GO:0006885

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Name regulation of pH
Categary Process
Go Slim No
Go Link GO:0006885
Unique Molecular Interactions 284
Total Molecular Interactions 411
Total Single Events 2675
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of pH. They are ordered first by their pain relevance and then by number of times they were reported for regulation of pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
3 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
4 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
5 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
6 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
7 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
8 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
9 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
10 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
11 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
12 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
13 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
14 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
15 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
16 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
17 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
18 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
19 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
20 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
21 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
22 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
23 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
24 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
25 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
26 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
27 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
28 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
29 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
30 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
31 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
32 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
33 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
34 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
35 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
36 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
37 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
38 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
39 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
40 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
41 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
42 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
43 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
44 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
45 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
46 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
47 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
48 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
49 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
50 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
51 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
52 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
53 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
54 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
55 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
56 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
57 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
58 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
59 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
60 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
61 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
62 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
63 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
64 INT103795 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of NFKB1 1 0.12 0.47 0.37
65 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
66 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
67 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
68 INT103386 Negative_regulation of SLC9A1 Negative_regulation of Gene_expression of IL8 1 0.02 0.97 0.36
69 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
70 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
71 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
72 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
73 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
74 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
75 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
76 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
77 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
78 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
79 INT103391 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of Nfkb1 1 0.01 0.88 0.32
80 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
81 INT103385 Negative_regulation of SLC9A1 Negative_regulation of Positive_regulation of CDK20 1 0.02 0.88 0.32
82 INT103390 Negative_regulation of SLC9A1 Negative_regulation of Nfkb1 1 0.01 0.88 0.32
83 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
84 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
85 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
86 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
87 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
88 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
89 INT334666 Slc9a1 Positive_regulation of Grin1 1 0.09 0.09 0.27
90 INT334667 Slc9a1 Positive_regulation of Ltp 1 0.13 0.09 0.27
91 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
92 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
93 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
94 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
95 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
96 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
97 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
98 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
99 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
100 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
101 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
102 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
103 INT91686 Mb Positive_regulation of Edn1 1 0.03 0.29 0.22
104 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
105 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
106 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
107 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
108 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
109 INT80049 Adcyap1 Positive_regulation of Positive_regulation of Slc4a4 1 0.19 0 0.2
110 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
111 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
112 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
113 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
114 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
115 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
116 INT219915 Edn1 Regulation of Positive_regulation of Trpv1 1 0.33 0 0.18
117 INT140096 Gtf3a Positive_regulation of Gene_expression of Edn1 1 0.02 0.44 0.18
118 INT171386 Edn1 Positive_regulation of Mapk1 1 0.05 0.13 0.18
119 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
120 INT284450 Edn1 Positive_regulation of Gene_expression of MMP9 1 0.01 0.3 0.18
121 INT140094 Ifng Regulation of Gene_expression of Edn1 1 0.18 0.44 0.18
122 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
123 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
124 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
125 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
126 INT324899 Edn1 Positive_regulation of Positive_regulation of Mmp9 1 0.10 0.66 0.16
127 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
128 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
129 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
130 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
131 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
132 INT324894 Edn1 Positive_regulation of Gene_expression of Mmp3 1 0.07 0.66 0.16
133 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
134 INT21509 Agt Regulation of Edn1 1 0.53 0 0.15
135 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
136 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
137 INT50500 Edn1 Positive_regulation of PTGS1 1 0.00 0.07 0.14
138 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
139 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
140 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
141 INT51367 Slc14a2 Positive_regulation of Localization of Slc4a4 1 0.03 0.1 0.14
142 INT89940 Ednrb Positive_regulation of Positive_regulation of TNF 1 0.01 0.09 0.14
143 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
144 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14
145 INT89939 Ednrb Regulation of Gene_expression of TNF 1 0.00 0.09 0.13
146 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
147 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
148 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
149 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
150 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
151 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
152 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
153 INT110176 Nts Regulation of Negative_regulation of Agtr1a 1 0.24 0.09 0.12
154 INT72729 Adcyap1 Positive_regulation of Localization of Slc4a4 1 0.23 0 0.12
155 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
156 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
157 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
158 INT284140 Binding of EDNRB and PAH 1 0.08 0.1 0.1
159 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
160 INT181570 Binding of Edn1 and Mapk1 1 0.13 2.72 0.1
161 INT236040 VIP Negative_regulation of SLC9A3 1 0.10 0 0.1
162 INT6674 Edn1 Positive_regulation of Gene_expression of FOS 1 0.08 0.19 0.1
163 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
164 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
165 INT92956 Edn1 Regulation of Positive_regulation of Nos2 1 0.18 0.17 0.09
166 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09
167 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09
168 INT120152 Binding of PMEL and SLC9A7 1 0.07 0 0.09
169 INT120153 Binding of PMEL and SLC9A3 1 0.07 0 0.09
170 INT92957 Edn1 Regulation of Gene_expression of Nos2 1 0.18 0.17 0.09
171 INT178072 Gene_expression of EDNRB Positive_regulation of EDN3 1 0.05 1.11 0.08
172 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
173 INT249994 Binding of Agtr1a and Igkv4-55 1 0.01 0.38 0.08
174 INT181584 Binding of EDNRB and Edn1 1 0.46 0.85 0.08
175 INT137632 Rasa1 Regulation of Ednrb 1 0.05 0 0.08
176 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
177 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
178 INT113369 Edn1 Regulation of Adarb1 1 0.02 0.14 0.08
179 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
180 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
181 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07
182 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
183 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
184 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
185 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
186 INT178093 EDN3 Positive_regulation of Gene_expression of EDNRB 1 0.05 1.01 0.07
187 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
188 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
189 INT192907 Edn1 Positive_regulation of Ednrb 1 0.10 0.35 0.07
190 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
191 INT191219 Edn1 Positive_regulation of Amigo2 1 0.06 1.26 0.07
192 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
193 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
194 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
195 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
196 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06
197 INT257511 Regulation of Binding of Slc12a2 and Slc4a4 1 0.02 0.16 0.06
198 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
199 INT257510 Binding of Slc12a2 and Slc4a4 1 0.01 0.16 0.06
200 INT191216 Binding of Edn1 and Cotl1 1 0.14 0.63 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of pH. They are ordered first by their pain relevance and then by number of times they were reported in regulation of pH. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
2 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
3 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
4 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
6 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
7 INT5048 Binding of Edn1 55 0.47 18.86 19.16
8 INT11509 Localization of Slc4a4 66 0.67 2.34 19.05
9 INT9191 Localization of EDN1 94 0.81 57.01 14.78
10 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
11 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
12 INT6365 Localization of Edn1 56 0.81 18.84 13.83
13 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
14 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
15 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
16 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
17 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
18 INT6361 Localization of Edn1 30 0.81 19.09 9.7
19 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
20 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
21 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
22 INT10237 Binding of EDN1 40 0.48 16 8.48
23 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
24 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
25 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
26 INT17207 Positive_regulation of Localization of Slc4a4 18 0.58 0.09 6.02
27 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
28 INT71974 Negative_regulation of SLC9A1 19 0.41 13.93 4.96
29 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
30 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
31 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
32 INT9758 Positive_regulation of Slc4a4 13 0.40 0.26 4.37
33 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
34 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
35 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
36 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
37 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
38 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
39 INT53374 Binding of Edn1 17 0.43 11.66 2.98
40 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
41 INT30608 Regulation of Localization of Slc4a4 6 0.38 0.1 2.58
42 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
43 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
44 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
45 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
46 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
47 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
48 INT30607 Negative_regulation of Localization of Slc4a4 9 0.37 1.48 1.88
49 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
50 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
51 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
52 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
53 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
54 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
55 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
56 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
57 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
58 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
59 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
60 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
61 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
62 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
63 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
64 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
65 INT9757 Regulation of Slc4a4 3 0.23 0.31 1.17
66 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
67 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
68 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
69 INT78181 Negative_regulation of EDNRB 6 0.57 4.46 0.95
70 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
71 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
72 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
73 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93
74 INT188123 Gene_expression of Slc9a1 12 0.75 6.75 0.9
75 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
76 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
77 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
78 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
79 INT103800 Positive_regulation of SLC9A1 4 0.33 2.5 0.81
80 INT178127 Positive_regulation of Gene_expression of EDNRB 7 0.51 5.24 0.78
81 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
82 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
83 INT17206 Regulation of Positive_regulation of Slc4a4 1 0.23 0 0.7
84 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
85 INT152621 Regulation of SLC9A1 2 0.57 2.09 0.67
86 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
87 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
88 INT113088 Negative_regulation of SLC9A7 1 0.00 0.25 0.66
89 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
90 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65
91 INT139513 Negative_regulation of Localization of EDNRB 2 0.41 0 0.62
92 INT114299 Transcription of Ednrb 2 0.19 0.32 0.59
93 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
94 INT236053 Negative_regulation of SLC9A3 1 0.52 0.58 0.57
95 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
96 INT159150 Negative_regulation of Positive_regulation of Agtr1a 1 0.38 0.72 0.56
97 INT63910 Regulation of Positive_regulation of Edn1 2 0.43 0.64 0.54
98 INT131641 Negative_regulation of Negative_regulation of Edn1 1 0.37 0.31 0.52
99 INT181581 Regulation of Positive_regulation of Edn1 4 0.23 3.76 0.51
100 INT38363 Negative_regulation of Slc4a4 4 0.36 0.09 0.5
101 INT71972 Positive_regulation of Negative_regulation of SLC9A1 1 0.19 0.35 0.48
102 INT120154 Gene_expression of SLC9A1 3 0.47 1.3 0.47
103 INT55372 Regulation of Localization of Edn1 2 0.38 0.64 0.46
104 INT201478 Regulation of Positive_regulation of Ednrb 1 0.35 0.68 0.44
105 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
106 INT131106 Positive_regulation of Positive_regulation of Ednrb 1 0.15 0.91 0.4
107 INT81433 Negative_regulation of Positive_regulation of Edn1 4 0.39 0.81 0.38
108 INT99061 Negative_regulation of Negative_regulation of SLC9A1 1 0.30 0.3 0.37
109 INT201476 Positive_regulation of Negative_regulation of Ednrb 1 0.49 0.62 0.36
110 INT224111 Phosphorylation of Agtr1a 1 0.01 0 0.35
111 INT113368 Regulation of Negative_regulation of Edn1 1 0.45 0.71 0.35
112 INT141013 Regulation of Gene_expression of Edn1 2 0.24 0.55 0.34
113 INT16368 Protein_catabolism of Edn1 2 0.72 0.18 0.31
114 INT152623 Regulation of Regulation of SLC9A1 1 0.25 0.73 0.31
115 INT26621 Negative_regulation of Slc26a4 2 0.32 2.51 0.3
116 INT350971 Negative_regulation of Binding of EDNRB 1 0.13 0.86 0.29
117 INT139512 Positive_regulation of Localization of EDNRB 3 0.37 0.69 0.26
118 INT84038 Protein_catabolism of Edn1 2 0.86 0.69 0.26
119 INT63417 Regulation of Negative_regulation of Agtr1a 1 0.26 0.1 0.25
120 INT181258 Gene_expression of Slc26a4 4 0.19 3.26 0.21
121 INT247022 Transcription of Agtr1a 2 0.46 1.47 0.21
122 INT67265 Positive_regulation of Negative_regulation of Edn1 1 0.61 0.05 0.21
123 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
124 INT230740 Regulation of Agtr1a 2 0.15 3.5 0.19
125 INT237079 Positive_regulation of Atp6v0a4 2 0.17 1.77 0.19
126 INT53372 Positive_regulation of Regulation of Edn1 1 0.50 0 0.19
127 INT100397 Regulation of Transcription of Edn1 1 0.00 0.1 0.19
128 INT120161 Transcription of SLC9A1 1 0.27 0 0.19
129 INT55013 Localization of Ednrb 2 0.16 0.98 0.18
130 INT274098 Regulation of EDNRB 1 0.33 2.41 0.18
131 INT131227 Negative_regulation of Positive_regulation of Slc4a4 1 0.32 0 0.15
132 INT242342 Regulation of Ednrb 1 0.09 2.03 0.15
133 INT209796 Positive_regulation of Agtr1a 1 0.15 0.56 0.15
134 INT256229 Protein_catabolism of EDNRB 3 0.64 0.96 0.14
135 INT355657 Negative_regulation of Transcription of Agtr1a 1 0.38 1.17 0.13
136 INT355655 Regulation of Transcription of Agtr1a 1 0.29 1.15 0.13
137 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
138 INT99725 Negative_regulation of Agtr1a 5 0.57 1.03 0.12
139 INT6362 Negative_regulation of Localization of Edn1 3 0.16 1.92 0.12
140 INT229356 Negative_regulation of Binding of Agtr1a 1 0.36 0.89 0.12
141 INT170621 Binding of SLC9A1 1 0.25 0.69 0.12
142 INT221196 Positive_regulation of Slc9a1 2 0.67 1.12 0.11
143 INT15391 Negative_regulation of Positive_regulation of Edn1 2 0.07 0.1 0.1
144 INT170744 Positive_regulation of Transcription of Edn1 2 0.20 1.3 0.1
145 INT236060 Regulation of SLC9A3 1 0.55 0.18 0.1
146 INT170622 Negative_regulation of Gene_expression of SLC9A1 1 0.26 0.38 0.1
147 INT120162 Gene_expression of SLC9A3 2 0.60 0.07 0.09
148 INT247024 Positive_regulation of Transcription of Agtr1a 1 0.19 0.33 0.09
149 INT120157 Localization of SLC9A7 1 0.37 0 0.09
150 INT120163 Transcription of SLC9A3 1 0.36 0 0.09
151 INT120160 Localization of SLC9A3 1 0.36 0 0.09
152 INT120156 Gene_expression of SLC9A7 1 0.32 0 0.09
153 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
154 INT266031 Positive_regulation of Gene_expression of Slc9a1 1 0.29 0.69 0.08
155 INT19117 Gene_expression of Slc4a4 1 0.52 0.09 0.08
156 INT209797 Regulation of Positive_regulation of Agtr1a 1 0.10 0.29 0.08
157 INT126441 Negative_regulation of Transcription of Edn1 1 0.40 0.17 0.08
158 INT181262 Positive_regulation of Slc26a4 1 0.13 1.3 0.08
159 INT181259 Regulation of Negative_regulation of Slc26a4 1 0.08 0.84 0.07
160 INT212126 Gene_expression of Slc4a4 7 0.55 0.19 0.06
161 INT324892 Binding of Ednrb 1 0.06 0.32 0.06
162 INT236066 Positive_regulation of SLC9A3 1 0.62 0 0.05
163 INT124244 Negative_regulation of Gene_expression of Atp6v0a4 1 0.16 0.77 0.05
164 INT124245 Gene_expression of Atp6v0a4 1 0.29 0.77 0.05
165 INT124248 Negative_regulation of Atp6v0a4 1 0.16 0.77 0.05
166 INT182487 Positive_regulation of Gene_expression of Agtr1a 2 0.19 1.32 0.04
167 INT253549 Gene_expression of Slc9a3 1 0.02 0 0.04
168 INT188119 Binding of Slc9a1 1 0.36 0.88 0.04
169 INT188126 Negative_regulation of Slc9a1 1 0.42 0.85 0.04
170 INT181260 Regulation of Slc26a4 2 0.30 1.67 0.03
171 INT264273 Localization of Ednrb 1 0.01 0 0.03
172 INT236055 Regulation of Negative_regulation of SLC9A3 1 0.40 0 0.03
173 INT212137 Transcription of Slc4a4 1 0.55 0 0
174 INT183548 Localization of SLC9A1 1 0.01 0.24 0
175 INT212133 Positive_regulation of Slc4a4 1 0.40 0 0
176 INT236052 Binding of SLC9A3 1 0.33 0 0
177 INT280682 Positive_regulation of Transcription of Edn1 1 0.34 0 0
178 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
179 INT293098 Transcription of Slc4a4 1 0.15 0.32 0
180 INT284148 Positive_regulation of Positive_regulation of EDNRB 1 0.29 0.54 0
181 INT236064 Negative_regulation of Negative_regulation of SLC9A3 1 0.38 0 0
182 INT188128 Negative_regulation of Gene_expression of Slc9a1 1 0.41 0.08 0
183 INT257489 Positive_regulation of Gene_expression of Slc4a4 1 0.03 0 0
184 INT236063 Negative_regulation of Gene_expression of SLC9A3 1 0.38 0 0
185 INT181578 Negative_regulation of Phosphorylation of Edn1 1 0.37 0.1 0
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