GO:0006590

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Name thyroid hormone generation
Categary Process
Go Slim No
Go Link GO:0006590
Unique Molecular Interactions 114
Total Molecular Interactions 155
Total Single Events 1936
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone generation. They are ordered first by their pain relevance and then by number of times they were reported for thyroid hormone generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
2 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
3 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
4 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
5 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
6 INT13098 POMC Regulation of Localization of CGA 1 0.58 0 1.14
7 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
8 INT25248 GNRH1 Regulation of CGA 4 0.30 1.22 0.62
9 INT144248 CGA Regulation of Positive_regulation of NFKB1 1 0.15 1.66 0.61
10 INT144256 CGA Regulation of Gene_expression of NFKB1 1 0.21 1.66 0.61
11 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
12 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
13 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
14 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
15 INT18248 Binding of CGA and GNRH1 1 0.15 0.92 0.52
16 INT33505 Oprd1 Regulation of Localization of CGA 1 0.00 0 0.52
17 INT48116 Negative_regulation of GH1 Positive_regulation of CGA 1 0.06 0 0.45
18 INT144245 CGA Negative_regulation of Positive_regulation of NFKB1 1 0.13 0.79 0.45
19 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
20 INT44513 PDYN Regulation of Localization of CGA 1 0.00 0 0.4
21 INT13097 POMC Negative_regulation of Localization of CGA 1 0.46 0 0.39
22 INT29618 Cga Positive_regulation of Gene_expression of Pomc 1 0.06 0 0.34
23 INT17301 Binding of CGA and Lhb 1 0.00 0 0.33
24 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
25 INT68482 Cga Regulation of Gh 1 0.00 1.89 0.31
26 INT144249 CGA Regulation of Gene_expression of TNF 1 0.13 0.83 0.31
27 INT144242 CGA Negative_regulation of Localization of TNF 1 0.12 0.64 0.3
28 INT144250 CGA Negative_regulation of TNF 1 0.12 0.64 0.3
29 INT41006 GNRH1 Negative_regulation of Localization of CGA 1 0.03 0.87 0.3
30 INT25028 GNRH1 Positive_regulation of CGA 1 0.03 0 0.29
31 INT25025 Regulation of GNRH1 Positive_regulation of CGA 1 0.03 0 0.29
32 INT33977 DIO2 Regulation of PCDHB17 1 0.00 0.44 0.27
33 INT93952 CGA Positive_regulation of ADCY1 1 0.03 0 0.27
34 INT93953 Negative_regulation of CGA Positive_regulation of ADCY1 1 0.03 0 0.27
35 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
36 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
37 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
38 INT25247 TRH Regulation of CGA 1 0.26 0 0.24
39 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
40 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
41 INT45752 Binding of CGA and Prl 1 0.00 0 0.22
42 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
43 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22
44 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22
45 INT266005 Binding of DIO3 and SGCG 1 0.00 0.86 0.22
46 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22
47 INT356089 Positive_regulation of Binding of Tg and Rab11a 1 0.00 0.07 0.21
48 INT356099 Binding of Tg and Rab11a 1 0.00 0.07 0.21
49 INT57250 ELANE Positive_regulation of Localization of CGA 1 0.08 0 0.21
50 INT110717 CGA Positive_regulation of Localization of INS 1 0.03 0.5 0.19
51 INT144252 CGA Positive_regulation of Positive_regulation of NFKB1 1 0.17 0.38 0.17
52 INT214691 Binding of CGA and CGB 1 0.01 0.7 0.17
53 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16
54 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
55 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
56 INT45944 Nts Regulation of Localization of Cga 1 0.20 0 0.15
57 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11
58 INT36216 Avp Negative_regulation of Positive_regulation of CGA 1 0.03 0 0.11
59 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1
60 INT324702 PLOD1 Positive_regulation of CGA 1 0.03 1.1 0.1
61 INT147936 CGA Regulation of Gene_expression of FSHR 1 0.31 0.71 0.1
62 INT41512 Oxt Regulation of Cga 1 0.01 0.09 0.09
63 INT21310 Binding of Gnrh1 and Positive_regulation of Localization of CGA 1 0.00 0 0.09
64 INT254641 CGA Positive_regulation of AGT 1 0.17 1.51 0.08
65 INT172568 Gene_expression of GNRH1 Regulation of Localization of CGA 1 0.05 0.66 0.08
66 INT254640 CGA Positive_regulation of REN 1 0.07 1.51 0.08
67 INT45834 CGA Negative_regulation of Localization of Lhb 1 0.00 0 0.08
68 INT254639 CGA Positive_regulation of Gene_expression of AGT 1 0.18 1.51 0.08
69 INT187671 CGA Negative_regulation of Gene_expression of GNRH1 1 0.01 0 0.06
70 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
71 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
72 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
73 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
74 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
75 INT334921 GNRHR Positive_regulation of Gene_expression of CGA 1 0.01 0.53 0
76 INT252910 PTTG1 Negative_regulation of Transcription of SLC5A5 1 0.02 0.36 0
77 INT324705 CGA Positive_regulation of PLOD1 1 0.04 0 0
78 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
79 INT63243 Gnrh1 Regulation of Localization of CGA 1 0.00 0.33 0
80 INT252898 Binding of SLC5A5 and USF1 1 0.01 0.22 0
81 INT272418 CGA Regulation of Gene_expression of PROK1 1 0.01 0.34 0
82 INT252906 Binding of SLC5A5 and PTTG1 1 0.01 0.69 0
83 INT334919 GNRH1 Positive_regulation of Gene_expression of CGA 1 0.03 0.52 0
84 INT356490 CGA Positive_regulation of Gene_expression of VEGFA 1 0.06 0 0
85 INT260131 CGA Negative_regulation of OFC1 1 0.01 0.17 0
86 INT356497 CGA Regulation of Edn1 1 0.02 0 0
87 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0
88 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0
89 INT252905 PTTG1IP Negative_regulation of Transcription of SLC5A5 1 0.01 0.35 0
90 INT260134 CGA Positive_regulation of Gene_expression of Nos3 1 0.16 0.13 0
91 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
92 INT177286 Binding of CXADR and MED1 1 0.27 0 0
93 INT356489 CGA Positive_regulation of Gene_expression of B4GALNT1 1 0.00 0 0
94 INT74031 Cga Regulation of Transcription of Penk 1 0.02 0.2 0
95 INT7037 CGA Positive_regulation of Pdyn 1 0.00 0 0
96 INT269770 Binding of DIO2 and NOVA2 1 0.07 0 0
97 INT26540 CGA Positive_regulation of Gene_expression of Penk 1 0.01 0 0
98 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
99 INT324706 CGA Positive_regulation of HRASLS 1 0.01 0 0
100 INT43688 Gnrh1 Positive_regulation of CGA 1 0.06 0 0
101 INT277803 Regulation of GNRH1 Regulation of CGA 1 0.00 0.61 0
102 INT288252 Binding of CGA and NUPL2 1 0.15 1 0
103 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
104 INT252903 PTTG1IP Regulation of Gene_expression of SLC5A5 1 0.00 0.43 0
105 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0
106 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0
107 INT252899 PTTG1 Regulation of Gene_expression of SLC5A5 1 0.01 0.43 0
108 INT252890 PTTG1IP Negative_regulation of SLC5A5 1 0.01 0.34 0
109 INT289669 Negative_regulation of GNRH1 Regulation of Localization of CGA 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone generation. They are ordered first by their pain relevance and then by number of times they were reported in thyroid hormone generation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1793 Localization of CGA 379 0.81 67.38 114.69
2 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
3 INT7035 Regulation of CGA 87 0.45 29.04 28.45
4 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
5 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
6 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
7 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
8 INT2165 Localization of Cga 41 0.80 4.02 19.53
9 INT8088 Regulation of Localization of Cga 28 0.60 2.37 13.91
10 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
11 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
12 INT31780 Binding of DIO2 17 0.36 10.07 10
13 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
14 INT23104 Positive_regulation of Cga 20 0.70 10.35 8.03
15 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
16 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28
17 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
18 INT27316 Negative_regulation of TPO 7 0.38 7.26 4.42
19 INT15837 Binding of CGA 31 0.41 12.06 3.17
20 INT202577 Localization of DIO2 9 0.56 1.3 2.97
21 INT13095 Positive_regulation of Localization of Cga 6 0.69 0.69 2.96
22 INT7976 Regulation of Gene_expression of CGA 8 0.19 1.09 2.71
23 INT2136 Gene_expression of Cga 21 0.77 9.83 2.62
24 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
25 INT7034 Regulation of Regulation of CGA 5 0.16 0.17 2.29
26 INT27315 Positive_regulation of TPO 17 0.45 9.84 2.28
27 INT97308 Gene_expression of TPO 15 0.65 13.26 2.12
28 INT2138 Negative_regulation of Cga 5 0.43 3.37 2.1
29 INT29678 Negative_regulation of Localization of Cga 4 0.42 0.06 2.01
30 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99
31 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
32 INT33225 Gene_expression of Cga 4 0.75 0.09 1.65
33 INT43479 Positive_regulation of Positive_regulation of CGA 9 0.39 4.24 1.46
34 INT122894 Transcription of DIO3 1 0.52 0.71 1.19
35 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16
36 INT2981 Negative_regulation of Gene_expression of CGA 14 0.42 3.41 1.05
37 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04
38 INT40540 Localization of DIO3 2 0.73 1.11 0.96
39 INT70101 Negative_regulation of Positive_regulation of Cga 2 0.43 0.07 0.92
40 INT7619 Regulation of TPO 3 0.24 3.09 0.89
41 INT7620 Localization of TPO 4 0.26 5.35 0.88
42 INT44100 Regulation of Cga 2 0.60 0.35 0.86
43 INT23054 Binding of Cga 4 0.36 2.17 0.78
44 INT35832 Regulation of Cga 1 0.04 0.94 0.74
45 INT154706 Gene_expression of Tg 9 0.38 4.95 0.64
46 INT13096 Positive_regulation of Cga 3 0.69 1.23 0.61
47 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61
48 INT257949 Regulation of Gene_expression of DIO2 1 0.15 0.17 0.6
49 INT150155 Binding of TPO 3 0.30 3.98 0.58
50 INT4102 Positive_regulation of Gene_expression of Cga 3 0.47 0.34 0.52
51 INT257946 Regulation of Positive_regulation of DIO2 1 0.13 0.45 0.49
52 INT39018 Protein_catabolism of DIO2 1 0.02 0 0.49
53 INT55850 Negative_regulation of Positive_regulation of CGA 2 0.55 0.08 0.46
54 INT349611 Positive_regulation of Localization of DIO2 1 0.26 0 0.46
55 INT36686 Regulation of Tg 7 0.19 3.12 0.45
56 INT23053 Positive_regulation of Binding of Cga 1 0.05 0.06 0.45
57 INT60429 Regulation of Gene_expression of Cga 1 0.27 0 0.45
58 INT40541 Negative_regulation of Positive_regulation of DIO2 2 0.41 0.86 0.4
59 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
60 INT148608 Positive_regulation of Positive_regulation of Cga 1 0.03 0.39 0.39
61 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
62 INT44101 Negative_regulation of Cga 1 0.08 0.31 0.38
63 INT15836 Positive_regulation of Binding of CGA 1 0.38 0.54 0.34
64 INT105457 Regulation of Binding of CGA 2 0.45 0.48 0.33
65 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
66 INT39197 Positive_regulation of Regulation of CGA 1 0.02 0.24 0.27
67 INT15792 Regulation of Positive_regulation of CGA 2 0.59 0.4 0.24
68 INT288255 Protein_catabolism of CGA 5 0.75 1.87 0.19
69 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19
70 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
71 INT349614 Negative_regulation of Binding of DIO2 1 0.27 0.77 0.16
72 INT324723 Transcription of CGA 1 0.07 4.35 0.15
73 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
74 INT95761 Negative_regulation of DIO3 1 0.25 0.52 0.1
75 INT356496 Phosphorylation of CGA 1 0.42 0.49 0.1
76 INT335654 Negative_regulation of Gene_expression of DIO2 1 0.17 0.72 0.1
77 INT41112 Negative_regulation of Regulation of CGA 1 0.19 0.25 0.09
78 INT34303 Localization of Cga 1 0.78 0 0.08
79 INT34304 Negative_regulation of Localization of Cga 1 0.57 0 0.08
80 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
81 INT209181 Negative_regulation of Binding of CGA 1 0.02 0.07 0.07
82 INT100859 Negative_regulation of Regulation of TPO 1 0.38 0.38 0.07
83 INT89933 Negative_regulation of Tg 2 0.04 1.78 0.06
84 INT39690 Positive_regulation of DIO3 2 0.02 0.48 0.06
85 INT201049 Negative_regulation of SLC5A5 5 0.05 2.25 0.03
86 INT201051 Gene_expression of SLC5A5 6 0.09 2.08 0
87 INT201053 Positive_regulation of Gene_expression of SLC5A5 3 0.06 1.18 0
88 INT307189 Localization of Med1 3 0.53 0.32 0
89 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
90 INT201052 Negative_regulation of Gene_expression of SLC5A5 2 0.07 0.55 0
91 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
92 INT252985 Transcription of SLC5A5 1 0.05 0.35 0
93 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
94 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
95 INT184567 Binding of Tg 1 0.07 0.27 0
96 INT341925 Positive_regulation of Localization of SLC5A5 1 0.03 0.17 0
97 INT184569 Regulation of Positive_regulation of Tg 1 0.09 0 0
98 INT307188 Transcription of Med1 1 0.48 0.7 0
99 INT293569 Positive_regulation of Gene_expression of TPO 1 0.05 0.37 0
100 INT252987 Positive_regulation of SLC5A5 1 0.03 0.35 0
101 INT280013 Binding of SLC5A5 1 0.01 1.03 0
102 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
103 INT177320 Binding of MED1 1 0.25 0 0
104 INT225457 Binding of Med1 1 0.35 0.28 0
105 INT132330 Regulation of Negative_regulation of CGA 1 0.01 0.08 0
106 INT324725 Negative_regulation of Transcription of CGA 1 0.04 0.88 0
107 INT276140 Regulation of Negative_regulation of DIO2 1 0.34 0.07 0
108 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
109 INT184570 Transcription of Tg 1 0.12 0.08 0
110 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
111 INT341927 Localization of SLC5A5 1 0.04 0.17 0
112 INT288257 Positive_regulation of Protein_catabolism of CGA 1 0.28 0.43 0
113 INT184568 Regulation of Binding of Tg 1 0.08 0.15 0
114 INT262673 Localization of Tg 1 0.13 0 0
115 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
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