GO:0006695

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Name cholesterol biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006695
Unique Molecular Interactions 287
Total Molecular Interactions 367
Total Single Events 3065
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cholesterol biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for cholesterol biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18593 Binding of Sst and Fdft1 2 0.11 0.08 2.12
2 INT29554 Ebp Positive_regulation of LH 2 0.40 0.12 1.41
3 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
4 INT348380 Binding of Fdps and Lpar5 1 0.07 1.45 1.25
5 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
6 INT18596 Fdft1 Regulation of Localization of Acot1 1 0.06 0 1.14
7 INT18594 Binding of Fdft1 and Positive_regulation of Localization of Acot1 1 0.11 0 1.11
8 INT52435 Positive_regulation of Binding of Sst and Fdft1 1 0.09 0.08 0.98
9 INT18595 Fdft1 Positive_regulation of Localization of Acot1 1 0.08 0 0.96
10 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
11 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
12 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
13 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
14 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
15 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
16 INT64068 Tp63 Regulation of Fdft1 1 0.00 0.06 0.69
17 INT348396 Binding of LPAR5 and Fdps 1 0.07 0.81 0.69
18 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67
19 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
20 INT348381 Fdps Positive_regulation of Lpar5 1 0.07 0.75 0.64
21 INT348399 Fdps Positive_regulation of LPAR5 1 0.08 0.75 0.64
22 INT96765 LBR Positive_regulation of Gene_expression of TP53INP2 1 0.11 0.5 0.62
23 INT77379 Tmie Negative_regulation of Ebp 1 0.03 0 0.59
24 INT170833 Cftr Negative_regulation of Slc10a2 1 0.47 0.31 0.56
25 INT176371 LBR Positive_regulation of IL12A 1 0.04 1.22 0.55
26 INT176367 LBR Positive_regulation of IFNA1 1 0.02 1.22 0.55
27 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
28 INT69291 Cftr Positive_regulation of Localization of Slc4a8 1 0.04 0.38 0.51
29 INT117482 CFTR Negative_regulation of THRB 1 0.01 0.15 0.51
30 INT48102 Positive_regulation of LBR Positive_regulation of Positive_regulation of OR7A5 1 0.21 0 0.48
31 INT176366 LBR Regulation of IFNA1 1 0.04 0.91 0.46
32 INT341623 Binding of CFTR and CTRC 1 0.35 1.22 0.46
33 INT341624 Binding of CFTR and PRSS1 1 0.39 1.01 0.45
34 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
35 INT213027 Binding of Apoa1 and Scarb1 6 0.09 7.52 0.43
36 INT307780 Apoa1 Positive_regulation of Soat1 1 0.04 1.14 0.42
37 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
38 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
39 INT176361 Positive_regulation of LBR Positive_regulation of Gene_expression of IL18 1 0.10 0.84 0.39
40 INT37270 Negative_regulation of Ebp Positive_regulation of LH 1 0.37 0 0.38
41 INT190003 Binding of MVD and Slc6a3 1 0.13 0.19 0.37
42 INT157147 LSS Positive_regulation of PTGIR 1 0.09 0.96 0.36
43 INT157148 LSS Negative_regulation of TNF 1 0.25 0.74 0.35
44 INT171874 Binding of SQLE and MRAP 1 0.00 1.29 0.35
45 INT352547 Binding of CFTR and DMD 1 0.01 1.42 0.35
46 INT176363 IFNA1 Regulation of Positive_regulation of LBR 1 0.04 0.69 0.34
47 INT46788 Chrna7 Positive_regulation of G6pd 1 0.50 0 0.33
48 INT307017 LBR Positive_regulation of Gene_expression of TNF 1 0.02 0.58 0.32
49 INT307014 LBR Positive_regulation of Gene_expression of IL6 1 0.01 0.58 0.32
50 INT21321 Pomc Positive_regulation of LBR 1 0.04 0 0.31
51 INT299557 Binding of CRS and SQLE 1 0.00 0.7 0.29
52 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
53 INT196695 Prkaca Positive_regulation of CFTR 1 0.46 0.13 0.27
54 INT213029 Positive_regulation of Binding of Apoa1 and Scarb1 1 0.09 3.38 0.27
55 INT274697 Binding of CFTR and Cftr 1 0.08 0.69 0.27
56 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25
57 INT190052 Binding of Cdx2 and Ebp 1 0.08 0.82 0.24
58 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24
59 INT305798 Binding of APOA1 and OxP-11D 1 0.02 0.45 0.23
60 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
61 INT186957 Nsdhl Positive_regulation of Tmed4 1 0.04 0.71 0.23
62 INT190045 Binding of Ebp and Scrib 1 0.10 0.79 0.22
63 INT170834 Cftr Regulation of Slc10a2 1 0.58 0.37 0.22
64 INT175911 Binding of SERPINE1 and CNBP 1 0.01 1.02 0.22
65 INT299592 SQLE Regulation of RatNP-3b 1 0.01 0.99 0.22
66 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
67 INT157146 LSS Negative_regulation of Positive_regulation of TNF 1 0.25 1.08 0.21
68 INT115148 PPARG Negative_regulation of Gene_expression of INSIG2 1 0.01 0.34 0.21
69 INT189321 Binding of Apoa1 and Hdlcl1 1 0.00 0.68 0.2
70 INT175909 Binding of ROS1 and CNBP 1 0.01 1.78 0.19
71 INT196610 IFNG Negative_regulation of CFTR 1 0.17 0.21 0.19
72 INT261373 Nsdhl Positive_regulation of Gene_expression of Gfap 1 0.10 2.05 0.19
73 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
74 INT161746 Binding of G6PD and HBG2 1 0.21 0.36 0.19
75 INT135463 Binding of DHCR24 and Fos 1 0.35 0.17 0.19
76 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18
77 INT135462 Binding of DHCR24 and Cfp 1 0.00 0.17 0.18
78 INT267660 CFTR Regulation of Gene_expression of P2RX2 1 0.25 0.51 0.18
79 INT110274 Binding of Fdps and Plin2 1 0.00 0.22 0.18
80 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17
81 INT196606 IFNG Positive_regulation of CFTR 1 0.16 0.45 0.16
82 INT186954 Binding of Des and Nsdhl 1 0.06 0.32 0.16
83 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16
84 INT196608 TNF Negative_regulation of CFTR 1 0.16 0.11 0.14
85 INT261384 Nsdhl Negative_regulation of Gene_expression of Mbp 1 0.01 1.43 0.14
86 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
87 INT152628 Mvk Negative_regulation of Cysltr1 1 0.46 0 0.13
88 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13
89 INT164012 Regulation of Binding of CNBP and Chdh 1 0.06 0.99 0.13
90 INT164011 Binding of CNBP and Chdh 1 0.05 0.99 0.13
91 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12
92 INT270723 Negative_regulation of HMGCR Positive_regulation of LDLR 1 0.02 0.52 0.12
93 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12
94 INT281192 Casr Positive_regulation of Insig1 1 0.23 0 0.12
95 INT213042 Apoa1 Positive_regulation of Nos3 1 0.10 2.17 0.11
96 INT176020 IL8 Negative_regulation of Phosphorylation of HMGCR 1 0.00 0.1 0.11
97 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11
98 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
99 INT39207 LBR Positive_regulation of Gene_expression of IL2 1 0.23 0 0.11
100 INT161747 Positive_regulation of Binding of G6PD and HBG2 1 0.28 0.18 0.1
101 INT305780 Binding of APOA1 and LRCH2 1 0.00 0.19 0.1
102 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1
103 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
104 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
105 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09
106 INT206075 Negative_regulation of FDPS Negative_regulation of Binding of GGPS1 1 0.01 0 0.09
107 INT206078 Binding of FDPS and GGPS1 1 0.00 0 0.09
108 INT52836 ESR1 Positive_regulation of HSD17B7 1 0.43 0.41 0.09
109 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08
110 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08
111 INT261386 Nsdhl Positive_regulation of Map2 1 0.08 0.59 0.07
112 INT261395 Nsdhl Positive_regulation of Syn1 1 0.00 0.59 0.07
113 INT261392 Binding of Nsdhl and Syn1 1 0.00 0.65 0.07
114 INT335129 PPARA Positive_regulation of Gene_expression of Insig1 1 0.20 0.15 0.07
115 INT279652 PPARA Positive_regulation of Gene_expression of Apoa1 1 0.00 0.75 0.07
116 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
117 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
118 INT102505 VEGFA Negative_regulation of Fdft1 1 0.00 0.56 0.06
119 INT329429 Binding of Col7a1 and Hmgcr 1 0.01 0.28 0.06
120 INT216545 Gene_expression of Cftr Negative_regulation of Kcnma1 1 0.00 0.59 0.06
121 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
122 INT335047 PPARA Positive_regulation of Gene_expression of APOA1 1 0.20 0.42 0.05
123 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
124 INT239348 Binding of Apoa1 and Hdl1 1 0.03 3.34 0.05
125 INT287222 Cytip Regulation of Transcription of Insig1 1 0.02 0.56 0.05
126 INT296023 Positive_regulation of Apoa2 Negative_regulation of APOA1 1 0.50 0.35 0.05
127 INT270134 BPs Negative_regulation of FDPS 1 0.01 0.36 0.05
128 INT157151 LSS Positive_regulation of CPOX 1 0.17 0.89 0.05
129 INT261385 LH Regulation of Localization of Nsdhl 1 0.02 0.65 0.05
130 INT307007 MT1JP Positive_regulation of Localization of LBR 1 0.01 0 0.05
131 INT287221 Tcf3 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
132 INT296025 Apoa2 Negative_regulation of APOA1 1 0.47 0.35 0.05
133 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04
134 INT236722 Ppara Positive_regulation of Binding of Apoa1 1 0.10 0.18 0.04
135 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
136 INT239320 Eef1a2 Negative_regulation of Hmgcr 1 0.06 0.89 0.04
137 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
138 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
139 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
140 INT288908 Apoa1 Positive_regulation of Gene_expression of HSD11B1 1 0.03 0.53 0.04
141 INT253365 Il6 Negative_regulation of Prkaa2 1 0.23 0 0.04
142 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
143 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
144 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
145 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03
146 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
147 INT323707 LBR Positive_regulation of MIR146A 1 0.02 0.1 0.03
148 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
149 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
150 INT299556 SQLE Regulation of CRS 1 0.00 0.77 0.03
151 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
152 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03
153 INT196639 Negative_regulation of NA Negative_regulation of Transcription of CFTR 1 0.02 0.63 0.03
154 INT213585 Binding of CFTR and FLNA 1 0.14 0.11 0.03
155 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03
156 INT239345 Apoa1 Positive_regulation of RCT 1 0.02 1.15 0.03
157 INT186960 Positive_regulation of Nsdhl Positive_regulation of Tmed4 1 0.03 0.05 0.03
158 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
159 INT310694 Tlr4 Positive_regulation of Cftr 1 0.16 0.34 0.03
160 INT308747 Binding of Cftr and Prkag1 1 0.02 0 0
161 INT301243 Mir29a Positive_regulation of Mvd 1 0.03 1.66 0
162 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
163 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
164 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0
165 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
166 INT206085 FDPS Positive_regulation of AGFG1 1 0.00 0.4 0
167 INT233323 GAD1 Regulation of HMGCR 1 0.09 0.2 0
168 INT239332 Hdl1 Positive_regulation of Gene_expression of Apoa1 1 0.04 0.84 0
169 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
170 INT207259 Binding of CNBP and TXNIP 1 0.01 0.94 0
171 INT259451 Binding of DHCR7 and Cyp11a1 1 0.01 0.3 0
172 INT316355 Binding of CR1 and Hmgcr 1 0.01 0.59 0
173 INT262212 Positive_regulation of Nr1i2 Positive_regulation of Insig1 1 0.12 0 0
174 INT247444 Binding of APOA1 and APOC3 1 0.28 0.39 0
175 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0
176 INT205863 Binding of FDPS and HTLVR 1 0.00 0.07 0
177 INT339693 HMGCR Positive_regulation of SREBF2 1 0.05 0.54 0
178 INT213017 Apoa1 Negative_regulation of Positive_regulation of Gtf3a 1 0.00 1.16 0
179 INT247436 Binding of APOA1 and SACM1L 1 0.27 0.39 0
180 INT335042 Binding of CNBP and ANAPC16 1 0.01 0.4 0
181 INT290193 Binding of APOA1 and Hdl1 1 0.01 1 0
182 INT330048 G6pd Positive_regulation of Gene_expression of Ros1 1 0.03 0.61 0
183 INT206060 FDPS Positive_regulation of AKT1 1 0.00 0.4 0
184 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0
185 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0
186 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
187 INT301242 Mvd Positive_regulation of Gene_expression of Mir29a 1 0.04 0.1 0
188 INT239353 CETP Regulation of Apoa1 1 0.16 0.65 0
189 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
190 INT239342 Lcat Regulation of Apoa1 1 0.16 0.65 0
191 INT191276 Binding of ABP1 and LSS 1 0.17 0.68 0
192 INT247030 Prkaca Regulation of Positive_regulation of Cftr 1 0.05 0 0
193 INT330225 Binding of Tmprss5 and Positive_regulation of Positive_regulation of Prkaa2 1 0.01 0.18 0
194 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0
195 INT330224 Tmprss5 Positive_regulation of Prkaa2 1 0.01 0 0
196 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
197 INT326060 Binding of ABCA1 and APOA1 1 0.39 1.5 0
198 INT320702 Binding of PMVK and C1QL3 1 0.01 0.06 0
199 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
200 INT326058 Negative_regulation of PRKCA Negative_regulation of APOA1 1 0.15 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cholesterol biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in cholesterol biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
2 INT84307 Binding of Cftr 31 0.47 26.19 12.8
3 INT879 Localization of Fdft1 16 0.59 1.11 12.59
4 INT92493 Gene_expression of Fdps 19 0.75 11.28 10.08
5 INT119892 Gene_expression of Cftr 54 0.77 23.76 9.73
6 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65
7 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55
8 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85
9 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64
10 INT182750 Gene_expression of Hmgcr 61 0.58 17.23 7.4
11 INT14029 Regulation of Fdft1 9 0.19 0.68 7.4
12 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
13 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02
14 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97
15 INT7695 Positive_regulation of Fdft1 13 0.30 1.51 6.51
16 INT2552 Binding of Fdft1 6 0.15 0.48 5.88
17 INT86119 Regulation of Cftr 13 0.45 14.08 5.75
18 INT7696 Negative_regulation of Fdft1 9 0.21 2.8 5.64
19 INT151102 Positive_regulation of CFTR 22 0.61 15.27 5.12
20 INT5411 Positive_regulation of G6pd 20 0.70 4.74 5.11
21 INT74614 Positive_regulation of Apoa1 16 0.68 23.95 5.04
22 INT89114 Binding of Cftr 13 0.37 11.29 4.99
23 INT170757 Positive_regulation of Gene_expression of Cftr 3 0.51 11.41 4.75
24 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58
25 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56
26 INT169756 Binding of CFTR 9 0.35 9.65 4.55
27 INT37139 Negative_regulation of Fdps 9 0.38 4.33 4.46
28 INT48993 Positive_regulation of Cftr 17 0.57 6.02 4.12
29 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1
30 INT89113 Regulation of Cftr 11 0.62 6.83 4.01
31 INT151099 Negative_regulation of CFTR 12 0.59 10.28 3.79
32 INT36142 Negative_regulation of Hmgcr 33 0.46 15.91 3.54
33 INT18591 Positive_regulation of Localization of Fdft1 4 0.12 0.73 3.48
34 INT26641 Gene_expression of Fdft1 4 0.20 1.61 3.15
35 INT10830 Regulation of Apoa1 11 0.44 15.1 3.04
36 INT111820 Positive_regulation of Fdps 10 0.42 10.63 3.01
37 INT151947 Positive_regulation of MVD 3 0.67 1.53 2.97
38 INT5412 Regulation of G6pd 9 0.62 1.64 2.87
39 INT48106 Positive_regulation of LBR 11 0.49 5.14 2.86
40 INT179867 Localization of Fdps 7 0.63 3.62 2.86
41 INT11139 Gene_expression of LBR 20 0.75 5.13 2.78
42 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64
43 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63
44 INT69290 Localization of Cftr 11 0.75 3.69 2.52
45 INT61907 Negative_regulation of Ebp 9 0.37 4.77 2.49
46 INT181880 Positive_regulation of Apoa1 19 0.66 21.19 2.43
47 INT86315 Transcription of Cftr 7 0.53 4.24 2.3
48 INT202522 Negative_regulation of Gene_expression of Cftr 11 0.57 5.9 2.24
49 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08
50 INT166710 Positive_regulation of Gene_expression of CFTR 9 0.46 3.72 2.03
51 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03
52 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01
53 INT119891 Regulation of Gene_expression of Cftr 4 0.59 2.67 1.98
54 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94
55 INT173576 Negative_regulation of FDPS 25 0.57 8.42 1.91
56 INT151101 Regulation of CFTR 4 0.62 3.69 1.89
57 INT22863 Negative_regulation of Apoa1 10 0.57 10.68 1.86
58 INT97073 Positive_regulation of Ebp 6 0.42 2.68 1.8
59 INT164010 Gene_expression of CNBP 7 0.53 9.13 1.71
60 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
61 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67
62 INT84308 Localization of Cftr 12 0.75 6.16 1.65
63 INT156484 Binding of Apoa1 4 0.47 6.78 1.63
64 INT46786 Positive_regulation of Positive_regulation of G6pd 3 0.47 0.47 1.52
65 INT181881 Positive_regulation of Gene_expression of Apoa1 13 0.48 14.31 1.45
66 INT132917 Phosphorylation of CNBP 1 0.11 0 1.44
67 INT270631 Gene_expression of Insig1 15 0.32 5.19 1.43
68 INT108281 Negative_regulation of Binding of Cftr 4 0.43 3.1 1.38
69 INT181882 Localization of Apoa1 8 0.71 7.94 1.37
70 INT40720 Negative_regulation of Localization of Fdft1 2 0.36 0 1.36
71 INT113777 Binding of Hmgcr 3 0.09 2.29 1.35
72 INT139625 Regulation of Gene_expression of Cftr 5 0.50 3.59 1.32
73 INT116903 Negative_regulation of Hmgcr 32 0.43 10.71 1.3
74 INT5410 Gene_expression of G6pd 15 0.75 4.59 1.28
75 INT173208 Binding of CNBP 9 0.25 11.01 1.23
76 INT14028 Transcription of Fdft1 2 0.34 0.07 1.21
77 INT196675 Localization of CFTR 4 0.64 1.95 1.19
78 INT59029 Positive_regulation of DHCR24 2 0.22 0.51 1.18
79 INT877 Regulation of Localization of Fdft1 2 0.19 0 1.18
80 INT28643 Positive_regulation of Gene_expression of LBR 3 0.11 2.43 1.16
81 INT31805 Localization of LBR 3 0.73 1.23 1.13
82 INT156804 Transcription of Ebp 1 0.41 0.49 1.13
83 INT236163 Localization of Hmgcr 6 0.64 0.66 1.12
84 INT181879 Negative_regulation of Apoa1 8 0.55 8.18 1.11
85 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09
86 INT97777 Positive_regulation of CNBP 7 0.37 9.85 1.09
87 INT15346 Negative_regulation of Regulation of Fdft1 1 0.13 0.21 1.08
88 INT156805 Gene_expression of Ebp 6 0.40 6.09 1.07
89 INT98975 Positive_regulation of Hmgcr 7 0.16 3.4 1.06
90 INT116512 Gene_expression of MVD 4 0.75 1.61 1.06
91 INT167 Regulation of Ebp 3 0.44 0.77 1.03
92 INT71378 Transcription of LBR 2 0.07 1.34 1.03
93 INT99496 Gene_expression of HSD17B7 5 0.78 1.24 1.02
94 INT176063 Positive_regulation of SQLE 4 0.36 4.28 1
95 INT71747 Positive_regulation of Prkaa2 19 0.46 8.76 0.98
96 INT44772 Negative_regulation of Negative_regulation of LBR 2 0.42 0.38 0.92
97 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89
98 INT1011 Positive_regulation of Ebp 3 0.50 1.59 0.86
99 INT81904 Positive_regulation of FDPS 5 0.67 2.83 0.85
100 INT96012 Gene_expression of EBP 3 0.67 0.8 0.85
101 INT181885 Binding of Apoa1 7 0.35 5.66 0.84
102 INT86314 Regulation of Transcription of Cftr 2 0.33 1.81 0.83
103 INT4103 Regulation of G6PD 6 0.60 0.78 0.82
104 INT62247 Positive_regulation of Transcription of Fdft1 1 0.08 0 0.82
105 INT61290 Regulation of Phosphorylation of CFTR 1 0.44 0.25 0.81
106 INT77375 Phosphorylation of Ebp 1 0.13 0 0.81
107 INT274693 Positive_regulation of Gene_expression of Cftr 6 0.49 2.93 0.8
108 INT4762 Negative_regulation of DHCR24 5 0.45 0.68 0.8
109 INT17855 Binding of G6pd 4 0.34 1.42 0.8
110 INT61291 Phosphorylation of CFTR 1 0.80 0.25 0.8
111 INT132913 Positive_regulation of Phosphorylation of CNBP 1 0.07 0 0.75
112 INT186941 Localization of Nsdhl 2 0.46 2.7 0.74
113 INT196682 Negative_regulation of Gene_expression of CFTR 6 0.34 1.96 0.73
114 INT62233 Regulation of Regulation of Fdft1 1 0.10 0 0.73
115 INT151100 Negative_regulation of Positive_regulation of CFTR 1 0.43 1.11 0.73
116 INT127204 Negative_regulation of Positive_regulation of Cftr 1 0.43 1.9 0.69
117 INT140711 Positive_regulation of EBP 1 0.29 0.72 0.68
118 INT215828 Regulation of Binding of Cftr 2 0.33 1.56 0.66
119 INT190002 Regulation of MVD 1 0.13 0.87 0.66
120 INT46148 Binding of LBR 5 0.31 1.58 0.64
121 INT171878 Binding of SQLE 8 0.04 4 0.63
122 INT37252 Binding of Fdps 4 0.20 3.57 0.63
123 INT103841 Negative_regulation of Gene_expression of Cftr 3 0.43 1.93 0.63
124 INT151098 Positive_regulation of Positive_regulation of CFTR 2 0.50 0.9 0.63
125 INT307027 Positive_regulation of Localization of LBR 1 0.05 0.82 0.61
126 INT181888 Regulation of Apoa1 5 0.26 5.07 0.6
127 INT213118 Negative_regulation of Gene_expression of Apoa1 2 0.42 2.86 0.6
128 INT170759 Positive_regulation of Binding of Cftr 2 0.50 1.82 0.6
129 INT90213 Negative_regulation of Mvk 3 0.05 6.28 0.59
130 INT348872 Positive_regulation of Regulation of Cftr 1 0.34 1.3 0.55
131 INT176375 Positive_regulation of Positive_regulation of LBR 1 0.10 1.12 0.53
132 INT203688 Positive_regulation of Hmgcr 10 0.17 6.08 0.52
133 INT20239 Regulation of APOA1 10 0.60 10.98 0.51
134 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51
135 INT228570 Phosphorylation of Prkaa2 24 0.61 7.9 0.5
136 INT62104 Localization of INSIG2 1 0.01 0 0.5
137 INT147919 Regulation of Ebp 1 0.08 0.94 0.48
138 INT348392 Positive_regulation of Phosphorylation of Fdps 1 0.16 0.59 0.47
139 INT348389 Phosphorylation of Fdps 1 0.26 0.59 0.47
140 INT36450 Regulation of Negative_regulation of G6PD 2 0.40 1.59 0.46
141 INT80624 Regulation of CNBP 5 0.36 3.36 0.45
142 INT4553 Binding of G6PD 7 0.37 3 0.44
143 INT191583 Positive_regulation of Gene_expression of Fdps 2 0.15 1.55 0.44
144 INT190882 Regulation of Gene_expression of Apoa1 4 0.23 3.67 0.43
145 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43
146 INT31603 Regulation of Gene_expression of G6pd 1 0.59 0 0.43
147 INT261353 Negative_regulation of Gene_expression of Nsdhl 1 0.17 0.71 0.43
148 INT147918 Positive_regulation of Negative_regulation of Ebp 1 0.14 0.88 0.42
149 INT348395 Negative_regulation of Gene_expression of Fdps 1 0.16 0.49 0.42
150 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4
151 INT310689 Positive_regulation of Negative_regulation of Cftr 1 0.47 1.41 0.4
152 INT190691 Negative_regulation of APOA1 12 0.42 15.9 0.39
153 INT181883 Negative_regulation of Negative_regulation of Apoa1 1 0.40 1.24 0.39
154 INT226184 Protein_catabolism of Cftr 3 0.87 1.52 0.38
155 INT72673 Transcription of APOA1 2 0.52 1.2 0.36
156 INT46787 Regulation of Regulation of G6pd 1 0.24 0 0.36
157 INT65352 Negative_regulation of CNBP 6 0.37 4.59 0.35
158 INT84110 Negative_regulation of Ebp 5 0.42 0.32 0.35
159 INT168166 Positive_regulation of Mvk 3 0.37 0 0.35
160 INT3044 Regulation of LBR 2 0.44 0.1 0.35
161 INT212761 Regulation of SQLE 2 0.23 1.21 0.35
162 INT170758 Positive_regulation of Localization of Cftr 2 0.50 2.4 0.35
163 INT139779 Negative_regulation of Negative_regulation of G6PD 1 0.42 0.29 0.35
164 INT186939 Positive_regulation of Positive_regulation of Nsdhl 2 0.31 0.86 0.34
165 INT14181 Binding of DHCR24 1 0.04 0 0.34
166 INT261209 Localization of Apoa1 4 0.73 2.61 0.33
167 INT191601 Negative_regulation of Fdft1 2 0.04 2.13 0.33
168 INT281177 Regulation of Insig1 2 0.25 0.93 0.33
169 INT273132 Regulation of FDPS 1 0.31 1.28 0.33
170 INT142695 Gene_expression of HMGCR 17 0.65 3.75 0.32
171 INT54557 Positive_regulation of Positive_regulation of Fdft1 1 0.13 0 0.32
172 INT299574 Localization of SQLE 1 0.10 1.41 0.32
173 INT92249 Gene_expression of FDPS 7 0.46 4.97 0.31
174 INT232236 Negative_regulation of Gene_expression of Hmgcr 3 0.35 1.36 0.31
175 INT81908 Binding of FDPS 3 0.36 1.27 0.31
176 INT54558 Positive_regulation of Gene_expression of Fdft1 1 0.18 0 0.31
177 INT307779 Positive_regulation of Localization of Apoa1 1 0.49 0.88 0.31
178 INT170756 Negative_regulation of Localization of Cftr 1 0.42 1.74 0.31
179 INT71752 Negative_regulation of Prkaa2 17 0.39 2.81 0.3
180 INT189968 Binding of APOA1 12 0.47 10.1 0.3
181 INT80664 Phosphorylation of G6PD 3 0.08 0.58 0.3
182 INT267666 Regulation of Localization of CFTR 1 0.22 0.39 0.3
183 INT71750 Regulation of Prkaa2 12 0.41 2.98 0.29
184 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29
185 INT322907 Positive_regulation of Gene_expression of Hmgcr 4 0.03 1.45 0.28
186 INT297865 Positive_regulation of Gene_expression of Insig1 2 0.21 0.4 0.28
187 INT120959 Protein_catabolism of CFTR 1 0.03 0.14 0.28
188 INT132710 Negative_regulation of Regulation of Cftr 1 0.06 0.1 0.27
189 INT157155 Positive_regulation of LSS 1 0.26 1.92 0.25
190 INT196688 Positive_regulation of Binding of CFTR 1 0.26 0.33 0.24
191 INT250545 Regulation of Hmgcr 5 0.11 4.94 0.23
192 INT84109 Binding of Ebp 2 0.34 0.27 0.23
193 INT187504 Gene_expression of Prkaa2 5 0.65 1.3 0.22
194 INT182749 Binding of Hmgcr 3 0.32 0.55 0.22
195 INT176036 Phosphorylation of HMGCR 1 0.05 0.19 0.22
196 INT262077 Positive_regulation of Insig1 3 0.29 0.34 0.21
197 INT157154 Regulation of LSS 2 0.25 1.73 0.21
198 INT270625 Regulation of Gene_expression of Insig1 2 0.19 1.4 0.21
199 INT297868 Regulation of Regulation of Insig1 1 0.11 0.82 0.21
200 INT115158 Gene_expression of INSIG2 1 0.01 0.33 0.21
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