GO:0006730

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Name one-carbon metabolic process
Categary Process
Go Slim No
Go Link GO:0006730
Unique Molecular Interactions 455
Total Molecular Interactions 572
Total Single Events 6472
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for one-carbon metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for one-carbon metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
2 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
3 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
4 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
5 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
6 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
7 INT45816 Binding of Car2 and Gabrg1 2 0.28 0.15 1.63
8 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
9 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
10 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
11 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
12 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
13 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
14 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
15 INT317553 Binding of Car2 and Grin1 1 0.07 0 1.14
16 INT317552 Binding of Calm3 and Car2 2 0.06 0.07 1.05
17 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
18 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02
19 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
20 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
21 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
22 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
23 INT110118 A630055G03Rik Regulation of Car2 1 0.01 0.35 0.81
24 INT270217 Binding of C2 and Ca2 1 0.03 1.63 0.81
25 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
26 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
27 INT296279 Positive_regulation of Rbm39 Positive_regulation of Positive_regulation of Car2 1 0.01 0.58 0.78
28 INT69225 Pnoc Negative_regulation of Car1 1 0.42 0 0.78
29 INT296297 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Car2 1 0.01 0.59 0.77
30 INT170369 Binding of Car2 and Nono 1 0.01 0 0.76
31 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
32 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73
33 INT136538 Nrgn Regulation of Car2 1 0.33 0 0.73
34 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72
35 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72
36 INT296290 Binding of Car1 and Grin1 1 0.11 0.32 0.72
37 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
38 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71
39 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
40 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
41 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68
42 INT283049 Car2 Positive_regulation of Trpa1 1 0.20 1.33 0.67
43 INT41224 Pdyn Positive_regulation of Car1 1 0.19 0 0.66
44 INT309123 Edc4 Positive_regulation of Car1 1 0.02 0.51 0.66
45 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
46 INT251165 Trpv1 Positive_regulation of Gene_expression of Ca2 1 0.15 0.54 0.65
47 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
48 INT326193 Bdnf Positive_regulation of Car2 2 0.14 0.11 0.62
49 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
50 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62
51 INT50816 Penk Positive_regulation of Localization of Ca2 1 0.32 0 0.62
52 INT123301 Car2 Positive_regulation of Creb1 1 0.21 0.28 0.61
53 INT70254 Binding of Htr1a and Ca2 1 0.31 0.5 0.6
54 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
55 INT240070 KCNIP3 Regulation of CA2 1 0.02 0.72 0.59
56 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
57 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
58 INT184244 Mthfd1 Negative_regulation of Gene_expression of TNF 1 0.01 0.88 0.56
59 INT218844 Cysltr1 Regulation of Car1 1 0.01 1.42 0.55
60 INT218839 Ppp1r9a Regulation of Car1 1 0.12 1.42 0.55
61 INT218841 Ltp Regulation of Car1 1 0.15 1.42 0.55
62 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54
63 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
64 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54
65 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53
66 INT118138 Binding of Ca2 and Mgat4a 1 0.01 0 0.53
67 INT187333 Binding of C4bpa and Car1 1 0.08 0 0.52
68 INT297479 Ryr2 Positive_regulation of Ca2 1 0.22 0 0.52
69 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51
70 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51
71 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
72 INT250077 Positive_regulation of Ltp Positive_regulation of Localization of Ca2 1 0.10 0 0.48
73 INT338940 Fpgs Positive_regulation of Mtx1 1 0.32 0.32 0.47
74 INT177782 PDCD2 Positive_regulation of MTHFD2 1 0.06 0.76 0.46
75 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
76 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
77 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45
78 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45
79 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
80 INT265359 Efs Positive_regulation of Car2 1 0.19 0.42 0.45
81 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45
82 INT185191 Binding of Car9 and Pif 1 0.01 2.33 0.45
83 INT309136 Dlat Positive_regulation of Gene_expression of Car1 1 0.03 0.99 0.45
84 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44
85 INT254460 Binding of Calm2 and Ca2 5 0.03 0.48 0.43
86 INT257806 Binding of Car1 and Gopc 1 0.13 0 0.43
87 INT325701 Aacs Regulation of Car3 1 0.17 0 0.4
88 INT291449 Car2 Positive_regulation of SK 1 0.03 0 0.39
89 INT334662 Ltp Regulation of Car2 1 0.09 0.22 0.39
90 INT168200 Binding of CA1 and Nav1 1 0.11 0 0.39
91 INT15028 NA Positive_regulation of Localization of Ca2 1 0.04 0 0.39
92 INT204793 T Positive_regulation of Mthfd1 1 0.00 1.32 0.39
93 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
94 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38
95 INT235083 CA2 Positive_regulation of Gene_expression of CALM1 1 0.01 0.63 0.37
96 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
97 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
98 INT263226 Prkcg Negative_regulation of Positive_regulation of Ca2 1 0.01 0.58 0.36
99 INT26168 Car2 Positive_regulation of Hrasls 1 0.10 0 0.36
100 INT309192 Binding of Car2 and Rbms1 1 0.05 0 0.34
101 INT353689 Binding of Slc8a1 and Ca2 1 0.15 0.58 0.33
102 INT252292 CCL21 Regulation of Binding of Mthfd1 1 0.03 0.41 0.33
103 INT241966 Binding of Ca2 and Acpt 1 0.06 0.06 0.33
104 INT322129 Binding of Prkcg and Ca2 1 0.00 0.57 0.33
105 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
106 INT34449 Binding of Ca2 and Pck1 1 0.17 0.18 0.33
107 INT350701 Mthfd1 Regulation of Gene_expression of Cd4 1 0.03 1.46 0.33
108 INT317566 Car2 Positive_regulation of Camk2a 2 0.19 0.58 0.32
109 INT16382 Binding of Grin1 and Gnmt 1 0.04 0.17 0.32
110 INT195146 Cpm Regulation of Localization of CA2 1 0.00 0.22 0.32
111 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
112 INT241971 Ca2 Regulation of Localization of Abat 1 0.01 0 0.31
113 INT317557 Calm3 Positive_regulation of Car2 1 0.05 0 0.31
114 INT232614 Positive_regulation of Car2 Positive_regulation of Cysltr1 1 0.01 0.62 0.31
115 INT232616 Car2 Positive_regulation of Cysltr1 1 0.02 0.62 0.31
116 INT276602 Paf Positive_regulation of Gene_expression of Mthfd1 1 0.13 0.37 0.31
117 INT156261 Negative_regulation of Binding of Oxt and Ca2 1 0.16 0.12 0.3
118 INT26738 Ca2 Positive_regulation of Localization of Ins1 1 0.12 0.09 0.3
119 INT261047 MZB1 Positive_regulation of Positive_regulation of CA2 1 0.02 0.09 0.3
120 INT156262 Binding of Oxt and Ca2 1 0.14 0.12 0.3
121 INT209233 Tg(Ngf)47Kma Regulation of Car2 1 0.01 0.1 0.28
122 INT209232 Tg(Ngf)47Kma Regulation of Localization of Car2 1 0.02 0.1 0.28
123 INT154834 Stim1 Regulation of Regulation of Ca2 1 0.13 0.9 0.28
124 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
125 INT334669 Negative_regulation of Car1 Negative_regulation of Positive_regulation of Psmd1 1 0.13 1.17 0.27
126 INT305623 Ca2 Positive_regulation of Cabin1 1 0.00 0.27 0.27
127 INT322127 Binding of Mbp and Ca2 1 0.01 0.39 0.27
128 INT323147 Binding of CA2 and DBT 1 0.01 0.17 0.26
129 INT250461 Binding of Car2 and Ba2 1 0.01 0 0.26
130 INT272174 Acot1 Regulation of Ca2 1 0.01 0 0.26
131 INT105003 Binding of PDYN and SHMT2 1 0.04 0.49 0.26
132 INT35022 Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
133 INT35020 Regulation of Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
134 INT257805 Binding of Car3 and Gopc 1 0.18 0 0.25
135 INT209230 Positive_regulation of Car2 Positive_regulation of Ltp 1 0.04 0.12 0.25
136 INT283028 Nav1 Regulation of Ca2 1 0.08 0 0.24
137 INT283027 Pirt Regulation of Ca2 1 0.00 0 0.24
138 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
139 INT130714 CA2 Positive_regulation of Eif2s1 1 0.16 0.59 0.24
140 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
141 INT309141 Dlat Positive_regulation of Car1 1 0.03 0.19 0.24
142 INT52585 RPL35AP35 Positive_regulation of Positive_regulation of Ca2 1 0.00 0.34 0.24
143 INT130689 CA2 Positive_regulation of ATF4 1 0.13 0.59 0.24
144 INT252340 Binding of Cd70 and Mthfd1 1 0.03 1.05 0.24
145 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
146 INT330797 Positive_regulation of Accn2 Positive_regulation of Ca2 1 0.03 0 0.23
147 INT268946 Ros1 Regulation of Gene_expression of Ca2 1 0.00 0.18 0.23
148 INT191480 Htr3a Positive_regulation of Ca2 1 0.02 0.12 0.23
149 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
150 INT251452 Binding of Car1 and Kcnc1 1 0.11 0 0.22
151 INT265360 Binding of Car2 and Daf2 1 0.18 0.09 0.22
152 INT89238 Positive_regulation of RUNX1 Positive_regulation of Positive_regulation of CA2 1 0.01 0 0.22
153 INT248173 Car2 Positive_regulation of GRIN1 1 0.08 0 0.22
154 INT353691 Slc8a1 Positive_regulation of Ca2 1 0.18 0.45 0.22
155 INT330546 Positive_regulation of Trpm8 Positive_regulation of Positive_regulation of Ca2 1 0.13 0.67 0.22
156 INT264778 Binding of CA2 and Gabbr1 1 0.02 0 0.21
157 INT80620 CA2 Regulation of KCNIP3 1 0.11 0.08 0.21
158 INT261048 CHR Positive_regulation of CA2 1 0.03 0.21 0.21
159 INT190745 Adcyap1 Regulation of Car2 1 0.08 0 0.21
160 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2
161 INT290855 PPR Regulation of Ca2 1 0.01 0.45 0.2
162 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
163 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2
164 INT350348 Binding of Car1 and Chrm1 1 0.09 0 0.2
165 INT80927 Acot1 Positive_regulation of Car2 1 0.31 0 0.2
166 INT212921 Positive_regulation of Binding of Car2 and Tg(CAG-EGFP)D4Nagy 1 0.12 0.22 0.19
167 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19
168 INT212920 Binding of Car2 and Tg(CAG-EGFP)D4Nagy 1 0.09 0.22 0.19
169 INT291797 Binding of CA2 and Positive_regulation of MYLK 1 0.15 0.33 0.19
170 INT354223 Binding of Car2 and Igfbp7 1 0.02 0.4 0.19
171 INT330795 Positive_regulation of Accn2 Positive_regulation of Positive_regulation of Ca2 1 0.03 0 0.18
172 INT207640 Binding of Car2 and Nrgn 1 0.04 0 0.18
173 INT290858 Positive_regulation of Ca2 Regulation of PPR 1 0.01 0.5 0.18
174 INT285183 Cd2 Regulation of Ca2 1 0.30 0.23 0.18
175 INT290856 Ca2 Regulation of PPR 1 0.01 0.5 0.18
176 INT328923 Car2 Positive_regulation of Prkca 1 0.00 0 0.18
177 INT11790 CA2 Regulation of Localization of PRL 1 0.23 0 0.18
178 INT69949 Car2 Positive_regulation of MTAP 1 0.02 0.41 0.18
179 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
180 INT351759 Gria2 Regulation of Car2 1 0.07 0.4 0.17
181 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17
182 INT284558 Tlr4 Positive_regulation of Mat1a 1 0.14 0.24 0.17
183 INT216487 Ca2 Negative_regulation of Kcnma1 1 0.00 0.1 0.17
184 INT204790 Binding of Lat2 and Mthfd1 1 0.05 0.85 0.16
185 INT264277 Binding of Car2 and P2rx1 1 0.10 0 0.16
186 INT190744 Adcyap1 Positive_regulation of Car2 1 0.10 0.08 0.16
187 INT40845 Ca2 Positive_regulation of Pla2g1b 1 0.16 0 0.16
188 INT5737 Hk1 Positive_regulation of Ca2 1 0.06 0.16 0.16
189 INT345176 Lpar1 Positive_regulation of Gene_expression of Car2 1 0.03 0.11 0.16
190 INT235085 NOS1 Positive_regulation of CA2 1 0.07 0.18 0.15
191 INT216601 Itpr3 Positive_regulation of Localization of Ca2 1 0.00 0.05 0.15
192 INT77121 WDTC1 Positive_regulation of Localization of CA2 1 0.10 0.39 0.15
193 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15
194 INT342150 Ca2 Positive_regulation of Localization of Gast 1 0.03 0.27 0.14
195 INT182937 KCNIP3 Regulation of Binding of CA2 1 0.05 0.2 0.14
196 INT283947 Positive_regulation of Car1 Positive_regulation of Ptgfrn 1 0.01 0 0.14
197 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
198 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
199 INT182958 Binding of CA2 and CREB1 1 0.04 0.25 0.13
200 INT323149 Positive_regulation of DBT Regulation of CA2 1 0.01 0 0.13

Single Events

The table below shows the top 100 pain related interactions that have been reported for one-carbon metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in one-carbon metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
2 INT4822 Localization of Ca2 417 0.80 99.57 96.45
3 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35
4 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
5 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
6 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
7 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76
8 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
9 INT17561 Localization of Car2 303 0.79 60.95 44.52
10 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39
11 INT5489 Localization of CA2 172 0.80 39.46 33.56
12 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03
13 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64
14 INT13145 Positive_regulation of Car1 60 0.70 16.32 23.23
15 INT17962 Regulation of Car2 124 0.41 33.98 22.71
16 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86
17 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
18 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36
19 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
20 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35
21 INT197375 Gene_expression of Car1 84 0.65 16.46 16.45
22 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
23 INT19799 Binding of Ca2 71 0.48 13.69 12.92
24 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
25 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63
26 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24
27 INT311552 Positive_regulation of Gene_expression of CA1 3 0.67 21.83 11.2
28 INT3535 Regulation of CA2 61 0.32 16.48 10.8
29 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29
30 INT29967 Positive_regulation of Positive_regulation of Car2 40 0.40 8.03 10.13
31 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
32 INT14881 Gene_expression of Car3 49 0.73 14.89 9.94
33 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
34 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
35 INT1129 Binding of Car2 69 0.35 14.01 9.2
36 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45
37 INT12028 Regulation of Car1 28 0.43 9.01 7.84
38 INT159946 Gene_expression of Mat1a 23 0.77 15.33 7.49
39 INT202868 Positive_regulation of Car1 30 0.44 15.48 7.42
40 INT12032 Negative_regulation of Gene_expression of Car1 16 0.34 7.23 7.03
41 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
42 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59
43 INT96164 Positive_regulation of CA1 8 0.67 10.99 6.23
44 INT245587 Regulation of Car1 13 0.27 4.68 5.72
45 INT5490 Binding of CA2 52 0.36 9.73 5.53
46 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53
47 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48
48 INT22160 Negative_regulation of Positive_regulation of Car2 18 0.38 4.94 5.45
49 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4
50 INT12030 Positive_regulation of Gene_expression of Car1 15 0.50 3.98 5.27
51 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1
52 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03
53 INT128353 Negative_regulation of Car3 16 0.37 4.93 4.61
54 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37
55 INT76467 Regulation of Gene_expression of Car2 41 0.37 12.88 4.21
56 INT159119 Negative_regulation of Car1 17 0.37 6.6 4.01
57 INT2073 Regulation of CA1 5 0.26 4.9 3.86
58 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73
59 INT14319 Localization of SHMT2 3 0.03 1.91 3.61
60 INT41541 Regulation of Gene_expression of Car1 9 0.41 3.82 3.52
61 INT76468 Regulation of Positive_regulation of Car2 13 0.29 4.54 3.46
62 INT218814 Negative_regulation of Gene_expression of Car1 12 0.24 3.95 3.24
63 INT3869 Gene_expression of SHMT2 7 0.37 3.6 3.03
64 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92
65 INT91520 Negative_regulation of Positive_regulation of CA2 7 0.30 0.99 2.92
66 INT50535 Gene_expression of CA3 25 0.51 9.25 2.89
67 INT188590 Positive_regulation of Gene_expression of Mthfd1 23 0.49 16.56 2.84
68 INT82841 Localization of Car1 11 0.68 3.91 2.84
69 INT108433 Negative_regulation of Mat1a 16 0.57 14.15 2.82
70 INT2042 Phosphorylation of Ca2 21 0.55 1.54 2.81
71 INT14883 Regulation of Car3 8 0.58 5.57 2.75
72 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69
73 INT245671 Positive_regulation of Gene_expression of Car1 15 0.28 4.31 2.67
74 INT196870 Positive_regulation of Phosphorylation of Car2 6 0.26 3.43 2.63
75 INT83681 Positive_regulation of CA3 3 0.49 0.06 2.6
76 INT80319 Negative_regulation of Negative_regulation of Car1 3 0.59 2 2.58
77 INT93562 Negative_regulation of Localization of CA2 15 0.59 1.87 2.51
78 INT167858 Regulation of Gene_expression of Mat1a 3 0.61 2.97 2.33
79 INT31550 Binding of Car1 10 0.30 1.54 2.24
80 INT72743 Positive_regulation of Negative_regulation of Ca2 4 0.49 1.41 2.11
81 INT149066 Regulation of CA3 5 0.44 0.89 2.02
82 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94
83 INT157816 Positive_regulation of Positive_regulation of Mthfd1 5 0.33 3.73 1.93
84 INT245669 Negative_regulation of Gene_expression of Car3 7 0.37 1.87 1.9
85 INT167853 Positive_regulation of Gene_expression of Mat1a 5 0.35 3.8 1.88
86 INT168068 Positive_regulation of Mat1a 3 0.46 8.82 1.77
87 INT24283 Regulation of Positive_regulation of CA2 8 0.30 3.06 1.74
88 INT64807 Positive_regulation of Positive_regulation of CA2 10 0.41 1.21 1.7
89 INT35325 Regulation of Localization of CA2 10 0.32 1.13 1.69
90 INT2074 Negative_regulation of CA1 6 0.58 4.44 1.68
91 INT146566 Transcription of Car2 8 0.56 1.51 1.6
92 INT291968 Localization of CA1 5 0.73 4.21 1.6
93 INT44493 Regulation of SHMT2 3 0.29 0.45 1.55
94 INT19798 Positive_regulation of Binding of Ca2 2 0.41 1.37 1.54
95 INT119936 Transcription of Ca2 13 0.59 1.71 1.47
96 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47
97 INT159947 Negative_regulation of Gene_expression of Mat1a 2 0.42 4.01 1.46
98 INT68772 Regulation of Negative_regulation of Car1 2 0.44 0.17 1.45
99 INT19619 Positive_regulation of SHMT2 6 0.08 1.05 1.35
100 INT261406 Positive_regulation of Positive_regulation of Car1 1 0.27 1.09 1.34
101 INT204772 Negative_regulation of Gene_expression of Mthfd1 10 0.15 3.48 1.29
102 INT184750 Positive_regulation of Car9 3 0.08 6.38 1.27
103 INT60281 Negative_regulation of Negative_regulation of Car2 4 0.36 1.88 1.26
104 INT47278 Positive_regulation of Positive_regulation of Car1 7 0.45 1.88 1.24
105 INT205889 Gene_expression of Mat2b 1 0.66 0.78 1.19
106 INT22480 Binding of SHMT2 5 0.19 2.31 1.14
107 INT199386 Negative_regulation of Phosphorylation of Car2 1 0.16 1.37 1.14
108 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13
109 INT23847 Phosphorylation of CA2 8 0.61 0.67 1.12
110 INT104913 Regulation of Positive_regulation of Car1 2 0.44 0 1.1
111 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09
112 INT238532 Negative_regulation of Binding of Car2 4 0.29 0.61 1.07
113 INT81418 Positive_regulation of Localization of SHMT2 1 0.02 0.75 1.06
114 INT70327 Regulation of Gene_expression of CA2 11 0.28 1.92 1.05
115 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97
116 INT47757 Transcription of CA2 5 0.67 1.16 0.97
117 INT197365 Localization of Car1 7 0.73 1.11 0.94
118 INT32693 Positive_regulation of Gene_expression of Car3 6 0.42 2.7 0.89
119 INT205884 Positive_regulation of Gene_expression of Mat2b 1 0.59 0.72 0.89
120 INT132690 Negative_regulation of Positive_regulation of CA1 1 0.40 1.26 0.87
121 INT96480 Negative_regulation of Positive_regulation of Mthfd1 5 0.30 0.99 0.83
122 INT146568 Positive_regulation of Transcription of Car2 1 0.31 1.39 0.78
123 INT247935 Transcription of Car1 4 0.44 1.43 0.76
124 INT212006 Transcription of CA1 2 0.66 1.14 0.76
125 INT287841 Positive_regulation of Phosphorylation of Ca2 2 0.18 0.58 0.75
126 INT119933 Transcription of Car1 4 0.52 1.06 0.74
127 INT281853 Regulation of Regulation of Car1 1 0.13 0.27 0.74
128 INT34496 Negative_regulation of Binding of Car1 3 0.37 0.61 0.7
129 INT188591 Positive_regulation of Binding of Mthfd1 3 0.26 0.9 0.69
130 INT197371 Regulation of Gene_expression of Car3 2 0.39 0.64 0.65
131 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
132 INT353145 Negative_regulation of Gene_expression of CA1 1 0.42 1.01 0.65
133 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
134 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
135 INT68403 Positive_regulation of Negative_regulation of Car1 1 0.41 0.33 0.59
136 INT287810 Regulation of Gene_expression of Mthfd1 4 0.17 2.14 0.58
137 INT17964 Negative_regulation of Regulation of Car2 3 0.36 0.58 0.58
138 INT105723 Negative_regulation of Mat1a 2 0.41 0.96 0.58
139 INT23095 Negative_regulation of Regulation of Ca2 2 0.36 0.34 0.56
140 INT72294 Binding of CA3 3 0.32 0.54 0.55
141 INT264594 Negative_regulation of Binding of CA2 4 0.20 1.1 0.52
142 INT223444 Binding of Mat1a 3 0.28 2.95 0.52
143 INT248783 Positive_regulation of Protein_catabolism of CA2 1 0.13 0 0.52
144 INT248784 Protein_catabolism of CA2 1 0.22 0 0.52
145 INT32137 Regulation of Negative_regulation of Ca2 7 0.36 2.17 0.49
146 INT323258 Positive_regulation of Dhfr 1 0.20 0.66 0.49
147 INT324578 Positive_regulation of Regulation of Car2 1 0.20 0.23 0.49
148 INT197369 Regulation of Gene_expression of Car1 4 0.24 0.25 0.47
149 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46
150 INT177878 Positive_regulation of Gene_expression of MTHFD2 1 0.26 1.16 0.46
151 INT177882 Gene_expression of MTHFD2 1 0.40 1.16 0.46
152 INT122156 Binding of CA1 3 0.47 1.52 0.44
153 INT230267 Negative_regulation of CA3 3 0.28 1.4 0.44
154 INT237470 Negative_regulation of Localization of Car1 1 0.32 0.26 0.43
155 INT348865 Regulation of Transcription of CA2 1 0.21 0.69 0.43
156 INT47758 Positive_regulation of Transcription of CA2 3 0.49 0.54 0.42
157 INT249246 Positive_regulation of Phosphorylation of CA2 2 0.26 0.06 0.42
158 INT209498 Negative_regulation of Negative_regulation of Mthfd1 1 0.09 0 0.4
159 INT250447 Positive_regulation of Binding of Car2 3 0.11 0.36 0.39
160 INT135677 Protein_catabolism of Car1 1 0.74 0.41 0.39
161 INT2043 Negative_regulation of Phosphorylation of Ca2 2 0.38 0 0.38
162 INT72295 Regulation of Binding of CA3 1 0.39 0.1 0.38
163 INT349132 Positive_regulation of Localization of Car1 1 0.29 0.1 0.37
164 INT338937 Positive_regulation of Gene_expression of Fpgs 1 0.48 0.13 0.37
165 INT338933 Gene_expression of Fpgs 1 0.54 0.13 0.37
166 INT276021 Regulation of Transcription of Car2 2 0.30 0.08 0.36
167 INT235342 Localization of Car3 2 0.41 0.43 0.33
168 INT16380 Positive_regulation of Gnmt 1 0.05 0.25 0.33
169 INT249273 Regulation of Regulation of CA2 3 0.23 0.26 0.31
170 INT280121 Negative_regulation of Binding of Mthfd1 2 0.41 0.38 0.3
171 INT257799 Phosphorylation of Car1 2 0.43 0.19 0.3
172 INT149737 Positive_regulation of Regulation of Ca2 3 0.58 1 0.27
173 INT102828 Protein_catabolism of SHMT2 1 0.02 0 0.26
174 INT217386 Negative_regulation of Positive_regulation of Car1 2 0.18 1.67 0.25
175 INT84919 Localization of CA3 1 0.59 0.4 0.25
176 INT343362 Positive_regulation of Regulation of Car1 1 0.35 0 0.25
177 INT32301 Regulation of Binding of Ca2 5 0.38 1.07 0.24
178 INT269040 Regulation of Negative_regulation of Car1 1 0.28 0.3 0.24
179 INT349970 Regulation of Localization of Car1 1 0.41 0 0.23
180 INT269032 Binding of Car1 2 0.20 0.67 0.22
181 INT201150 Protein_catabolism of Ca2 4 0.75 2.63 0.21
182 INT235354 Regulation of Localization of Car3 1 0.19 0.12 0.21
183 INT185187 Regulation of Car9 1 0.00 0.96 0.21
184 INT273219 Regulation of Positive_regulation of Car1 1 0.22 1.1 0.2
185 INT235620 Regulation of Transcription of Ca2 1 0.38 0 0.2
186 INT122155 Negative_regulation of Binding of CA1 1 0.42 0.6 0.2
187 INT240712 Negative_regulation of Negative_regulation of Ca2 4 0.36 0.38 0.19
188 INT293693 Phosphorylation of Mthfd1 1 0.34 0.18 0.18
189 INT318561 Negative_regulation of Phosphorylation of CA2 1 0.02 0 0.18
190 INT241468 Binding of Dhfr 2 0.13 1.41 0.17
191 INT236049 Negative_regulation of SHMT2 1 0.04 0.13 0.17
192 INT126762 Gene_expression of Mat2a 1 0.08 0.08 0.17
193 INT81942 Regulation of Regulation of Car2 5 0.29 0.43 0.16
194 INT57182 Negative_regulation of Dhfr 2 0.55 0.37 0.16
195 INT187326 Regulation of Regulation of Car1 1 0.15 0 0.16
196 INT311548 Positive_regulation of Positive_regulation of CA1 1 0.30 0.75 0.16
197 INT184749 Gene_expression of Car9 9 0.31 9.45 0.14
198 INT243530 Positive_regulation of Gene_expression of CA3 1 0.10 0.47 0.14
199 INT195698 Positive_regulation of CA13 1 0.22 1.75 0.13
200 INT330082 Negative_regulation of Positive_regulation of Car1 1 0.17 0.17 0.13
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