GO:0006605

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Name protein targeting
Categary Process
Go Slim Yes
Go Link GO:0006605
Unique Molecular Interactions 153
Total Molecular Interactions 231
Total Single Events 693
Pain Genes Associated 20

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein targeting. They are ordered first by their pain relevance and then by number of times they were reported for protein targeting. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
2 INT103669 Hps4 Positive_regulation of Mors1 1 0.01 0 2.7
3 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
4 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
5 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9
6 INT43447 Binding of H3 and Hps4 1 0.07 0 1.82
7 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
8 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
9 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
10 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
11 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
12 INT107566 Penk Regulation of Hps4 1 0.00 0.1 1.04
13 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
14 INT38579 Binding of POMC and Hps4 1 0.00 0.32 0.99
15 INT302309 Hps4 Positive_regulation of Cia1 1 0.01 1.34 0.95
16 INT4915 Binding of Tac2 and Gipc1 1 0.01 0 0.74
17 INT281083 Binding of Gria1 and Gipc1 1 0.01 0 0.65
18 INT153796 NUBPL Negative_regulation of YWHAQ 1 0.02 0.69 0.64
19 INT113611 Binding of Pick1 and Grip2 1 0.31 0.6 0.63
20 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
21 INT111184 Binding of GIPC1 and CHCHD8 1 0.00 0 0.59
22 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59
23 INT296486 Binding of Pick1 and GRIP1 1 0.03 0.32 0.59
24 INT296475 Binding of Pick1 and Myo18a 2 0.01 1.63 0.57
25 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
26 INT205733 Gphn Regulation of Gene_expression of Gabrd 1 0.03 0.18 0.51
27 INT47226 Asap1 Regulation of Hps4 1 0.10 0.18 0.49
28 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
29 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 0.02 0.25 0.43
30 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
31 INT354719 Binding of ASIC1 and Pick1 1 0.40 2.34 0.4
32 INT106114 Binding of ASIC2 and Pick1 1 0.14 0.1 0.4
33 INT106116 Binding of ASIC1 and Pick1 1 0.04 0.1 0.4
34 INT235887 CALM1 Regulation of Akap5 1 0.00 0 0.39
35 INT106115 Pick1 Positive_regulation of Phosphorylation of ASIC2 1 0.13 0.07 0.39
36 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
37 INT106117 Pick1 Positive_regulation of ASIC2 1 0.14 0.09 0.39
38 INT296476 Binding of Pick1 and Rbm39 1 0.00 0.57 0.37
39 INT227943 Binding of Vip and Mlph 1 0.01 0.33 0.36
40 INT235861 Binding of Prkaca and Akap5 1 0.20 0 0.35
41 INT235862 Binding of Ppp3r2 and Akap5 1 0.01 0 0.35
42 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
43 INT117589 Binding of C5AR1 and GIPC1 1 0.10 0.39 0.34
44 INT354697 Positive_regulation of Binding of Gria2 and Pick1 1 0.08 0.73 0.33
45 INT296447 Pick1 Regulation of Gria2 1 0.16 0.49 0.3
46 INT334834 Binding of Pick1 and Camkk1 1 0.00 0.5 0.3
47 INT154194 Binding of KCNK2 and Akap5 1 0.08 0.19 0.29
48 INT274946 Binding of Pick1 and Insrr 1 0.00 0 0.28
49 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
50 INT172465 Binding of Rab27a and Rab27b 2 0.41 1.71 0.27
51 INT274934 Binding of Pick1 and Grip1 1 0.05 0 0.27
52 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26
53 INT72226 Binding of AP1M2 and EMID1 1 0.00 0 0.26
54 INT72228 Negative_regulation of Binding of OPRD1 and AP1M2 1 0.04 0 0.25
55 INT72224 Binding of OPRD1 and AP1M2 1 0.03 0 0.25
56 INT354710 Pick1 Regulation of ASIC1 1 0.37 1.12 0.21
57 INT354721 Pick1 Regulation of Gene_expression of ASIC1 1 0.37 1.1 0.2
58 INT354700 Binding of Pick1 and Bfar 1 0.05 0.9 0.19
59 INT81789 Binding of MC1R and GIPC1 1 0.01 0 0.13
60 INT81786 Binding of AGRP and GIPC1 1 0.01 0 0.13
61 INT354712 Pick1 Positive_regulation of Gene_expression of ASIC1 1 0.39 0.74 0.11
62 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
63 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
64 INT354713 Pick1 Regulation of Localization of ASIC1 1 0.22 0.48 0.08
65 INT208555 YWHAQ Positive_regulation of Atxn1 1 0.77 1.02 0.08
66 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08
67 INT208556 Binding of YWHAQ and Akt1 1 0.22 1.02 0.08
68 INT232902 Binding of YWHAQ and Krt18 1 0.34 0.96 0.07
69 INT232901 Regulation of Binding of YWHAQ and Krt18 1 0.41 0.96 0.07
70 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
71 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04
72 INT354709 Gene_expression of Pick1 Positive_regulation of ASIC1 1 0.39 0.17 0.04
73 INT215244 Binding of Racgap1 and Mlph 1 0.04 0.76 0.04
74 INT244018 Binding of Neurod1 and Trak2 1 0.01 0 0.04
75 INT129331 Binding of Trpv1 and Gipc1 1 0.01 0 0.03
76 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03
77 INT354711 Regulation of Binding of ASIC1 and Pick1 1 0.51 0.19 0.03
78 INT244030 Binding of Gabrg1 and Trak2 1 0.03 0 0.03
79 INT354716 Pick1 Regulation of Binding of ASIC1 1 0.37 0.2 0.03
80 INT270938 Binding of Pick1 and Wnt2 1 0.00 0.18 0.03
81 INT354722 Pick1 Positive_regulation of Localization of ASIC1 1 0.39 0 0
82 INT244057 Binding of Gabarap and Zdhhc3 1 0.06 0 0
83 INT329996 Binding of SGCD and AKAP6 1 0.37 0.46 0
84 INT292511 Mlph Regulation of AKT1 1 0.01 0.21 0
85 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
86 INT292500 Mlph Regulation of Gene_expression of BAX 1 0.00 0.4 0
87 INT232890 Binding of Rab27a and Gopc 1 0.01 0.3 0
88 INT299946 Binding of Tlr4 and Synj2bp 1 0.00 0.28 0
89 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
90 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
91 INT354706 Pick1 Positive_regulation of ASIC1 1 0.36 0 0
92 INT292514 Mlph Regulation of Positive_regulation of AKT1 1 0.01 0.42 0
93 INT234800 RAB27A Positive_regulation of INS 1 0.02 1.26 0
94 INT250316 Mlph Positive_regulation of Regulation of Ccr9 1 0.01 0.11 0
95 INT329995 Binding of KCNMA1 and AKAP6 1 0.40 0.48 0
96 INT244029 Binding of Nr1i3 and Zdhhc3 1 0.00 0 0
97 INT215246 Binding of Rab27a and Rph3a 1 0.07 0.26 0
98 INT172464 Binding of Rab27a and Myc 1 0.13 0.69 0
99 INT290483 RAB27A Regulation of Gene_expression of Mitf 1 0.25 0.64 0
100 INT338162 Positive_regulation of Binding of YWHAQ and Nxnl1 1 0.49 0.26 0
101 INT290046 RAB27A Regulation of RPE 1 0.03 0.75 0
102 INT292502 Mlph Regulation of Gene_expression of BAD 1 0.01 0.4 0
103 INT292507 Mlph Regulation of Gene_expression of GEM 1 0.01 0.74 0
104 INT215239 Binding of Rab27a and Sytl4 1 0.26 0.26 0
105 INT354696 Positive_regulation of Binding of Pick1 and Bfar 1 0.06 0.27 0
106 INT292495 Mlph Regulation of Gene_expression of PTK2 1 0.03 0.21 0
107 INT290045 RAB27A Positive_regulation of CHM 1 0.16 0.92 0
108 INT292494 Mlph Positive_regulation of Phosphorylation of AKT1 1 0.01 0.84 0
109 INT292508 Mlph Regulation of Phosphorylation of BAD 1 0.01 1.52 0
110 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0
111 INT354699 Binding of Accn2 and Pick1 1 0.07 0.22 0
112 INT234793 RAB27A Positive_regulation of Localization of INS 1 0.03 1.26 0
113 INT292510 Mlph Regulation of Gene_expression of GOPC 1 0.00 0.41 0
114 INT292501 Mlph Positive_regulation of Phosphorylation of BAD 1 0.01 0.39 0
115 INT329992 Binding of SNRNP70 and AKAP6 1 0.03 0.95 0
116 INT292504 Mlph Regulation of EIF2AK3 1 0.00 0.21 0
117 INT315055 Binding of YWHAQ and PAR4 1 0.52 0.78 0
118 INT292499 Mlph Positive_regulation of AKT1 1 0.01 0.87 0
119 INT215242 Binding of Rab27a and Noc2l 1 0.07 0.26 0
120 INT292506 Mlph Regulation of PTK2 1 0.01 0.21 0
121 INT292496 Mlph Regulation of MAPK1 1 0.00 0.21 0
122 INT315072 Binding of AKT1 and YWHAQ 1 0.34 0.78 0
123 INT292513 Mlph Regulation of Gene_expression of AKT1 1 0.01 0.21 0
124 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0
125 INT234795 Negative_regulation of CHM Negative_regulation of RAB27A 1 0.01 0.8 0
126 INT292509 Mlph Positive_regulation of CALM1 1 0.00 0.4 0
127 INT292493 Mlph Regulation of Gene_expression of MAPK1 1 0.00 0.21 0
128 INT338161 Binding of YWHAQ and Nxnl1 1 0.37 0.26 0
129 INT292492 Mlph Regulation of Gene_expression of Birc5 1 0.04 1.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein targeting. They are ordered first by their pain relevance and then by number of times they were reported in protein targeting. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT30440 Gene_expression of Hps4 15 0.29 2.39 15.31
2 INT18430 Positive_regulation of Hps4 14 0.24 0.81 14.82
3 INT30236 Negative_regulation of Hps4 8 0.15 1.03 11.4
4 INT18429 Localization of Hps4 8 0.31 1.23 9.01
5 INT63852 Gene_expression of Gphn 21 0.63 5.64 8.2
6 INT43441 Binding of Hps4 7 0.24 0.46 7.43
7 INT31911 Regulation of Hps4 5 0.19 2.16 6.83
8 INT154198 Binding of Pick1 9 0.48 6.91 3.16
9 INT94688 Negative_regulation of Gphn 4 0.21 2.35 2.95
10 INT166378 Positive_regulation of Gene_expression of Pick1 6 0.61 1.94 2.77
11 INT30437 Negative_regulation of Gene_expression of Hps4 1 0.03 0 2.74
12 INT211733 Phosphorylation of Gipc1 2 0.01 0 2.68
13 INT89830 Positive_regulation of Gphn 4 0.45 0.81 2.61
14 INT161978 Positive_regulation of Localization of GIPC1 1 0.19 1.98 2.12
15 INT166380 Positive_regulation of Pick1 5 0.44 1.26 1.95
16 INT72237 Binding of AP1M2 3 0.25 0 1.94
17 INT161979 Positive_regulation of Gene_expression of GIPC1 1 0.19 1.96 1.93
18 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9
19 INT351285 Localization of AP1M2 1 0.07 0.79 1.89
20 INT97062 Binding of PML 10 0.41 11.63 1.65
21 INT42277 Gene_expression of GIPC1 6 0.25 2.06 1.61
22 INT172752 Protein_catabolism of Hps4 2 0.16 0.22 1.51
23 INT179550 Phosphorylation of Ywhaq 8 0.03 6.24 1.48
24 INT30439 Positive_regulation of Gene_expression of Hps4 1 0.02 0 1.47
25 INT111186 Positive_regulation of GIPC1 4 0.67 1.44 1.46
26 INT63845 Regulation of Gene_expression of Gphn 5 0.36 0.23 1.23
27 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
28 INT71863 Negative_regulation of YWHAQ 4 0.58 1.8 1.19
29 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
30 INT113607 Positive_regulation of Pick1 1 0.48 0.82 1.13
31 INT90898 Negative_regulation of Rab27a 5 0.43 1.99 1.04
32 INT116659 Regulation of Pick1 3 0.41 0.86 1.01
33 INT166377 Gene_expression of Pick1 3 0.68 2.9 0.97
34 INT72990 Binding of Gphn 4 0.25 0.34 0.94
35 INT227935 Gene_expression of Mlph 4 0.08 0.51 0.94
36 INT59995 Localization of GIPC1 2 0.28 0.66 0.87
37 INT102842 Binding of YWHAQ 6 0.47 3.48 0.86
38 INT44800 Negative_regulation of Positive_regulation of Hps4 1 0.16 0 0.85
39 INT72992 Transcription of Gphn 3 0.50 0.19 0.8
40 INT100833 Transcription of Akap12 1 0.64 0.28 0.78
41 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74
42 INT262726 Localization of PML 6 0.57 7.13 0.72
43 INT106106 Gene_expression of Pick1 3 0.70 0.66 0.68
44 INT77397 Phosphorylation of GIPC1 1 0.01 0 0.56
45 INT90897 Regulation of Rab27a 6 0.45 3.28 0.5
46 INT52920 Phosphorylation of Gipc1 1 0.04 0 0.5
47 INT89829 Positive_regulation of Positive_regulation of Gphn 1 0.00 0.29 0.47
48 INT166384 Positive_regulation of Positive_regulation of Pick1 1 0.15 0.19 0.44
49 INT205271 Binding of Synj2bp 1 0.01 0.29 0.42
50 INT100832 Regulation of Akap12 1 0.25 0.08 0.4
51 INT106108 Phosphorylation of Pick1 1 0.54 0.07 0.39
52 INT72991 Regulation of Gphn 4 0.22 0.34 0.38
53 INT46545 Binding of Gipc1 2 0.02 0 0.38
54 INT208553 Phosphorylation of YWHAQ 4 0.80 3.42 0.36
55 INT119612 Positive_regulation of Gipc1 1 0.01 0 0.35
56 INT299942 Gene_expression of Synj2bp 1 0.01 1.3 0.32
57 INT299944 Regulation of Gene_expression of Synj2bp 1 0.01 1.31 0.32
58 INT354672 Positive_regulation of Binding of Pick1 1 0.61 1.32 0.31
59 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
60 INT53212 Negative_regulation of RAB27A 4 0.57 2.46 0.26
61 INT42278 Binding of GIPC1 3 0.03 0.33 0.26
62 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
63 INT72236 Negative_regulation of AP1M2 1 0.19 0 0.25
64 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
65 INT72994 Localization of Gphn 2 0.51 0 0.23
66 INT320581 Positive_regulation of Gene_expression of Gphn 1 0.34 0 0.23
67 INT246641 Gene_expression of YWHAQ 5 0.58 3 0.22
68 INT172442 Binding of Rab27a 3 0.37 1.5 0.21
69 INT321011 Negative_regulation of Protein_catabolism of Hps4 1 0.09 0 0.2
70 INT270417 Binding of Ywhaq 1 0.00 0.52 0.2
71 INT129672 Positive_regulation of Rab27a 2 0.69 2.72 0.19
72 INT302246 Localization of YWHAQ 1 0.08 0.81 0.18
73 INT331147 Positive_regulation of Phosphorylation of YWHAQ 1 0.45 0.6 0.18
74 INT270959 Binding of Pick1 2 0.35 0.2 0.16
75 INT243966 Binding of Trak2 5 0.34 0 0.15
76 INT227937 Regulation of Mlph 1 0.01 0.34 0.13
77 INT317296 Regulation of YWHAQ 1 0.44 1.99 0.13
78 INT354674 Negative_regulation of Pick1 1 0.37 0.48 0.12
79 INT320585 Negative_regulation of Gene_expression of Pick1 1 0.31 0.1 0.11
80 INT320586 Positive_regulation of Gene_expression of Pick1 1 0.50 0.1 0.11
81 INT72993 Regulation of Localization of Gphn 1 0.09 0 0.11
82 INT311132 Regulation of Regulation of Gphn 1 0.22 0.34 0.11
83 INT349072 Positive_regulation of Gene_expression of PML 1 0.13 1.49 0.1
84 INT282824 Regulation of PML 3 0.44 2.66 0.09
85 INT40116 Regulation of Gipc1 1 0.01 0 0.09
86 INT286253 Negative_regulation of Localization of Hps4 1 0.01 0 0.09
87 INT227936 Localization of Mlph 3 0.10 0.1 0.08
88 INT354677 Negative_regulation of Gene_expression of Pick1 1 0.51 0.06 0.08
89 INT263690 Negative_regulation of Gipc1 1 0.01 0 0.08
90 INT320584 Negative_regulation of Pick1 1 0.31 0.09 0.08
91 INT354660 Positive_regulation of Negative_regulation of Pick1 1 0.44 0.49 0.08
92 INT227938 Binding of Mlph 1 0.01 0.07 0.07
93 INT232883 Regulation of Binding of YWHAQ 1 0.26 0.95 0.07
94 INT329999 Binding of AKAP6 1 0.36 0.91 0.07
95 INT354664 Regulation of Gene_expression of Pick1 1 0.39 0 0.04
96 INT356186 Positive_regulation of Regulation of PML 1 0.49 1.14 0.04
97 INT172463 Gene_expression of RAB27A 6 0.65 3.95 0.03
98 INT172449 Positive_regulation of Gene_expression of Rab27a 4 0.50 2.37 0.03
99 INT354680 Regulation of Binding of Pick1 1 0.39 0.51 0.03
100 INT243941 Gene_expression of Trak2 1 0.08 0 0.03
101 INT169815 Positive_regulation of Mlph 3 0.04 0.32 0
102 INT172459 Localization of Rab27a 2 0.75 1.57 0
103 INT290075 Regulation of RAB27A 2 0.44 1.31 0
104 INT329998 Localization of AKAP6 1 0.72 0.26 0
105 INT215223 Regulation of Localization of Rab27a 1 0.45 0.73 0
106 INT330002 Gene_expression of AKAP6 1 0.75 0.11 0
107 INT292440 Negative_regulation of Mlph 1 0.02 0.42 0
108 INT292439 Phosphorylation of Mlph 1 0.05 8.87 0
109 INT234815 Phosphorylation of RAB27A 1 0.37 0.77 0
110 INT175049 Gene_expression of Gipc1 1 0.07 0.07 0
111 INT330665 Negative_regulation of PML 1 0.13 1.15 0
112 INT286382 Transcription of Trak2 1 0.62 0 0
113 INT172455 Protein_catabolism of Rab27a 1 1.00 2.11 0
114 INT311859 Positive_regulation of RAB27A 1 0.19 2.95 0
115 INT331148 Positive_regulation of YWHAQ 1 0.45 0.37 0
116 INT172443 Negative_regulation of Transcription of Rab27a 1 0.43 0.4 0
117 INT292442 Positive_regulation of Phosphorylation of Mlph 1 0.03 1.31 0
118 INT172457 Positive_regulation of Localization of Rab27a 1 0.50 0.38 0
119 INT354663 Localization of Pick1 1 0.65 0 0
120 INT172450 Regulation of Gene_expression of Rab27a 1 0.45 0.37 0
121 INT292438 Positive_regulation of Positive_regulation of Mlph 1 0.03 0.21 0
122 INT151246 Regulation of GIPC1 1 0.01 0.22 0
123 INT172446 Transcription of Rab27a 1 0.69 0.39 0
124 INT311860 Binding of RAB27A 1 0.10 0.52 0
125 INT283563 Regulation of Localization of Mlph 1 0.06 0 0
126 INT260516 Localization of Gipc1 1 0.01 0.83 0
127 INT292441 Negative_regulation of Phosphorylation of Mlph 1 0.03 1.79 0
128 INT243973 Gene_expression of Zdhhc3 1 0.20 0 0
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