GO:0006699

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Name bile acid biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006699
Unique Molecular Interactions 122
Total Molecular Interactions 144
Total Single Events 1028
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bile acid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for bile acid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
2 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58
3 INT7791 Akr1d1 Regulation of Nts 1 0.03 0 1.58
4 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
5 INT7797 Akr1d1 Regulation of Sst 1 0.02 0 1.54
6 INT81097 Akr1d1 Regulation of Localization of Abat 1 0.00 0 1.2
7 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
8 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
9 INT97721 Akr1d1 Regulation of Gene_expression of Penk 1 0.00 0 0.98
10 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
11 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
12 INT80601 Akr1d1 Regulation of Positive_regulation of Fos 1 0.06 0 0.94
13 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
14 INT7799 Akr1d1 Regulation of Positive_regulation of Ptgdr 1 0.01 0 0.86
15 INT261461 Positive_regulation of Akr1d1 Regulation of Sftpd 1 0.01 0 0.86
16 INT261458 Akr1d1 Regulation of Sftpd 1 0.01 0 0.82
17 INT261447 Sftpd Positive_regulation of Akr1d1 1 0.01 0 0.77
18 INT82039 Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.74
19 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
20 INT7792 Akr1d1 Regulation of Gene_expression of Npy 1 0.02 0 0.65
21 INT261453 Binding of Akr1d1 and Ptgdr 1 0.00 0.56 0.65
22 INT82038 Positive_regulation of Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.64
23 INT63161 Akr1d1 Regulation of Gene_expression of Pdyn 1 0.01 0 0.59
24 INT54485 Positive_regulation of Akr1d1 Positive_regulation of Gene_expression of Rabep2 1 0.00 0 0.53
25 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
26 INT7291 Akr1d1 Regulation of Regulation of Penk 1 0.01 0 0.48
27 INT195192 Akr1d1 Regulation of Msn 1 0.01 0.34 0.47
28 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
29 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
30 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
31 INT340850 Binding of IGHE and Baat 1 0.07 0.27 0.37
32 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
33 INT261462 Akr1d1 Positive_regulation of Hrasls 1 0.00 0.3 0.33
34 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
35 INT207355 ZNF398 Regulation of CYP27A1 1 0.00 0 0.31
36 INT51858 Akr1d1 Positive_regulation of Phosphorylation of Creb1 1 0.01 0 0.27
37 INT64290 Akr1d1 Regulation of Penk 1 0.00 0 0.26
38 INT335049 PPARA Negative_regulation of Gene_expression of CYP7B1 1 0.27 0 0.26
39 INT335015 Fgf15 Negative_regulation of Gene_expression of Cyp7a1 1 0.57 0.2 0.24
40 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
41 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23
42 INT64291 Akr1d1 Regulation of Slc3a1 1 0.01 0 0.23
43 INT64289 Slc3a1 Regulation of Akr1d1 1 0.01 0 0.23
44 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
45 INT132680 HNF1A Positive_regulation of Gene_expression of UGT1A6 1 0.30 0.08 0.21
46 INT132679 HNF1A Regulation of Gene_expression of UGT1A6 1 0.16 0.08 0.21
47 INT90772 Binding of AKR1C4 and AKR1C1 1 0.39 0.08 0.2
48 INT180560 Binding of COMP and CYP27A1 1 0.12 0.47 0.18
49 INT207339 TBXA2R Negative_regulation of Negative_regulation of CYP27A1 1 0.01 0 0.17
50 INT207354 TBXA2R Regulation of Gene_expression of CYP27A1 1 0.01 0 0.17
51 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
52 INT207351 ZNF398 Negative_regulation of CYP27A1 1 0.00 0 0.17
53 INT207340 PTGER2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0.17
54 INT207357 TBXA2R Positive_regulation of CYP27A1 1 0.01 0 0.16
55 INT207349 TBXA2R Regulation of CYP27A1 1 0.01 0 0.16
56 INT229289 FGF19 Negative_regulation of CYP7A1 1 0.26 0.32 0.16
57 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
58 INT261460 Binding of Sftpd and Akr1d1 1 0.01 0.43 0.16
59 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
60 INT207346 PTGER2 Negative_regulation of Negative_regulation of CYP27A1 1 0.00 0 0.14
61 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12
62 INT104327 Fen1 Negative_regulation of Baat 1 0.31 0.75 0.12
63 INT104325 Regulation of Fen1 Negative_regulation of Baat 1 0.19 0.75 0.12
64 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1
65 INT227303 Zbp1 Regulation of Transcription of Baat 1 0.09 1.43 0.08
66 INT27376 Binding of IK and Slc27a5 1 0.22 0.07 0.07
67 INT264300 CTSK Positive_regulation of CYP27A1 1 0.03 0.69 0.07
68 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
69 INT291174 Rpa1 Positive_regulation of Baat 1 0.03 0.63 0.04
70 INT207362 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP27A1 1 0.01 0 0.03
71 INT207356 PTGER2 Regulation of Gene_expression of CYP27A1 1 0.00 0.05 0.03
72 INT207361 PTGDS Regulation of Gene_expression of CYP27A1 1 0.01 0.05 0.03
73 INT199527 Ceacam1 Negative_regulation of CYP27A1 1 0.02 0.06 0.03
74 INT284095 HNF1A Positive_regulation of TIMP3 1 0.38 2.3 0
75 INT284092 HNF1A Positive_regulation of FGD2 1 0.15 1.16 0
76 INT333842 Hnf1a Positive_regulation of Mir194-1 1 0.02 0.18 0
77 INT299438 Foxl2 Negative_regulation of Star 1 0.37 0.16 0
78 INT284098 HNF1A Positive_regulation of SLC2A1 1 0.36 1.16 0
79 INT104328 Fen1 Positive_regulation of Baat 1 0.33 0.63 0
80 INT180568 Binding of CYP27A1 and DMD 1 0.02 0 0
81 INT104326 Regulation of Fen1 Positive_regulation of Baat 1 0.19 0.63 0
82 INT207363 Negative_regulation of CPOX Negative_regulation of CYP27A1 1 0.01 0 0
83 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
84 INT181835 Binding of Baat and Ppara 1 0.09 0.31 0
85 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for bile acid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in bile acid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7787 Positive_regulation of Akr1d1 52 0.66 3.55 31.71
2 INT20575 Gene_expression of Akr1d1 48 0.57 6.2 22.5
3 INT7920 Binding of Akr1d1 26 0.27 3.64 19.73
4 INT34569 Regulation of Akr1d1 26 0.24 3.06 18.37
5 INT11034 Negative_regulation of Akr1d1 23 0.18 3.43 14.84
6 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
7 INT20579 Transcription of Akr1d1 9 0.04 2.91 8.37
8 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
9 INT50572 Localization of Akr1d1 14 0.59 0.51 5.87
10 INT35928 Positive_regulation of Baat 12 0.69 12.23 5.43
11 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28
12 INT26754 Positive_regulation of Positive_regulation of Akr1d1 8 0.05 0.28 4.75
13 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56
14 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44
15 INT122511 Negative_regulation of Binding of Akr1d1 1 0.04 0.14 3.29
16 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67
17 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45
18 INT50571 Regulation of Gene_expression of Akr1d1 3 0.33 0.33 2.4
19 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18
20 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15
21 INT20578 Positive_regulation of Gene_expression of Akr1d1 5 0.22 0.26 2.1
22 INT35937 Negative_regulation of Positive_regulation of Akr1d1 2 0.40 0 1.72
23 INT73616 Positive_regulation of Localization of Akr1d1 2 0.07 0 1.68
24 INT262117 Negative_regulation of Gene_expression of Cyp7a1 3 0.25 0.91 1.6
25 INT56309 Positive_regulation of Baat 9 0.39 8.47 1.51
26 INT61553 Positive_regulation of Regulation of Akr1d1 1 0.05 0 1.46
27 INT180581 Negative_regulation of Protein_catabolism of CYP27A1 2 0.29 3.19 1.43
28 INT133112 Regulation of Baat 2 0.61 11.99 1.2
29 INT20576 Negative_regulation of Gene_expression of Akr1d1 2 0.03 0.23 1.13
30 INT56310 Gene_expression of Baat 15 0.44 15.5 1.11
31 INT123577 Negative_regulation of Positive_regulation of Baat 2 0.58 1.78 1.02
32 INT334977 Regulation of Gene_expression of Cyp7a1 2 0.40 0.43 0.94
33 INT82533 Regulation of Positive_regulation of Akr1d1 1 0.08 0 0.94
34 INT269764 Positive_regulation of Localization of CYP27A1 4 0.38 2.45 0.8
35 INT54353 Regulation of Transcription of Akr1d1 1 0.03 0.08 0.74
36 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7
37 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7
38 INT187079 Gene_expression of CYP7B1 2 0.32 1 0.66
39 INT20577 Negative_regulation of Transcription of Akr1d1 1 0.02 0.23 0.66
40 INT44696 Gene_expression of Baat 5 0.64 3.1 0.59
41 INT257885 Negative_regulation of Positive_regulation of CYP27A1 2 0.37 1.62 0.57
42 INT262093 Positive_regulation of Gene_expression of Cyp7a1 2 0.44 0.81 0.55
43 INT299420 Negative_regulation of Gene_expression of Star 1 0.33 6.66 0.5
44 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49
45 INT61552 Regulation of Binding of Akr1d1 1 0.06 0 0.49
46 INT340845 Regulation of Baat 1 0.08 0 0.47
47 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46
48 INT229307 Positive_regulation of Negative_regulation of CYP7A1 1 0.31 0.1 0.43
49 INT104324 Negative_regulation of Baat 4 0.38 9.79 0.42
50 INT188613 Gene_expression of CYP8B1 2 0.58 1.04 0.41
51 INT173810 Positive_regulation of Gene_expression of CYP27A1 5 0.49 1.35 0.4
52 INT187078 Positive_regulation of Gene_expression of CYP7B1 1 0.01 1 0.4
53 INT176186 Negative_regulation of Cyp7a1 5 0.46 2.07 0.39
54 INT104323 Regulation of Positive_regulation of Baat 2 0.39 1.61 0.38
55 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37
56 INT329889 Positive_regulation of CYP8B1 1 0.41 0.47 0.37
57 INT34570 Regulation of Regulation of Akr1d1 1 0.01 0 0.35
58 INT296900 Negative_regulation of Binding of CYP27A1 1 0.17 0.83 0.33
59 INT176170 Regulation of Cyp7a1 2 0.21 0.5 0.32
60 INT335088 Regulation of Regulation of Cyp7a1 1 0.19 0.1 0.32
61 INT44695 Binding of Baat 1 0.26 0.67 0.32
62 INT176200 Positive_regulation of Cyp7a1 2 0.37 0.4 0.31
63 INT78997 Negative_regulation of AKR1C4 2 0.57 0.23 0.27
64 INT51857 Positive_regulation of Phosphorylation of Akr1d1 1 0.01 0 0.27
65 INT51854 Phosphorylation of Akr1d1 1 0.02 0 0.27
66 INT270115 Negative_regulation of Localization of CYP27A1 2 0.02 1.11 0.26
67 INT44697 Positive_regulation of Gene_expression of Baat 1 0.42 0.6 0.24
68 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23
69 INT133113 Positive_regulation of Positive_regulation of Baat 1 0.46 0.57 0.22
70 INT20301 Positive_regulation of Binding of Hnf1a 1 0.02 0 0.21
71 INT181826 Transcription of Baat 4 0.35 4.43 0.2
72 INT90773 Binding of AKR1C4 2 0.36 0.52 0.2
73 INT20302 Binding of Hnf1a 1 0.02 0 0.2
74 INT181819 Binding of Baat 2 0.24 0.96 0.19
75 INT78998 Regulation of AKR1C4 1 0.44 0.2 0.19
76 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18
77 INT155442 Negative_regulation of Slc27a5 1 0.42 0.22 0.17
78 INT207368 Positive_regulation of Positive_regulation of CYP27A1 1 0.04 0.37 0.17
79 INT329893 Regulation of Positive_regulation of CYP8B1 1 0.37 0.18 0.16
80 INT97662 Positive_regulation of AKR1C4 1 0.49 0 0.15
81 INT227280 Regulation of Gene_expression of Baat 4 0.26 3.82 0.14
82 INT173171 Gene_expression of CYP7A1 2 0.45 1.02 0.14
83 INT180585 Positive_regulation of Protein_catabolism of CYP27A1 1 0.23 0.39 0.14
84 INT249107 Positive_regulation of HNF1A 1 0.49 0.2 0.13
85 INT173188 Regulation of Gene_expression of CYP7A1 1 0.22 0.48 0.12
86 INT299416 Gene_expression of Star 1 0.53 1.72 0.1
87 INT229319 Regulation of Positive_regulation of CYP7A1 1 0.30 0.42 0.08
88 INT27375 Binding of Slc27a5 1 0.19 0.07 0.07
89 INT78145 Transcription of AKR1C4 1 0.67 0.06 0.06
90 INT227277 Regulation of Transcription of Baat 1 0.19 1.02 0.05
91 INT229325 Positive_regulation of Gene_expression of CYP7A1 1 0.34 0.6 0.05
92 INT227263 Negative_regulation of Gene_expression of Baat 2 0.24 2.78 0.03
93 INT345480 Binding of CYP7A1 1 0.29 0 0.03
94 INT299403 Regulation of Star 5 0.39 0.78 0
95 INT173811 Regulation of Gene_expression of CYP27A1 3 0.44 0.78 0
96 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0
97 INT176172 Transcription of Cyp7a1 1 0.57 1.04 0
98 INT176179 Negative_regulation of Positive_regulation of Cyp7a1 1 0.34 0.4 0
99 INT181830 Positive_regulation of Transcription of Baat 1 0.18 0.31 0
100 INT352867 Regulation of CYP7B1 1 0.20 0.13 0
101 INT240923 Regulation of Hnf1a 1 0.19 0.48 0
102 INT187419 Regulation of CYP7A1 1 0.05 0.23 0
103 INT227264 Localization of Baat 1 0.32 0.46 0
104 INT176215 Regulation of Transcription of Cyp7a1 1 0.49 0.79 0
105 INT299423 Transcription of Star 1 0.54 0.06 0
106 INT299405 Positive_regulation of Star 1 0.39 0.07 0
107 INT205577 Positive_regulation of Gene_expression of Hnf1a 1 0.49 1.1 0
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