GO:0006878

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Name cellular copper ion homeostasis
Categary Process
Go Slim No
Go Link GO:0006878
Unique Molecular Interactions 321
Total Molecular Interactions 476
Total Single Events 6155
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular copper ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for cellular copper ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
3 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
4 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
5 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
6 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
7 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
8 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
9 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
10 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
11 INT2700 Binding of App and Cpe 1 0.00 0 0.63
12 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
13 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
14 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
15 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
16 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
17 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
18 INT87683 Binding of HLA-B and Prnd 1 0.00 0.59 0.59
19 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
20 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
21 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
22 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
23 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
24 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
25 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
26 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
27 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
28 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
29 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
30 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
31 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
32 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
33 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
34 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
35 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
36 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
37 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
38 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
39 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
40 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
41 INT137625 Ntf3 Positive_regulation of Atp7b 1 0.04 0 0.36
42 INT239398 Atp7b Regulation of OAP 1 0.03 1.1 0.35
43 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
44 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
45 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
46 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
47 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
48 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
49 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
50 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
51 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
52 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
53 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
54 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 0.07 1.69 0.26
55 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
56 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
57 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
58 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
59 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
60 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
61 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
62 INT53902 Atp7b Positive_regulation of Scn7a 1 0.04 0 0.21
63 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
64 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
65 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
66 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
67 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
68 INT149798 Atp7b Positive_regulation of Trpa1 1 0.23 0.18 0.17
69 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
70 INT239393 Atp7b Positive_regulation of Gene_expression of Amigo2 1 0.03 1.37 0.16
71 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
72 INT239395 Atp7b Positive_regulation of Amigo2 1 0.03 1.36 0.16
73 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
74 INT239394 Atp7b Positive_regulation of Positive_regulation of Amigo2 1 0.03 1.36 0.16
75 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
76 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
77 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
78 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
79 INT134698 Regulation of Prnp Positive_regulation of Nup214 1 0.26 1.18 0.14
80 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
81 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
82 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
83 INT134697 Prnp Positive_regulation of Nup214 1 0.44 1.18 0.13
84 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
85 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
86 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
87 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
88 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
89 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
90 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
91 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
92 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
93 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
94 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09
95 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
96 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
97 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
98 INT94523 Binding of MT2A and ALG1 1 0.16 0.72 0.09
99 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08
100 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
101 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
102 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
103 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
104 INT229539 Cpz Negative_regulation of Localization of Prnp 1 0.05 0.58 0.07
105 INT229538 Cpz Negative_regulation of Positive_regulation of Prnp 1 0.05 0.58 0.07
106 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
107 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
108 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
109 INT288099 Binding of APP and App 1 0.01 1.04 0.05
110 INT231300 Positive_regulation of Grin2b Positive_regulation of Prnp 1 0.39 0.16 0.05
111 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
112 INT231299 Prnp Regulation of Grin2d 1 0.28 0 0.05
113 INT251944 Binding of GH1 and PRNP 1 0.09 1.14 0.05
114 INT231302 Binding of Grin2d and Prnp 1 0.38 0.11 0.05
115 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
116 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
117 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
118 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
119 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
120 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
121 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
122 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
123 INT231311 Prnp Negative_regulation of Helt 1 0.04 0.05 0.03
124 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
125 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
126 INT231308 Prnp Negative_regulation of Gene_expression of Grin1 1 0.41 0.05 0.03
127 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
128 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
129 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
130 INT231312 Prnp Negative_regulation of Grin1 1 0.42 0.05 0.03
131 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
132 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
133 INT260518 Binding of Prnp and Gopc 2 0.13 1.06 0
134 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
135 INT268647 ATP2B3 Positive_regulation of Prnp 1 0.01 0.57 0
136 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
137 INT335952 Prnp Positive_regulation of can 1 0.17 0.58 0
138 INT268183 Gene_expression of Rab22a Negative_regulation of Gene_expression of Prnp 1 0.28 0.1 0
139 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
140 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
141 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
142 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0
143 INT260523 Binding of Cnp and Prnp 1 0.33 0.34 0
144 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
145 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
146 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
147 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
148 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
149 INT268192 Gene_expression of Rab22a Positive_regulation of Protein_catabolism of Prnp 1 0.30 0.08 0
150 INT260561 Binding of AFM and PRNP 1 0.22 0 0
151 INT356083 Binding of App and Notch1 1 0.02 0.2 0
152 INT260519 Binding of Prnp and Scarb1 1 0.41 0.21 0
153 INT268191 Rab4a Regulation of Gene_expression of Prnp 1 0.23 0.22 0
154 INT96976 Binding of Atp7b and LOC682801 1 0.00 0.06 0
155 INT260522 Binding of Myc and Prnp 1 0.30 0.35 0
156 INT335950 Negative_regulation of Prnp Positive_regulation of can 1 0.16 0.59 0
157 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
158 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
159 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
160 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
161 INT268197 Gene_expression of Rab22a Regulation of Prnp 1 0.29 0.08 0
162 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
163 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
164 INT268184 Prnp Regulation of Gene_expression of Rab22a 1 0.34 0.17 0
165 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
166 INT231313 Prnp Positive_regulation of Grin2d 1 0.47 0.16 0
167 INT96975 Binding of Atp7b and Esr1 1 0.07 0.14 0
168 INT198933 Binding of Apoe and App 1 0.33 0.19 0
169 INT268201 Tg(CAG-EGFP)D4Nagy Regulation of Prnp 1 0.01 0.22 0
170 INT268198 Prnp Positive_regulation of Erc1 1 0.04 0.26 0
171 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
172 INT268194 Erc1 Positive_regulation of Gene_expression of Prnp 1 0.05 0.2 0
173 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
174 INT334643 Binding of APP and HM13 1 0.02 0 0
175 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
176 INT344000 PROC Positive_regulation of PRNP 1 0.00 0.07 0
177 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
178 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
179 INT268190 Gene_expression of Rab22a Negative_regulation of Prnp 1 0.32 0.08 0
180 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
181 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
182 INT268177 Rab4a Regulation of Prnp 1 0.14 0.22 0
183 INT268182 Positive_regulation of Binding of Prnp and Erc1 1 0.06 0.1 0
184 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
185 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
186 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
187 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
188 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
189 INT96974 Binding of Atp7b and Tfrc 1 0.06 0.06 0
190 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
191 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
192 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
193 INT333773 Bace1 Regulation of App 1 0.25 0 0
194 INT230143 OSBP Regulation of Gene_expression of APP 1 0.50 0.1 0
195 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
196 INT268188 Binding of Prnp and Erc1 1 0.04 0.27 0
197 INT268185 Rab22a Negative_regulation of Gene_expression of Prnp 1 0.32 0.08 0
198 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
199 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
200 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular copper ion homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in cellular copper ion homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
6 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
7 INT11625 Localization of App 98 0.78 55.46 20.86
8 INT16794 Binding of App 103 0.48 64.87 19.79
9 INT65502 Regulation of App 77 0.62 52.05 19.44
10 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
11 INT54052 Gene_expression of App 33 0.78 25.08 14.7
12 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
13 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5
14 INT29745 Binding of APP 47 0.48 26.49 12.4
15 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
16 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
17 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
18 INT41569 Regulation of APP 32 0.62 17.15 9.4
19 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
20 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
21 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
22 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
23 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1
24 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09
25 INT69572 Localization of Prnp 96 0.81 38.11 5.45
26 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
27 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
28 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
29 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
30 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
31 INT20196 Negative_regulation of Gene_expression of Atp7b 8 0.07 2.49 4.63
32 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
33 INT36767 Localization of Atp7b 11 0.20 4.13 4.5
34 INT69570 Binding of Prnp 75 0.48 44.26 4.37
35 INT58003 Localization of APP 32 0.80 13.75 4.2
36 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
37 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
38 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
39 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
40 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
41 INT28583 Positive_regulation of Gene_expression of Atp7b 4 0.06 0.34 3.24
42 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
43 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
44 INT178772 Transcription of App 17 0.70 10.79 2.79
45 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
46 INT54054 Binding of App 4 0.48 10.89 2.78
47 INT5432 Regulation of Atp7b 7 0.36 0.87 2.65
48 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
49 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
50 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
51 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
52 INT56030 Regulation of App 8 0.62 4.06 2.32
53 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
54 INT39008 Localization of App 13 0.77 9.07 2.05
55 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
56 INT167203 Binding of PRNP 25 0.48 20.09 1.84
57 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
58 INT94534 Gene_expression of MT2A 8 0.75 11.28 1.76
59 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
60 INT38998 Negative_regulation of Localization of Atp7b 4 0.11 1.72 1.6
61 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
62 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
63 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
64 INT25943 Transcription of App 5 0.53 1.79 1.44
65 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
66 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
67 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
68 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
69 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
70 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
71 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
72 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
73 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
74 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
75 INT28582 Positive_regulation of Positive_regulation of Atp7b 1 0.04 0.1 1
76 INT94532 Regulation of MT2A 5 0.36 4.25 0.98
77 INT288625 Localization of MT2A 1 0.46 0.46 0.95
78 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
79 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
80 INT136634 Transcription of Prnp 9 0.72 3.34 0.83
81 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
82 INT32188 Regulation of Atp7b 7 0.04 3.01 0.81
83 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
84 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
85 INT100601 Localization of PRNP 17 0.66 13.61 0.71
86 INT190662 Regulation of Positive_regulation of Prnp 4 0.24 1.15 0.7
87 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68
88 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68
89 INT69571 Positive_regulation of Positive_regulation of Prnp 6 0.70 5.88 0.67
90 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
91 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63
92 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
93 INT275637 Positive_regulation of Gene_expression of MT2A 2 0.28 2.49 0.6
94 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
95 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
96 INT104446 Binding of Atp7b 2 0.09 0.77 0.53
97 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
98 INT239390 Positive_regulation of Phosphorylation of Atp7b 1 0.39 3.49 0.49
99 INT62659 Regulation of Localization of Atp7b 1 0.00 0.45 0.47
100 INT124164 Protein_catabolism of Prnp 20 1.00 8.58 0.44
101 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44
102 INT34154 Regulation of Gene_expression of Atp7b 1 0.00 0.28 0.44
103 INT94543 Binding of MT2A 5 0.29 0.96 0.36
104 INT239386 Gene_expression of Atp7b 4 0.52 3.24 0.32
105 INT54056 Negative_regulation of Binding of App 2 0.37 0.99 0.32
106 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
107 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
108 INT251949 Negative_regulation of Gene_expression of PRNP 6 0.43 4.16 0.3
109 INT335949 Positive_regulation of Positive_regulation of PRNP 2 0.25 0.82 0.29
110 INT52353 Binding of Prnd 2 0.03 0.24 0.28
111 INT38919 Negative_regulation of Positive_regulation of Atp7b 2 0.01 0.15 0.28
112 INT318932 Regulation of ATP7B 2 0.40 1.12 0.28
113 INT239387 Negative_regulation of Atp7b 1 0.33 1.86 0.28
114 INT229518 Phosphorylation of Prnp 5 0.69 1.62 0.27
115 INT331055 Positive_regulation of Phosphorylation of Prnp 1 0.07 0.24 0.27
116 INT38918 Regulation of Positive_regulation of Atp7b 1 0.03 0.6 0.27
117 INT69568 Positive_regulation of Localization of Prnp 5 0.50 2.43 0.26
118 INT115708 Phosphorylation of PRNP 2 0.71 1.61 0.26
119 INT179508 Negative_regulation of Negative_regulation of Atp7b 1 0.01 0.66 0.26
120 INT268171 Negative_regulation of Binding of Prnp 3 0.42 0.82 0.25
121 INT239388 Phosphorylation of Atp7b 1 0.63 1.74 0.25
122 INT53839 Positive_regulation of ATP7B 1 0.67 0.23 0.24
123 INT349751 Gene_expression of ATP7B 1 0.51 0.73 0.24
124 INT288627 Positive_regulation of MT2A 1 0.33 0.3 0.23
125 INT262690 Gene_expression of Aplp2 3 0.56 1.14 0.16
126 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
127 INT325414 Regulation of Regulation of PRNP 1 0.26 0.7 0.16
128 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
129 INT239384 Localization of Atp7b 1 0.58 1 0.14
130 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13
131 INT190664 Regulation of Binding of Prnp 3 0.52 4.29 0.1
132 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
133 INT207304 Positive_regulation of Protein_catabolism of Prnp 9 0.69 2.08 0.09
134 INT318931 Localization of ATP7B 1 0.55 0.84 0.09
135 INT293049 Positive_regulation of Localization of PRNP 1 0.07 2.67 0.09
136 INT303459 Transcription of PRNP 4 0.69 1.44 0.08
137 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08
138 INT262676 Positive_regulation of Gene_expression of Aplp2 1 0.29 0.24 0.08
139 INT354480 Regulation of Gene_expression of PRNP 1 0.39 1.96 0.08
140 INT32189 Positive_regulation of Regulation of Atp7b 1 0.04 0.69 0.08
141 INT354479 Positive_regulation of Transcription of PRNP 1 0.50 0.4 0.08
142 INT94531 Transcription of MT2A 2 0.56 1.52 0.07
143 INT94535 Negative_regulation of Gene_expression of MT2A 1 0.34 1.7 0.07
144 INT193831 Localization of Aplp2 2 0.42 1.85 0.06
145 INT207302 Positive_regulation of Transcription of Prnp 1 0.47 0.71 0.06
146 INT193852 Positive_regulation of Localization of Aplp2 1 0.23 0.81 0.06
147 INT229516 Negative_regulation of Positive_regulation of Prnp 5 0.42 0.95 0.04
148 INT188125 Binding of Aplp2 2 0.22 0.64 0.04
149 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
150 INT229519 Regulation of Localization of Prnp 4 0.61 0.7 0.03
151 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
152 INT318933 Binding of ATP7B 2 0.37 0.96 0.03
153 INT255657 Negative_regulation of Protein_catabolism of App 1 0.20 1.07 0.03
154 INT293047 Protein_catabolism of PRNP 1 0.57 2 0.03
155 INT287031 Positive_regulation of Negative_regulation of Prnp 1 0.46 0.16 0.03
156 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
157 INT268144 Negative_regulation of Localization of Prnp 3 0.37 0.71 0
158 INT190666 Positive_regulation of Binding of Prnp 2 0.50 1.87 0
159 INT50103 Regulation of Localization of App 2 0.26 0.2 0
160 INT268161 Regulation of Negative_regulation of Prnp 2 0.39 0.33 0
161 INT234255 Transcription of APP 2 0.49 0.98 0
162 INT96973 Binding of Atp7b 1 0.11 0.08 0
163 INT229517 Regulation of Phosphorylation of Prnp 1 0.39 0.26 0
164 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
165 INT296123 Negative_regulation of Transcription of MT2A 1 0.13 0.44 0
166 INT188131 Negative_regulation of Regulation of PRNP 1 0.41 0.06 0
167 INT293048 Regulation of Protein_catabolism of PRNP 1 0.06 1.01 0
168 INT344005 Regulation of Positive_regulation of PRNP 1 0.20 0.08 0
169 INT296125 Regulation of Gene_expression of MT2A 1 0.14 0.49 0
170 INT240690 Positive_regulation of Binding of PRNP 1 0.07 0.53 0
171 INT285051 Negative_regulation of Gene_expression of Atp7b 1 0.01 0.49 0
172 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
173 INT315417 Negative_regulation of Transcription of Prnp 1 0.43 0.14 0
174 INT268173 Negative_regulation of Negative_regulation of Prnp 1 0.37 0 0
175 INT222723 Negative_regulation of Localization of PRNP 1 0.05 2.06 0
176 INT296127 Negative_regulation of MT2A 1 0.06 0.43 0
177 INT268148 Regulation of Protein_catabolism of Prnp 1 0.45 0 0
178 INT190556 Regulation of Aplp2 1 0.10 0.33 0
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