GO:0006783

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Name heme biosynthetic process
Categary Process
Go Slim No
Go Link GO:0006783
Unique Molecular Interactions 321
Total Molecular Interactions 399
Total Single Events 9210
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heme biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for heme biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
3 INT115443 Regulation of Binding of Cpox and Defb40 1 0.00 1.28 1.76
4 INT115442 Binding of Cpox and Defb40 1 0.00 1.28 1.76
5 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64
6 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
7 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
8 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38
9 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
10 INT69279 Regulation of Binding of TSPO and Gabrg1 1 0.00 2.05 1.26
11 INT190130 Binding of CPOX and MRXS5 1 0.00 1.4 1.23
12 INT107029 Cpox Regulation of Pag1 1 0.01 1.24 1.15
13 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05
14 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
15 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96
16 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
17 INT75920 Slc8a1 Negative_regulation of Cpox 1 0.03 0.85 0.89
18 INT115444 Cpox Positive_regulation of Localization of Defb42 1 0.00 0.64 0.87
19 INT271780 Zfp560 Negative_regulation of Cpox 1 0.00 0.62 0.86
20 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
21 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
22 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
23 INT352201 Negative_regulation of ALOX5 Negative_regulation of Cpox 1 0.02 0.89 0.81
24 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
25 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
26 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
27 INT141911 Arih2 Regulation of Positive_regulation of Cpox 1 0.01 1.19 0.76
28 INT141910 Arih2 Regulation of Cpox 1 0.01 1.19 0.76
29 INT107702 DCSTAMP Positive_regulation of Gene_expression of CPOX 1 0.04 0.32 0.75
30 INT119313 Cpox Regulation of Gene_expression of Ptger2 1 0.02 0.6 0.74
31 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72
32 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
33 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
34 INT69280 Negative_regulation of Binding of TSPO and Gabrg1 1 0.00 1.03 0.63
35 INT69278 Binding of TSPO and Gabrg1 1 0.00 1.01 0.62
36 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
37 INT270099 Negative_regulation of Binding of CPOX and PLA2G2A 1 0.01 0.51 0.59
38 INT157141 Cpox Positive_regulation of Gene_expression of Camk2a 1 0.19 0.13 0.58
39 INT270103 Binding of CPOX and PLA2G2A 1 0.01 0.5 0.58
40 INT145491 PROC Positive_regulation of Cpox 1 0.00 1.08 0.58
41 INT122313 Nfkb1 Regulation of Gene_expression of Cpox 1 0.00 0.51 0.57
42 INT122314 Nfkb1 Regulation of Cpox 1 0.00 0.51 0.56
43 INT270101 CPOX Negative_regulation of PLA2G2A 1 0.01 0.48 0.56
44 INT122315 Negative_regulation of Nfkb1 Regulation of Cpox 1 0.00 0.51 0.56
45 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56
46 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
47 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
48 INT112659 Cpox Positive_regulation of Gene_expression of TNF 1 0.01 0.79 0.52
49 INT112661 Cpox Positive_regulation of Localization of TNF 1 0.01 0.79 0.52
50 INT285688 Cpox Positive_regulation of PPARA 1 0.02 1 0.5
51 INT282285 Cpox Regulation of Gene_expression of Ptger2 1 0.00 0.84 0.5
52 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
53 INT145433 Binding of CPOX and HMOX2 1 0.01 0.42 0.49
54 INT217760 Il1f5 Positive_regulation of Gene_expression of Cpox 1 0.00 0.27 0.47
55 INT331928 Negative_regulation of Cpox Negative_regulation of VEGFA 1 0.01 0.97 0.47
56 INT217759 Il1f5 Positive_regulation of Cpox 1 0.00 0.27 0.47
57 INT203177 Negative_regulation of CPOX Positive_regulation of Gene_expression of Lts1 1 0.00 0.72 0.46
58 INT131819 Binding of Cpox and Nfkb1 1 0.15 0.44 0.46
59 INT116926 Cpox Regulation of AKR1C3 1 0.01 0.28 0.45
60 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
61 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44
62 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
63 INT107701 Negative_regulation of FN1 Positive_regulation of CPOX 1 0.11 0.13 0.42
64 INT107696 FN1 Positive_regulation of CPOX 1 0.12 0.13 0.41
65 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41
66 INT205926 Helt Regulation of Cpox 1 0.01 0 0.41
67 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
68 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4
69 INT107706 PPARA Positive_regulation of Gene_expression of CPOX 1 0.18 0.14 0.4
70 INT139047 Negative_regulation of AR Negative_regulation of Positive_regulation of CPOX 1 0.07 0.76 0.4
71 INT107700 Positive_regulation of DCSTAMP Positive_regulation of CPOX 1 0.04 0.14 0.38
72 INT107697 DCSTAMP Positive_regulation of CPOX 1 0.06 0.14 0.38
73 INT354820 Creb1 Negative_regulation of Transcription of Cpox 1 0.03 0.59 0.38
74 INT350814 Negative_regulation of TNF Positive_regulation of Gene_expression of Cpox 1 0.06 1.33 0.37
75 INT235432 Ppara Negative_regulation of Gene_expression of Cpox 1 0.01 1 0.37
76 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37
77 INT350816 TNF Positive_regulation of Gene_expression of Cpox 1 0.05 1.33 0.37
78 INT106511 Binding of Cpox and Ptges3 2 0.01 0.7 0.36
79 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35
80 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
81 INT134301 Cpox Negative_regulation of Gene_expression of Ptger2 1 0.00 0.77 0.34
82 INT141848 Mthfs Negative_regulation of Cpox 1 0.01 0 0.34
83 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34
84 INT240434 PPARA Negative_regulation of Gene_expression of CPOX 1 0.03 0.64 0.33
85 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.44 0.33
86 INT99597 Negative_regulation of CPOX Regulation of Negative_regulation of ZNF398 1 0.02 0.44 0.33
87 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33
88 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
89 INT124261 Jun Regulation of Gene_expression of Cpox 1 0.13 0.44 0.32
90 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32
91 INT194733 Binding of CPOX and HNRNPA0 1 0.01 0.44 0.32
92 INT124258 Creb1 Regulation of Gene_expression of Cpox 1 0.17 0.44 0.32
93 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31
94 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31
95 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
96 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
97 INT74940 HGF Positive_regulation of CPOX 1 0.13 0.25 0.3
98 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29
99 INT93580 Hgf Positive_regulation of Cpox 1 0.19 2.2 0.29
100 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29
101 INT158922 Positive_regulation of Binding of TSPO and Tspo 1 0.54 0.83 0.28
102 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
103 INT156440 Cpox Positive_regulation of NOS1 1 0.01 0.52 0.28
104 INT116592 CPOX Regulation of PTGER2 1 0.02 0.45 0.28
105 INT158923 Binding of TSPO and Tspo 1 0.40 0.82 0.28
106 INT116593 CPOX Regulation of IL6 1 0.10 0.45 0.28
107 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
108 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
109 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 0.03 0.3 0.26
110 INT156587 Hst1 Negative_regulation of Gene_expression of Cpox 1 0.15 0.82 0.26
111 INT102621 IL6 Regulation of Gene_expression of CPOX 1 0.13 0.78 0.25
112 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
113 INT278967 MST1 Regulation of Gene_expression of CPOX 1 0.00 0.41 0.25
114 INT278945 NOS2 Regulation of Gene_expression of CPOX 1 0.02 0.41 0.25
115 INT124078 Binding of Ace and Cpox 1 0.09 0.14 0.24
116 INT110061 Binding of Alox5 and Cpox 1 0.28 0.37 0.23
117 INT139045 Negative_regulation of AR Negative_regulation of CPOX 1 0.07 0.34 0.23
118 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
119 INT143629 CPOX Positive_regulation of Gene_expression of MRXS5 1 0.05 0.55 0.23
120 INT142446 Regulation of CPOX Regulation of Gene_expression of PTGIS 1 0.10 0.26 0.22
121 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
122 INT132680 HNF1A Positive_regulation of Gene_expression of UGT1A6 1 0.30 0.08 0.21
123 INT97472 CPOX Regulation of Gene_expression of MRXS5 1 0.02 0.16 0.21
124 INT132679 HNF1A Regulation of Gene_expression of UGT1A6 1 0.16 0.08 0.21
125 INT152748 Negative_regulation of Cpox Negative_regulation of Localization of Tnf 1 0.17 0.98 0.21
126 INT124263 Plat Positive_regulation of Gene_expression of Cpox 1 0.07 0.42 0.21
127 INT172895 Binding of Cpox and Selenbp2 1 0.00 0.64 0.2
128 INT145140 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP19A1 1 0.13 0.47 0.2
129 INT158466 FECH Negative_regulation of Fech 1 0.23 0.57 0.2
130 INT113809 Negative_regulation of Cpox Negative_regulation of Gene_expression of VEGFA 1 0.02 0.97 0.18
131 INT139877 CPOX Regulation of Gene_expression of PTGES 1 0.17 0.07 0.18
132 INT139881 CPOX Regulation of Transcription of PTGES 1 0.17 0.07 0.18
133 INT240435 JUN Positive_regulation of Gene_expression of CPOX 1 0.01 0.81 0.18
134 INT130932 Negative_regulation of Cpox Positive_regulation of Gene_expression of TSC1 1 0.00 0.42 0.18
135 INT138323 Positive_regulation of CPOX Regulation of PPAP2A 1 0.09 0.18 0.18
136 INT139878 PTGES Regulation of Gene_expression of CPOX 1 0.17 0.07 0.18
137 INT139879 PTGES Regulation of Transcription of CPOX 1 0.17 0.07 0.18
138 INT207375 Negative_regulation of CPOX Negative_regulation of Gene_expression of Chol1 1 0.10 0.37 0.17
139 INT207348 TBXA2R Negative_regulation of CPOX 1 0.03 0 0.17
140 INT314270 CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.17
141 INT235441 HMBS Regulation of PPARA 1 0.03 0.76 0.16
142 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16
143 INT354819 Binding of Cpox and Ptgs2 1 0.02 0.45 0.16
144 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
145 INT191338 Binding of TSPO and IDO1 1 0.02 0.65 0.16
146 INT207338 Negative_regulation of CPOX Negative_regulation of ABCA1 1 0.11 0 0.16
147 INT248147 PLAT Positive_regulation of Gene_expression of CPOX 1 0.00 0.51 0.15
148 INT89597 Binding of CPOX and TBXAS1 1 0.04 0.05 0.14
149 INT114967 ERI1 Negative_regulation of CPOX 1 0.00 0.25 0.14
150 INT173499 EEF1A2 Negative_regulation of Cpox 1 0.07 0.39 0.14
151 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14
152 INT252177 VEGFA Regulation of Gene_expression of CPOX 1 0.03 0.56 0.14
153 INT93579 Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 1.1 0.14
154 INT207352 ZNF398 Regulation of CPOX 1 0.00 0 0.14
155 INT207347 PTGER1 Negative_regulation of CPOX 1 0.00 0 0.14
156 INT141001 Negative_regulation of CPOX Regulation of Localization of INS 1 0.17 0.07 0.14
157 INT207341 PTGER2 Negative_regulation of CPOX 1 0.01 0 0.14
158 INT204159 Slc11a2 Regulation of Gene_expression of HAMP 1 0.11 1.08 0.14
159 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14
160 INT173498 EEF1A2 Regulation of Cpox 1 0.04 0.39 0.14
161 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
162 INT105439 IL6 Positive_regulation of CPOX 1 0.11 0.75 0.12
163 INT105434 TNF Positive_regulation of CPOX 1 0.27 0.75 0.12
164 INT178593 Binding of CPOX and TPX2 1 0.02 0.88 0.12
165 INT105436 IRF6 Positive_regulation of CPOX 1 0.08 0.74 0.11
166 INT180980 UROD Positive_regulation of Pcts 1 0.04 0.55 0.1
167 INT91454 MAPK1 Positive_regulation of Gene_expression of CPOX 1 0.20 0.6 0.1
168 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 0.04 0.33 0.1
169 INT249925 Cpox Negative_regulation of Pah 1 0.01 0.18 0.1
170 INT234601 Tlr4 Regulation of Cpox 1 0.05 0.12 0.09
171 INT172911 Cpox Positive_regulation of Gene_expression of VEGFA 1 0.01 0.72 0.09
172 INT220412 Cpox Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.9 0.09
173 INT314264 Negative_regulation of CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.09
174 INT314267 Binding of CPOX and PTGES 1 0.03 0.34 0.09
175 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08
176 INT217271 Cpox Regulation of Gene_expression of Ptges 1 0.01 0.14 0.08
177 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
178 INT279420 CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07
179 INT336030 PGE Regulation of Gene_expression of Cpox 1 0.05 0.22 0.07
180 INT199311 Ptger2 Regulation of Cpox 1 0.01 0.73 0.07
181 INT279415 Gene_expression of CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07
182 INT40240 CPOX Negative_regulation of Localization of LYZ 1 0.22 0.16 0.07
183 INT188520 Ptges Positive_regulation of Cpox 1 0.01 0.05 0.06
184 INT188523 Ppara Negative_regulation of Positive_regulation of Cpox 1 0.02 0 0.06
185 INT313652 C8A Regulation of CPOX 1 0.00 0.11 0.06
186 INT116388 Binding of Adm and Cpox 1 0.14 0.2 0.05
187 INT336032 tf Positive_regulation of Gene_expression of Cpox 1 0.05 0.09 0.05
188 INT157151 LSS Positive_regulation of CPOX 1 0.17 0.89 0.05
189 INT217277 Cpox Negative_regulation of Gene_expression of Ptges 1 0.01 0.09 0.04
190 INT228212 Cpox Negative_regulation of Localization of Ptger2 1 0.00 0.88 0.04
191 INT106515 Binding of Ptges and Cpox 1 0.00 0.17 0.04
192 INT217276 Avp Negative_regulation of Cpox 1 0.02 0.09 0.04
193 INT207362 Negative_regulation of CPOX Negative_regulation of Gene_expression of CYP27A1 1 0.01 0 0.03
194 INT172909 Cpox Regulation of Lox 1 0.03 0.51 0.03
195 INT170326 Ido1 Positive_regulation of Cpox 1 0.07 0.12 0.03
196 INT170327 Ido1 Positive_regulation of Gene_expression of Cpox 1 0.07 0.12 0.03
197 INT201379 RARS Regulation of Gene_expression of CPOX 1 0.04 0.23 0.03
198 INT207343 Negative_regulation of CPOX Negative_regulation of Gene_expression of ABCA1 1 0.09 0 0.03
199 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03
200 INT172900 Binding of Cpox and Lox 1 0.02 0.4 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for heme biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in heme biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29
2 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19
3 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02
4 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46
5 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81
6 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17
7 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4
8 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06
9 INT35975 Regulation of Cpox 109 0.39 57.88 49.69
10 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03
11 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77
12 INT64171 Regulation of CPOX 109 0.36 55.36 32.96
13 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93
14 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07
15 INT69993 Positive_regulation of Gene_expression of Cpox 93 0.55 69.4 22.05
16 INT81194 Binding of CPOX 40 0.29 23.7 18.95
17 INT55335 Binding of Cpox 49 0.34 15.48 18.46
18 INT78990 Regulation of Cpox 72 0.57 35.22 18.16
19 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26
20 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4
21 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87
22 INT50671 Regulation of Gene_expression of CPOX 45 0.54 30.99 13.83
23 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5
24 INT74272 Localization of CPOX 39 0.63 25.12 10.53
25 INT424 Positive_regulation of TSPO 34 0.61 15.04 10.02
26 INT72759 Transcription of Cpox 40 0.39 17.26 10
27 INT76426 Positive_regulation of Negative_regulation of Cpox 18 0.35 6.84 9.95
28 INT74812 Negative_regulation of Positive_regulation of Cpox 17 0.34 10.1 9.94
29 INT75768 Transcription of Cpox 37 0.27 19.41 9.79
30 INT51922 Localization of Cpox 24 0.68 12.05 8.59
31 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05
32 INT50290 Binding of Cpox 29 0.27 17.19 8.01
33 INT76427 Regulation of Negative_regulation of Cpox 17 0.31 6.75 7.93
34 INT6335 Binding of TSPO 39 0.44 10.88 7.66
35 INT83529 Positive_regulation of Positive_regulation of Cpox 8 0.29 7.22 6.7
36 INT89603 Regulation of Negative_regulation of Cpox 11 0.30 10.59 6.28
37 INT14258 Regulation of TSPO 32 0.60 10.16 6.24
38 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15
39 INT49440 Localization of Cpox 27 0.53 11.26 5.79
40 INT64176 Transcription of CPOX 35 0.41 15.1 5.5
41 INT85653 Regulation of Gene_expression of Cpox 24 0.24 20.55 5.22
42 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8
43 INT72758 Positive_regulation of Transcription of Cpox 15 0.34 5.46 4.75
44 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64
45 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64
46 INT99905 Negative_regulation of Negative_regulation of Cpox 11 0.35 7.01 4.37
47 INT69967 Negative_regulation of Positive_regulation of CPOX 11 0.35 7.73 4.07
48 INT88651 Phosphorylation of Cpox 5 0.41 2.92 4.04
49 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58
50 INT74022 Regulation of Positive_regulation of Cpox 6 0.24 5.73 3.41
51 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08
52 INT220335 Gene_expression of UROD 34 0.54 24.53 2.89
53 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78
54 INT58380 Binding of ALAD 13 0.47 9.87 2.44
55 INT243496 Positive_regulation of Gene_expression of FECH 4 0.40 4.02 2.34
56 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2
57 INT106307 Positive_regulation of UROD 27 0.49 16.63 2.19
58 INT3784 Regulation of Hmbs 4 0.38 2.79 2.11
59 INT130199 Negative_regulation of Binding of CPOX 4 0.30 1.89 2.1
60 INT121036 Positive_regulation of Transcription of Cpox 12 0.21 6.34 2.04
61 INT66929 Positive_regulation of Localization of Cpox 6 0.25 4.68 1.98
62 INT14257 Localization of TSPO 9 0.73 1.48 1.87
63 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85
64 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82
65 INT101166 Negative_regulation of Binding of Cpox 4 0.15 2.66 1.79
66 INT22591 Negative_regulation of Hmbs 6 0.51 5.04 1.74
67 INT78005 Negative_regulation of Binding of Cpox 7 0.31 3.19 1.7
68 INT72760 Regulation of Transcription of Cpox 6 0.24 1.84 1.54
69 INT68766 Positive_regulation of Transcription of CPOX 10 0.30 4.76 1.49
70 INT74178 Gene_expression of HMBS 24 0.76 9.62 1.36
71 INT102747 Gene_expression of Hmbs 17 0.78 10.53 1.34
72 INT93702 Localization of Hmbs 1 0.81 4.84 1.26
73 INT82248 Positive_regulation of Regulation of Cpox 4 0.44 2.57 1.19
74 INT114243 Positive_regulation of Positive_regulation of Cpox 4 0.39 3.06 1.18
75 INT84714 Negative_regulation of Transcription of Cpox 3 0.25 1.5 1.18
76 INT158469 Regulation of FECH 3 0.36 1.76 1.13
77 INT115264 Binding of FECH 9 0.41 7.93 1.1
78 INT170317 Protein_catabolism of Cpox 4 0.15 0.43 1.1
79 INT78354 Positive_regulation of Positive_regulation of CPOX 8 0.19 2.82 1.06
80 INT3320 Regulation of ALAS2 3 0.33 0.93 1.05
81 INT154842 Positive_regulation of Phosphorylation of Cpox 1 0.13 0.07 1.05
82 INT201393 Positive_regulation of Regulation of CPOX 1 0.09 1.51 0.98
83 INT132883 Gene_expression of Slc11a2 5 0.75 2.96 0.89
84 INT22592 Positive_regulation of Hmbs 2 0.48 2.27 0.87
85 INT154905 Negative_regulation of Phosphorylation of Cpox 1 0.18 0.91 0.87
86 INT62288 Positive_regulation of ALAD 4 0.67 4.27 0.82
87 INT57135 Gene_expression of Hmbs 1 0.32 0.55 0.82
88 INT44919 Negative_regulation of ALAD 5 0.43 3.11 0.8
89 INT102745 Positive_regulation of Hmbs 17 0.61 12.41 0.78
90 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77
91 INT64172 Regulation of Transcription of CPOX 1 0.19 0.31 0.75
92 INT199649 Gene_expression of Fxn 12 0.72 20.9 0.74
93 INT50291 Positive_regulation of HMBS 10 0.67 8.89 0.73
94 INT328226 Negative_regulation of Positive_regulation of Cpox 3 0.11 1.49 0.73
95 INT69003 Negative_regulation of Binding of TSPO 4 0.03 2.78 0.69
96 INT220338 Positive_regulation of Gene_expression of UROD 2 0.49 3.55 0.69
97 INT90607 Positive_regulation of Binding of CPOX 4 0.17 0.79 0.67
98 INT272291 Regulation of Binding of CPOX 1 0.11 0.37 0.67
99 INT191341 Negative_regulation of Gene_expression of TSPO 3 0.34 1.66 0.64
100 INT22593 Negative_regulation of Positive_regulation of Hmbs 1 0.41 1.58 0.64
101 INT73850 Transcription of TSPO 6 0.59 0.83 0.61
102 INT94423 Binding of ALAS2 4 0.32 2.1 0.61
103 INT204138 Regulation of Gene_expression of TSPO 2 0.36 0.99 0.6
104 INT105444 Regulation of Localization of CPOX 1 0.22 1.28 0.59
105 INT76372 Regulation of Transcription of Cpox 3 0.16 0.57 0.57
106 INT226176 Protein_catabolism of Hmbs 15 0.61 13.17 0.56
107 INT64174 Negative_regulation of Transcription of CPOX 3 0.18 0.84 0.56
108 INT178718 Phosphorylation of TSPO 1 0.79 0.91 0.56
109 INT178717 Negative_regulation of Localization of TSPO 1 0.41 0.92 0.56
110 INT205917 Regulation of Localization of Cpox 2 0.19 0.22 0.54
111 INT73849 Negative_regulation of TSPO 8 0.59 2.4 0.53
112 INT99909 Regulation of Positive_regulation of CPOX 2 0.35 1.88 0.53
113 INT220333 Binding of UROD 4 0.30 2.66 0.52
114 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49
115 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49
116 INT261557 Positive_regulation of Localization of Cpox 2 0.04 0.17 0.45
117 INT76100 Gene_expression of ALAD 6 0.65 2.33 0.44
118 INT78991 Regulation of Positive_regulation of Cpox 2 0.22 3.86 0.44
119 INT235471 Regulation of HMBS 6 0.13 1.8 0.43
120 INT61831 Regulation of Regulation of TSPO 1 0.03 0.16 0.43
121 INT224399 Positive_regulation of Positive_regulation of UROD 1 0.40 0.61 0.42
122 INT158463 Regulation of Hmbs 7 0.31 4.87 0.4
123 INT93546 Regulation of UROD 4 0.32 2.9 0.37
124 INT102744 Positive_regulation of Gene_expression of Hmbs 4 0.70 2.97 0.35
125 INT138010 Positive_regulation of Gene_expression of ALAD 1 0.49 1.32 0.35
126 INT92908 Negative_regulation of Regulation of Cpox 1 0.01 0.21 0.34
127 INT118264 Binding of Hmbs 6 0.37 4.87 0.33
128 INT160498 Regulation of Binding of Cpox 2 0.10 1.78 0.33
129 INT3321 Positive_regulation of ALAS2 10 0.51 3.08 0.32
130 INT146646 Protein_catabolism of TSPO 3 0.86 0.58 0.32
131 INT74177 Positive_regulation of Gene_expression of HMBS 6 0.49 2.77 0.3
132 INT112531 Negative_regulation of Localization of Cpox 1 0.07 0.46 0.3
133 INT102042 Regulation of ALAD 2 0.44 2.42 0.29
134 INT141725 Regulation of Binding of Cpox 1 0.15 0.33 0.28
135 INT224397 Regulation of Gene_expression of UROD 1 0.32 1.39 0.28
136 INT117830 Positive_regulation of Localization of CPOX 1 0.28 0.41 0.26
137 INT224398 Localization of UROD 3 0.49 1.71 0.25
138 INT131132 Protein_catabolism of HMBS 5 0.86 1.02 0.24
139 INT120656 Localization of HMBS 3 0.16 2.6 0.23
140 INT282679 Localization of FECH 1 0.12 9.57 0.23
141 INT3323 Gene_expression of ALAS2 10 0.58 7.51 0.21
142 INT20301 Positive_regulation of Binding of Hnf1a 1 0.02 0 0.21
143 INT191929 Negative_regulation of Transcription of Cpox 1 0.13 0.18 0.2
144 INT20302 Binding of Hnf1a 1 0.02 0 0.2
145 INT131133 Binding of HMBS 9 0.36 2.13 0.19
146 INT183623 Phosphorylation of Cpox 3 0.25 3.76 0.18
147 INT204148 Regulation of Gene_expression of Slc11a2 1 0.15 1.1 0.15
148 INT199642 Positive_regulation of Fxn 3 0.41 3.6 0.14
149 INT199640 Positive_regulation of Positive_regulation of Fxn 2 0.41 2.97 0.14
150 INT249107 Positive_regulation of HNF1A 1 0.49 0.2 0.13
151 INT288681 Regulation of Transcription of Slc11a2 1 0.44 0.37 0.13
152 INT288683 Transcription of Slc11a2 1 0.69 0.37 0.13
153 INT224396 Negative_regulation of UROD 2 0.30 1.57 0.12
154 INT288682 Binding of Slc11a2 1 0.47 0 0.12
155 INT224400 Negative_regulation of Gene_expression of UROD 1 0.41 0.69 0.12
156 INT199652 Negative_regulation of Fxn 3 0.54 12.37 0.11
157 INT73848 Positive_regulation of Transcription of TSPO 3 0.42 0.58 0.1
158 INT315643 Negative_regulation of Gene_expression of FECH 1 0.29 0.71 0.1
159 INT235464 Regulation of Gene_expression of HMBS 1 0.44 0.23 0.1
160 INT130338 Regulation of Binding of ALAD 1 0.26 0.91 0.1
161 INT158692 Negative_regulation of Gene_expression of HMBS 1 0.25 0.67 0.09
162 INT3782 Regulation of Fech 1 0.00 1.05 0.09
163 INT120657 Positive_regulation of Localization of HMBS 1 0.00 0.83 0.09
164 INT199646 Transcription of Fxn 2 0.67 4.78 0.08
165 INT138325 Negative_regulation of Localization of CPOX 1 0.16 0.08 0.08
166 INT199643 Phosphorylation of Fxn 1 0.40 1.04 0.08
167 INT353911 Negative_regulation of Regulation of UROD 1 0.10 0.59 0.08
168 INT199655 Negative_regulation of Gene_expression of Fxn 2 0.47 3.34 0.07
169 INT58381 Negative_regulation of Binding of ALAD 1 0.41 0.47 0.07
170 INT213624 Localization of ALAS2 1 0.05 0 0.07
171 INT265987 Protein_catabolism of ALAS2 1 0.01 2.77 0.07
172 INT315622 Protein_catabolism of FECH 1 0.77 0.49 0.07
173 INT235472 Negative_regulation of Binding of HMBS 1 0.09 0.28 0.07
174 INT235465 Regulation of Binding of HMBS 1 0.10 0.28 0.07
175 INT315598 Localization of FXN 1 0.43 1.04 0.07
176 INT315630 Gene_expression of FXN 8 0.64 20.05 0.05
177 INT199654 Positive_regulation of Gene_expression of Fxn 3 0.64 2.95 0.05
178 INT53568 Positive_regulation of Negative_regulation of FECH 1 0.47 0.78 0.05
179 INT266687 Regulation of Regulation of Cpox 1 0.16 0.38 0.04
180 INT199641 Regulation of Transcription of Fxn 1 0.29 1.89 0.04
181 INT199648 Regulation of Fxn 1 0.29 2.14 0.04
182 INT201388 Phosphorylation of CPOX 1 0.16 0.43 0.04
183 INT199651 Binding of Fxn 3 0.30 1.45 0.03
184 INT220334 Transcription of UROD 1 0.26 1.88 0.03
185 INT291518 Positive_regulation of Negative_regulation of Fxn 1 0.47 1.1 0.03
186 INT315563 Positive_regulation of Gene_expression of FXN 4 0.41 5.05 0
187 INT3322 Positive_regulation of Gene_expression of ALAS2 4 0.43 3.25 0
188 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0
189 INT315635 Positive_regulation of FXN 2 0.41 5.76 0
190 INT315628 Negative_regulation of Gene_expression of FXN 2 0.36 2.37 0
191 INT315551 Negative_regulation of Gene_expression of ALAS2 1 0.37 1.11 0
192 INT316567 Negative_regulation of Localization of Cpox 1 0.08 0.35 0
193 INT291511 Positive_regulation of Transcription of Fxn 1 0.47 0.09 0
194 INT241017 Positive_regulation of Protein_catabolism of Hmbs 1 0.07 0.05 0
195 INT271725 Regulation of Protein_catabolism of Hmbs 1 0.31 0.22 0
196 INT315614 Negative_regulation of Transcription of FXN 1 0.25 0.82 0
197 INT240923 Regulation of Hnf1a 1 0.19 0.48 0
198 INT213625 Regulation of Gene_expression of ALAS2 1 0.03 0.06 0
199 INT331131 Regulation of Gene_expression of FXN 1 0.37 1.49 0
200 INT291516 Negative_regulation of Transcription of Fxn 1 0.54 0.77 0
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