GO:0006805

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Name xenobiotic metabolic process
Categary Process
Go Slim No
Go Link GO:0006805
Unique Molecular Interactions 811
Total Molecular Interactions 1044
Total Single Events 12079
Pain Genes Associated 88

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for xenobiotic metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for xenobiotic metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
3 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
4 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
5 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
6 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
7 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
8 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
9 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
10 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
11 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
12 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
13 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
14 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
15 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
16 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
17 INT168459 Sult1a1 Negative_regulation of Gene_expression of Arr3 1 0.05 2.98 1.23
18 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
19 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
20 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
21 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
22 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
23 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03
24 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
25 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
26 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
27 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
28 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
29 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
30 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
31 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
32 INT136540 Binding of CYP2C9 and Ugt1a6a 1 0.27 0.81 0.86
33 INT28185 CYP2B6 Positive_regulation of Positive_regulation of RYBP 1 0.29 0 0.82
34 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
35 INT92372 CYP2B6 Positive_regulation of Binding of RYBP 1 0.17 0.09 0.81
36 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
37 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
38 INT117604 AKR1C1 Negative_regulation of Positive_regulation of Mpo 1 0.00 1.45 0.78
39 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
40 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
41 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
42 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76
43 INT166672 YY1 Regulation of Binding of UGT1A6 1 0.48 0 0.76
44 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
45 INT90959 PPIG Regulation of CYP2C9 1 0.43 0 0.75
46 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
47 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
48 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
49 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
50 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
51 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
52 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71
53 INT166671 YY1 Regulation of Positive_regulation of UGT1A6 1 0.48 0 0.7
54 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
55 INT67809 Ugt2b1 Negative_regulation of Ugt2b7 1 0.47 0 0.7
56 INT303691 KNG1 Positive_regulation of AHR 1 0.03 0.98 0.69
57 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
58 INT303689 Regulation of KNG1 Positive_regulation of AHR 1 0.03 0.99 0.69
59 INT172698 Ugt1a6 Negative_regulation of Localization of Acot1 1 0.01 0 0.68
60 INT113685 Binding of Cyp3a23/3a1 and Cyp2c11 1 0.35 0 0.65
61 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
62 INT102316 Ugt1a6a Positive_regulation of Cyb5 1 0.16 0.08 0.64
63 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
64 INT135471 Binding of CYP2B6 and UGT2B7 1 0.49 0 0.63
65 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
66 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
67 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
68 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
69 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
70 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
71 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
72 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
73 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
74 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
75 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
76 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
77 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56
78 INT60481 Binding of Ugt1a1 and UGT1A6 1 0.23 0 0.55
79 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
80 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
81 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
82 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
83 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 0.66 2.42 0.54
84 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
85 INT123896 CYP2B6 Regulation of UGT2B7 1 0.42 0 0.53
86 INT147576 Positive_regulation of Ahr Positive_regulation of Gene_expression of Scrg1 1 0.00 0.17 0.52
87 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
88 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
89 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
90 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49
91 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
92 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
93 INT200325 Ahrr Regulation of Oprm1 1 0.00 0.09 0.49
94 INT340110 MAOB Positive_regulation of Ltp 1 0.02 0.59 0.49
95 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
96 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
97 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
98 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
99 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
100 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
101 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
102 INT92801 Binding of CYP2B6 and GRHPR 1 0.03 0.1 0.47
103 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
104 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
105 INT149690 M1 Negative_regulation of CYP2C8 1 0.19 0.05 0.46
106 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
107 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
108 INT115914 AHR Regulation of Gene_expression of PPIG 1 0.25 0.36 0.44
109 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44
110 INT115916 AHR Regulation of Gene_expression of SLC45A2 1 0.64 0.36 0.44
111 INT80679 Abat Regulation of Localization of Sult1b1 1 0.01 0 0.44
112 INT115915 AHR Regulation of Gene_expression of CYP2B6 1 0.06 0.36 0.43
113 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41
114 INT168460 Sult1a1 Negative_regulation of Gene_expression of Ifih1 1 0.02 0.96 0.41
115 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
116 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
117 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
118 INT168463 Sult1a1 Negative_regulation of TNF 1 0.01 1 0.4
119 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
120 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
121 INT68066 Binding of MAOA and NRL 1 0.34 0 0.39
122 INT168461 Sult1a1 Positive_regulation of Gpx1 1 0.12 0.83 0.39
123 INT168454 Sult1a1 Negative_regulation of Ifih1 1 0.02 0.89 0.39
124 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
125 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38
126 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
127 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
128 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
129 INT69468 CYP2B6 Positive_regulation of Localization of CYP3A 1 0.25 0 0.36
130 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
131 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
132 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
133 INT167045 TRPA1 Regulation of PTGS1 1 0.19 0.1 0.35
134 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35
135 INT106998 PAR4 Positive_regulation of NR1I2 1 0.22 0.67 0.35
136 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
137 INT134427 Alb Regulation of GGT1 1 0.05 0.7 0.35
138 INT159903 Binding of CYP2C8 and CYP2C9 1 0.42 0.22 0.35
139 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
140 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34
141 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
142 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34
143 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
144 INT68557 ZNF697 Negative_regulation of PTGS1 1 0.02 0.59 0.33
145 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
146 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32
147 INT222299 Binding of CYP19A1 and AIS 2 0.25 1.65 0.31
148 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
149 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
150 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
151 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
152 INT122168 AKR1C1 Regulation of PPARG 1 0.12 0.25 0.31
153 INT207355 ZNF398 Regulation of CYP27A1 1 0.00 0 0.31
154 INT213062 PTGS1 Regulation of Gene_expression of MMP9 1 0.04 0.25 0.3
155 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
156 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
157 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
158 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
159 INT65539 PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.18 0.3
160 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
161 INT74942 HGF Positive_regulation of PTGS1 1 0.11 0.25 0.29
162 INT118239 Binding of CCKAR and CYP2B6 1 0.32 0.19 0.29
163 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
164 INT65540 Gene_expression of PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.05 0.17 0.29
165 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29
166 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
167 INT122000 Negative_regulation of PTGS1 Positive_regulation of Gene_expression of TNF 1 0.23 0.11 0.28
168 INT301666 Binding of CYP4F2 and Ltb4r1 1 0.02 0.57 0.28
169 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
170 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
171 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27
172 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
173 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27
174 INT142450 B4GALNT1 Regulation of Gene_expression of PTGIS 1 0.02 0.24 0.27
175 INT301670 Binding of CYP4F2 and Cyp4f18 1 0.02 1.04 0.27
176 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
177 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
178 INT114230 NR1I2 Positive_regulation of Positive_regulation of CYP2C9 1 0.13 0.61 0.27
179 INT142447 PTGS2 Regulation of Gene_expression of PTGIS 1 0.30 0.24 0.27
180 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26
181 INT69120 MOCS1 Regulation of PTGS2 1 0.00 0.39 0.26
182 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26
183 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
184 INT335049 PPARA Negative_regulation of Gene_expression of CYP7B1 1 0.27 0 0.26
185 INT64860 PTGS1 Negative_regulation of PTGS2 1 0.07 0 0.26
186 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26
187 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
188 INT130677 CYP2C9 Regulation of Binding of Ugt2b7 1 0.18 0 0.26
189 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
190 INT110373 CYP4A11 Positive_regulation of PPARG 1 0.00 0.94 0.26
191 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
192 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
193 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
194 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
195 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
196 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
197 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
198 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25
199 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25
200 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25

Single Events

The table below shows the top 100 pain related interactions that have been reported for xenobiotic metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in xenobiotic metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
2 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
3 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
4 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
5 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
6 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
7 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
8 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
9 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
10 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
11 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
12 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
13 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
14 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
15 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
16 INT2499 Positive_regulation of Sult1b1 51 0.43 2.83 32.38
17 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
18 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
19 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
20 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
21 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
22 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
23 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6
24 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21
25 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
26 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
27 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
28 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
29 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
30 INT135629 Binding of COMT 33 0.48 16.68 19.37
31 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26
32 INT7258 Localization of Sult1b1 42 0.68 0.17 17.85
33 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
34 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
35 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
36 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
37 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
38 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39
39 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
40 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
41 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
42 INT59665 Positive_regulation of Ugt1a6 24 0.69 7.24 13.25
43 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66
44 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
45 INT17619 Regulation of COMT 12 0.45 8.46 12.22
46 INT2415 Binding of MAOA 26 0.47 13.26 11.86
47 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
48 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
49 INT2496 Gene_expression of Sult1b1 32 0.66 3 10.97
50 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
51 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51
52 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
53 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17
54 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53
55 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
56 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
57 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
58 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
59 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
60 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
61 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
62 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
63 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81
64 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76
65 INT2500 Negative_regulation of Positive_regulation of Sult1b1 13 0.18 0.6 8.6
66 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39
67 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34
68 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33
69 INT173808 Positive_regulation of CYP27A1 35 0.68 23.7 7.87
70 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73
71 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
72 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55
73 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53
74 INT70252 Gene_expression of Ugt1a6 20 0.77 3.89 7.45
75 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23
76 INT2501 Positive_regulation of Positive_regulation of Sult1b1 19 0.19 2.38 7.16
77 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13
78 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
79 INT58625 Gene_expression of Ugt2b1 19 0.77 1.95 7.05
80 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
81 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
82 INT270 Regulation of MAOA 17 0.60 2.58 6.84
83 INT83745 Gene_expression of SULT2A1 34 0.59 15.96 6.66
84 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
85 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
86 INT51137 Negative_regulation of GSTM1 39 0.43 14.74 6.5
87 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43
88 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36
89 INT13683 Regulation of Ugt1a6 9 0.28 2.5 6.33
90 INT29561 Binding of GSTM1 35 0.48 25.86 6.24
91 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
92 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1
93 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06
94 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04
95 INT6229 Positive_regulation of Gene_expression of Sult1b1 18 0.22 2.21 6.04
96 INT60478 Gene_expression of UGT1A6 26 0.78 1.57 5.98
97 INT43415 Gene_expression of CYP4A11 11 0.56 7.65 5.94
98 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
99 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87
100 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
101 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
102 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4
103 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4
104 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37
105 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28
106 INT121801 Binding of Aip 18 0.36 24.1 5.26
107 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
108 INT2497 Regulation of Positive_regulation of Sult1b1 7 0.23 0.49 5.11
109 INT39256 Localization of PTGS1 17 0.74 6.62 5.1
110 INT23551 Negative_regulation of CNDP2 13 0.38 3.05 5.05
111 INT110549 Negative_regulation of CYP2C8 15 0.59 0.54 4.78
112 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
113 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
114 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
115 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
116 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
117 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
118 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
119 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
120 INT23440 Negative_regulation of Sult1b1 12 0.45 1.77 4.33
121 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
122 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
123 INT35744 Binding of MAOB 13 0.46 7.52 4.26
124 INT112989 Gene_expression of AIP 3 0.56 25.4 4.23
125 INT89925 Gene_expression of NR1I2 22 0.75 9.63 4.21
126 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
127 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
128 INT127681 Binding of Ugt1a6 7 0.47 0.79 4
129 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91
130 INT7257 Positive_regulation of Localization of Sult1b1 8 0.59 0 3.91
131 INT120062 Binding of AIP 4 0.42 28.86 3.91
132 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
133 INT6956 Gene_expression of PTGIS 29 0.76 12.1 3.8
134 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
135 INT187 Positive_regulation of Ephx1 17 0.69 0.51 3.69
136 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66
137 INT170182 Negative_regulation of SULT2A1 14 0.34 11.47 3.63
138 INT3564 Positive_regulation of Aip 11 0.58 15.38 3.62
139 INT9295 Regulation of MAOB 12 0.56 3.32 3.6
140 INT9854 Localization of GGT1 11 0.78 6.09 3.57
141 INT134694 Binding of CYP27A1 10 0.47 5.61 3.56
142 INT115921 Positive_regulation of AHR 22 0.49 12.03 3.53
143 INT59662 Localization of Ugt1a6 4 0.71 0.44 3.52
144 INT180591 Protein_catabolism of CYP27A1 18 0.56 8.46 3.44
145 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38
146 INT184 Regulation of Ephx1 10 0.60 0.54 3.27
147 INT147572 Gene_expression of Ahr 73 0.75 38.99 3.15
148 INT53388 Negative_regulation of Cyp2c11 18 0.53 2.66 3.11
149 INT107011 Positive_regulation of NR1I2 14 0.49 8.85 3.11
150 INT222742 Regulation of S100A12 4 0.53 12.09 3.03
151 INT47207 Negative_regulation of Ahr 25 0.52 16.11 3.02
152 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
153 INT15584 Binding of S100A12 14 0.48 15.14 3
154 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99
155 INT113277 Positive_regulation of Gene_expression of CYP19A1 13 0.69 10.23 2.97
156 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89
157 INT154334 Localization of S100A12 9 0.80 9.32 2.89
158 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89
159 INT7256 Negative_regulation of Localization of Sult1b1 5 0.37 0 2.81
160 INT2502 Regulation of Gene_expression of Sult1b1 5 0.11 0.92 2.8
161 INT44661 Regulation of Ahr 15 0.45 12.69 2.79
162 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
163 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
164 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77
165 INT61231 Gene_expression of SULT1A1 14 0.75 3.01 2.76
166 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
167 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
168 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
169 INT194289 Transcription of COMT 3 0.72 3.56 2.72
170 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
171 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
172 INT207366 Negative_regulation of Gene_expression of CYP27A1 11 0.44 4.82 2.67
173 INT202257 Localization of COMT 7 0.75 2.13 2.65
174 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
175 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
176 INT58624 Positive_regulation of Ugt2b1 5 0.69 0.22 2.5
177 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5
178 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
179 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
180 INT31231 Protein_catabolism of MAOA 7 0.96 2.44 2.4
181 INT96876 Gene_expression of AHR 20 0.77 10.43 2.39
182 INT101342 Negative_regulation of CYP2A6 11 0.53 3.68 2.39
183 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
184 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
185 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
186 INT129902 Regulation of Nr1i2 16 0.58 6.3 2.31
187 INT100886 Gene_expression of GCLC 16 0.76 5.63 2.29
188 INT92075 Regulation of GSTM1 12 0.50 16.18 2.27
189 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
190 INT71048 Transcription of CYP19A1 11 0.72 8.74 2.24
191 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23
192 INT89701 Binding of CYP2A6 4 0.36 0.92 2.23
193 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18
194 INT54969 Binding of Sult1a1 4 0.35 1.4 2.18
195 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
196 INT60476 Positive_regulation of UGT1A6 5 0.48 1.24 2.16
197 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
198 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15
199 INT54823 Phosphorylation of PTGS1 4 0.51 1.61 2.14
200 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
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