GO:0006725

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Name cellular aromatic compound metabolic process
Categary Process
Go Slim No
Go Link GO:0006725
Unique Molecular Interactions 62
Total Molecular Interactions 68
Total Single Events 1058
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular aromatic compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cellular aromatic compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
2 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
3 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
4 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
5 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
6 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
7 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
8 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
9 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
10 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
11 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
12 INT19690 Enpep Regulation of Negative_regulation of Penk 1 0.28 0 0.54
13 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
14 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
15 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
16 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
17 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 0.02 0.25 0.43
18 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
19 INT171874 Binding of SQLE and MRAP 1 0.00 1.29 0.35
20 INT299557 Binding of CRS and SQLE 1 0.00 0.7 0.29
21 INT239041 Binding of Sqle and Gtf3a 1 0.00 1.08 0.27
22 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
23 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
24 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
25 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
26 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
27 INT299592 SQLE Regulation of RatNP-3b 1 0.01 0.99 0.22
28 INT51034 Slc30a2 Positive_regulation of Enpep 1 0.01 0 0.19
29 INT104702 KNG1 Negative_regulation of Anpep 1 0.11 0.47 0.19
30 INT75030 Slc6a14 Positive_regulation of Gene_expression of Ephx1 1 0.01 0.17 0.17
31 INT272608 Binding of cla and Clybl 1 0.02 0.75 0.12
32 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
33 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
34 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
35 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
36 INT75031 Slc6a14 Positive_regulation of Ephx1 1 0.01 0.07 0.07
37 INT75038 Ass1 Positive_regulation of Transcription of Ephx1 1 0.00 0.08 0.07
38 INT75037 Ass1 Positive_regulation of Ephx1 1 0.00 0.08 0.07
39 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
40 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
41 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
42 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
43 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
44 INT272591 Dlg4 Positive_regulation of Gene_expression of Clybl 1 0.09 0.53 0.04
45 INT272590 Dlg4 Positive_regulation of Clybl 1 0.09 0.52 0.04
46 INT299556 SQLE Regulation of CRS 1 0.00 0.77 0.03
47 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
48 INT230711 Binding of Sqle and Gbgt1 1 0.01 0 0
49 INT275667 Binding of CYP1B1 and GLC3C 1 0.27 0.99 0
50 INT344880 Binding of ANPEP and Mapt 1 0.08 0.15 0
51 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
52 INT205393 MME Regulation of Gene_expression of ANPEP 1 0.26 1.49 0
53 INT292135 Binding of Anpep and Rtn4r 1 0.01 0.91 0
54 INT70122 NAGLU Positive_regulation of Localization of Anpep 1 0.10 0 0
55 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
56 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
57 INT205389 Binding of ANPEP and DCLK1 1 0.09 1.42 0
58 INT205392 Binding of ANPEP and PCSK1 1 0.06 1.4 0
59 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
60 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0
61 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
62 INT205391 MME Regulation of ANPEP 1 0.26 1.36 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular aromatic compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cellular aromatic compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7
2 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
3 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
4 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28
5 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
6 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
7 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
8 INT18941 Regulation of Enpep 17 0.55 2.56 9.38
9 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
10 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51
11 INT24504 Localization of Anpep 19 0.80 3.44 6.23
12 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
13 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
14 INT3768 Negative_regulation of ANPEP 16 0.59 4.96 5.52
15 INT33291 Protein_catabolism of Enpep 15 0.85 0.51 5.41
16 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
17 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
18 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
19 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26
20 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18
21 INT187 Positive_regulation of Ephx1 17 0.69 0.51 3.69
22 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38
23 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
24 INT184 Regulation of Ephx1 10 0.60 0.54 3.27
25 INT18477 Protein_catabolism of ANPEP 7 0.79 0.41 3.26
26 INT29333 Positive_regulation of Enpep 8 0.70 3.22 3.25
27 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
28 INT22492 Binding of Enpep 10 0.47 0.7 3.2
29 INT30228 Protein_catabolism of Anpep 3 0.42 0.82 2.87
30 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
31 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
32 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
33 INT24997 Protein_catabolism of Anpep 6 0.96 0 2.34
34 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
35 INT31796 Gene_expression of Enpep 5 0.65 0.42 2.32
36 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
37 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13
38 INT177778 Gene_expression of SQLE 28 0.40 16.42 2.08
39 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
40 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
41 INT51570 Regulation of Anpep 6 0.43 1.7 2
42 INT48357 Positive_regulation of Anpep 7 0.39 2.04 1.75
43 INT239016 Binding of Sqle 1 0.01 5.43 1.63
44 INT54366 Gene_expression of Anpep 6 0.77 1.38 1.52
45 INT37330 Regulation of Binding of Enpep 1 0.27 0 1.26
46 INT32786 Localization of Enpep 4 0.68 0 1.16
47 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
48 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
49 INT96873 Gene_expression of CYP1B1 28 0.78 11.81 1.09
50 INT130814 Binding of ANPEP 8 0.48 4.83 1.05
51 INT31314 Positive_regulation of Negative_regulation of Enpep 3 0.35 0.18 1.02
52 INT84325 Regulation of Gene_expression of Anpep 2 0.62 0.06 1.02
53 INT176063 Positive_regulation of SQLE 4 0.36 4.28 1
54 INT79862 Negative_regulation of Gene_expression of ANPEP 3 0.38 1.67 0.98
55 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
56 INT61191 Negative_regulation of Clybl 1 0.08 0.32 0.96
57 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
58 INT79861 Localization of ANPEP 4 0.62 0.54 0.86
59 INT213960 Localization of Anpep 1 0.09 0.28 0.83
60 INT96879 Positive_regulation of CYP1B1 14 0.70 5.73 0.78
61 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
62 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
63 INT45661 Negative_regulation of Protein_catabolism of Enpep 2 0.36 0 0.76
64 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
65 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
66 INT31607 Gene_expression of Ephx1 3 0.35 0.35 0.74
67 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
68 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
69 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
70 INT18479 Negative_regulation of Protein_catabolism of ANPEP 1 0.34 0 0.69
71 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
72 INT171878 Binding of SQLE 8 0.04 4 0.63
73 INT147323 Transcription of Anpep 1 0.42 0.19 0.56
74 INT147321 Negative_regulation of Transcription of Anpep 1 0.34 0.2 0.56
75 INT52780 Positive_regulation of Protein_catabolism of Anpep 1 0.17 0 0.55
76 INT2437 Regulation of Positive_regulation of Ephx1 1 0.21 0 0.53
77 INT65215 Negative_regulation of Protein_catabolism of Anpep 1 0.36 0 0.53
78 INT124614 Transcription of ANPEP 3 0.52 1.1 0.51
79 INT2436 Regulation of Regulation of Ephx1 1 0.47 0 0.51
80 INT28507 Regulation of ANPEP 4 0.26 1.84 0.5
81 INT29334 Positive_regulation of Positive_regulation of Enpep 2 0.47 1.12 0.44
82 INT61867 Positive_regulation of Regulation of Anpep 1 0.36 0.33 0.44
83 INT46155 Binding of Ephx1 2 0.28 0.16 0.43
84 INT46042 Positive_regulation of Protein_catabolism of Enpep 1 0.28 0 0.43
85 INT46156 Regulation of Binding of Ephx1 1 0.34 0.09 0.43
86 INT48356 Binding of Anpep 1 0.32 0 0.4
87 INT130815 Regulation of Gene_expression of ANPEP 3 0.62 1.88 0.37
88 INT48355 Transcription of Anpep 1 0.40 0 0.37
89 INT48358 Positive_regulation of Transcription of Anpep 1 0.35 0 0.37
90 INT212761 Regulation of SQLE 2 0.23 1.21 0.35
91 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
92 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
93 INT299574 Localization of SQLE 1 0.10 1.41 0.32
94 INT31610 Regulation of Gene_expression of Ephx1 2 0.20 0.1 0.31
95 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
96 INT31740 Positive_regulation of Localization of Anpep 1 0.16 0 0.27
97 INT31741 Positive_regulation of Positive_regulation of Anpep 1 0.15 0 0.27
98 INT62618 Positive_regulation of Negative_regulation of Anpep 1 0.14 0 0.27
99 INT147324 Positive_regulation of Gene_expression of Anpep 1 0.40 0.09 0.24
100 INT96888 Negative_regulation of Gene_expression of CYP1B1 5 0.43 1.13 0.23
101 INT96885 Localization of CYP1B1 4 0.80 2.11 0.23
102 INT96883 Positive_regulation of Gene_expression of CYP1B1 3 0.70 1.24 0.22
103 INT272565 Gene_expression of Clybl 1 0.12 0.53 0.22
104 INT111495 Regulation of Clybl 1 0.06 0.26 0.22
105 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
106 INT96887 Regulation of Gene_expression of CYP1B1 2 0.45 0.9 0.2
107 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
108 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
109 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
110 INT339163 Negative_regulation of Positive_regulation of SQLE 1 0.22 0.26 0.13
111 INT39824 Regulation of Protein_catabolism of Enpep 1 0.16 0 0.13
112 INT31309 Binding of Anpep 1 0.36 0 0.13
113 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
114 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
115 INT272568 Binding of Clybl 1 0.09 0.75 0.12
116 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
117 INT42630 Negative_regulation of Ephx1 1 0.01 0 0.09
118 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
119 INT75007 Transcription of Ephx1 1 0.12 0.08 0.07
120 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
121 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
122 INT177775 Negative_regulation of SQLE 7 0.06 5.97 0.04
123 INT341318 Positive_regulation of Gene_expression of ANPEP 1 0.45 1.97 0.04
124 INT36995 Negative_regulation of Negative_regulation of Enpep 1 0.37 0 0.04
125 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
126 INT341317 Positive_regulation of Binding of ANPEP 1 0.45 0.98 0.04
127 INT262005 Regulation of CYP1B1 4 0.62 4.52 0
128 INT262004 Negative_regulation of CYP1B1 4 0.59 3.24 0
129 INT262003 Binding of CYP1B1 3 0.48 3.34 0
130 INT146789 Regulation of Anpep 2 0.20 0 0
131 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
132 INT300413 Localization of Sqle 1 0.00 0.06 0
133 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
134 INT230662 Positive_regulation of Sqle 1 0.09 0 0
135 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
136 INT320463 Transcription of CYP1B1 1 0.68 0.14 0
137 INT299573 Regulation of Gene_expression of SQLE 1 0.05 0.21 0
138 INT339172 Transcription of SQLE 1 0.43 0.91 0
139 INT339211 Positive_regulation of Gene_expression of SQLE 1 0.26 0.91 0
140 INT257565 Negative_regulation of Gene_expression of SQLE 1 0.06 1.16 0
141 INT167110 Regulation of Binding of CYP1A2 1 0.45 0 0
142 INT300416 Gene_expression of Sqle 1 0.00 0.05 0
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