GO:0006750

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Name glutathione biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006750
Unique Molecular Interactions 64
Total Molecular Interactions 64
Total Single Events 970
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for glutathione biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for glutathione biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
2 INT124099 Binding of GGT5 and RYBP 1 0.00 0.34 1.26
3 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75
4 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 0.32 0.06 0.38
5 INT111265 Binding of Gnb5 and Ggt5 1 0.52 0.07 0.37
6 INT148467 Ccl4 Positive_regulation of Gclc 1 0.32 0.05 0.37
7 INT134427 Alb Regulation of GGT1 1 0.05 0.7 0.35
8 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19
9 INT101812 Binding of KEAP1 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
10 INT101808 Binding of NFE2L2 and Positive_regulation of Gene_expression of GCLC 1 0.54 0.1 0.19
11 INT19042 ESR1 Positive_regulation of GGT5 1 0.03 0.6 0.17
12 INT155839 Binding of GGT1 and Shbg 1 0.07 1.21 0.12
13 INT101809 Gene_expression of NFE2L2 Positive_regulation of Gene_expression of GCLC 1 0.75 0 0.12
14 INT101811 NFE2L2 Regulation of Gene_expression of GCLC 1 0.67 0.06 0.12
15 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
16 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
17 INT97080 CYP2E1 Regulation of HAGH 1 0.02 0 0.11
18 INT101807 Gene_expression of KEAP1 Negative_regulation of Positive_regulation of GCLC 1 0.46 0 0.08
19 INT295260 Positive_regulation of Nfe2l2 Positive_regulation of Gene_expression of Gclm 1 0.26 0.23 0.07
20 INT89724 RYBP Positive_regulation of Gclc 1 0.01 0.21 0.07
21 INT279907 Binding of GCLM and IRF8 1 0.22 0.82 0.05
22 INT279902 Binding of GCLM and CARD8 1 0.28 0.82 0.05
23 INT279896 Binding of GCLM and STX6 1 0.24 0.82 0.05
24 INT250151 Binding of GSS and MCM3 1 0.01 1.38 0.04
25 INT278183 Binding of Crp and Ggt1 1 0.01 1.09 0.04
26 INT164188 SLPI Negative_regulation of Localization of CNDP2 1 0.03 0 0
27 INT164181 NLRP2 Negative_regulation of Localization of CNDP2 1 0.05 0 0
28 INT164184 NLRP2 Negative_regulation of CNDP2 1 0.05 0 0
29 INT284094 VWF Negative_regulation of CNDP2 1 0.14 1.16 0
30 INT298081 Binding of OVGP1 and Ggt5 1 0.01 0 0
31 INT264936 Binding of TRGV9 and Ggt1 1 0.02 0.1 0
32 INT164187 SLPI Negative_regulation of CNDP2 1 0.03 0 0
33 INT298082 Regulation of Binding of OVGP1 and Ggt5 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for glutathione biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in glutathione biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55
2 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1
3 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28
4 INT38251 Negative_regulation of Gclc 7 0.57 1.37 5.06
5 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
6 INT9854 Localization of GGT1 11 0.78 6.09 3.57
7 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
8 INT100897 Positive_regulation of Gene_expression of GCLC 9 0.68 1.84 1.99
9 INT5279 Localization of Ggt1 9 0.81 2.8 1.99
10 INT12097 Regulation of GGT1 8 0.44 5.76 1.95
11 INT36398 Localization of Ggt5 1 0.49 0.23 1.84
12 INT12168 Negative_regulation of Ggt1 6 0.57 1.9 1.76
13 INT41395 Positive_regulation of Gclc 9 0.61 1.34 1.66
14 INT30945 Positive_regulation of Localization of GGT1 3 0.49 1.34 1.24
15 INT30731 Positive_regulation of Gene_expression of GGT1 8 0.49 6.55 1.15
16 INT16669 Gene_expression of CNDP2 8 0.26 1.7 1.12
17 INT19044 Positive_regulation of GGT5 10 0.65 7.7 1.11
18 INT155838 Binding of GGT1 7 0.47 13.27 1.11
19 INT100892 Positive_regulation of GCLC 8 0.68 3.44 1.08
20 INT8107 Gene_expression of Ggt1 9 0.75 4.04 1.05
21 INT11028 Binding of CNDP2 6 0.24 3.47 0.87
22 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87
23 INT36552 Regulation of Gene_expression of GGT1 2 0.44 1.29 0.87
24 INT94194 Transcription of Gclc 1 0.58 0.53 0.87
25 INT31775 Positive_regulation of Gclc 3 0.38 0.52 0.84
26 INT61226 Binding of Gclc 1 0.14 0 0.67
27 INT41394 Regulation of Gclc 5 0.43 1.78 0.64
28 INT30273 Regulation of Ggt1 3 0.44 1.04 0.62
29 INT215180 Positive_regulation of CNDP2 1 0.15 0.69 0.58
30 INT15 Regulation of GGT5 2 0.20 0 0.57
31 INT60570 Regulation of Gclm 2 0.26 1.3 0.54
32 INT11824 Negative_regulation of GGT1 3 0.57 1.39 0.53
33 INT35567 Negative_regulation of GGT5 4 0.09 1.77 0.47
34 INT147960 Negative_regulation of GCLC 8 0.28 4.4 0.45
35 INT14293 Regulation of Localization of GGT1 1 0.44 0.9 0.37
36 INT27265 Localization of GGT5 1 0.02 1.26 0.35
37 INT30693 Binding of Ggt1 3 0.36 1.76 0.33
38 INT103188 Phosphorylation of Ggt1 1 0.18 0.98 0.32
39 INT103189 Positive_regulation of Phosphorylation of Ggt1 1 0.11 0.98 0.32
40 INT84946 Gene_expression of GGT5 5 0.06 2.31 0.31
41 INT59998 Regulation of CNDP2 2 0.21 0.05 0.31
42 INT30272 Positive_regulation of Gene_expression of Ggt1 1 0.67 0.89 0.3
43 INT190692 Positive_regulation of Binding of GGT1 1 0.49 1.38 0.3
44 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28
45 INT109097 Positive_regulation of Gene_expression of GGT5 2 0.05 2.19 0.24
46 INT101822 Negative_regulation of Positive_regulation of GCLC 1 0.57 0.07 0.23
47 INT18440 Binding of GGT5 1 0.31 0.18 0.21
48 INT288300 Positive_regulation of Phosphorylation of GGT1 1 0.49 1.94 0.21
49 INT288303 Phosphorylation of GGT1 1 0.79 1.74 0.2
50 INT30274 Negative_regulation of Positive_regulation of Ggt1 1 0.42 0.07 0.19
51 INT96951 Positive_regulation of Gene_expression of Gclc 5 0.34 1.45 0.16
52 INT59996 Localization of CNDP2 3 0.63 0.17 0.16
53 INT322766 Regulation of GSS 2 0.06 0.89 0.16
54 INT14046 Negative_regulation of Ggt5 3 0.18 0.08 0.15
55 INT322764 Regulation of GCLM 2 0.27 0.85 0.15
56 INT101819 Positive_regulation of Positive_regulation of GCLC 2 0.59 1.47 0.15
57 INT48515 Regulation of Gene_expression of CNDP2 1 0.16 0.09 0.15
58 INT53923 Negative_regulation of Phosphorylation of GGT5 1 0.01 0.28 0.15
59 INT261021 Positive_regulation of Gene_expression of Gclm 4 0.67 1.45 0.13
60 INT197565 Gene_expression of GCLM 3 0.25 1.47 0.13
61 INT351823 Transcription of GGT1 1 0.29 0.71 0.11
62 INT26602 Negative_regulation of HAGH 1 0.09 0 0.11
63 INT250157 Gene_expression of GSS 2 0.22 1.54 0.1
64 INT142508 Gene_expression of HAGH 1 0.02 0 0.1
65 INT45501 Negative_regulation of GSS 1 0.43 0.36 0.1
66 INT53921 Positive_regulation of Positive_regulation of GGT5 1 0.01 0.14 0.1
67 INT351822 Transcription of GCLM 1 0.27 0.66 0.1
68 INT166520 Positive_regulation of Binding of Ggt1 1 0.03 0 0.09
69 INT223331 Negative_regulation of Gene_expression of GGT5 1 0.03 0.08 0.08
70 INT351827 Negative_regulation of Gene_expression of GCLM 1 0.16 0.69 0.08
71 INT261007 Gene_expression of Gclm 7 0.75 4.25 0.06
72 INT261026 Localization of Gclc 3 0.36 0.88 0.06
73 INT261017 Regulation of Gclc 2 0.22 0.88 0.06
74 INT164777 Negative_regulation of Gclm 1 0.21 0.51 0.06
75 INT53922 Phosphorylation of GGT5 1 0.01 0.14 0.05
76 INT137310 Positive_regulation of GCLM 1 0.49 0.4 0.05
77 INT186262 Transcription of GCLC 3 0.23 1.19 0
78 INT319631 Positive_regulation of Transcription of Gclc 1 0.17 0 0
79 INT239174 Protein_catabolism of GGT1 1 0.86 0.47 0
80 INT261016 Regulation of Positive_regulation of Gclc 1 0.22 0.23 0
81 INT261012 Regulation of Gene_expression of Gclm 1 0.26 0.23 0
82 INT261003 Positive_regulation of Positive_regulation of Gclm 1 0.29 0.23 0
83 INT261009 Regulation of Positive_regulation of Gclm 1 0.26 0.23 0
84 INT261319 Positive_regulation of Gene_expression of Ggt5 1 0.04 0 0
85 INT319621 Transcription of Gclc 1 0.20 0 0
86 INT228008 Negative_regulation of Gene_expression of GGT1 1 0.41 0.54 0
87 INT261006 Positive_regulation of Positive_regulation of Gclc 1 0.24 0.23 0
88 INT313321 Negative_regulation of Transcription of GCLC 1 0.15 0 0
89 INT322936 Positive_regulation of GSS 1 0.15 0.37 0
90 INT250158 Binding of GSS 1 0.14 0.57 0
91 INT246068 Regulation of GCLC 1 0.24 0.11 0
92 INT312375 Transcription of CNDP2 1 0.18 0.81 0
93 INT261321 Gene_expression of Ggt5 1 0.06 0 0
94 INT241848 Protein_catabolism of CNDP2 1 0.02 0.81 0
95 INT261029 Binding of Gclm 1 0.21 0 0
96 INT239173 Regulation of Protein_catabolism of GGT1 1 0.44 0.47 0
97 INT261023 Localization of Gclm 1 0.43 0.39 0
98 INT298079 Positive_regulation of Ggt5 1 0.07 0 0
99 INT241849 Positive_regulation of Protein_catabolism of CNDP2 1 0.01 0.82 0
100 INT261005 Regulation of Localization of Gclc 1 0.13 0.39 0
101 INT261027 Binding of Gclc 1 0.18 0 0
102 INT261025 Positive_regulation of Gclm 1 0.29 0.23 0
103 INT261320 Binding of Ggt5 1 0.03 0 0
104 INT261022 Regulation of Gene_expression of Gclc 1 0.22 0.23 0
105 INT161444 Positive_regulation of Localization of Ggt1 1 0.03 0.19 0
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