GO:0006778

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Name porphyrin-containing compound metabolic process
Categary Process
Go Slim No
Go Link GO:0006778
Unique Molecular Interactions 194
Total Molecular Interactions 253
Total Single Events 3946
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for porphyrin-containing compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for porphyrin-containing compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
3 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64
4 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
5 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
6 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38
7 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
8 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23
9 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
10 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
11 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05
12 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
13 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96
14 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
15 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
16 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
17 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
18 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
19 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
20 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
21 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
22 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
23 INT107702 DCSTAMP Positive_regulation of Gene_expression of CPOX 1 0.04 0.32 0.75
24 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
25 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
26 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
27 INT270099 Negative_regulation of Binding of CPOX and PLA2G2A 1 0.01 0.51 0.59
28 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
29 INT270103 Binding of CPOX and PLA2G2A 1 0.01 0.5 0.58
30 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
31 INT172133 IL4 Negative_regulation of Gene_expression of HMOX2 1 0.00 0.81 0.58
32 INT270101 CPOX Negative_regulation of PLA2G2A 1 0.01 0.48 0.56
33 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
34 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
35 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
36 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
37 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
38 INT145433 Binding of CPOX and HMOX2 1 0.01 0.42 0.49
39 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
40 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
41 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
42 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
43 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46
44 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44
45 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
46 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
47 INT107701 Negative_regulation of FN1 Positive_regulation of CPOX 1 0.11 0.13 0.42
48 INT107696 FN1 Positive_regulation of CPOX 1 0.12 0.13 0.41
49 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41
50 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4
51 INT107706 PPARA Positive_regulation of Gene_expression of CPOX 1 0.18 0.14 0.4
52 INT139047 Negative_regulation of AR Negative_regulation of Positive_regulation of CPOX 1 0.07 0.76 0.4
53 INT107700 Positive_regulation of DCSTAMP Positive_regulation of CPOX 1 0.04 0.14 0.38
54 INT107697 DCSTAMP Positive_regulation of CPOX 1 0.06 0.14 0.38
55 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
56 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34
57 INT240434 PPARA Negative_regulation of Gene_expression of CPOX 1 0.03 0.64 0.33
58 INT99597 Negative_regulation of CPOX Regulation of Negative_regulation of ZNF398 1 0.02 0.44 0.33
59 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
60 INT194733 Binding of CPOX and HNRNPA0 1 0.01 0.44 0.32
61 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
62 INT74940 HGF Positive_regulation of CPOX 1 0.13 0.25 0.3
63 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29
64 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29
65 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
66 INT116592 CPOX Regulation of PTGER2 1 0.02 0.45 0.28
67 INT116593 CPOX Regulation of IL6 1 0.10 0.45 0.28
68 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
69 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
70 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
71 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
72 INT102621 IL6 Regulation of Gene_expression of CPOX 1 0.13 0.78 0.25
73 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
74 INT278967 MST1 Regulation of Gene_expression of CPOX 1 0.00 0.41 0.25
75 INT278945 NOS2 Regulation of Gene_expression of CPOX 1 0.02 0.41 0.25
76 INT139045 Negative_regulation of AR Negative_regulation of CPOX 1 0.07 0.34 0.23
77 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
78 INT143629 CPOX Positive_regulation of Gene_expression of MRXS5 1 0.05 0.55 0.23
79 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
80 INT142446 Regulation of CPOX Regulation of Gene_expression of PTGIS 1 0.10 0.26 0.22
81 INT97472 CPOX Regulation of Gene_expression of MRXS5 1 0.02 0.16 0.21
82 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
83 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
84 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2
85 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2
86 INT139877 CPOX Regulation of Gene_expression of PTGES 1 0.17 0.07 0.18
87 INT139881 CPOX Regulation of Transcription of PTGES 1 0.17 0.07 0.18
88 INT240435 JUN Positive_regulation of Gene_expression of CPOX 1 0.01 0.81 0.18
89 INT138323 Positive_regulation of CPOX Regulation of PPAP2A 1 0.09 0.18 0.18
90 INT139878 PTGES Regulation of Gene_expression of CPOX 1 0.17 0.07 0.18
91 INT139879 PTGES Regulation of Transcription of CPOX 1 0.17 0.07 0.18
92 INT207375 Negative_regulation of CPOX Negative_regulation of Gene_expression of Chol1 1 0.10 0.37 0.17
93 INT207348 TBXA2R Negative_regulation of CPOX 1 0.03 0 0.17
94 INT314270 CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.17
95 INT235441 HMBS Regulation of PPARA 1 0.03 0.76 0.16
96 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
97 INT207338 Negative_regulation of CPOX Negative_regulation of ABCA1 1 0.11 0 0.16
98 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
99 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
100 INT248147 PLAT Positive_regulation of Gene_expression of CPOX 1 0.00 0.51 0.15
101 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
102 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
103 INT89597 Binding of CPOX and TBXAS1 1 0.04 0.05 0.14
104 INT114967 ERI1 Negative_regulation of CPOX 1 0.00 0.25 0.14
105 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
106 INT252177 VEGFA Regulation of Gene_expression of CPOX 1 0.03 0.56 0.14
107 INT207352 ZNF398 Regulation of CPOX 1 0.00 0 0.14
108 INT207347 PTGER1 Negative_regulation of CPOX 1 0.00 0 0.14
109 INT141001 Negative_regulation of CPOX Regulation of Localization of INS 1 0.17 0.07 0.14
110 INT207341 PTGER2 Negative_regulation of CPOX 1 0.01 0 0.14
111 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
112 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14
113 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
114 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
115 INT105439 IL6 Positive_regulation of CPOX 1 0.11 0.75 0.12
116 INT231761 TNF Negative_regulation of HMOX1 1 0.19 1.2 0.12
117 INT105434 TNF Positive_regulation of CPOX 1 0.27 0.75 0.12
118 INT178593 Binding of CPOX and TPX2 1 0.02 0.88 0.12
119 INT105436 IRF6 Positive_regulation of CPOX 1 0.08 0.74 0.11
120 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
121 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
122 INT231772 TNF Positive_regulation of Gene_expression of HMOX1 1 0.21 0.96 0.1
123 INT180980 UROD Positive_regulation of Pcts 1 0.04 0.55 0.1
124 INT91454 MAPK1 Positive_regulation of Gene_expression of CPOX 1 0.20 0.6 0.1
125 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 0.04 0.33 0.1
126 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
127 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
128 INT231773 IRF6 Negative_regulation of Gene_expression of HMOX1 1 0.06 1.27 0.09
129 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
130 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
131 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
132 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
133 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
134 INT314264 Negative_regulation of CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.09
135 INT314267 Binding of CPOX and PTGES 1 0.03 0.34 0.09
136 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08
137 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
138 INT279420 CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07
139 INT279415 Gene_expression of CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07
140 INT40240 CPOX Negative_regulation of Localization of LYZ 1 0.22 0.16 0.07
141 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
142 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
143 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
144 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
145 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
146 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
147 INT313652 C8A Regulation of CPOX 1 0.00 0.11 0.06
148 INT231760 TNF Positive_regulation of Protein_catabolism of HMOX1 1 0.31 0.41 0.06
149 INT231758 IRF6 Regulation of Gene_expression of HMOX1 1 0.08 0.23 0.05
150 INT157151 LSS Positive_regulation of CPOX 1 0.17 0.89 0.05
151 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
152 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
153 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04
154 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
155 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
156 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
157 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
158 INT207362 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP27A1 1 0.01 0 0.03
159 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
160 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03
161 INT201379 RARS Regulation of Gene_expression of CPOX 1 0.04 0.23 0.03
162 INT207343 Negative_regulation of CPOX Negative_regulation of Gene_expression of ABCA1 1 0.09 0 0.03
163 INT303251 HMBS Positive_regulation of Protein_catabolism of Dlgap1 1 0.01 0 0
164 INT106724 ALAD Regulation of IFI27 1 0.17 0.21 0
165 INT353910 Binding of CRP and UROD 1 0.06 0.34 0
166 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
167 INT102626 PTAFR Positive_regulation of Gene_expression of CPOX 1 0.11 0.1 0
168 INT203587 MCF2 Negative_regulation of Gene_expression of CPOX 1 0.00 0.6 0
169 INT195052 PTHLH Positive_regulation of Positive_regulation of CPOX 1 0.07 0.67 0
170 INT315541 ACO1 Negative_regulation of Gene_expression of ALAS2 1 0.17 0.18 0
171 INT97566 CPOX Positive_regulation of Gene_expression of PRKCA 1 0.06 0.07 0
172 INT105533 Binding of ALAD and S100A8 1 0.40 0.14 0
173 INT102618 PTAFR Regulation of Gene_expression of CPOX 1 0.08 0.38 0
174 INT330735 GSTK1 Regulation of HMOX1 1 0.08 0.25 0
175 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
176 INT106725 ALAD Regulation of CIB1 1 0.10 0.21 0
177 INT343155 ACSL4 Regulation of CPOX 1 0.01 1.03 0
178 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
179 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
180 INT102627 IL6 Positive_regulation of Gene_expression of CPOX 1 0.20 0.34 0
181 INT331116 Binding of BLVRB and EBNA1BP2 1 0.04 0.38 0
182 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
183 INT207363 Negative_regulation of CPOX Negative_regulation of CYP27A1 1 0.01 0 0
184 INT315535 Binding of ABCB7 and FECH 1 0.28 0.7 0
185 INT315533 Negative_regulation of GLRX5 Negative_regulation of Gene_expression of ALAS2 1 0.38 1.06 0
186 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
187 INT156700 Binding of Crp and UGT1A1 1 0.40 0 0
188 INT102623 Negative_regulation of PRKCA Negative_regulation of Gene_expression of CPOX 1 0.09 0.12 0
189 INT195053 PTHLH Regulation of Gene_expression of CPOX 1 0.03 0.71 0
190 INT301906 Binding of HMOX1 and HSD11B1 1 0.05 2.41 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for porphyrin-containing compound metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in porphyrin-containing compound metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19
2 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02
3 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06
4 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03
5 INT64171 Regulation of CPOX 109 0.36 55.36 32.96
6 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07
7 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
8 INT81194 Binding of CPOX 40 0.29 23.7 18.95
9 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
10 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83
11 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
12 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
13 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
14 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
15 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78
16 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
17 INT74272 Localization of CPOX 39 0.63 25.12 10.53
18 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
19 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
20 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15
21 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
22 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
23 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
24 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
25 INT64176 Transcription of CPOX 35 0.41 15.1 5.5
26 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
27 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
28 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
29 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
30 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8
31 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
32 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64
33 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64
34 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
35 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
36 INT69967 Negative_regulation of Positive_regulation of CPOX 11 0.35 7.73 4.07
37 INT83887 Gene_expression of HMOX2 10 0.77 7.99 3.85
38 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
39 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
40 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
41 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08
42 INT220335 Gene_expression of UROD 34 0.54 24.53 2.89
43 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78
44 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
45 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
46 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
47 INT58380 Binding of ALAD 13 0.47 9.87 2.44
48 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
49 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34
50 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
51 INT106307 Positive_regulation of UROD 27 0.49 16.63 2.19
52 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
53 INT130199 Negative_regulation of Binding of CPOX 4 0.30 1.89 2.1
54 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
55 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
56 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
57 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
58 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
59 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
60 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82
61 INT97707 Regulation of HMOX2 4 0.18 1.96 1.5
62 INT68766 Positive_regulation of Transcription of CPOX 10 0.30 4.76 1.49
63 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
64 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
65 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
66 INT97704 Positive_regulation of Gene_expression of HMOX2 3 0.13 2.54 1.37
67 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36
68 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
69 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
70 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
71 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
72 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
73 INT158469 Regulation of FECH 3 0.36 1.76 1.13
74 INT115264 Binding of FECH 9 0.41 7.93 1.1
75 INT78354 Positive_regulation of Positive_regulation of CPOX 8 0.19 2.82 1.06
76 INT3320 Regulation of ALAS2 3 0.33 0.93 1.05
77 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
78 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
79 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
80 INT201393 Positive_regulation of Regulation of CPOX 1 0.09 1.51 0.98
81 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
82 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
83 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
84 INT97705 Positive_regulation of HMOX2 2 0.08 0.89 0.83
85 INT97703 Regulation of Gene_expression of HMOX2 1 0.01 0.89 0.83
86 INT97706 Regulation of Positive_regulation of HMOX2 1 0.02 0.89 0.83
87 INT62288 Positive_regulation of ALAD 4 0.67 4.27 0.82
88 INT44919 Negative_regulation of ALAD 5 0.43 3.11 0.8
89 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
90 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
91 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
92 INT64172 Regulation of Transcription of CPOX 1 0.19 0.31 0.75
93 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
94 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
95 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73
96 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
97 INT220338 Positive_regulation of Gene_expression of UROD 2 0.49 3.55 0.69
98 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
99 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
100 INT90607 Positive_regulation of Binding of CPOX 4 0.17 0.79 0.67
101 INT272291 Regulation of Binding of CPOX 1 0.11 0.37 0.67
102 INT94423 Binding of ALAS2 4 0.32 2.1 0.61
103 INT105444 Regulation of Localization of CPOX 1 0.22 1.28 0.59
104 INT172168 Transcription of HMOX2 1 0.01 0.81 0.57
105 INT64174 Negative_regulation of Transcription of CPOX 3 0.18 0.84 0.56
106 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
107 INT99909 Regulation of Positive_regulation of CPOX 2 0.35 1.88 0.53
108 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53
109 INT220333 Binding of UROD 4 0.30 2.66 0.52
110 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
111 INT76100 Gene_expression of ALAD 6 0.65 2.33 0.44
112 INT235471 Regulation of HMBS 6 0.13 1.8 0.43
113 INT83885 Negative_regulation of Gene_expression of HMOX2 1 0.09 0.26 0.42
114 INT224399 Positive_regulation of Positive_regulation of UROD 1 0.40 0.61 0.42
115 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
116 INT80446 Localization of BLVRB 1 0.03 0.08 0.39
117 INT103444 Binding of HMOX2 2 0.48 0.7 0.38
118 INT93546 Regulation of UROD 4 0.32 2.9 0.37
119 INT157157 Negative_regulation of Localization of HMOX1 1 0.37 0.74 0.37
120 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
121 INT138010 Positive_regulation of Gene_expression of ALAD 1 0.49 1.32 0.35
122 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
123 INT281659 Regulation of Transcription of HMOX1 2 0.27 2.12 0.33
124 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
125 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32
126 INT74177 Positive_regulation of Gene_expression of HMBS 6 0.49 2.77 0.3
127 INT145525 Positive_regulation of Regulation of HMOX2 1 0.18 0.43 0.3
128 INT135772 Regulation of Positive_regulation of HMOX1 3 0.39 1.52 0.29
129 INT102042 Regulation of ALAD 2 0.44 2.42 0.29
130 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
131 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
132 INT224397 Regulation of Gene_expression of UROD 1 0.32 1.39 0.28
133 INT100740 Positive_regulation of BLVRB 1 0.05 0.17 0.28
134 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
135 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
136 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
137 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
138 INT117830 Positive_regulation of Localization of CPOX 1 0.28 0.41 0.26
139 INT224398 Localization of UROD 3 0.49 1.71 0.25
140 INT131132 Protein_catabolism of HMBS 5 0.86 1.02 0.24
141 INT120656 Localization of HMBS 3 0.16 2.6 0.23
142 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
143 INT282679 Localization of FECH 1 0.12 9.57 0.23
144 INT278672 Positive_regulation of Transcription of UGT1A1 1 0.27 0.07 0.22
145 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21
146 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
147 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
148 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
149 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
150 INT131133 Binding of HMBS 9 0.36 2.13 0.19
151 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
152 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
153 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
154 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
155 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13
156 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
157 INT201467 Protein_catabolism of HMOX1 2 0.77 0.83 0.13
158 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
159 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
160 INT224396 Negative_regulation of UROD 2 0.30 1.57 0.12
161 INT288682 Binding of Slc11a2 1 0.47 0 0.12
162 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
163 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
164 INT224400 Negative_regulation of Gene_expression of UROD 1 0.41 0.69 0.12
165 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
166 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
167 INT224332 Localization of HMOX2 1 0.02 1.15 0.11
168 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
169 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
170 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1
171 INT235464 Regulation of Gene_expression of HMBS 1 0.44 0.23 0.1
172 INT130338 Regulation of Binding of ALAD 1 0.26 0.91 0.1
173 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
174 INT158692 Negative_regulation of Gene_expression of HMBS 1 0.25 0.67 0.09
175 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
176 INT120657 Positive_regulation of Localization of HMBS 1 0.00 0.83 0.09
177 INT138325 Negative_regulation of Localization of CPOX 1 0.16 0.08 0.08
178 INT353911 Negative_regulation of Regulation of UROD 1 0.10 0.59 0.08
179 INT58381 Negative_regulation of Binding of ALAD 1 0.41 0.47 0.07
180 INT213624 Localization of ALAS2 1 0.05 0 0.07
181 INT274054 Localization of CYP1A1 1 0.12 0 0.07
182 INT265987 Protein_catabolism of ALAS2 1 0.01 2.77 0.07
183 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07
184 INT235472 Negative_regulation of Binding of HMBS 1 0.09 0.28 0.07
185 INT235465 Regulation of Binding of HMBS 1 0.10 0.28 0.07
186 INT278678 Positive_regulation of Gene_expression of UGT1A1 1 0.37 0.09 0.06
187 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
188 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
189 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
190 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
191 INT53568 Positive_regulation of Negative_regulation of FECH 1 0.47 0.78 0.05
192 INT293311 Positive_regulation of Positive_regulation of HMOX1 3 0.69 1.99 0.04
193 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
194 INT201388 Phosphorylation of CPOX 1 0.16 0.43 0.04
195 INT220334 Transcription of UROD 1 0.26 1.88 0.03
196 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0
197 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
198 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0
199 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
200 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
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