GO:0006549

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Name isoleucine metabolic process
Categary Process
Go Slim No
Go Link GO:0006549
Unique Molecular Interactions 24
Total Molecular Interactions 34
Total Single Events 358
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for isoleucine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for isoleucine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
2 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
3 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
4 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
5 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
6 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
7 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
8 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
9 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
10 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
11 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
12 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
13 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
14 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
15 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
16 INT268798 Binding of Gh and Ghr 1 0.26 1.18 0.04
17 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
18 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
19 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
20 INT216465 Gh Positive_regulation of Ghr 1 0.26 0.23 0
21 INT247003 Binding of Ghr and Gh1 1 0.00 0 0
22 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for isoleucine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in isoleucine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9895 Binding of GHR 18 0.36 4.8 5.65
2 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
3 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
4 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
5 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
6 INT22019 Regulation of GHR 9 0.62 2.56 2.39
7 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
8 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
9 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
10 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
11 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
12 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
13 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
14 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
15 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
16 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
17 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
18 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
19 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
20 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
21 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
22 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
23 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
24 INT167942 Binding of Stat5b 1 0.26 0 0.82
25 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
26 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
27 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
28 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
29 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
30 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
31 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
32 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
33 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
34 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
35 INT28299 Negative_regulation of Gene_expression of GHR 1 0.03 0.1 0.35
36 INT67350 Binding of Ghr 9 0.43 1.83 0.28
37 INT67349 Localization of Ghr 6 0.66 2.53 0.23
38 INT67351 Positive_regulation of Localization of Ghr 2 0.44 0.78 0.23
39 INT167940 Regulation of Stat5b 1 0.43 0 0.19
40 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
41 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
42 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
43 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
44 INT75314 Regulation of Gene_expression of Ghr 3 0.26 0.42 0.15
45 INT220367 Regulation of Positive_regulation of Ghr 1 0.44 0.45 0.14
46 INT22020 Regulation of Positive_regulation of GHR 1 0.39 1.03 0.14
47 INT268793 Protein_catabolism of Ghr 1 0.69 0.54 0.12
48 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
49 INT245586 Phosphorylation of Ghr 1 0.44 0.35 0.1
50 INT173756 Positive_regulation of Transcription of Ghr 3 0.36 0.83 0.09
51 INT268791 Positive_regulation of Protein_catabolism of Ghr 1 0.39 0.29 0.09
52 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
53 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
54 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07
55 INT184168 Localization of GHR 1 0.08 0.34 0.05
56 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
57 INT356345 Negative_regulation of Negative_regulation of Ghr 1 0.35 0.24 0.04
58 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
59 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
60 INT319565 Positive_regulation of Gene_expression of GHR 1 0.25 0.4 0
61 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
62 INT173755 Binding of Ghr 1 0.14 0 0
63 INT181205 Negative_regulation of Binding of GHR 1 0.07 0.2 0
64 INT75317 Regulation of Gene_expression of Ghr 1 0.03 0.26 0
65 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
66 INT353174 Gene_expression of Stat5b 1 0.48 0 0
67 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
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