GO:0006884

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Name cell volume homeostasis
Categary Process
Go Slim No
Go Link GO:0006884
Unique Molecular Interactions 114
Total Molecular Interactions 156
Total Single Events 1505
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell volume homeostasis. They are ordered first by their pain relevance and then by number of times they were reported for cell volume homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25
2 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
3 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
4 INT306823 Binding of E2F4 and GOPC 1 0.06 0.23 0.91
5 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
6 INT306831 Positive_regulation of Binding of E2F4 and NOLC1 1 0.10 0.46 0.85
7 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
8 INT306826 Binding of E2F4 and NOLC1 1 0.08 0.41 0.84
9 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
10 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
11 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
12 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
13 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
14 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
15 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
16 INT125492 D2Mit212 Negative_regulation of Slc12a7 1 0.00 0 0.54
17 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
18 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
19 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
20 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
21 INT309157 Aqp1 Positive_regulation of Bdnf 1 0.00 0.74 0.42
22 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
23 INT84600 Binding of Avp and Aqp2 1 0.17 0 0.35
24 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
25 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
26 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
27 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
28 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
29 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
30 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
31 INT139778 Binding of AQP1 and GBE1 1 0.00 0.22 0.3
32 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
33 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28
34 INT293118 Avp Regulation of Aqp2 1 0.04 0.7 0.27
35 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
36 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
37 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
38 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
39 INT58305 AQP1 Regulation of Localization of TNF 1 0.10 0.16 0.22
40 INT58303 AQP1 Regulation of Gene_expression of IL1B 1 0.10 0.16 0.22
41 INT246971 Binding of Clns1a and Csf2 1 0.10 1.31 0.22
42 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
43 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
44 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
45 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
46 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
47 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
48 INT246970 Binding of Clns1a and Dcps 1 0.05 0.42 0.18
49 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
50 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
51 INT327829 Aqp1 Regulation of Binding of Csf2 1 0.11 1 0.14
52 INT293117 Agt Regulation of Gene_expression of Aqp2 1 0.23 0.36 0.14
53 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
54 INT244338 Slc12a7 Positive_regulation of SERPINH1 1 0.00 0.26 0.13
55 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
56 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
57 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1
58 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
59 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
60 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
61 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
62 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
63 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
64 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
65 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
66 INT309722 TRPV4 Positive_regulation of CA2 1 0.11 0 0.08
67 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
68 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
69 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07
70 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
71 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
72 INT293122 Avp Regulation of Gene_expression of Aqp2 1 0.04 0.81 0.05
73 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
74 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
75 INT169962 Binding of Rb1 and E2f4 1 0.25 0.56 0.04
76 INT169960 Binding of Rbl2 and E2f4 1 0.27 1.06 0.04
77 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
78 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 0.08 0.17 0
79 INT297693 Binding of Aqp2 and Fut1 1 0.03 0 0
80 INT309745 Negative_regulation of Binding of CALM3 and TRPV4 1 0.12 0 0
81 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
82 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
83 INT79900 NFE2L2 Positive_regulation of Gene_expression of AQP1 1 0.03 0 0
84 INT253630 Binding of HNRNPA1 and Npm1 1 0.00 0.19 0
85 INT162407 TNF Positive_regulation of Gene_expression of TRPV4 1 0.47 0.22 0
86 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
87 INT354080 Avpr2 Positive_regulation of Localization of Aqp2 1 0.02 0.07 0
88 INT293114 Fig4 Regulation of Gene_expression of Aqp2 1 0.08 1.53 0
89 INT309736 PACSIN3 Regulation of TRPV4 1 0.55 0 0
90 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
91 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
92 INT309728 TRPV4 Positive_regulation of CFP 1 0.10 0 0
93 INT234803 AVP Regulation of AQP2 1 0.11 1.3 0
94 INT98626 Aqp1 Positive_regulation of Aqp4 1 0.52 0 0
95 INT234796 Binding of AQP2 and AVP 1 0.15 1.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell volume homeostasis. They are ordered first by their pain relevance and then by number of times they were reported in cell volume homeostasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68
3 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
4 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
5 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
6 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23
7 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
8 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
9 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24
10 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
11 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
12 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
13 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
14 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
15 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
16 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3
17 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94
18 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55
19 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
20 INT24377 Localization of Slc12a7 5 0.06 0 4.26
21 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
22 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71
23 INT104570 Localization of Aqp1 8 0.77 5.83 3.51
24 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
25 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
26 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
27 INT24376 Negative_regulation of Localization of Slc12a7 3 0.02 0 2.67
28 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
29 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
30 INT84599 Gene_expression of Aqp2 31 0.77 22.58 2.54
31 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15
32 INT141721 Binding of Aqp1 5 0.37 1.77 2.15
33 INT203308 Regulation of Aqp1 4 0.48 2.59 2.13
34 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
35 INT306869 Gene_expression of E2F4 1 0.58 1.1 2.11
36 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
37 INT84595 Negative_regulation of Aqp2 11 0.58 4.88 1.78
38 INT306853 Binding of E2F4 1 0.28 1.37 1.63
39 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
40 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
41 INT156133 Regulation of Gene_expression of Aqp2 4 0.39 1.43 1.53
42 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
43 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
44 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41
45 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37
46 INT73553 Gene_expression of Aqp1 23 0.67 4.65 1.34
47 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
48 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
49 INT314186 Gene_expression of Npm1 1 0.01 1.78 1.22
50 INT100328 Gene_expression of AQP2 6 0.75 2.41 1.21
51 INT79557 Localization of Aqp2 5 0.73 2 1.13
52 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
53 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
54 INT166889 Positive_regulation of Gene_expression of AQP1 10 0.70 6.43 0.99
55 INT84597 Transcription of Aqp2 3 0.55 2.11 0.98
56 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
57 INT183362 Regulation of AQP1 3 0.23 1.49 0.92
58 INT30072 Positive_regulation of Clns1a 5 0.20 0.85 0.9
59 INT306888 Positive_regulation of Binding of E2F4 1 0.37 0.58 0.87
60 INT84598 Regulation of Aqp2 13 0.45 4.28 0.86
61 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
62 INT108348 Positive_regulation of Aqp2 10 0.68 4.94 0.82
63 INT306840 Positive_regulation of Gene_expression of E2F4 1 0.37 0.58 0.82
64 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
65 INT149238 Positive_regulation of Gene_expression of Aqp2 5 0.66 3.07 0.73
66 INT327798 Transcription of Aqp2 1 0.34 1.02 0.72
67 INT241788 Positive_regulation of Gene_expression of AQP2 3 0.67 1.26 0.7
68 INT112326 Binding of Aqp2 3 0.11 1.01 0.69
69 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
70 INT306884 Negative_regulation of E2F4 1 0.44 0.61 0.62
71 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
72 INT84596 Negative_regulation of Gene_expression of Aqp2 3 0.58 8.49 0.6
73 INT84594 Negative_regulation of Transcription of Aqp2 1 0.43 0 0.59
74 INT100322 Localization of AQP2 5 0.80 0.56 0.56
75 INT125490 Regulation of Negative_regulation of Slc12a7 1 0.00 0 0.56
76 INT139780 Binding of AQP1 7 0.32 4.62 0.54
77 INT125491 Negative_regulation of Slc12a7 1 0.00 0 0.54
78 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
79 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
80 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
81 INT19592 Localization of AQP1 4 0.81 1.09 0.44
82 INT327786 Negative_regulation of Gene_expression of AQP1 3 0.29 4.21 0.44
83 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
84 INT38022 Gene_expression of Slc12a7 3 0.17 2.78 0.41
85 INT306864 Negative_regulation of Gene_expression of E2F4 1 0.32 0.28 0.41
86 INT306859 Localization of E2F4 1 0.56 0.65 0.4
87 INT149235 Positive_regulation of Transcription of Aqp2 1 0.45 0.72 0.4
88 INT149244 Positive_regulation of Localization of Aqp2 1 0.49 0.72 0.4
89 INT314185 Localization of Npm1 1 0.02 0.44 0.39
90 INT100324 Regulation of Localization of AQP2 1 0.27 0.19 0.38
91 INT157836 Regulation of Gene_expression of Aqp2 9 0.57 8.37 0.37
92 INT203374 Positive_regulation of Regulation of Aqp1 2 0.36 0.91 0.37
93 INT100323 Regulation of Gene_expression of AQP2 1 0.45 0.18 0.36
94 INT79558 Binding of Aqp2 2 0.31 0.25 0.33
95 INT314188 Regulation of Npm1 1 0.01 0.33 0.33
96 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
97 INT293551 Regulation of Positive_regulation of Aqp1 1 0.13 0 0.31
98 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
99 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
100 INT118446 Positive_regulation of Transcription of TRPV4 1 0.49 0.26 0.21
101 INT118447 Transcription of TRPV4 1 0.67 0.26 0.21
102 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
103 INT104568 Negative_regulation of Localization of Aqp1 1 0.36 2.47 0.2
104 INT209259 Regulation of Gene_expression of TRPV4 1 0.22 0.93 0.19
105 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
106 INT215814 Negative_regulation of Gene_expression of Aqp1 2 0.31 0.25 0.17
107 INT98625 Regulation of Aqp1 1 0.27 0.1 0.17
108 INT162409 Positive_regulation of Gene_expression of TRPV4 2 0.45 0 0.16
109 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
110 INT215831 Regulation of Transcription of Clns1a 1 0.05 0.07 0.16
111 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
112 INT215829 Positive_regulation of Transcription of Clns1a 1 0.05 0.07 0.14
113 INT215819 Transcription of Clns1a 1 0.07 0.07 0.14
114 INT246699 Positive_regulation of Gene_expression of Slc12a7 1 0.13 2.05 0.12
115 INT246704 Positive_regulation of Slc12a7 1 0.13 2.05 0.12
116 INT104566 Negative_regulation of Aqp2 3 0.44 1.23 0.11
117 INT215820 Negative_regulation of Aqp1 3 0.23 0.83 0.1
118 INT159343 Positive_regulation of Localization of AQP1 1 0.11 0 0.1
119 INT111047 Negative_regulation of Gene_expression of Aqp2 3 0.34 3.56 0.09
120 INT157832 Phosphorylation of Aqp2 2 0.77 2.04 0.08
121 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
122 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
123 INT309764 Regulation of Binding of TRPV4 1 0.36 0 0.08
124 INT327827 Negative_regulation of Gene_expression of Aqp1 1 0.45 0.8 0.08
125 INT262510 Regulation of Gene_expression of Aqp1 1 0.33 1.18 0.07
126 INT293110 Positive_regulation of Phosphorylation of Aqp2 1 0.47 1.39 0.05
127 INT293105 Positive_regulation of Positive_regulation of Aqp2 1 0.47 0.72 0.03
128 INT246952 Gene_expression of Clns1a 1 0.19 1.16 0.03
129 INT241787 Negative_regulation of AQP2 1 0.57 1.38 0.03
130 INT280794 Localization of Aqp2 2 0.36 0.07 0
131 INT262504 Positive_regulation of Aqp1 1 0.25 0.43 0
132 INT157833 Negative_regulation of Negative_regulation of Aqp2 1 0.36 0 0
133 INT286264 Positive_regulation of Negative_regulation of AQP1 1 0.01 0.79 0
134 INT280786 Phosphorylation of Aqp2 1 0.32 0.24 0
135 INT262513 Negative_regulation of Binding of Aqp1 1 0.23 0.64 0
136 INT297668 Positive_regulation of Aqp2 1 0.45 0 0
137 INT108349 Regulation of AQP2 1 0.44 0 0
138 INT100325 Positive_regulation of AQP2 1 0.69 0 0
139 INT253599 Binding of Npm1 1 0.01 0.19 0
140 INT169925 Localization of E2f4 1 0.55 0.08 0
141 INT341042 Positive_regulation of Protein_catabolism of Aqp2 1 0.34 0.07 0
142 INT169922 Binding of E2f4 1 0.25 0.08 0
143 INT262514 Binding of Aqp1 1 0.20 0.64 0
144 INT100326 Positive_regulation of Localization of AQP2 1 0.69 0 0
145 INT169938 Gene_expression of E2f4 1 0.46 0.07 0
146 INT341039 Protein_catabolism of Aqp2 1 0.47 0.06 0
147 INT309763 Localization of TRPV4 1 0.60 0 0
148 INT299193 Transcription of Aqp1 1 0.56 0.62 0
149 INT262511 Positive_regulation of Gene_expression of Aqp1 1 0.37 1.78 0
150 INT327782 Regulation of Gene_expression of AQP1 1 0.36 1.63 0
151 INT100327 Regulation of Positive_regulation of AQP2 1 0.39 0 0
152 INT169915 Regulation of Gene_expression of E2f4 1 0.19 0 0
153 INT309758 Negative_regulation of Gene_expression of TRPV4 1 0.34 0 0
154 INT262512 Localization of Aqp1 1 0.40 0.7 0
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