GO:0006703

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Name estrogen biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006703
Unique Molecular Interactions 55
Total Molecular Interactions 69
Total Single Events 1045
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for estrogen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for estrogen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122350 Ngf Regulation of Hsd3b1 1 0.34 0 0.87
2 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
3 INT107751 POMC Negative_regulation of HSD17B1 1 0.33 0.39 0.33
4 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
5 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
6 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
7 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
8 INT107747 CRH Negative_regulation of HSD17B1 1 0.40 0.41 0.3
9 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
10 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
11 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27
12 INT199970 CYP19A1 Positive_regulation of Gene_expression of ESR1 1 0.06 0.72 0.25
13 INT107749 IL1B Positive_regulation of HSD17B1 1 0.20 0.21 0.22
14 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
15 INT107746 TNF Positive_regulation of HSD17B1 1 0.39 0.2 0.17
16 INT107750 CRH Regulation of Transcription of HSD17B1 1 0.19 0.21 0.17
17 INT107748 POMC Regulation of Transcription of HSD17B1 1 0.15 0.21 0.17
18 INT107745 POMC Regulation of Gene_expression of HSD17B1 1 0.25 0.21 0.17
19 INT64188 ART3 Negative_regulation of HSD17B2 1 0.00 0 0.09
20 INT220394 MRXS5 Positive_regulation of Gene_expression of CYP19A1 1 0.00 0.89 0.09
21 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09
22 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
23 INT261262 AIS Negative_regulation of Cyp19a1 1 0.01 0.2 0.08
24 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07
25 INT187732 Binding of CYP19A1 and Cyp11a1 1 0.01 0.68 0.04
26 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03
27 INT187676 Binding of CYP19A1 and SHBG 1 0.01 0.63 0.03
28 INT133804 Binding of CYP2B6 and CYP19A1 3 0.09 2.26 0
29 INT176564 Binding of Cyp17a1 and Cyp19a1 1 0.03 0.33 0
30 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0
31 INT259451 Binding of DHCR7 and Cyp11a1 1 0.01 0.3 0
32 INT242176 AIS Negative_regulation of CYP19A1 1 0.07 0.69 0
33 INT299438 Foxl2 Negative_regulation of Star 1 0.37 0.16 0
34 INT220411 Ptger2 Positive_regulation of Cyp19a1 1 0.09 0.83 0
35 INT187674 FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.24 0 0
36 INT299459 Foxl2 Positive_regulation of Cyp19a1 1 0.34 0.07 0
37 INT242178 CYP19A1 Regulation of Cyp11a1 1 0.01 0.35 0
38 INT176569 Binding of FSHR and Cyp19a1 1 0.04 0.06 0
39 INT242179 Cyp11a1 Regulation of CYP19A1 1 0.01 0.7 0
40 INT259452 Binding of STAR and Cyp11a1 1 0.25 0.06 0
41 INT187670 Gene_expression of FSHR Positive_regulation of Gene_expression of CYP19A1 1 0.16 0 0
42 INT201799 PGR Regulation of HSD17B2 1 0.12 0.08 0
43 INT277622 Esr1 Positive_regulation of Gene_expression of Cyp19a1 1 0.03 1.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for estrogen biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in estrogen biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
2 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
3 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
4 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
5 INT135760 Regulation of Gene_expression of Cyp19a1 2 0.62 1.15 5.81
6 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
7 INT112340 Gene_expression of Cyp11a1 11 0.77 5.19 3.7
8 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61
9 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56
10 INT116376 Transcription of Cyp19a1 2 0.40 0.74 3.04
11 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01
12 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
13 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
14 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
15 INT111113 Binding of CYP19A1 15 0.36 9.17 2.12
16 INT342803 Positive_regulation of Transcription of Cyp19a1 1 0.30 0.33 2.08
17 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94
18 INT122346 Gene_expression of Hsd3b1 1 0.75 0 1.78
19 INT89826 Transcription of HSD17B1 5 0.69 2.75 1.71
20 INT112339 Localization of Cyp11a1 2 0.71 0.94 1.68
21 INT89824 Gene_expression of HSD17B1 5 0.75 2.69 1.66
22 INT10596 Positive_regulation of Cyp19a1 10 0.42 2.08 1.62
23 INT113279 Gene_expression of HSD17B2 3 0.24 3.65 1.59
24 INT127889 Regulation of Gene_expression of CYP19A1 11 0.62 6.7 1.41
25 INT10570 Positive_regulation of Cyp11a1 9 0.47 2.67 1.4
26 INT122345 Positive_regulation of Gene_expression of Hsd3b1 1 0.49 0 1.34
27 INT168395 Transcription of Cyp19a1 2 0.51 2.5 1.06
28 INT168397 Gene_expression of Cyp19a1 2 0.06 1.77 1.06
29 INT132770 Positive_regulation of Gene_expression of HSD17B2 1 0.02 2.28 1.01
30 INT122347 Transcription of Hsd3b1 1 0.52 0 0.99
31 INT91035 Positive_regulation of HSD17B2 7 0.66 5.2 0.98
32 INT168398 Localization of Cyp19a1 1 0.08 0.89 0.97
33 INT10578 Transcription of Cyp11a1 3 0.53 0.84 0.93
34 INT79344 Binding of Cyp19a1 4 0.33 0.61 0.8
35 INT161339 Localization of Cyp19a1 1 0.73 1.32 0.71
36 INT134599 Regulation of HSD17B2 2 0.44 1.28 0.63
37 INT171105 Positive_regulation of Positive_regulation of CYP19A1 5 0.39 4.02 0.58
38 INT353896 Negative_regulation of Phosphorylation of Cyp19a1 1 0.22 0.47 0.55
39 INT353893 Phosphorylation of Cyp19a1 1 0.31 0.46 0.55
40 INT299420 Negative_regulation of Gene_expression of Star 1 0.33 6.66 0.5
41 INT137556 Negative_regulation of Cyp19a1 3 0.35 1.53 0.48
42 INT71046 Localization of CYP19A1 2 0.78 1.38 0.48
43 INT122348 Regulation of Hsd3b1 1 0.60 0 0.46
44 INT187717 Regulation of Negative_regulation of CYP19A1 11 0.42 2.85 0.45
45 INT127890 Positive_regulation of Negative_regulation of CYP19A1 6 0.50 1.41 0.45
46 INT107755 Positive_regulation of HSD17B1 1 0.52 0.71 0.45
47 INT68725 Regulation of Cyp11a1 6 0.19 2.62 0.44
48 INT121113 Protein_catabolism of Cyp11a1 2 0.65 0.37 0.44
49 INT84915 Negative_regulation of Gene_expression of Cyp19a1 2 0.15 1.29 0.42
50 INT181122 Positive_regulation of Gene_expression of Cyp19a1 1 0.02 0.68 0.36
51 INT209323 Positive_regulation of Transcription of CYP19A1 5 0.32 4.22 0.33
52 INT107754 Regulation of HSD17B1 1 0.46 0.68 0.31
53 INT130070 Negative_regulation of Gene_expression of HSD17B2 1 0.08 0.7 0.3
54 INT282487 Regulation of Negative_regulation of Cyp19a1 1 0.22 0.6 0.27
55 INT107752 Negative_regulation of HSD17B1 1 0.32 0.74 0.26
56 INT117760 Regulation of Gene_expression of Cyp11a1 2 0.42 0.36 0.25
57 INT175360 Regulation of Transcription of CYP19A1 1 0.04 1 0.19
58 INT107753 Positive_regulation of Transcription of HSD17B1 1 0.35 0.25 0.19
59 INT10575 Positive_regulation of Transcription of Cyp11a1 1 0.05 0 0.17
60 INT10572 Positive_regulation of Positive_regulation of Cyp11a1 1 0.05 0 0.16
61 INT299416 Gene_expression of Star 1 0.53 1.72 0.1
62 INT91036 Transcription of HSD17B2 1 0.44 0.9 0.1
63 INT91037 Positive_regulation of Transcription of HSD17B2 1 0.39 0.9 0.1
64 INT220399 Positive_regulation of Cyp19a1 4 0.43 2.2 0.07
65 INT354856 Regulation of Cyp19a1 1 0.37 1.36 0.06
66 INT187718 Negative_regulation of Positive_regulation of CYP19A1 1 0.33 0.61 0.05
67 INT140315 Regulation of Positive_regulation of Cyp11a1 1 0.19 0.07 0.05
68 INT187720 Negative_regulation of Negative_regulation of CYP19A1 5 0.34 0.99 0
69 INT299403 Regulation of Star 5 0.39 0.78 0
70 INT187725 Positive_regulation of Localization of CYP19A1 1 0.39 0.23 0
71 INT220400 Positive_regulation of Transcription of Cyp19a1 1 0.49 0.84 0
72 INT213932 Negative_regulation of Negative_regulation of Cyp19a1 1 0.31 0.7 0
73 INT194353 Negative_regulation of Binding of Cyp19a1 1 0.15 0 0
74 INT145141 Negative_regulation of Transcription of CYP19A1 1 0.59 0.3 0
75 INT187719 Negative_regulation of Localization of CYP19A1 1 0.33 0.78 0
76 INT299423 Transcription of Star 1 0.54 0.06 0
77 INT222306 Negative_regulation of Binding of CYP19A1 1 0.20 1.04 0
78 INT259446 Positive_regulation of Gene_expression of Cyp11a1 1 0.28 0 0
79 INT299405 Positive_regulation of Star 1 0.39 0.07 0
80 INT201807 Localization of HSD17B2 1 0.68 0.19 0
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