GO:0006779

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Name porphyrin-containing compound biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006779
Unique Molecular Interactions 88
Total Molecular Interactions 102
Total Single Events 2211
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for porphyrin-containing compound biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for porphyrin-containing compound biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115443 Regulation of Binding of Cpox and Defb40 1 0.00 1.28 1.76
2 INT115442 Binding of Cpox and Defb40 1 0.00 1.28 1.76
3 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
4 INT21858 Maoa Regulation of Gene_expression of Spna1 1 0.12 0.18 1.24
5 INT21859 Maoa Regulation of Spna1 1 0.12 0.18 1.23
6 INT115444 Cpox Positive_regulation of Localization of Defb42 1 0.00 0.64 0.87
7 INT271780 Zfp560 Negative_regulation of Cpox 1 0.00 0.62 0.86
8 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
9 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
10 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 0.00 0.94 0.62
11 INT239489 Spna1 Negative_regulation of Timp1 1 0.00 0.89 0.57
12 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56
13 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
14 INT285688 Cpox Positive_regulation of PPARA 1 0.02 1 0.5
15 INT282285 Cpox Regulation of Gene_expression of Ptger2 1 0.00 0.84 0.5
16 INT217760 Il1f5 Positive_regulation of Gene_expression of Cpox 1 0.00 0.27 0.47
17 INT331928 Negative_regulation of Cpox Negative_regulation of VEGFA 1 0.01 0.97 0.47
18 INT217759 Il1f5 Positive_regulation of Cpox 1 0.00 0.27 0.47
19 INT131819 Binding of Cpox and Nfkb1 1 0.15 0.44 0.46
20 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
21 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
22 INT205926 Helt Regulation of Cpox 1 0.01 0 0.41
23 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
24 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38
25 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 0.06 1.33 0.37
26 INT235432 Ppara Negative_regulation of Gene_expression of Cpox 1 0.01 1 0.37
27 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 0.05 1.33 0.37
28 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.44 0.33
29 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
30 INT124261 Jun Regulation of Gene_expression of Cpox 1 0.13 0.44 0.32
31 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32
32 INT124258 Creb1 Regulation of Gene_expression of Cpox 1 0.17 0.44 0.32
33 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31
34 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
35 INT156440 Cpox Positive_regulation of NOS1 1 0.01 0.52 0.28
36 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
37 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 0.03 0.3 0.26
38 INT156587 Hst1 Negative_regulation of Gene_expression of Cpox 1 0.15 0.82 0.26
39 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
40 INT147626 Spna1 Negative_regulation of Ctrc 1 0.01 0 0.24
41 INT147627 Spna1 Positive_regulation of Ctrc 1 0.01 0 0.24
42 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
43 INT152748 Negative_regulation of Cpox Negative_regulation of Localization of Tnf 1 0.17 0.98 0.21
44 INT124263 Plat Positive_regulation of Gene_expression of Cpox 1 0.07 0.42 0.21
45 INT172895 Binding of Cpox and Selenbp2 1 0.00 0.64 0.2
46 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2
47 INT113809 Negative_regulation of Cpox Negative_regulation of Gene_expression of VEGFA 1 0.02 0.97 0.18
48 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
49 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
50 INT354819 Binding of Cpox and Ptgs2 1 0.02 0.45 0.16
51 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
52 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
53 INT202619 Binding of Ppara and Spna1 1 0.01 0.27 0.1
54 INT214012 Binding of Ank1 and Nav1 1 0.01 0.51 0.1
55 INT214011 Negative_regulation of Binding of Ank1 and Nav1 1 0.01 0.51 0.1
56 INT249925 Cpox Negative_regulation of Pah 1 0.01 0.18 0.1
57 INT234601 Tlr4 Regulation of Cpox 1 0.05 0.12 0.09
58 INT172911 Cpox Positive_regulation of Gene_expression of VEGFA 1 0.01 0.72 0.09
59 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
60 INT147774 Binding of HLA-B and ABCB6 2 0.40 1.03 0.08
61 INT300246 Binding of ABCB6 and HSR 1 0.11 1.86 0.08
62 INT336030 PGE Regulation of Gene_expression of Cpox 1 0.05 0.22 0.07
63 INT199311 Ptger2 Regulation of Cpox 1 0.01 0.73 0.07
64 INT336032 tf Positive_regulation of Gene_expression of Cpox 1 0.05 0.09 0.05
65 INT263751 Binding of Dlg4 and Spna1 1 0.03 0 0.05
66 INT228212 Cpox Negative_regulation of Localization of Ptger2 1 0.00 0.88 0.04
67 INT172909 Cpox Regulation of Lox 1 0.03 0.51 0.03
68 INT170326 Ido1 Positive_regulation of Cpox 1 0.07 0.12 0.03
69 INT170327 Ido1 Positive_regulation of Gene_expression of Cpox 1 0.07 0.12 0.03
70 INT172900 Binding of Cpox and Lox 1 0.02 0.4 0.03
71 INT241031 Gopc Positive_regulation of Hmbs 1 0.04 0.83 0
72 INT241019 Positive_regulation of Mapk1 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
73 INT317316 Park7 Positive_regulation of Protein_catabolism of Hmbs 1 0.11 0.68 0
74 INT227483 pk Positive_regulation of Gene_expression of Cpox 1 0.08 0.27 0
75 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0
76 INT302927 Binding of Spna1 and Chrm2 1 0.00 0.35 0
77 INT263863 Binding of Mab21l1 and Spna1 1 0.00 1.6 0
78 INT209391 Binding of ELANE and Cpox 1 0.01 0.25 0
79 INT178206 Binding of Cd4 and Spna1 1 0.02 0.51 0
80 INT227488 pk Regulation of Gene_expression of Cpox 1 0.04 0.16 0
81 INT302929 Binding of Pnp and Spna1 1 0.00 0.35 0
82 INT231926 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptger2 1 0.00 0.1 0
83 INT191933 Itgam Positive_regulation of Cpox 1 0.07 0.36 0
84 INT241029 Agtrap Positive_regulation of Hmbs 1 0.07 0.83 0
85 INT282287 Binding of Cpox and Hmgcr 1 0.01 0.99 0
86 INT263865 Binding of Crlf1 and Spna1 1 0.00 0.12 0
87 INT315483 Spna1 Regulation of Slfn5 1 0.01 0.53 0
88 INT241018 Hmbs Positive_regulation of Protein_catabolism of Sypl 1 0.00 0.44 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for porphyrin-containing compound biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in porphyrin-containing compound biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46
2 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17
3 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77
4 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05
5 INT78990 Regulation of Cpox 72 0.57 35.22 18.16
6 INT21850 Gene_expression of Spna1 107 0.50 51.4 11.81
7 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5
8 INT75768 Transcription of Cpox 37 0.27 19.41 9.79
9 INT21846 Localization of Spna1 27 0.78 5.14 9.22
10 INT50290 Binding of Cpox 29 0.27 17.19 8.01
11 INT23782 Positive_regulation of Spna1 58 0.50 35.41 6.94
12 INT89603 Regulation of Negative_regulation of Cpox 11 0.30 10.59 6.28
13 INT49440 Localization of Cpox 27 0.53 11.26 5.79
14 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22
15 INT21856 Regulation of Spna1 9 0.51 3.74 5.02
16 INT21854 Positive_regulation of Localization of Spna1 8 0.61 0.14 4.85
17 INT99905 Negative_regulation of Negative_regulation of Cpox 11 0.35 7.01 4.37
18 INT24711 Negative_regulation of Spna1 22 0.35 14.75 3.59
19 INT21845 Regulation of Gene_expression of Spna1 5 0.22 0.9 2.78
20 INT155218 Binding of ABCB6 18 0.35 13.93 2.25
21 INT21851 Negative_regulation of Localization of Spna1 3 0.38 0.14 2.23
22 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2
23 INT121036 Positive_regulation of Transcription of Cpox 12 0.21 6.34 2.04
24 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85
25 INT29833 Binding of Spna1 39 0.27 19.4 1.74
26 INT23781 Regulation of Localization of Spna1 2 0.54 0 1.71
27 INT78005 Negative_regulation of Binding of Cpox 7 0.31 3.19 1.7
28 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43
29 INT129179 Gene_expression of Ank1 4 0.31 0.47 1.35
30 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34
31 INT82248 Positive_regulation of Regulation of Cpox 4 0.44 2.57 1.19
32 INT114243 Positive_regulation of Positive_regulation of Cpox 4 0.39 3.06 1.18
33 INT170317 Protein_catabolism of Cpox 4 0.15 0.43 1.1
34 INT239482 Positive_regulation of Gene_expression of Spna1 10 0.41 5.06 1.05
35 INT30093 Positive_regulation of Positive_regulation of Spna1 8 0.41 4.48 0.95
36 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
37 INT30092 Negative_regulation of Positive_regulation of Spna1 3 0.25 1.33 0.84
38 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78
39 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77
40 INT328226 Negative_regulation of Positive_regulation of Cpox 3 0.11 1.49 0.73
41 INT76372 Regulation of Transcription of Cpox 3 0.16 0.57 0.57
42 INT226176 Protein_catabolism of Hmbs 15 0.61 13.17 0.56
43 INT205917 Regulation of Localization of Cpox 2 0.19 0.22 0.54
44 INT219713 Negative_regulation of Gene_expression of Spna1 4 0.29 2.63 0.52
45 INT239483 Protein_catabolism of Spna1 3 0.11 2.25 0.47
46 INT261557 Positive_regulation of Localization of Cpox 2 0.04 0.17 0.45
47 INT78991 Regulation of Positive_regulation of Cpox 2 0.22 3.86 0.44
48 INT139827 Negative_regulation of ABCB6 5 0.57 2.91 0.43
49 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4
50 INT102744 Positive_regulation of Gene_expression of Hmbs 4 0.70 2.97 0.35
51 INT118264 Binding of Hmbs 6 0.37 4.87 0.33
52 INT160498 Regulation of Binding of Cpox 2 0.10 1.78 0.33
53 INT112531 Negative_regulation of Localization of Cpox 1 0.07 0.46 0.3
54 INT216554 Localization of ABCB6 5 0.28 0.75 0.23
55 INT219717 Negative_regulation of Binding of Spna1 2 0.25 2.24 0.22
56 INT115663 Regulation of Gene_expression of ABCB6 1 0.44 1.2 0.21
57 INT191929 Negative_regulation of Transcription of Cpox 1 0.13 0.18 0.2
58 INT183623 Phosphorylation of Cpox 3 0.25 3.76 0.18
59 INT272881 Positive_regulation of Protein_catabolism of Spna1 1 0.02 1.01 0.18
60 INT292984 Positive_regulation of Binding of Spna1 1 0.30 1.55 0.16
61 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
62 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
63 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
64 INT288682 Binding of Slc11a2 1 0.47 0 0.12
65 INT214008 Negative_regulation of Ank1 4 0.03 1.49 0.09
66 INT178200 Phosphorylation of Spna1 2 0.10 0.85 0.09
67 INT300253 Negative_regulation of Gene_expression of ABCB6 2 0.18 0.74 0.09
68 INT3782 Regulation of Fech 1 0.00 1.05 0.09
69 INT300261 Positive_regulation of ABCB6 9 0.22 5.82 0.08
70 INT338438 Regulation of Binding of ABCB6 1 0.12 0.06 0.08
71 INT144562 Negative_regulation of Negative_regulation of Spna1 1 0.02 0.44 0.08
72 INT300258 Phosphorylation of ABCB6 1 0.24 1.02 0.05
73 INT159766 Positive_regulation of Ank1 1 0.07 0.1 0.04
74 INT208887 Regulation of Ank1 1 0.01 0.08 0.04
75 INT354957 Binding of Ank1 1 0.02 0 0.04
76 INT187894 Positive_regulation of Gene_expression of ABCB6 5 0.19 1.97 0.03
77 INT178197 Transcription of Spna1 2 0.14 1.45 0
78 INT241017 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
79 INT271725 Regulation of Protein_catabolism of Hmbs 1 0.31 0.22 0
80 INT271551 Localization of Ank1 1 0.03 0.11 0
81 INT300264 Positive_regulation of Positive_regulation of ABCB6 1 0.19 0.99 0
82 INT263844 Regulation of Binding of Spna1 1 0.07 0.33 0
83 INT321658 Positive_regulation of Fech 1 0.02 0.8 0
84 INT300256 Regulation of Positive_regulation of ABCB6 1 0.17 1.31 0
85 INT235423 Positive_regulation of Phosphorylation of Cpox 1 0.06 3.29 0
86 INT240993 Positive_regulation of Positive_regulation of Hmbs 1 0.07 0.26 0
87 INT237437 Phosphorylation of Hmbs 1 0.15 0 0
88 INT282353 Positive_regulation of Negative_regulation of Spna1 1 0.10 0.75 0
89 INT282354 Negative_regulation of Transcription of Spna1 1 0.09 0.93 0
90 INT300259 Negative_regulation of Positive_regulation of ABCB6 1 0.16 0.9 0
91 INT321657 Positive_regulation of Positive_regulation of Fech 1 0.02 0.8 0
92 INT241000 Transcription of Hmbs 1 0.10 0.82 0
93 INT271740 Negative_regulation of Binding of Hmbs 1 0.30 0.59 0
94 INT300252 Regulation of ABCB6 1 0.17 0 0
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