GO:0006729

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Name tetrahydrobiopterin biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006729
Unique Molecular Interactions 39
Total Molecular Interactions 128
Total Single Events 503
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tetrahydrobiopterin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for tetrahydrobiopterin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
3 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
4 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
5 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
6 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
7 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
8 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
9 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58
10 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
11 INT146248 Pcbd1 Positive_regulation of Trpv1 1 0.02 0 0.31
12 INT146247 Pcbd1 Positive_regulation of Trpa1 1 0.02 0 0.31
13 INT242094 Binding of ACLY and Pts 1 0.01 0 0.22
14 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
15 INT119457 Binding of Pts and Del(7)Tyr<c-23DVT>-p 1 0.01 1.34 0.1
16 INT158110 Negative_regulation of Del(7)Tyr<c-23DVT>-p Negative_regulation of Pts 1 0.00 1.92 0.08
17 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05
18 INT218929 Pts Negative_regulation of Ephb1 1 0.05 0.69 0.03
19 INT218927 Pts Positive_regulation of Ephb1 1 0.06 0.69 0.03
20 INT170910 Negative_regulation of Pcbd1 Positive_regulation of Positive_regulation of Mapk8 1 0.00 0.21 0.03
21 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0
22 INT100424 Bcl2 Regulation of Pcbd1 1 0.14 0.06 0
23 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
24 INT197547 Binding of PTS and KEAP1 1 0.08 1.23 0
25 INT178324 Pts Regulation of Akt1 1 0.00 0.23 0
26 INT100425 Bax Regulation of Pcbd1 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tetrahydrobiopterin biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in tetrahydrobiopterin biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
2 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
3 INT152347 Binding of GCH1 8 0.37 6.13 7.36
4 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46
5 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
6 INT170443 Gene_expression of Spr 1 0.12 0.07 5.88
7 INT80473 Gene_expression of Spr 5 0.46 2.76 3.86
8 INT135815 Transcription of Gch1 1 0.60 0 3.32
9 INT101406 Regulation of Spr 3 0.25 1.32 2.95
10 INT65481 Positive_regulation of Gene_expression of Pts 5 0.48 0.57 2.85
11 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
12 INT170439 Positive_regulation of Spr 1 0.10 0.3 2.67
13 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
14 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43
15 INT165434 Regulation of SPR 4 0.24 2.14 2.33
16 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
17 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
18 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
19 INT52865 Positive_regulation of Spr 2 0.49 0.56 2.06
20 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
21 INT135820 Regulation of Gch1 1 0.59 0 1.88
22 INT80469 Negative_regulation of Spr 2 0.30 1.62 1.61
23 INT25240 Negative_regulation of Pcbd1 11 0.43 3.1 1.59
24 INT101405 Binding of Spr 1 0.20 0.43 1.55
25 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54
26 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
27 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24
28 INT170440 Positive_regulation of Gene_expression of Spr 1 0.10 0 1.21
29 INT80471 Negative_regulation of Gene_expression of Spr 1 0.22 1.19 1.16
30 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
31 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
32 INT283972 Localization of GCH1 1 0.67 0.99 1.13
33 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
34 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
35 INT48944 Binding of Pts 8 0.41 3.23 1.03
36 INT48636 Positive_regulation of Pts 8 0.42 7.14 1.01
37 INT164779 Negative_regulation of Gene_expression of Pts 2 0.01 0.71 1.01
38 INT80450 Positive_regulation of SPR 3 0.41 0.9 0.93
39 INT101402 Positive_regulation of Gene_expression of Spr 1 0.27 0.26 0.88
40 INT101403 Transcription of Spr 1 0.29 0.26 0.88
41 INT101400 Positive_regulation of Transcription of Spr 1 0.25 0.26 0.88
42 INT9033 Positive_regulation of Pcbd1 14 0.39 3.88 0.86
43 INT147867 Localization of Spr 1 0.65 1.16 0.84
44 INT101404 Regulation of Gene_expression of Spr 1 0.34 0.28 0.8
45 INT165430 Gene_expression of SPR 2 0.59 1.27 0.75
46 INT122893 Gene_expression of Pts 4 0.10 0.97 0.61
47 INT199029 Binding of SPR 2 0.06 0.85 0.6
48 INT47375 Localization of Pts 4 0.59 2.7 0.44
49 INT65479 Positive_regulation of Negative_regulation of Pts 1 0.32 0 0.43
50 INT147866 Regulation of Localization of Spr 1 0.43 0.49 0.41
51 INT307593 Localization of PTS 1 0.67 0.4 0.4
52 INT39150 Gene_expression of Pcbd1 5 0.28 1.3 0.38
53 INT80449 Negative_regulation of SPR 1 0.24 0.08 0.38
54 INT173213 Regulation of PTS 2 0.38 2.18 0.31
55 INT9034 Regulation of Pcbd1 6 0.20 3.28 0.28
56 INT325209 Localization of Gch1 1 0.25 0.72 0.28
57 INT325214 Positive_regulation of Localization of Gch1 1 0.17 0.73 0.28
58 INT325216 Positive_regulation of Gch1 2 0.23 1.5 0.27
59 INT325218 Negative_regulation of Positive_regulation of Gch1 2 0.14 1.51 0.27
60 INT170924 Negative_regulation of Positive_regulation of Pcbd1 1 0.02 0.4 0.26
61 INT100914 Binding of PTS 5 0.36 3.81 0.21
62 INT170509 Regulation of Qdpr 1 0.27 1.11 0.2
63 INT325205 Positive_regulation of Gene_expression of Gch1 1 0.17 0.77 0.19
64 INT175569 Binding of Pcbd1 1 0.17 0.96 0.19
65 INT170505 Positive_regulation of Qdpr 2 0.22 0.15 0.16
66 INT170515 Gene_expression of Qdpr 8 0.34 0.27 0.14
67 INT316642 Negative_regulation of Gene_expression of Qdpr 1 0.26 0.08 0.14
68 INT163781 Phosphorylation of Pts 1 0.47 2.07 0.14
69 INT28506 Positive_regulation of Pts 1 0.07 0 0.09
70 INT43108 Binding of Pcbd1 2 0.12 0.16 0.08
71 INT39149 Positive_regulation of Negative_regulation of Pcbd1 1 0.14 0.08 0.08
72 INT170510 Negative_regulation of Qdpr 3 0.19 0.19 0.05
73 INT330755 Protein_catabolism of Pts 1 0.13 0.29 0.05
74 INT170508 Binding of Qdpr 4 0.16 0.06 0.03
75 INT45174 Positive_regulation of PTS 3 0.45 0 0
76 INT175571 Negative_regulation of Pcbd1 1 0.19 0.93 0
77 INT200400 Negative_regulation of Binding of PTS 1 0.27 0.82 0
78 INT344013 Gene_expression of Pcbd1 1 0.03 0.06 0
79 INT269015 Positive_regulation of Gene_expression of SPR 1 0.08 0.12 0
80 INT170926 Regulation of Positive_regulation of Pcbd1 1 0.02 0.22 0
81 INT316638 Positive_regulation of Gene_expression of Qdpr 1 0.22 0 0
82 INT177542 Localization of Pcbd1 1 0.01 0.1 0
83 INT175570 Positive_regulation of Pcbd1 1 0.21 2.07 0
84 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0
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