GO:0006766

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Name vitamin metabolic process
Categary Process
Go Slim No
Go Link GO:0006766
Unique Molecular Interactions 51
Total Molecular Interactions 68
Total Single Events 634
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vitamin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for vitamin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT322812 Binding of SLC12A1 and MOCOS 1 0.00 1.69 1.49
2 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
3 INT169082 Binding of GRIA1 and MOCOS 2 0.07 1.23 1.17
4 INT322808 Binding of RS1 and MOCOS 1 0.00 0.86 1.01
5 INT266659 Binding of MMP9 and MOCS1 1 0.01 1.71 0.94
6 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
7 INT188531 Binding of TNF and PDXK 1 0.03 1.99 0.78
8 INT180496 Binding of CTS and PDXK 1 0.04 0.69 0.77
9 INT44503 Cubn Positive_regulation of Prl 1 0.18 0 0.74
10 INT180961 Binding of MOCS1 and PLAU 1 0.00 0.61 0.67
11 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
12 INT114951 PPARA Positive_regulation of Gene_expression of RXRA 1 0.34 0.25 0.64
13 INT114949 NCOA1 Positive_regulation of Gene_expression of RXRA 1 0.13 0.24 0.61
14 INT169083 Binding of GRIA3 and MOCOS 2 0.07 0.51 0.5
15 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5
16 INT326514 Sugt1 Negative_regulation of MTHFR 1 0.01 0.77 0.42
17 INT333453 Binding of PPARA and RXRA 1 0.02 0 0.31
18 INT264841 NAMPT Positive_regulation of GRM5 1 0.01 0.72 0.27
19 INT45196 Cubn Negative_regulation of Prl 1 0.05 0 0.27
20 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
21 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
22 INT118257 Binding of ENPP1 and SUGT1 1 0.00 0.87 0.16
23 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
24 INT256320 Binding of CYP26A1 and Hapln1 1 0.01 1.27 0.14
25 INT347806 Binding of MOCS1 and SMAP2 1 0.00 0.48 0.12
26 INT220240 IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.12
27 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12
28 INT156832 MAPK7 Positive_regulation of Transcription of CYP24A1 1 0.35 0 0.1
29 INT306945 NAMPT Positive_regulation of Positive_regulation of MAPK1 1 0.10 0.33 0.08
30 INT156839 Binding of CYP24A1 and MAPK3 1 0.31 0 0.07
31 INT156830 Binding of CYP24A1 and TRPV6 1 0.32 0 0.07
32 INT156828 Positive_regulation of Binding of CYP24A1 and TRPV6 1 0.42 0 0.07
33 INT218009 AHR Positive_regulation of CYP27B1 1 0.16 0.06 0.05
34 INT255166 Binding of MOCS1 and MPO 1 0.00 0.7 0.05
35 INT267046 Binding of SLC2A1 and SV2A 1 0.12 0 0.05
36 INT218010 EE Positive_regulation of CYP27B1 1 0.05 0 0.04
37 INT218011 AHR Positive_regulation of Transcription of CYP27B1 1 0.16 0 0.04
38 INT220242 IL1B Positive_regulation of Gene_expression of MOCS1 1 0.01 0 0.04
39 INT220236 Positive_regulation of IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.03
40 INT306947 NAMPT Regulation of INS 1 0.13 1.41 0
41 INT312956 Regulation of Binding of MOCS1 and MTTP 1 0.00 0.21 0
42 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
43 INT298585 TNFSF11 Positive_regulation of ACP5 1 0.16 0.09 0
44 INT284098 HNF1A Positive_regulation of SLC2A1 1 0.36 1.16 0
45 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
46 INT322931 Binding of MOCS1 and Litaf 1 0.00 0.82 0
47 INT173905 Binding of CD69 and LRP2 1 0.14 0.32 0
48 INT312955 Binding of MOCS1 and MTTP 1 0.00 0.21 0
49 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
50 INT315532 Binding of NFS1 and ISCU 1 0.19 0.37 0
51 INT20323 Binding of CYP2E1 and CYP26A1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vitamin metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in vitamin metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8249 Positive_regulation of Cubn 15 0.66 4.05 9.35
2 INT13893 Negative_regulation of Cubn 9 0.36 1.78 9.24
3 INT138833 Binding of MTHFR 12 0.46 16.08 6.4
4 INT102836 Binding of LRP2 12 0.38 11.27 5.58
5 INT4683 Negative_regulation of PDXK 17 0.55 12.81 4.39
6 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
7 INT18822 Regulation of Cubn 4 0.27 0.17 3.74
8 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
9 INT109448 Negative_regulation of MTHFR 8 0.58 7.62 3.11
10 INT306949 Gene_expression of NAMPT 27 0.67 24.47 2.86
11 INT91647 Gene_expression of PDXK 2 0.49 7.71 2.82
12 INT124063 Gene_expression of MTHFR 9 0.65 6.22 2.67
13 INT97452 Positive_regulation of MOCS1 20 0.39 11.4 2.59
14 INT97453 Negative_regulation of MOCS1 25 0.04 13.4 2.4
15 INT134944 Gene_expression of MOCS1 37 0.06 10.76 2.17
16 INT195191 Gene_expression of Cubn 2 0.06 0 2.17
17 INT14010 Gene_expression of SLC2A1 19 0.78 15.22 2.12
18 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97
19 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
20 INT41633 Positive_regulation of Positive_regulation of Cubn 2 0.48 0.1 1.89
21 INT53343 Positive_regulation of NAMPT 13 0.60 10.94 1.58
22 INT128865 Regulation of Positive_regulation of RXRA 1 0.08 0.64 1.48
23 INT128863 Positive_regulation of RXRA 1 0.12 0.63 1.47
24 INT188533 Regulation of PDXK 1 0.05 2.92 1.23
25 INT44498 Localization of Cubn 2 0.34 0.38 1.19
26 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
27 INT173916 Regulation of LRP2 6 0.44 7.96 1.14
28 INT41333 Negative_regulation of Positive_regulation of Cubn 2 0.15 0.47 1.12
29 INT65093 Gene_expression of ACP5 8 0.56 2.1 1.02
30 INT123536 Positive_regulation of MTHFR 7 0.57 4.74 1
31 INT173914 Regulation of Gene_expression of LRP2 3 0.60 6.49 0.78
32 INT44500 Regulation of Localization of Cubn 1 0.20 0 0.75
33 INT306954 Binding of NAMPT 8 0.36 7.98 0.74
34 INT188543 Negative_regulation of Gene_expression of PDXK 1 0.04 1.51 0.73
35 INT306951 Positive_regulation of Gene_expression of NAMPT 1 0.60 6.08 0.72
36 INT280447 Negative_regulation of Positive_regulation of MOCS1 1 0.00 0.75 0.69
37 INT188538 Regulation of Gene_expression of PDXK 1 0.05 1.85 0.69
38 INT13654 Regulation of SLC2A1 1 0.44 0.44 0.68
39 INT35705 Regulation of CYP27B1 1 0.23 0 0.66
40 INT39059 Binding of PDXK 2 0.31 1.37 0.65
41 INT176013 Negative_regulation of Binding of MTHFR 2 0.42 1.18 0.63
42 INT114959 Gene_expression of RXRA 2 0.50 1.06 0.63
43 INT153699 Regulation of MTHFR 2 0.45 1.54 0.63
44 INT13894 Regulation of Negative_regulation of Cubn 1 0.13 0.09 0.63
45 INT114960 Positive_regulation of Gene_expression of RXRA 1 0.32 0.24 0.61
46 INT124269 Binding of Cubn 1 0.28 0.2 0.59
47 INT65089 Positive_regulation of ACP5 4 0.50 1.67 0.57
48 INT7630 Negative_regulation of SLC2A1 4 0.45 0.73 0.56
49 INT41989 Regulation of NFS1 1 0.01 0.75 0.53
50 INT306959 Transcription of NAMPT 2 0.62 1.19 0.52
51 INT343800 Negative_regulation of Transcription of NAMPT 1 0.37 0.37 0.5
52 INT253325 Positive_regulation of Negative_regulation of MTHFR 2 0.44 1.22 0.49
53 INT128569 Regulation of Positive_regulation of Cubn 1 0.09 0 0.49
54 INT169089 Binding of MOCOS 3 0.07 0.55 0.46
55 INT60540 Positive_regulation of CYP26A1 1 0.35 2.94 0.46
56 INT188532 Positive_regulation of PDXK 1 0.05 1.28 0.46
57 INT188537 Localization of PDXK 1 0.07 0.8 0.43
58 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42
59 INT188542 Regulation of Positive_regulation of PDXK 1 0.05 1.07 0.42
60 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41
61 INT218020 Positive_regulation of CYP27B1 3 0.49 0.15 0.41
62 INT156845 Negative_regulation of CYP24A1 2 0.41 2.04 0.41
63 INT188535 Protein_catabolism of PDXK 1 0.09 0.82 0.41
64 INT41988 Positive_regulation of NFS1 2 0.02 1.28 0.4
65 INT173920 Transcription of LRP2 1 0.52 2.63 0.4
66 INT65092 Negative_regulation of Gene_expression of ACP5 1 0.31 0 0.4
67 INT65094 Negative_regulation of ACP5 2 0.31 0.08 0.39
68 INT65091 Negative_regulation of Positive_regulation of ACP5 1 0.42 0 0.39
69 INT246514 Negative_regulation of NAMPT 4 0.51 2.98 0.37
70 INT285391 Binding of RXRA 2 0.03 0.08 0.36
71 INT301168 Localization of LRP2 1 0.59 0.83 0.36
72 INT206440 Binding of MOCS1 13 0.01 3.76 0.35
73 INT306957 Localization of NAMPT 1 0.70 8.78 0.35
74 INT134943 Localization of MOCS1 7 0.07 4.23 0.34
75 INT306952 Regulation of NAMPT 4 0.53 8.52 0.33
76 INT347246 Positive_regulation of Gene_expression of SLC2A1 1 0.21 0.28 0.32
77 INT347245 Regulation of Gene_expression of SLC2A1 1 0.14 0.28 0.32
78 INT109156 Negative_regulation of ENPP1 2 0.34 1.34 0.29
79 INT186509 Regulation of MOCOS 1 0.02 0.69 0.29
80 INT220261 Negative_regulation of Gene_expression of MOCS1 2 0.01 0.35 0.26
81 INT320171 Positive_regulation of Gene_expression of MOCS1 2 0.01 0.87 0.25
82 INT119707 Gene_expression of CYP24A1 4 0.73 1.11 0.24
83 INT176012 Localization of MTHFR 1 0.74 0.38 0.24
84 INT188541 Positive_regulation of Binding of PDXK 1 0.05 0.79 0.23
85 INT119705 Positive_regulation of CYP24A1 4 0.49 1.11 0.22
86 INT173211 Regulation of MOCS1 4 0.01 1.94 0.22
87 INT136401 Binding of SLC2A1 2 0.36 1.75 0.22
88 INT218021 Positive_regulation of Gene_expression of CYP27B1 2 0.67 0.73 0.21
89 INT119702 Transcription of CYP24A1 4 0.69 1.61 0.16
90 INT206971 Positive_regulation of Localization of MOCS1 2 0.01 0.71 0.16
91 INT173909 Positive_regulation of Gene_expression of LRP2 1 0.41 1.05 0.16
92 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16
93 INT156862 Positive_regulation of Gene_expression of CYP24A1 2 0.66 0.54 0.15
94 INT156858 Regulation of CYP24A1 2 0.58 0.54 0.14
95 INT238489 Negative_regulation of Gene_expression of LRP2 1 0.57 2.74 0.14
96 INT88677 Negative_regulation of Gene_expression of CYP27B1 2 0.57 0.91 0.11
97 INT188539 Positive_regulation of Negative_regulation of PDXK 1 0.05 0.63 0.11
98 INT156849 Phosphorylation of CYP24A1 1 0.59 0 0.1
99 INT156852 Positive_regulation of Transcription of CYP24A1 1 0.44 0 0.1
100 INT119706 Regulation of Transcription of CYP24A1 2 0.44 0.57 0.09
101 INT306948 Positive_regulation of Localization of NAMPT 1 0.40 0.8 0.09
102 INT214072 Regulation of Gene_expression of RXRA 1 0.01 0.83 0.09
103 INT253327 Negative_regulation of Positive_regulation of MTHFR 1 0.41 1.17 0.09
104 INT156844 Regulation of Gene_expression of CYP24A1 1 0.58 0 0.09
105 INT156861 Regulation of Positive_regulation of CYP24A1 1 0.43 0 0.08
106 INT88676 Negative_regulation of CYP27B1 2 0.30 1.96 0.07
107 INT188536 Negative_regulation of Binding of PDXK 1 0.04 0.42 0.07
108 INT315554 Localization of NFS1 1 0.43 0.28 0.07
109 INT164225 Protein_catabolism of MOCS1 1 0.03 0 0.07
110 INT156857 Negative_regulation of Regulation of CYP24A1 1 0.41 0 0.07
111 INT238496 Negative_regulation of Negative_regulation of LRP2 1 0.42 1.84 0.07
112 INT158977 Transcription of SLC2A1 6 0.53 3.44 0.06
113 INT158982 Positive_regulation of Transcription of SLC2A1 3 0.45 1.66 0.06
114 INT189231 Binding of ENPP1 1 0.07 0.56 0.06
115 INT306955 Negative_regulation of Gene_expression of NAMPT 1 0.51 0.33 0.06
116 INT218026 Localization of CYP27B1 1 0.73 0.07 0.05
117 INT275140 Negative_regulation of Regulation of MOCS1 1 0.00 0.49 0.05
118 INT188540 Negative_regulation of Positive_regulation of PDXK 1 0.04 0.27 0.05
119 INT119704 Transcription of CYP27B1 2 0.69 0.48 0.04
120 INT218025 Positive_regulation of Transcription of CYP27B1 1 0.49 0 0.04
121 INT341617 Positive_regulation of Positive_regulation of MOCS1 1 0.01 0.07 0.04
122 INT220253 Regulation of Gene_expression of MOCS1 1 0.00 0.08 0.03
123 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03
124 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03
125 INT257291 Gene_expression of CYP26A1 5 0.75 4.04 0
126 INT296982 Positive_regulation of SLC2A1 3 0.53 1.95 0
127 INT315583 Positive_regulation of Binding of NFS1 1 0.25 0 0
128 INT220264 Positive_regulation of Negative_regulation of MOCS1 1 0.01 0 0
129 INT188534 Positive_regulation of Gene_expression of PDXK 1 0.05 0.06 0
130 INT178545 Regulation of Transcription of MOCS1 1 0.00 0.11 0
131 INT262770 Binding of SLC25A16 1 0.05 1.04 0
132 INT330965 Localization of CYP24A1 1 0.51 0.08 0
133 INT257293 Regulation of Gene_expression of CYP26A1 1 0.34 1.2 0
134 INT158981 Regulation of Transcription of SLC2A1 1 0.20 0 0
135 INT315571 Binding of NFS1 1 0.19 0 0
136 INT306953 Regulation of Gene_expression of NAMPT 1 0.23 1.34 0
137 INT290825 Negative_regulation of Gene_expression of SLC2A1 1 0.29 0.32 0
138 INT346487 Negative_regulation of Phosphorylation of RXRA 1 0.01 0.63 0
139 INT178541 Transcription of MOCS1 1 0.01 0.06 0
140 INT330966 Positive_regulation of Localization of CYP24A1 1 0.34 0.08 0
141 INT315573 Negative_regulation of Gene_expression of NFS1 1 0.24 0.74 0
142 INT341614 Positive_regulation of Binding of MOCS1 1 0.01 0 0
143 INT306950 Positive_regulation of Binding of NAMPT 1 0.52 0.47 0
144 INT257287 Regulation of CYP26A1 1 0.34 0.82 0
145 INT315619 Regulation of Gene_expression of NFS1 1 0.26 0.74 0
146 INT315612 Gene_expression of NFS1 1 0.39 1.68 0
147 INT257277 Negative_regulation of CYP26A1 1 0.33 0.82 0
148 INT346494 Phosphorylation of RXRA 1 0.01 0.63 0
149 INT257273 Positive_regulation of Gene_expression of CYP26A1 1 0.35 1.2 0
150 INT267062 Negative_regulation of Binding of SLC2A1 1 0.14 0 0
151 INT311771 Negative_regulation of Positive_regulation of SLC2A1 1 0.33 0.17 0
152 INT315103 Localization of SLC2A1 1 0.51 0.26 0
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