GO:0006548

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Name histidine catabolic process
Categary Process
Go Slim No
Go Link GO:0006548
Unique Molecular Interactions 79
Total Molecular Interactions 98
Total Single Events 886
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histidine catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for histidine catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
2 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
3 INT88583 Hal Positive_regulation of Prl 1 0.15 0.44 0.95
4 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
5 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
6 INT34099 Hal Positive_regulation of Localization of Gnrh1 1 0.00 0 0.64
7 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
8 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
9 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
10 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
11 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
12 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
13 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
14 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
15 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
16 INT88582 Negative_regulation of Hal Positive_regulation of Prl 1 0.12 0.15 0.27
17 INT107955 Gtf3a Positive_regulation of Hdc 1 0.07 0.3 0.26
18 INT107954 Il1f5 Positive_regulation of Hdc 1 0.09 0.3 0.26
19 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
20 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
21 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
22 INT126795 RASL12 Positive_regulation of Hal 1 0.01 2.62 0.22
23 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
24 INT62341 Sst Negative_regulation of Hdc 1 0.03 0 0.18
25 INT62342 Gast Positive_regulation of Hdc 1 0.10 0 0.18
26 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
27 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
28 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
29 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13
30 INT271478 Tacr1 Regulation of Binding of Mthfd1 1 0.09 0.48 0.13
31 INT289407 Mthfd1 Negative_regulation of Cd55 1 0.01 0.6 0.12
32 INT188594 Binding of Mthfd1 and Radil 1 0.01 0.25 0.12
33 INT289404 Mthfd1 Positive_regulation of Hc 1 0.04 0.58 0.12
34 INT289405 Mthfd1 Positive_regulation of C3ar1 1 0.00 0.53 0.11
35 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1
36 INT218733 Trh Positive_regulation of Gene_expression of Hdc 1 0.27 0 0.09
37 INT252344 Binding of Cd40 and Mthfd1 2 0.16 0.34 0.08
38 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
39 INT297309 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Ifng 1 0.07 0.79 0.08
40 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
41 INT311986 Csf2 Positive_regulation of Mthfd1 1 0.03 0.28 0.08
42 INT184113 Socs1 Negative_regulation of Mthfd1 1 0.08 0.5 0.08
43 INT302529 Hal Regulation of Cpz 1 0.26 0.43 0.08
44 INT10986 Nfasc Regulation of Hal 1 0.00 0.07 0.07
45 INT184121 Socs1 Regulation of Mthfd1 1 0.05 0.44 0.07
46 INT302528 Hal Regulation of Negative_regulation of Mbp 1 0.16 0.1 0.07
47 INT284565 Gopc Positive_regulation of Mthfd1 1 0.11 0.22 0.05
48 INT284564 Binding of Itgax and Mthfd1 1 0.08 0.09 0.05
49 INT314967 Binding of Cd4 and Mthfd1 1 0.09 0.11 0.04
50 INT252346 Binding of Apcs and Mthfd1 1 0.02 0.13 0.03
51 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
52 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03
53 INT252339 Binding of Cd40 and Positive_regulation of Mthfd1 1 0.04 0.19 0
54 INT189108 Mthfd1 Positive_regulation of H2 1 0.00 0.17 0
55 INT143067 Mthfd1 Positive_regulation of Serpine1 1 0.00 0 0
56 INT189106 Mthfd1 Positive_regulation of Gene_expression of H2 1 0.00 0.17 0
57 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
58 INT143066 Mthfd1 Regulation of Gene_expression of Plau 1 0.00 0 0
59 INT307284 DCP2 Positive_regulation of HAL 1 0.00 0 0
60 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
61 INT315941 Binding of Tlr4 and Mthfd1 1 0.05 0 0
62 INT252337 Mthfd1 Positive_regulation of Gene_expression of Cd80 1 0.04 0.1 0
63 INT284556 Tspan7 Positive_regulation of Mthfd1 1 0.00 1.66 0
64 INT143065 Mthfd1 Positive_regulation of Gene_expression of Serpine1 1 0.00 0 0
65 INT286884 Binding of Gopc and Mthfd1 1 0.02 0 0
66 INT293694 Binding of Ccl21a and Mthfd1 1 0.01 0 0
67 INT314969 Binding of Lbr and Mthfd1 1 0.01 0 0
68 INT34102 NA Positive_regulation of Positive_regulation of Hal 1 0.00 0 0
69 INT252333 Mthfd1 Positive_regulation of Gene_expression of Cd86 1 0.04 0.1 0
70 INT189114 Mtap1a Positive_regulation of Gene_expression of Mthfd1 1 0.01 0.3 0
71 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histidine catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in histidine catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
2 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
3 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
4 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51
5 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
6 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
7 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32
8 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
9 INT52871 Regulation of Hdc 6 0.60 3.26 2.51
10 INT30061 Negative_regulation of Hdc 8 0.59 2.14 2.27
11 INT108710 Gene_expression of HAL 36 0.58 14.75 2.16
12 INT22503 Positive_regulation of Hal 10 0.36 4.44 2.12
13 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96
14 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
15 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
16 INT63716 Transcription of Hdc 10 0.69 7.57 1.82
17 INT30039 Negative_regulation of HAL 7 0.42 4.32 1.61
18 INT108913 Positive_regulation of HAL 10 0.28 5.71 1.59
19 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
20 INT63719 Positive_regulation of Transcription of Hdc 3 0.52 3.91 1.01
21 INT108914 Negative_regulation of Positive_regulation of HAL 1 0.26 0.51 0.99
22 INT30041 Binding of HAL 8 0.35 2.36 0.95
23 INT96482 Positive_regulation of Hal 1 0.36 0 0.9
24 INT9125 Localization of Hal 3 0.79 0.43 0.84
25 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
26 INT158414 Binding of Hal 4 0.22 2.07 0.81
27 INT49215 Binding of Hal 3 0.40 1.43 0.8
28 INT30006 Regulation of Hal 3 0.27 0.26 0.74
29 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
30 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
31 INT148564 Localization of HAL 8 0.68 2.46 0.62
32 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
33 INT9123 Regulation of Hal 3 0.61 0.5 0.56
34 INT34097 Localization of Hal 4 0.45 0.59 0.52
35 INT169103 Negative_regulation of Hal 7 0.34 4.25 0.48
36 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
37 INT27527 Negative_regulation of Hal 2 0.42 0.66 0.42
38 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
39 INT9124 Positive_regulation of Localization of Hal 1 0.46 0.14 0.36
40 INT84392 Localization of Hdc 2 0.70 0.98 0.34
41 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
42 INT34096 Negative_regulation of Positive_regulation of Hal 1 0.00 0 0.29
43 INT88579 Gene_expression of Hal 2 0.21 0.52 0.28
44 INT88578 Positive_regulation of Gene_expression of Hal 1 0.14 0.14 0.28
45 INT34095 Negative_regulation of Localization of Hal 1 0.00 0 0.21
46 INT136187 Positive_regulation of Positive_regulation of Hdc 1 0.61 0.81 0.2
47 INT63721 Regulation of Transcription of Hdc 3 0.45 1.72 0.19
48 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
49 INT19627 Negative_regulation of Localization of Hal 1 0.55 0.15 0.15
50 INT210916 Regulation of Gene_expression of HAL 3 0.18 2.22 0.14
51 INT62337 Negative_regulation of Positive_regulation of Hdc 1 0.07 0 0.14
52 INT172209 Regulation of HAL 3 0.25 2.23 0.13
53 INT289385 Negative_regulation of Localization of Mthfd1 1 0.03 0.6 0.12
54 INT63717 Negative_regulation of Transcription of Hdc 1 0.43 0.89 0.1
55 INT112167 Regulation of Localization of Hdc 1 0.27 0.27 0.09
56 INT63720 Protein_catabolism of Hdc 1 0.57 0.8 0.08
57 INT218726 Binding of Hdc 1 0.19 0.26 0.08
58 INT63718 Positive_regulation of Protein_catabolism of Hdc 1 0.41 0.83 0.08
59 INT218728 Negative_regulation of Gene_expression of Hdc 1 0.22 0.4 0.07
60 INT218727 Negative_regulation of Binding of Hdc 1 0.22 0.14 0.05
61 INT290175 Positive_regulation of Binding of HAL 1 0.11 0.47 0.05
62 INT96481 Regulation of Positive_regulation of Mthfd1 2 0.02 1.3 0.04
63 INT188589 Transcription of Mthfd1 1 0.35 0.07 0.03
64 INT302524 Positive_regulation of Gene_expression of Hal 1 0.30 0 0.03
65 INT218730 Positive_regulation of Gene_expression of Hdc 1 0.26 0.32 0
66 INT341613 Protein_catabolism of HAL 1 0.01 0 0
67 INT290177 Positive_regulation of Gene_expression of HAL 1 0.11 0.49 0
68 INT180621 Negative_regulation of Gene_expression of HAL 1 0.05 0 0
69 INT290176 Positive_regulation of Localization of HAL 1 0.11 0.55 0
70 INT180620 Positive_regulation of Positive_regulation of HAL 1 0.06 0.09 0
71 INT290178 Negative_regulation of Binding of HAL 1 0.09 0.5 0
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