GO:0006595

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Name polyamine metabolic process
Categary Process
Go Slim No
Go Link GO:0006595
Unique Molecular Interactions 70
Total Molecular Interactions 88
Total Single Events 1355
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for polyamine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for polyamine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
2 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
3 INT168185 Binding of PLXNA2 and MRI1 1 0.25 0.78 1.08
4 INT71000 Positive_regulation of Adarb1 Positive_regulation of Odc1 1 0.01 0 1
5 INT56779 Pomc Negative_regulation of Gene_expression of Odc1 2 0.31 0 0.89
6 INT61052 Binding of Adarb1 and Negative_regulation of Gene_expression of Odc1 1 0.02 0 0.81
7 INT77526 Oprd1 Regulation of Positive_regulation of Odc1 1 0.01 0.12 0.78
8 INT61050 Oprd1 Positive_regulation of Odc1 1 0.25 0 0.74
9 INT77529 PDYN Positive_regulation of Odc1 1 0.02 0 0.63
10 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
11 INT350169 Binding of DMD and MRI1 1 0.11 3.08 0.54
12 INT61051 Pomc Negative_regulation of Odc1 1 0.22 0 0.54
13 INT30028 Ins1 Regulation of Odc1 2 0.11 0 0.51
14 INT37583 Naga Regulation of Odc1 1 0.20 0 0.51
15 INT39870 Odc1 Negative_regulation of Tk1 1 0.36 0.8 0.46
16 INT37584 Naga Positive_regulation of Odc1 1 0.51 0 0.4
17 INT37582 Pomc Regulation of Odc1 1 0.31 0 0.4
18 INT37032 ANTXR2 Positive_regulation of ODC1 1 0.09 0.07 0.34
19 INT19512 Prl Positive_regulation of Odc1 1 0.01 0.89 0.31
20 INT44759 Negative_regulation of PLAT Positive_regulation of ODC1 1 0.27 0 0.27
21 INT46500 Ins1 Positive_regulation of Odc1 1 0.27 0 0.27
22 INT44760 PLAT Positive_regulation of ODC1 1 0.29 0 0.27
23 INT323926 MRM1 Positive_regulation of MRI1 1 0.04 0.44 0.26
24 INT35014 IFNA1 Positive_regulation of ADI1 1 0.03 0.17 0.23
25 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21
26 INT35013 IFNG Positive_regulation of ADI1 1 0.22 0.16 0.21
27 INT109409 PPARA Positive_regulation of Gene_expression of SAT1 1 0.54 0.75 0.2
28 INT12694 SMS Regulation of Localization of EPO 1 0.06 0 0.19
29 INT47607 Psl1 Positive_regulation of Odc1 1 0.51 0.14 0.19
30 INT69949 Car2 Positive_regulation of MTAP 1 0.02 0.41 0.18
31 INT277112 Binding of AMD1 and CFH 1 0.16 2.45 0.18
32 INT62339 Gast Positive_regulation of Positive_regulation of Odc1 1 0.66 0 0.18
33 INT305371 Binding of IL1RL1 and MRI1 1 0.09 0.95 0.15
34 INT332581 Binding of Nqo1 and MRI1 1 0.01 1.68 0.12
35 INT142845 Binding of HLA-B and SAT1 1 0.35 0.61 0.12
36 INT3751 Binding of GOT1 and PIK3C2A 1 0.08 0.68 0.12
37 INT3752 Binding of GOT1 and LDHA 1 0.11 0.68 0.12
38 INT56781 Gh1 Positive_regulation of Odc1 1 0.39 0 0.11
39 INT47609 Positive_regulation of Psl1 Positive_regulation of Odc1 1 0.45 0 0.1
40 INT46502 Agt Positive_regulation of Odc1 1 0.18 0 0.1
41 INT47610 Regulation of Psl1 Positive_regulation of Odc1 1 0.26 0.06 0.1
42 INT62340 Sst Positive_regulation of Positive_regulation of Odc1 1 0.25 0 0.1
43 INT46501 Positive_regulation of Ins1 Positive_regulation of Odc1 1 0.27 0 0.09
44 INT11237 PAEP Positive_regulation of MRI1 1 0.07 0.46 0.07
45 INT193564 Binding of STMN1 and MRI1 1 0.07 0.06 0.07
46 INT289763 Ptgfr Positive_regulation of Gene_expression of Sat1 1 0.04 0 0.04
47 INT289762 Pgf Positive_regulation of Gene_expression of Sat1 1 0.21 0 0.04
48 INT47608 Negative_regulation of Psl1 Positive_regulation of Odc1 1 0.47 0.08 0
49 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0
50 INT259081 Binding of Hbb-ar and ENOPH1 1 0.00 1.36 0
51 INT195445 SAT1 Regulation of ODC1 1 0.27 0.8 0
52 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
53 INT299447 Lhb Positive_regulation of Gene_expression of Odc1 1 0.24 0.3 0
54 INT56782 Negative_regulation of Gh1 Regulation of Odc1 1 0.25 0 0
55 INT205964 SMOX Positive_regulation of GLI1 1 0.20 0.66 0
56 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
57 INT252805 ENOPH1 Positive_regulation of Gene_expression of ESR1 1 0.00 2.46 0
58 INT299373 Binding of DBT and ENOPH1 1 0.00 0.24 0
59 INT195446 Positive_regulation of SAT1 Positive_regulation of ODC1 1 0.47 0.82 0
60 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0
61 INT188749 Binding of HIVEP1 and ADC 1 0.02 0.92 0
62 INT351614 APRT Positive_regulation of MTAP 1 0.00 0.22 0
63 INT56780 Gh1 Regulation of Odc1 1 0.15 0 0
64 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
65 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
66 INT351615 MTAP Positive_regulation of Gene_expression of OR4G6P 1 0.00 0.22 0
67 INT252792 ENOPH1 Positive_regulation of Gene_expression of DDIT3 1 0.03 2.42 0
68 INT188750 Binding of CD4 and ADC 1 0.16 0.93 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for polyamine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in polyamine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98
2 INT2671 Positive_regulation of Odc1 82 0.70 11.03 29
3 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68
4 INT11829 Negative_regulation of Odc1 54 0.59 7.03 23.03
5 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38
6 INT180497 Binding of MRI1 45 0.42 28.35 14.77
7 INT70265 Regulation of MRI1 42 0.39 30.95 14.18
8 INT3112 Regulation of Odc1 39 0.62 4.73 13.69
9 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96
10 INT156827 Localization of MRI1 25 0.65 16.06 8.33
11 INT30025 Negative_regulation of Positive_regulation of Odc1 14 0.59 0.89 6.34
12 INT19110 Gene_expression of Odc1 19 0.78 4.51 6.11
13 INT151427 Gene_expression of ADC 31 0.55 21.86 3.81
14 INT200385 Negative_regulation of ADC 19 0.18 16.56 3.6
15 INT30024 Regulation of Positive_regulation of Odc1 3 0.50 0.19 3.17
16 INT109411 Gene_expression of SAT1 61 0.77 67.99 3.08
17 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91
18 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84
19 INT38632 Positive_regulation of Positive_regulation of Odc1 2 0.50 0.46 2.7
20 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53
21 INT200384 Regulation of ADC 12 0.25 5.46 2.41
22 INT44544 Gene_expression of ENOPH1 18 0.76 10.28 2.35
23 INT37041 Positive_regulation of ODC1 8 0.70 4.04 1.9
24 INT77523 Positive_regulation of ADC 14 0.63 13.81 1.81
25 INT46733 Positive_regulation of Odc1 16 0.70 2.1 1.71
26 INT62588 Negative_regulation of Gene_expression of Odc1 3 0.39 0 1.6
27 INT40453 Regulation of ODC1 7 0.45 1.08 1.58
28 INT99720 Positive_regulation of SAT1 21 0.69 26.55 1.56
29 INT46736 Negative_regulation of Odc1 10 0.51 7.6 1.39
30 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32
31 INT70999 Positive_regulation of Gene_expression of Odc1 4 0.43 2.73 1.3
32 INT36330 Positive_regulation of Positive_regulation of GOT1 4 0.32 4.42 1.26
33 INT37040 Negative_regulation of ODC1 5 0.59 1.72 1.1
34 INT25055 Regulation of Negative_regulation of Odc1 1 0.27 0.09 1.05
35 INT3529 Regulation of GOT1 6 0.52 2.4 1.01
36 INT177587 Regulation of Gene_expression of MRI1 4 0.22 0.88 0.97
37 INT10373 Gene_expression of ADI1 8 0.25 5.97 0.92
38 INT265569 Negative_regulation of Binding of MRI1 1 0.16 0.79 0.87
39 INT195454 Regulation of SAT1 5 0.45 7.65 0.85
40 INT30026 Regulation of Gene_expression of Odc1 2 0.62 0.09 0.85
41 INT16036 Negative_regulation of Negative_regulation of Odc1 1 0.43 0.17 0.81
42 INT46346 Localization of SMS 3 0.78 3.04 0.8
43 INT102439 Negative_regulation of SMOX 2 0.41 0.76 0.76
44 INT15783 Regulation of SMS 6 0.23 3.2 0.75
45 INT78329 Binding of ADC 7 0.31 7.57 0.73
46 INT12099 Localization of GOT1 2 0.35 2.54 0.72
47 INT38818 Transcription of Odc1 2 0.69 0.35 0.7
48 INT44761 Negative_regulation of Positive_regulation of ODC1 3 0.59 0.99 0.67
49 INT4344 Positive_regulation of MTAP 2 0.19 1.83 0.67
50 INT289724 Gene_expression of Sat1 1 0.55 2.29 0.61
51 INT202940 Binding of AMD1 13 0.41 16.43 0.56
52 INT195453 Negative_regulation of Gene_expression of SAT1 5 0.42 4.41 0.54
53 INT44762 Regulation of Positive_regulation of ODC1 1 0.45 0 0.54
54 INT246711 Negative_regulation of Gene_expression of ADC 5 0.06 4.12 0.53
55 INT163114 Positive_regulation of Gene_expression of GOT1 7 0.24 8.93 0.5
56 INT188759 Positive_regulation of Gene_expression of ADC 3 0.28 2.7 0.5
57 INT46347 Positive_regulation of Localization of SMS 1 0.67 0.44 0.5
58 INT327120 Positive_regulation of Positive_regulation of MRI1 1 0.05 0 0.5
59 INT309900 Regulation of Gene_expression of SAT1 1 0.14 1.92 0.49
60 INT69947 Negative_regulation of MTAP 5 0.40 2.63 0.48
61 INT186542 Regulation of MTAP 3 0.06 1.66 0.46
62 INT58679 Gene_expression of Odc1 13 0.78 9.55 0.45
63 INT245316 Negative_regulation of ADI1 1 0.01 0.77 0.45
64 INT245315 Negative_regulation of Gene_expression of ADI1 1 0.01 0.77 0.45
65 INT77525 Negative_regulation of Transcription of Odc1 1 0.35 0.08 0.44
66 INT50548 Binding of ENOPH1 8 0.35 2.64 0.43
67 INT47387 Negative_regulation of Positive_regulation of GOT1 2 0.26 1.04 0.43
68 INT195450 Binding of SAT1 3 0.37 4.11 0.39
69 INT46737 Negative_regulation of Positive_regulation of Odc1 7 0.58 0.87 0.38
70 INT342465 Protein_catabolism of MRI1 1 0.04 0.79 0.38
71 INT338169 Binding of MTAP 1 0.36 0.76 0.37
72 INT192648 Localization of ADC 5 0.53 3.69 0.33
73 INT225138 Positive_regulation of ENOPH1 4 0.15 2 0.28
74 INT269748 Positive_regulation of AMD1 4 0.43 3.56 0.28
75 INT225139 Positive_regulation of Binding of ENOPH1 1 0.12 0.7 0.28
76 INT46729 Regulation of Positive_regulation of Odc1 2 0.45 0.06 0.27
77 INT264998 Regulation of Binding of MRI1 1 0.31 1.34 0.27
78 INT28524 Gene_expression of SMOX 3 0.58 1.99 0.26
79 INT289740 Regulation of Sat1 1 0.44 1.16 0.26
80 INT38819 Regulation of Transcription of Odc1 1 0.45 0.27 0.26
81 INT109416 Transcription of SAT1 2 0.68 0.96 0.22
82 INT266791 Positive_regulation of Gene_expression of ENOPH1 1 0.04 0.85 0.22
83 INT289725 Positive_regulation of Gene_expression of Sat1 1 0.49 1.84 0.22
84 INT109417 Positive_regulation of Transcription of SAT1 1 0.66 0.74 0.22
85 INT82046 Gene_expression of ODC1 8 0.59 3.63 0.21
86 INT35015 Positive_regulation of ADI1 2 0.15 2.75 0.21
87 INT82047 Positive_regulation of Gene_expression of ODC1 2 0.29 1.79 0.21
88 INT289738 Negative_regulation of Gene_expression of Sat1 1 0.31 0.93 0.21
89 INT109414 Transcription of ODC1 3 0.67 1.68 0.2
90 INT183473 Negative_regulation of SMS 3 0.35 2.14 0.2
91 INT109413 Regulation of Transcription of ODC1 1 0.58 1.46 0.2
92 INT46731 Regulation of Odc1 2 0.46 0.99 0.19
93 INT55871 Binding of GOT1 1 0.04 2.22 0.19
94 INT355488 Positive_regulation of Binding of ADC 1 0.09 2.28 0.18
95 INT252151 Transcription of ADC 1 0.10 0.23 0.18
96 INT46730 Binding of Odc1 1 0.32 0 0.17
97 INT50551 Negative_regulation of Binding of ENOPH1 1 0.42 1.05 0.15
98 INT201193 Positive_regulation of Regulation of ADC 1 0.03 0.21 0.15
99 INT266600 Negative_regulation of Gene_expression of Odc1 1 0.51 1.06 0.15
100 INT300475 Binding of SMS 2 0.32 0.76 0.14
101 INT246712 Phosphorylation of ADC 1 0.05 0.3 0.14
102 INT84478 Negative_regulation of Gene_expression of ODC1 1 0.09 0.99 0.14
103 INT84479 Positive_regulation of Positive_regulation of ODC1 1 0.10 0.98 0.14
104 INT270555 Positive_regulation of SMS 3 0.30 2.97 0.13
105 INT269750 Localization of AMD1 2 0.64 2.82 0.13
106 INT195449 Positive_regulation of Gene_expression of SAT1 5 0.69 2.38 0.12
107 INT10372 Binding of ADI1 3 0.10 1.67 0.12
108 INT259060 Negative_regulation of ENOPH1 2 0.04 2.64 0.12
109 INT342900 Negative_regulation of Regulation of GOT1 1 0.04 0.42 0.12
110 INT289733 Regulation of Gene_expression of Sat1 1 0.19 0.38 0.12
111 INT50552 Transcription of ENOPH1 2 0.67 0.45 0.1
112 INT28525 Localization of SMOX 2 0.68 1.29 0.09
113 INT260526 Negative_regulation of Gene_expression of AMD1 2 0.36 0.71 0.09
114 INT50549 Localization of ENOPH1 2 0.64 0.45 0.09
115 INT58680 Transcription of Odc1 1 0.53 0 0.09
116 INT186543 Gene_expression of MTAP 1 0.11 0.48 0.08
117 INT47604 Positive_regulation of Positive_regulation of Odc1 1 0.50 0.07 0.08
118 INT58681 Positive_regulation of Gene_expression of Odc1 2 0.70 1.13 0.07
119 INT274026 Positive_regulation of Gene_expression of AMD1 1 0.16 0.41 0.07
120 INT200068 Phosphorylation of ENOPH1 1 0.17 0.11 0.06
121 INT260527 Negative_regulation of AMD1 6 0.37 5 0.05
122 INT269749 Transcription of AMD1 1 0.59 1.04 0.05
123 INT260524 Phosphorylation of AMD1 1 0.16 1.16 0.04
124 INT197485 Regulation of Positive_regulation of GOT1 1 0.01 0.44 0.04
125 INT197486 Positive_regulation of Regulation of GOT1 1 0.01 0.44 0.04
126 INT225689 Gene_expression of SMS 10 0.65 5.66 0.03
127 INT239799 Positive_regulation of Gene_expression of SMS 1 0.11 0.09 0.03
128 INT175217 Regulation of ENOPH1 5 0.06 0.44 0
129 INT202939 Regulation of AMD1 4 0.38 2.68 0
130 INT309901 Negative_regulation of SAT1 3 0.13 3.96 0
131 INT234117 Positive_regulation of Binding of MRI1 2 0.44 0.19 0
132 INT234406 Localization of ADI1 2 0.06 4.52 0
133 INT142712 Binding of Odc1 2 0.36 0.24 0
134 INT234401 Positive_regulation of Positive_regulation of ADI1 1 0.03 1.46 0
135 INT328248 Localization of SAT1 1 0.11 1.45 0
136 INT68931 Negative_regulation of Localization of ENOPH1 1 0.04 0 0
137 INT205970 Regulation of Gene_expression of SMOX 1 0.27 0.59 0
138 INT286842 Regulation of Gene_expression of SMS 1 0.27 0.3 0
139 INT234429 Positive_regulation of Localization of ADI1 1 0.03 1.92 0
140 INT289729 Binding of Sat1 1 0.25 0.79 0
141 INT195451 Binding of ODC1 1 0.32 0 0
142 INT245212 Localization of ODC1 1 0.00 0.2 0
143 INT205971 Negative_regulation of Gene_expression of SMOX 1 0.25 0.57 0
144 INT320048 Regulation of Binding of Odc1 1 0.09 0 0
145 INT19370 Positive_regulation of Negative_regulation of Odc1 1 0.21 0 0
146 INT30027 Regulation of Regulation of Odc1 1 0.27 0 0
147 INT286844 Negative_regulation of Gene_expression of SMS 1 0.25 0.65 0
148 INT269746 Positive_regulation of Localization of AMD1 1 0.43 2.54 0
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