GO:0006626

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Name protein targeting to mitochondrion
Categary Process
Go Slim No
Go Link GO:0006626
Unique Molecular Interactions 105
Total Molecular Interactions 125
Total Single Events 1049
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein targeting to mitochondrion. They are ordered first by their pain relevance and then by number of times they were reported for protein targeting to mitochondrion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
2 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
3 INT346266 MTX1 Regulation of IL17A 1 0.08 1.33 0.89
4 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
5 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
6 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83
7 INT278696 MTX1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
8 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
9 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74
10 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73
11 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
12 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
13 INT112701 Bid Regulation of RFFL 1 0.00 0.52 0.62
14 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
15 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
16 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61
17 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
18 INT278688 MTX1 Negative_regulation of Positive_regulation of SOAT1 1 0.04 0.69 0.54
19 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
20 INT278691 MTX1 Negative_regulation of DHFR 1 0.02 0.57 0.49
21 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
22 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
23 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
24 INT121856 BID Regulation of ROS1 1 0.05 0.52 0.41
25 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
26 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
27 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
28 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
29 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34
30 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
31 INT158922 Positive_regulation of Binding of TSPO and Tspo 1 0.54 0.83 0.28
32 INT158923 Binding of TSPO and Tspo 1 0.40 0.82 0.28
33 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24
34 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
35 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
36 INT191338 Binding of TSPO and IDO1 1 0.02 0.65 0.16
37 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14
38 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
39 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
40 INT167040 Binding of Aip and Drb1 1 0.10 0.54 0.1
41 INT167041 Binding of HLA-A and Aip 1 0.02 0.54 0.1
42 INT99910 Binding of MTX1 and ABCB1 1 0.25 0.09 0.1
43 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
44 INT145987 Binding of CTLA4 and Aip 1 0.08 0.61 0.09
45 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
46 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
47 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
48 INT328834 MTX1 Negative_regulation of KCNK4 1 0.01 0 0.05
49 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05
50 INT300449 VEGFA Positive_regulation of Protein_catabolism of Ppp2r2b 1 0.00 1.51 0.05
51 INT302975 Fadd Positive_regulation of Bid 1 0.13 1.14 0.04
52 INT204298 Bid Positive_regulation of Binding of Bak1 1 0.05 0.57 0.04
53 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
54 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
55 INT185851 BID Positive_regulation of BAK1 1 0.43 0.73 0
56 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
57 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
58 INT185854 BID Positive_regulation of BAD 1 0.39 0.74 0
59 INT282792 Binding of VGF and TIMM13 1 0.20 0.72 0
60 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
61 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
62 INT194333 Binding of MFN2 and Racgap1 1 0.01 0.38 0
63 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
64 INT161823 Positive_regulation of Binding of Igha and Aip 1 0.01 0.16 0
65 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
66 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0
67 INT321882 Binding of TSPO and Lm370 1 0.01 0.4 0
68 INT161822 Binding of Igha and Aip 1 0.00 0.16 0
69 INT330052 Binding of Bax and Bid 1 0.15 0.62 0
70 INT330057 Bid Positive_regulation of Bax 1 0.19 0.62 0
71 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
72 INT237918 BID Positive_regulation of Gene_expression of BAX 1 0.04 1.31 0
73 INT201763 BID Positive_regulation of Positive_regulation of Bax 1 0.01 0.43 0
74 INT185850 BID Positive_regulation of BAX 1 0.41 0.73 0
75 INT343161 ACSL4 Regulation of Gene_expression of TSPO 1 0.25 0.75 0
76 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
77 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
78 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
79 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
80 INT193147 CRAMP1L Regulation of TSPO 1 0.01 0.27 0
81 INT161825 Binding of IgG and Aip 1 0.01 0.32 0
82 INT330050 Binding of Bid and Hrk 1 0.02 0.62 0
83 INT198005 Binding of BID and MCL1 1 0.24 2.04 0
84 INT343156 Binding of TSPO and DBI 1 0.04 0.63 0
85 INT198023 Binding of BAK1 and BID 1 0.12 0.82 0
86 INT237917 BID Positive_regulation of Positive_regulation of BAX 1 0.04 1.31 0
87 INT219502 TSPO Positive_regulation of Positive_regulation of Ppib 1 0.01 0 0
88 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0
89 INT336034 CASP8 Positive_regulation of BID 1 0.03 0.5 0
90 INT161824 Positive_regulation of Binding of and Aip 1 0.01 0.32 0
91 INT219424 Binding of AHR and TSPO 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein targeting to mitochondrion. They are ordered first by their pain relevance and then by number of times they were reported in protein targeting to mitochondrion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32
2 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
3 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10
4 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
5 INT6335 Binding of TSPO 39 0.44 10.88 7.66
6 INT182320 Binding of MTX1 14 0.18 8.5 7.65
7 INT123787 Gene_expression of Bid 25 0.66 16 6.35
8 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
9 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
10 INT121801 Binding of Aip 18 0.36 24.1 5.26
11 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87
12 INT124136 Positive_regulation of YWHAZ 7 0.67 1.85 4.51
13 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23
14 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91
15 INT120062 Binding of AIP 4 0.42 28.86 3.91
16 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62
17 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
18 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
19 INT104928 Positive_regulation of BID 10 0.67 6.9 3.41
20 INT104930 Protein_catabolism of BID 12 0.86 10.82 3.15
21 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
22 INT99911 Localization of MTX1 5 0.45 3.81 3.07
23 INT211132 Positive_regulation of Gene_expression of MTX1 4 0.23 2.71 2.94
24 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
25 INT124138 Gene_expression of YWHAZ 9 0.62 4.04 2.21
26 INT211135 Positive_regulation of Localization of MTX1 2 0.23 2.14 2.14
27 INT112698 Gene_expression of Bid 8 0.64 6.52 1.97
28 INT211131 Regulation of Gene_expression of MTX1 3 0.21 1.45 1.97
29 INT14257 Localization of TSPO 9 0.73 1.48 1.87
30 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
31 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
32 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78
33 INT124137 Positive_regulation of Positive_regulation of YWHAZ 1 0.67 0 1.7
34 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
35 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
36 INT64529 Localization of Pde2a 1 0.59 0 1.63
37 INT211120 Negative_regulation of Binding of MTX1 2 0.18 0.64 1.6
38 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
39 INT17885 Negative_regulation of YWHAZ 6 0.56 2.74 1.58
40 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
41 INT162463 Localization of BID 6 0.73 7.47 1.5
42 INT121859 Negative_regulation of Protein_catabolism of BID 3 0.42 2.1 1.46
43 INT238653 Regulation of MTX1 2 0.30 1.71 1.42
44 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
45 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
46 INT117267 Transcription of MTX1 2 0.52 2.45 1.31
47 INT287798 Localization of AIP 1 0.63 5.96 1.31
48 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3
49 INT104926 Positive_regulation of Protein_catabolism of BID 2 0.49 2.12 1.22
50 INT287799 Positive_regulation of Gene_expression of AIP 1 0.42 7.39 1.19
51 INT121861 Regulation of BID 4 0.31 2.73 1.15
52 INT124135 Positive_regulation of Gene_expression of YWHAZ 2 0.45 0.21 1.05
53 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
54 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97
55 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
56 INT196583 Regulation of Phosphorylation of Mapk9 1 0.37 0.5 0.85
57 INT142025 Localization of Bid 13 0.69 8.24 0.84
58 INT104482 Positive_regulation of Phosphorylation of Mapk9 2 0.49 1.55 0.84
59 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
60 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
61 INT104488 Negative_regulation of Phosphorylation of Mapk9 1 0.41 1.03 0.72
62 INT340441 Positive_regulation of Binding of MTX1 1 0.17 1.7 0.72
63 INT69003 Negative_regulation of Binding of TSPO 4 0.03 2.78 0.69
64 INT103553 Positive_regulation of Positive_regulation of MTX1 1 0.01 0.53 0.69
65 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
66 INT123784 Positive_regulation of Gene_expression of Bid 4 0.40 2.41 0.66
67 INT191341 Negative_regulation of Gene_expression of TSPO 3 0.34 1.66 0.64
68 INT117266 Positive_regulation of Transcription of MTX1 1 0.45 0.73 0.62
69 INT73850 Transcription of TSPO 6 0.59 0.83 0.61
70 INT204138 Regulation of Gene_expression of TSPO 2 0.36 0.99 0.6
71 INT133765 Regulation of Gene_expression of Bid 1 0.29 0.45 0.58
72 INT104483 Positive_regulation of Positive_regulation of Mapk9 1 0.49 0.75 0.56
73 INT178718 Phosphorylation of TSPO 1 0.79 0.91 0.56
74 INT178717 Negative_regulation of Localization of TSPO 1 0.41 0.92 0.56
75 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
76 INT154613 Regulation of Aip 5 0.21 3.86 0.55
77 INT104484 Regulation of Mapk9 1 0.12 0.73 0.55
78 INT73849 Negative_regulation of TSPO 8 0.59 2.4 0.53
79 INT182323 Regulation of Binding of MTX1 2 0.19 1.32 0.53
80 INT154449 Positive_regulation of Gene_expression of Aip 2 0.43 2.88 0.52
81 INT282809 Negative_regulation of Positive_regulation of YWHAZ 1 0.03 1.07 0.52
82 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49
83 INT148985 Positive_regulation of Positive_regulation of BID 1 0.53 0.84 0.48
84 INT204293 Protein_catabolism of Bid 9 0.65 6.07 0.45
85 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
86 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
87 INT61831 Regulation of Regulation of TSPO 1 0.03 0.16 0.43
88 INT121860 Negative_regulation of BID 2 0.29 1.92 0.38
89 INT121862 Negative_regulation of Negative_regulation of BID 1 0.29 0.54 0.38
90 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
91 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
92 INT123783 Transcription of Bid 2 0.08 0.68 0.34
93 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
94 INT144179 Localization of Aip 4 0.61 2.59 0.33
95 INT116196 Protein_catabolism of Bid 7 0.66 6.24 0.32
96 INT146646 Protein_catabolism of TSPO 3 0.86 0.58 0.32
97 INT287800 Positive_regulation of Positive_regulation of AIP 1 0.42 2.15 0.3
98 INT281933 Localization of YWHAZ 2 0.09 1.08 0.27
99 INT356135 Positive_regulation of Binding of Aip 1 0.09 0.81 0.24
100 INT152745 Positive_regulation of Bid 2 0.32 2.67 0.23
101 INT154934 Negative_regulation of Positive_regulation of Mapk9 1 0.35 0.41 0.23
102 INT356136 Negative_regulation of Localization of Aip 1 0.08 0.88 0.23
103 INT199844 Binding of Bid 3 0.24 3.92 0.19
104 INT167038 Binding of Aip 2 0.21 2.13 0.19
105 INT204286 Positive_regulation of Localization of Bid 1 0.40 1.85 0.18
106 INT123785 Positive_regulation of Transcription of Bid 1 0.06 0.54 0.18
107 INT185911 Phosphorylation of BID 3 0.71 1.75 0.17
108 INT152630 Binding of Bid 2 0.32 0.54 0.17
109 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
110 INT131541 Negative_regulation of Gene_expression of YWHAZ 1 0.27 0.39 0.17
111 INT131539 Regulation of Gene_expression of YWHAZ 1 0.17 0.39 0.17
112 INT55496 Phosphorylation of Ppp2r2b 1 0.23 0 0.16
113 INT55497 Negative_regulation of Phosphorylation of Ppp2r2b 1 0.16 0 0.16
114 INT287797 Phosphorylation of AIP 1 0.78 2.04 0.16
115 INT194332 Localization of MFN2 2 0.74 1.45 0.15
116 INT55499 Localization of Ppp2r2b 1 0.26 0 0.15
117 INT55498 Negative_regulation of Ppp2r2b 1 0.16 0 0.15
118 INT54808 Positive_regulation of TIMM13 3 0.23 3.05 0.13
119 INT245803 Protein_catabolism of Ppp2r2b 2 0.02 3.02 0.13
120 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
121 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
122 INT89676 Gene_expression of BID 8 0.31 8.98 0.1
123 INT73848 Positive_regulation of Transcription of TSPO 3 0.42 0.58 0.1
124 INT237212 Gene_expression of TIMM13 2 0.39 2.54 0.1
125 INT319782 Localization of Bid 2 0.30 1.06 0.1
126 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
127 INT341412 Negative_regulation of Positive_regulation of Bid 1 0.38 0.99 0.1
128 INT112990 Negative_regulation of AIP 1 0.10 0.59 0.09
129 INT167037 Regulation of Aip 1 0.25 0.71 0.09
130 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
131 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07
132 INT54809 Regulation of TIMM13 2 0.14 2.31 0.07
133 INT54811 Negative_regulation of TIMM13 2 0.22 2.46 0.07
134 INT54810 Negative_regulation of Positive_regulation of TIMM13 1 0.22 1.89 0.07
135 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
136 INT204287 Phosphorylation of Bid 1 0.70 1.08 0.07
137 INT123786 Negative_regulation of Gene_expression of Bid 1 0.05 0.37 0.06
138 INT341415 Positive_regulation of Positive_regulation of Bid 1 0.45 0.88 0.06
139 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
140 INT300432 Negative_regulation of Protein_catabolism of Ppp2r2b 1 0.01 1.52 0.05
141 INT204294 Negative_regulation of Bid 1 0.37 1.09 0.05
142 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
143 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
144 INT308415 Negative_regulation of Transcription of Aip 1 0.48 0.82 0.03
145 INT308414 Negative_regulation of Gene_expression of Aip 1 0.48 0.82 0.03
146 INT194329 Positive_regulation of MFN2 1 0.40 0.74 0.03
147 INT304408 Regulation of YWHAZ 1 0.21 0.14 0.03
148 INT336054 Binding of BID 3 0.19 1.32 0
149 INT237967 Positive_regulation of Localization of BID 2 0.21 2.83 0
150 INT162918 Transcription of PDE2A 1 0.65 0 0
151 INT300435 Gene_expression of Ppp2r2b 1 0.02 0.56 0
152 INT336052 Negative_regulation of Binding of BID 1 0.22 0.56 0
153 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
154 INT336055 Regulation of Protein_catabolism of BID 1 0.14 0.5 0
155 INT194330 Regulation of Gene_expression of MFN2 1 0.45 0.3 0
156 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
157 INT300434 Positive_regulation of Ppp2r2b 1 0.01 0.67 0
158 INT308416 Regulation of Gene_expression of Aip 1 0.37 0.77 0
159 INT180906 Negative_regulation of Positive_regulation of TSPO 1 0.50 0 0
160 INT183430 Binding of Pde2a 1 0.07 0 0
161 INT155732 Transcription of YWHAZ 1 0.16 0 0
162 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
163 INT308417 Transcription of Aip 1 0.59 0.82 0
164 INT274728 Regulation of Binding of TSPO 1 0.02 0 0
165 INT293972 Positive_regulation of Binding of TSPO 1 0.04 1.01 0
166 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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