GO:0006518

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Name peptide metabolic process
Categary Process
Go Slim No
Go Link GO:0006518
Unique Molecular Interactions 217
Total Molecular Interactions 295
Total Single Events 2968
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for peptide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
2 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
3 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
4 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
5 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
6 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
7 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
8 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
9 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
10 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
11 INT111760 Dio1 Positive_regulation of Binding of Cpe 1 0.04 0.34 1.44
12 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
13 INT111756 Dio1 Positive_regulation of Cpe 1 0.04 0.34 1.42
14 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
15 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
16 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
17 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
18 INT43446 Binding of Cpe and H3 1 0.02 0 1.25
19 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
20 INT33605 DFP Positive_regulation of Cpe 1 0.16 0 1.16
21 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
22 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
23 INT84488 Negative_regulation of Binding of Cpe and Mif-ps1 1 0.06 0 1.13
24 INT84487 Binding of Cpe and Mif-ps1 1 0.05 0 1.13
25 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
26 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
27 INT161011 Binding of Cpe and St13 2 0.03 0.61 1.07
28 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
29 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
30 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
31 INT147232 Binding of tn and Cpe 1 0.03 1.55 0.95
32 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
33 INT12373 SCN5A Negative_regulation of Cpe 1 0.00 0 0.94
34 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
35 INT59482 Cpe Positive_regulation of Rbm39 1 0.02 0 0.89
36 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
37 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
38 INT92423 EC3 Negative_regulation of Mme 1 0.02 0.28 0.86
39 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85
40 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84
41 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
42 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
43 INT41864 Nts Regulation of Cpe 1 0.01 0 0.84
44 INT41867 GRP Regulation of Cpe 1 0.00 0 0.84
45 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83
46 INT61130 LTA4H Positive_regulation of CPQ 1 0.28 0 0.83
47 INT111743 Negative_regulation of Pcsk2 Positive_regulation of Cpe 1 0.06 0 0.8
48 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
49 INT26982 Cpe Regulation of Localization of Pomc 1 0.01 0 0.75
50 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
51 INT46916 Binding of Thop1 and Positive_regulation of Penk 1 0.14 0 0.74
52 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
53 INT46920 Thop1 Regulation of Vom1r1 1 0.03 0 0.74
54 INT46918 Binding of Thop1 and Positive_regulation of Vom1r1 1 0.03 0 0.74
55 INT26986 Cpe Regulation of Pomc 1 0.01 0 0.73
56 INT26990 Pomc Regulation of Cpe 1 0.01 0 0.73
57 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
58 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
59 INT29380 Binding of gp and Mme 1 0.01 0 0.71
60 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
61 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
62 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
63 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
64 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
65 INT29381 gp Regulation of Mme 1 0.01 0 0.65
66 INT29382 Positive_regulation of gp Regulation of Mme 1 0.02 0 0.65
67 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
68 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
69 INT2700 Binding of App and Cpe 1 0.00 0 0.63
70 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
71 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62
72 INT63525 Cpe Positive_regulation of Gpi1 1 0.03 0 0.59
73 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
74 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
75 INT270935 Cpe Regulation of Phosphorylation of Slc6a3 1 0.31 0 0.57
76 INT84489 Cpe Negative_regulation of Binding of Mif-ps1 1 0.06 0 0.56
77 INT28925 Cpe Regulation of Sh2b3 1 0.04 0.14 0.55
78 INT54239 Binding of Mme and Nts 1 0.21 0 0.54
79 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
80 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
81 INT270937 Cpe Regulation of Slc6a3 1 0.36 0 0.5
82 INT47225 Asap1 Regulation of Cpe 1 0.04 0.18 0.49
83 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
84 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
85 INT6280 Cpe Regulation of Gene_expression of Mc2r 1 0.09 0 0.46
86 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
87 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
88 INT6279 Cpe Regulation of Gene_expression of Pomc 1 0.27 0 0.46
89 INT41039 Thop1 Positive_regulation of Mme 1 0.01 0 0.45
90 INT90642 Cpe Negative_regulation of Negative_regulation of Slc6a3 1 0.04 0 0.44
91 INT92422 Mme Negative_regulation of EC3 1 0.01 0.14 0.43
92 INT189309 Binding of MME and PENK 1 0.15 1.16 0.42
93 INT61131 NEU2 Positive_regulation of CPQ 1 0.01 0 0.41
94 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
95 INT42847 Binding of Cpe and SLTM 1 0.00 0 0.38
96 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
97 INT80694 Cpe Negative_regulation of Positive_regulation of Fos 1 0.08 0 0.37
98 INT161004 Binding of Cpe and Cpb2 1 0.03 0.53 0.37
99 INT161000 Binding of Cpe and Gfap 1 0.05 0.53 0.37
100 INT4876 Regulation of TNF Regulation of MME 1 0.37 0.36 0.37
101 INT270939 Gene_expression of Cpe Positive_regulation of Slc6a3 1 0.20 0 0.36
102 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
103 INT75941 Negative_regulation of Binding of Cpe and Frk 1 0.01 1.28 0.34
104 INT75946 Binding of Cpe and Frk 1 0.01 1.28 0.34
105 INT92444 Cpe Negative_regulation of Phosphorylation of Cd3eap 1 0.01 0 0.34
106 INT37328 Binding of PDYN and Mme 1 0.02 0 0.34
107 INT75942 Positive_regulation of Binding of Cpe and Frk 1 0.02 1.28 0.34
108 INT75949 Negative_regulation of Binding of Cpe and Ptafr 1 0.03 1.27 0.33
109 INT75953 Binding of Cpe and Ptafr 1 0.03 1.27 0.33
110 INT24127 Cast Positive_regulation of Mme 1 0.15 0 0.33
111 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
112 INT75940 Positive_regulation of Binding of Cpe and Ptafr 1 0.04 1.27 0.33
113 INT115161 Adora2a Regulation of Gene_expression of Cpe 1 0.04 0.36 0.33
114 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
115 INT15141 MME Negative_regulation of IL1B 1 0.39 0.19 0.32
116 INT35216 Binding of KNG1 and Thop1 1 0.01 0 0.32
117 INT110462 Cpe Regulation of Phosphorylation of Gtf3a 1 0.00 0 0.32
118 INT31276 Oxt Negative_regulation of Cpe 1 0.01 0 0.31
119 INT31275 Avp Negative_regulation of Cpe 1 0.00 0 0.31
120 INT31277 Penk Negative_regulation of Cpe 1 0.12 0 0.29
121 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
122 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
123 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
124 INT270954 Gene_expression of Cpe Positive_regulation of Gene_expression of Slc6a3 1 0.23 0 0.28
125 INT15142 MME Regulation of IL1B 1 0.40 0.16 0.28
126 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
127 INT33584 Enpep Positive_regulation of Cpe 1 0.03 0 0.27
128 INT118928 Csf2 Regulation of Cpe 1 0.04 0.27 0.27
129 INT310771 Pam Positive_regulation of TNF 1 0.02 0.29 0.27
130 INT33583 Enpep Regulation of Positive_regulation of Cpe 1 0.03 0 0.27
131 INT310768 Pam Positive_regulation of Cxcl2 1 0.01 0.29 0.26
132 INT33582 Thop1 Regulation of Positive_regulation of Cpe 1 0.01 0 0.26
133 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
134 INT270955 Cpe Regulation of Gene_expression of Slc6a3 1 0.14 0 0.25
135 INT270951 Regulation of Binding of Slc6a3 and Cpe 1 0.23 0 0.25
136 INT64726 Ace Negative_regulation of KNG1 1 0.01 0.26 0.25
137 INT64727 Ace Positive_regulation of KNG1 1 0.01 0.26 0.25
138 INT239238 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.01 0.46 0.24
139 INT124078 Binding of Ace and Cpox 1 0.09 0.14 0.24
140 INT160464 Binding of Mme and Lnpep 1 0.31 0.37 0.24
141 INT270940 Negative_regulation of Binding of Slc6a3 and Cpe 1 0.25 0 0.23
142 INT270948 Cpe Regulation of Regulation of Slc6a3 1 0.14 0.28 0.23
143 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22
144 INT200637 Binding of Abpa and Ace 1 0.01 4.62 0.22
145 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
146 INT74431 Negative_regulation of Cpe Positive_regulation of Localization of PENK 1 0.44 0 0.2
147 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
148 INT74436 Negative_regulation of Cpe Positive_regulation of CHGA 1 0.44 0 0.2
149 INT74434 Negative_regulation of Cpe Positive_regulation of PENK 1 0.44 0 0.2
150 INT270947 Cpe Negative_regulation of Phosphorylation of Slc6a3 1 0.25 0 0.2
151 INT8164 Ace Positive_regulation of Gene_expression of Fos 1 0.24 0.32 0.16
152 INT258812 Sugt1 Positive_regulation of Ace 1 0.05 1.26 0.16
153 INT154367 Binding of Pam and Melc 1 0.02 0.15 0.15
154 INT307807 Ace Positive_regulation of ras 1 0.38 3 0.15
155 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
156 INT256021 Ace Negative_regulation of Gene_expression of Agtrap 1 0.05 0.37 0.13
157 INT270355 Vcsa1 Positive_regulation of Negative_regulation of Mme 1 0.13 0.52 0.12
158 INT43095 Binding of Ace and Mme 1 0.26 0 0.12
159 INT26316 Binding of MME and KRT20 1 0.16 0.57 0.12
160 INT294778 PAM Positive_regulation of Gene_expression of TLR2 1 0.01 0.41 0.11
161 INT229364 Ace Positive_regulation of Protein_catabolism of KNG1 1 0.02 0.86 0.11
162 INT294776 PAM Positive_regulation of TLR4 1 0.00 0.17 0.1
163 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1
164 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
165 INT294772 PAM Positive_regulation of TLR2 1 0.00 0.17 0.1
166 INT104737 Ace Positive_regulation of Gene_expression of Ren1 1 0.35 0.09 0.09
167 INT37744 Negative_regulation of CPQ Negative_regulation of GBE1 1 0.02 0 0.09
168 INT36128 Binding of Scd1 and Mme 1 0.00 0 0.09
169 INT168549 Binding of MME and NCAM1 1 0.00 1.43 0.08
170 INT307805 Ace Positive_regulation of Ang 1 0.32 1.52 0.07
171 INT307806 Ace Positive_regulation of Agt 1 0.28 1.51 0.07
172 INT270983 Binding of Cpe and GSTK1 1 0.01 0.12 0.07
173 INT330487 Binding of MME and HPSE 1 0.35 0 0.06
174 INT209611 Binding of Mme and Cd34 1 0.00 1.05 0.06
175 INT200635 Binding of Ace and Spink1 1 0.37 1.4 0.05
176 INT29521 Ace Positive_regulation of ACE 1 0.19 0 0.04
177 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04
178 INT270956 Slc6a3 Positive_regulation of Cpe 1 0.29 0 0.03
179 INT197784 Binding of Cpe and Ptgs1 1 0.20 0 0.03
180 INT270941 Slc6a3 Positive_regulation of Binding of Cpe 1 0.29 0 0.03
181 INT109818 Ace Regulation of ras 1 0.04 0.3 0
182 INT322250 Ace Regulation of Gene_expression of Agt 1 0.43 0.63 0
183 INT312372 Binding of MME and TCHP 1 0.06 1.56 0
184 INT307804 Ace Positive_regulation of Gene_expression of Scrib 1 0.21 2.43 0
185 INT134563 Cpe Positive_regulation of Gene_expression of Ifng 1 0.39 0 0
186 INT205393 MME Regulation of Gene_expression of ANPEP 1 0.26 1.49 0
187 INT205388 Binding of HSPB1 and MME 1 0.22 1.36 0
188 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0
189 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0
190 INT322240 Ace Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
191 INT322239 Ace Regulation of Gene_expression of Agtrap 1 0.44 0.63 0
192 INT1181 Negative_regulation of Ace Positive_regulation of Ren 1 0.52 0.23 0
193 INT74438 POMC Positive_regulation of Binding of Cpe 1 0.44 0 0
194 INT74432 Binding of POMC and Cpe 1 0.27 0 0
195 INT134560 Cpe Negative_regulation of Gene_expression of Il2 1 0.17 0 0
196 INT134562 Cpe Regulation of Gene_expression of Ifng 1 0.30 0 0
197 INT160761 Cma1 Regulation of Positive_regulation of ENG 1 0.01 0.07 0
198 INT322253 Agt Regulation of Gene_expression of Ace 1 0.43 0.63 0
199 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
200 INT65004 Negative_regulation of Ace Positive_regulation of Agt 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in peptide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
2 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
3 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
4 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
5 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
6 INT5214 Localization of Cpe 49 0.73 13.3 44.36
7 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
8 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
9 INT2699 Binding of Cpe 40 0.48 7.07 33.64
10 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
11 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
12 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
13 INT9490 Regulation of Mme 44 0.56 6.69 19.21
14 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
15 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
16 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
17 INT14453 Localization of Mme 44 0.80 2.46 14.75
18 INT17938 Binding of Cpe 28 0.48 11.17 13.62
19 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94
20 INT5959 Protein_catabolism of Cpe 17 0.90 0.98 12.43
21 INT12372 Negative_regulation of Localization of Cpe 12 0.53 1.85 11.39
22 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09
23 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
24 INT20425 Localization of Cpe 23 0.81 5.18 9.14
25 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87
26 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61
27 INT13840 Negative_regulation of CPQ 19 0.57 1.25 8.36
28 INT4880 Regulation of MME 17 0.61 7.78 8.2
29 INT14033 Negative_regulation of Gene_expression of Cpe 10 0.33 3.47 8.2
30 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
31 INT25958 Regulation of Ace 26 0.59 11.88 7.87
32 INT9389 Regulation of Cpe 14 0.61 2.23 7.79
33 INT8603 Binding of Mme 28 0.48 1.42 7.64
34 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
35 INT38466 Positive_regulation of Localization of Cpe 7 0.29 1.36 7.2
36 INT62691 Transcription of Cpe 11 0.40 3.5 6.66
37 INT25822 Negative_regulation of Positive_regulation of Cpe 7 0.29 2.43 6.02
38 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
39 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
40 INT8653 Protein_catabolism of Thop1 13 0.92 0.73 5.16
41 INT20064 Regulation of Gene_expression of Cpe 9 0.47 2.05 5.16
42 INT34358 Binding of MME 13 0.37 7.25 5.14
43 INT71841 Negative_regulation of Thop1 7 0.48 0.41 5.08
44 INT24619 Regulation of Thop1 11 0.44 1.24 4.5
45 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34
46 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
47 INT387 Regulation of Ace 18 0.45 5.24 4.24
48 INT21817 Binding of Thop1 9 0.48 0.88 4.19
49 INT26773 Protein_catabolism of CPQ 8 0.86 0.17 3.49
50 INT11616 Gene_expression of Thop1 10 0.74 0.32 3.34
51 INT35910 Binding of Mme 8 0.37 4.79 3.16
52 INT54364 Negative_regulation of Protein_catabolism of Cpe 4 0.53 0.15 3.14
53 INT37111 Regulation of Negative_regulation of Mme 7 0.44 2.61 3.13
54 INT35548 Regulation of Mme 9 0.45 10.62 2.97
55 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93
56 INT21343 Regulation of Localization of Cpe 3 0.21 1.38 2.83
57 INT11291 Positive_regulation of Gene_expression of Mme 6 0.61 5.93 2.81
58 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
59 INT7148 Negative_regulation of Negative_regulation of Mme 6 0.42 2.19 2.74
60 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
61 INT1488 Negative_regulation of Negative_regulation of Cpe 3 0.42 0.86 2.42
62 INT5958 Positive_regulation of Positive_regulation of Cpe 3 0.38 0.58 2.39
63 INT6404 Gene_expression of Thop1 3 0.64 0.18 2.36
64 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
65 INT9386 Transcription of Cpe 7 0.72 0.53 2.31
66 INT26434 Localization of MME 17 0.81 8.67 2.3
67 INT9354 Negative_regulation of Binding of Cpe 3 0.21 0.09 2.3
68 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27
69 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19
70 INT21819 Localization of Thop1 7 0.79 0.36 2.14
71 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
72 INT51980 Protein_catabolism of Mme 6 0.89 2.49 2.06
73 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2
74 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
75 INT43084 Binding of Ace 10 0.46 4.7 1.93
76 INT55606 Binding of Ace 14 0.37 10.73 1.82
77 INT110579 Negative_regulation of Gene_expression of MME 15 0.58 12.8 1.81
78 INT87315 Negative_regulation of Transcription of Cpe 3 0.13 1.76 1.81
79 INT29330 Positive_regulation of Thop1 6 0.46 1.05 1.8
80 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8
81 INT91560 Positive_regulation of Negative_regulation of Cpe 2 0.40 0.62 1.67
82 INT23306 Positive_regulation of CPQ 4 0.33 0.5 1.65
83 INT86558 Negative_regulation of Cma1 5 0.45 3.11 1.59
84 INT40271 Localization of Pam 1 0.74 0.65 1.51
85 INT112655 Negative_regulation of PAM 3 0.57 0.97 1.39
86 INT111755 Regulation of Positive_regulation of Cpe 1 0.03 0.27 1.37
87 INT26772 Regulation of CPQ 5 0.45 0.18 1.35
88 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33
89 INT11207 Positive_regulation of Gene_expression of Cpe 3 0.46 0.17 1.33
90 INT23308 Gene_expression of CPQ 12 0.71 0.54 1.3
91 INT20424 Protein_catabolism of Cpe 3 0.52 0 1.28
92 INT43941 Transcription of Mme 6 0.68 0.78 1.26
93 INT44142 Negative_regulation of Protein_catabolism of Thop1 1 0.41 0 1.24
94 INT43940 Regulation of Transcription of Mme 1 0.44 0 1.22
95 INT122783 Regulation of Transcription of Cpe 2 0.20 0.21 1.21
96 INT64948 Positive_regulation of Negative_regulation of MME 1 0.43 0 1.21
97 INT118781 Protein_catabolism of Thop1 1 0.15 0.05 1.2
98 INT118780 Positive_regulation of Protein_catabolism of Thop1 1 0.08 0.05 1.2
99 INT34704 Positive_regulation of Negative_regulation of Mme 6 0.47 0.17 1.17
100 INT49486 Gene_expression of Cma1 6 0.52 4.17 1.13
101 INT71541 Gene_expression of Pam 6 0.77 2.02 1.12
102 INT88948 Localization of Ace 9 0.69 9.18 1.11
103 INT25401 Negative_regulation of Gene_expression of Mme 2 0.43 0.08 1.1
104 INT40273 Gene_expression of Pam 2 0.57 0.28 1.08
105 INT43136 Regulation of Protein_catabolism of CPQ 3 0.31 0.17 1.01
106 INT74145 Localization of CPQ 2 0.68 1.7 1.01
107 INT58755 Binding of PAM 6 0.34 3.09 0.97
108 INT7149 Phosphorylation of Mme 3 0.60 0.34 0.97
109 INT74144 Positive_regulation of Localization of CPQ 1 0.21 0.51 0.97
110 INT21842 Regulation of Protein_catabolism of Mme 1 0.19 0.58 0.97
111 INT43648 Positive_regulation of Binding of Mme 3 0.50 0.24 0.94
112 INT12888 Positive_regulation of Protein_catabolism of Cpe 1 0.55 0.21 0.94
113 INT39226 Positive_regulation of Negative_regulation of Cpe 2 0.45 0.17 0.93
114 INT41480 Positive_regulation of Binding of Cpe 1 0.15 0.42 0.92
115 INT37377 Negative_regulation of Binding of Mme 2 0.38 1.79 0.88
116 INT255622 Positive_regulation of PAM 7 0.18 4.89 0.87
117 INT29636 Localization of PAM 5 0.73 2.1 0.87
118 INT58759 Positive_regulation of Binding of PAM 1 0.24 0.57 0.85
119 INT230803 Regulation of Negative_regulation of Ace 2 0.39 1.89 0.81
120 INT47740 Regulation of Regulation of Mme 2 0.24 0.52 0.8
121 INT40276 Binding of Pam 2 0.34 0.73 0.75
122 INT18889 Positive_regulation of Pam 2 0.61 0.14 0.73
123 INT38394 Regulation of Pam 2 0.39 0.08 0.69
124 INT15055 Regulation of Negative_regulation of Mme 2 0.42 0.24 0.67
125 INT38395 Protein_catabolism of Pam 1 0.57 0 0.67
126 INT48592 Positive_regulation of Regulation of MME 1 0.40 0.32 0.66
127 INT135376 Negative_regulation of Regulation of Cpe 1 0.32 0.13 0.66
128 INT154362 Binding of Pam 1 0.45 0.54 0.66
129 INT4878 Regulation of Gene_expression of MME 6 0.53 5.38 0.65
130 INT37329 Regulation of Binding of Mme 1 0.27 0 0.65
131 INT4785 Gene_expression of PAM 6 0.58 3.47 0.64
132 INT37517 Negative_regulation of Protein_catabolism of MME 1 0.43 0.1 0.62
133 INT34462 Binding of CPQ 1 0.17 0 0.61
134 INT200636 Regulation of Gene_expression of Ace 1 0.26 1.64 0.6
135 INT23039 Positive_regulation of Transcription of Cpe 1 0.46 0.06 0.6
136 INT33926 Negative_regulation of Gene_expression of Cpe 2 0.31 0 0.59
137 INT69252 Positive_regulation of Transcription of Cpe 2 0.09 0 0.58
138 INT28402 Negative_regulation of Negative_regulation of MME 3 0.43 1.51 0.57
139 INT106770 Negative_regulation of Protein_catabolism of CPQ 1 0.40 0 0.57
140 INT270969 Regulation of Gene_expression of Cpe 1 0.27 0 0.55
141 INT67738 Regulation of Pam 1 0.27 0.56 0.53
142 INT22333 Regulation of Negative_regulation of Ace 3 0.45 0.72 0.52
143 INT36764 Localization of Ace 7 0.80 1.53 0.51
144 INT37094 Positive_regulation of Negative_regulation of Mme 2 0.50 1.15 0.51
145 INT28550 Negative_regulation of Negative_regulation of Thop1 1 0.15 0.35 0.49
146 INT43091 Positive_regulation of Negative_regulation of Ace 3 0.30 1.51 0.48
147 INT30936 Regulation of Protein_catabolism of Cpe 1 0.35 0.16 0.48
148 INT217393 Negative_regulation of Gene_expression of Mme 3 0.43 5.98 0.46
149 INT23152 Regulation of Localization of Cpe 1 0.45 0.1 0.46
150 INT77688 Transcription of Mme 2 0.53 4.01 0.45
151 INT105987 Negative_regulation of Protein_catabolism of Cpe 1 0.04 0 0.45
152 INT226784 Positive_regulation of Cma1 3 0.32 3.46 0.44
153 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44
154 INT35545 Negative_regulation of Protein_catabolism of Mme 1 0.31 0 0.43
155 INT44032 Regulation of Positive_regulation of Ace 1 0.38 0.1 0.43
156 INT40182 Regulation of Binding of Cpe 1 0.01 0 0.41
157 INT40274 Negative_regulation of Gene_expression of Pam 1 0.40 0.13 0.41
158 INT77687 Regulation of Gene_expression of Mme 3 0.44 2.75 0.4
159 INT154361 Localization of Pam 2 0.76 0.26 0.4
160 INT114063 Negative_regulation of Localization of Ace 1 0.29 0.31 0.39
161 INT60040 Negative_regulation of Negative_regulation of Ace 6 0.43 3.64 0.38
162 INT42846 Regulation of Binding of Cpe 1 0.01 0 0.38
163 INT71869 Localization of Mme 2 0.70 2.13 0.37
164 INT77686 Transcription of Ace 2 0.65 2.65 0.37
165 INT23153 Positive_regulation of Positive_regulation of Cpe 1 0.50 0 0.36
166 INT267844 Positive_regulation of Gene_expression of Ace 10 0.57 15.35 0.35
167 INT270972 Phosphorylation of Cpe 1 0.33 0 0.33
168 INT110365 Negative_regulation of Positive_regulation of Mme 1 0.39 0.09 0.32
169 INT37120 Negative_regulation of Localization of Mme 1 0.42 0.07 0.32
170 INT21818 Phosphorylation of Thop1 1 0.62 0 0.31
171 INT160760 Regulation of Cma1 1 0.21 0.19 0.31
172 INT33578 Regulation of Negative_regulation of Cpe 1 0.04 0 0.3
173 INT127877 Regulation of Negative_regulation of MME 1 0.45 0.37 0.29
174 INT229358 Negative_regulation of Protein_catabolism of Ace 1 0.40 0.93 0.27
175 INT47070 Positive_regulation of Localization of Ace 2 0.32 0.55 0.26
176 INT84037 Negative_regulation of Regulation of Mme 1 0.37 0.64 0.26
177 INT229357 Regulation of Binding of Ace 1 0.43 0.86 0.26
178 INT37518 Regulation of Protein_catabolism of MME 1 0.27 0 0.25
179 INT71842 Localization of Thop1 1 0.34 0 0.24
180 INT65003 Negative_regulation of Negative_regulation of Ace 5 0.37 3.45 0.23
181 INT307794 Negative_regulation of Gene_expression of Ace 7 0.48 5.95 0.2
182 INT69192 Positive_regulation of Positive_regulation of Ace 1 0.02 0 0.19
183 INT110883 Positive_regulation of Localization of MME 1 0.40 0.74 0.19
184 INT44051 Positive_regulation of Protein_catabolism of Ace 1 0.41 0 0.16
185 INT314985 Positive_regulation of Negative_regulation of Pam 1 0.05 2.1 0.15
186 INT71840 Positive_regulation of Gene_expression of Thop1 1 0.23 0 0.14
187 INT197135 Transcription of MME 4 0.69 3.23 0.13
188 INT59791 Positive_regulation of Negative_regulation of Ace 3 0.49 0.57 0.13
189 INT329792 Positive_regulation of Positive_regulation of Mme 1 0.23 1.17 0.13
190 INT249970 Transcription of Ace 3 0.36 1.87 0.12
191 INT310764 Positive_regulation of Pam 1 0.02 0.5 0.12
192 INT43649 Positive_regulation of Binding of Thop1 1 0.15 0 0.12
193 INT57731 Negative_regulation of Positive_regulation of MME 1 0.38 0.05 0.12
194 INT43092 Negative_regulation of Binding of Ace 1 0.31 0 0.12
195 INT319121 Regulation of PAM 1 0.12 0.6 0.11
196 INT340501 Regulation of Transcription of Ace 1 0.10 0.84 0.1
197 INT294784 Transcription of PAM 1 0.00 0.18 0.1
198 INT82834 Positive_regulation of Gene_expression of Cma1 2 0.31 1.52 0.09
199 INT9388 Regulation of Transcription of Cpe 1 0.45 0.38 0.09
200 INT340500 Negative_regulation of Transcription of Ace 1 0.10 0.78 0.07
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