gene_expression of Psenen 1 0.11 0.75 0.45
133 INT167610 Positive_regulation of Protein_catabolism of Bace2 1 0.22 0.88 0.44
134 INT167613 Positive_regulation of Protein_catabolism of Psenen 1 0.09 0.88 0.44
135 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
136 INT167611 Protein_catabolism of Psenen 1 0.15 0.88 0.43
137 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
138 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
139 INT167615 Protein_catabolism of Bace2 1 0.40 0.88 0.42
140 INT193856 Localization of Psen1 19 0.73 9.79 0.41
141 INT137796 Regulation of BACE1 3 0.41 2.92 0.4
142 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
143 INT251556 Localization of Adam17 2 0.38 2 0.39
144 INT139984 Negative_regulation of BACE2 1 0.39 0.66 0.39
145 INT283120 Regulation of Gene_expression of Dag1 4 0.52 1.32 0.38
146 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
147 INT284325 Positive_regulation of Gene_expression of DAG1 3 0.13 1.08 0.36
148 INT133862 Positive_regulation of Positive_regulation of Bace2 1 0.35 1.14 0.33
149 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
150 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
151 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
152 INT316044 Positive_regulation of Ncstn 1 0.20 1.37 0.32
153 INT133860 Negative_regulation of Positive_regulation of Bace2 1 0.32 1.13 0.32
154 INT79244 Regulation of BACE2 1 0.03 1.21 0.32
155 INT246100 Positive_regulation of Gene_expression of Adam10 4 0.61 1.2 0.3
156 INT144732 Positive_regulation of Negative_regulation of Psenen 1 0.36 0.23 0.3
157 INT135096 Gene_expression of Bace2 1 0.03 0.76 0.3
158 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
159 INT130535 Regulation of Gene_expression of BACE1 2 0.54 2.61 0.29
160 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
161 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
162 INT62619 Positive_regulation of Negative_regulation of Erap1 1 0.05 0 0.27
163 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
164 INT356075 Negative_regulation of Gene_expression of Bace2 1 0.30 0.99 0.27
165 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
166 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
167 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
168 INT220598 Positive_regulation of Binding of Bace2 3 0.39 0.64 0.24
169 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
170 INT78865 Localization of Adam17 1 0.43 0.34 0.23
171 INT286203 Protein_catabolism of Dag1 2 0.26 1.56 0.22
172 INT316917 Negative_regulation of Protein_catabolism of Dag1 1 0.12 0.44 0.21
173 INT283102 Positive_regulation of Dag1 1 0.49 1.31 0.21
174 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
175 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
176 INT220603 Positive_regulation of Gene_expression of Bace2 2 0.54 0.38 0.19
177 INT133864 Positive_regulation of Protein_catabolism of Psenen 1 0.09 0.9 0.19
178 INT243937 Binding of Dag1 1 0.05 0.13 0.19
179 INT133861 Protein_catabolism of Psenen 1 0.16 0.89 0.19
180 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
181 INT203867 Localization of BACE2 2 0.43 1.38 0.17
182 INT283105 Positive_regulation of Gene_expression of Dag1 1 0.67 1.19 0.17
183 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
184 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
185 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
186 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
187 INT237404 Regulation of Positive_regulation of Adam10 1 0.30 0.83 0.16
188 INT220611 Binding of Bace2 4 0.29 1.47 0.15
189 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
190 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
191 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
192 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
193 INT342327 Positive_regulation of Erap1 1 0.43 1.1 0.13
194 INT130539 Transcription of BACE1 1 0.47 1.35 0.12
195 INT137794 Regulation of Transcription of BACE1 1 0.19 1.18 0.12
196 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
197 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
198 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
199 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
200 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
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