GO:0006897

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Name endocytosis
Categary Process
Go Slim No
Go Link GO:0006897
Unique Molecular Interactions 926
Total Molecular Interactions 1346
Total Single Events 10697
Pain Genes Associated 101

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endocytosis. They are ordered first by their pain relevance and then by number of times they were reported for endocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
3 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
4 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
5 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
6 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
7 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
8 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
9 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
10 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
11 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
12 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
13 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
14 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
15 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
16 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
17 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
18 INT133933 Binding of DNM2 and TP53INP2 1 0.00 0 1.38
19 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
20 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
21 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28
22 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
23 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
24 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
25 INT168459 Sult1a1 Negative_regulation of Gene_expression of Arr3 1 0.05 2.98 1.23
26 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
27 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
28 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
29 INT121725 Binding of Trpv1 and Pik3cb 1 0.35 0.62 1.15
30 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
31 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
32 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 0.45 0.69 1.11
33 INT121730 Pik3cb Regulation of Trpv1 1 0.58 0.54 1.09
34 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
35 INT54486 Npepo Positive_regulation of Gene_expression of Rabep2 1 0.14 0 1.08
36 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
37 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
38 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
39 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 0.01 0.07 1.06
40 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
41 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
42 INT144661 Dnm1 Negative_regulation of Binding of Hbegf 1 0.24 0 1.01
43 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
44 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
45 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
46 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
47 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
48 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
49 INT144551 Binding of Lrp8 and Sepp1 1 0.55 1.73 0.93
50 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
51 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
52 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
53 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
54 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
55 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
56 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
57 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
58 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
59 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
60 INT326663 Bdnf Regulation of Positive_regulation of Arc 1 0.16 1.46 0.88
61 INT305742 Binding of Sort1 and Gtf3a 1 0.01 0.64 0.88
62 INT305406 Binding of CAV3 and ST8SIA2 1 0.16 0 0.86
63 INT326664 Bdnf Positive_regulation of Arc 1 0.27 1.07 0.86
64 INT326661 Bdnf Positive_regulation of Gene_expression of Arc 1 0.27 1.96 0.86
65 INT146240 Binding of AP1B1 and Mrgprc 1 0.08 0.82 0.85
66 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
67 INT122833 AP1B1 Regulation of Gene_expression of Fos 1 0.16 0 0.83
68 INT269455 Binding of RAB5A and GOPC 1 0.08 0 0.82
69 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
70 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
71 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
72 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
73 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
74 INT66580 Binding of Ap1s1 and Rare2 1 0.00 0.07 0.76
75 INT133935 DNM2 Positive_regulation of OPRK1 1 0.11 0 0.76
76 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
77 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
78 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
79 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
80 INT133943 Binding of DNM2 and OPRL1 1 0.00 0 0.73
81 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
82 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
83 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
84 INT133936 Binding of DNM2 and YY1 1 0.29 0 0.69
85 INT60051 Ptger1 Positive_regulation of STAB2 1 0.00 0.77 0.68
86 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68
87 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
88 INT132696 Binding of Arc and Pag1 1 0.00 0.5 0.67
89 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
90 INT95560 Binding of Msr1 and Zfp940 1 0.00 0.24 0.66
91 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
92 INT191330 AMPH Positive_regulation of Vta1 1 0.07 0 0.66
93 INT191331 AMPH Positive_regulation of Gene_expression of Vta1 1 0.07 0 0.66
94 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
95 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
96 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
97 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
98 INT34211 DNM2 Regulation of Localization of Crh 1 0.01 0.09 0.63
99 INT2700 Binding of App and Cpe 1 0.00 0 0.63
100 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
101 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
102 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
103 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
104 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
105 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
106 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
107 INT54487 Rabep2 Regulation of Gene_expression of Jun 1 0.06 0 0.61
108 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 0.00 0.09 0.6
109 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
110 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
111 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
112 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
113 INT95559 Msr1 Negative_regulation of Binding of Zfp940 1 0.00 0.23 0.59
114 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
115 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
116 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
117 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56
118 INT147273 Bdnf Regulation of Syp 1 0.24 0 0.56
119 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
120 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
121 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55
122 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
123 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
124 INT240808 Arc Regulation of Ins1 1 0.09 1.41 0.54
125 INT269449 Positive_regulation of Binding of RAB5A and GOPC 1 0.11 0 0.53
126 INT54485 Positive_regulation of Akr1d1 Positive_regulation of Gene_expression of Rabep2 1 0.00 0 0.53
127 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51
128 INT243998 Binding of Prkaca and Dnm1 1 0.11 0.24 0.49
129 INT243999 Positive_regulation of Binding of Prkaca and Dnm1 1 0.14 0.24 0.49
130 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
131 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
132 INT96282 Cav2 Regulation of Positive_regulation of Gabrg1 1 0.25 0 0.48
133 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
134 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
135 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
136 INT122832 AP1B1 Negative_regulation of Gene_expression of FLII 1 0.01 0 0.47
137 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
138 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
139 INT143619 Bhlhe22 Positive_regulation of Regulation of Msr1 1 0.40 0.93 0.46
140 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
141 INT117888 Gfap Regulation of Arc 1 0.05 0.37 0.46
142 INT117887 Glul Regulation of Arc 1 0.02 0.37 0.46
143 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46
144 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
145 INT13247 Binding of Arc and Helt 1 0.00 0.37 0.45
146 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
147 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
148 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
149 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
150 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
151 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
152 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
153 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
154 INT270043 Binding of Ldlr and Hdl1 1 0.01 2.3 0.43
155 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
156 INT98726 Binding of Msr1 and Tacr2 1 0.00 0.06 0.42
157 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
158 INT354206 Arc Positive_regulation of Accn2 1 0.02 0.57 0.42
159 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
160 INT354208 Arc Positive_regulation of Accn3 1 0.08 0.97 0.42
161 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
162 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
163 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
164 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
165 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
166 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
167 INT322394 Hist1h1t Positive_regulation of Pik3cb 1 0.01 0 0.42
168 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
169 INT237896 Epn1 Regulation of Nps 1 0.06 0.19 0.41
170 INT215290 Siglec1 Negative_regulation of Decr1 1 0.00 0.68 0.41
171 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
172 INT141242 Binding of SYP and DNLZ 1 0.29 1.74 0.41
173 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
174 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
175 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
176 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
177 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
178 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4
179 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
180 INT288700 Binding of Cp and Tfrc 1 0.40 0 0.39
181 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
182 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
183 INT23663 Cd2 Negative_regulation of Snx9 1 0.06 0 0.39
184 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
185 INT263433 Abl1 Regulation of Abl1 1 0.04 0.28 0.38
186 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
187 INT289409 Binding of Icam5 and Cd209a 1 0.03 3.64 0.38
188 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37
189 INT300610 Rorb Regulation of Dnm2 1 0.01 0.27 0.37
190 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
191 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
192 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
193 INT300608 Arc Regulation of Dnm2 1 0.15 0.27 0.37
194 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
195 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
196 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
197 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35
198 INT353669 Binding of SNRNP70 and CD209 1 0.04 6.08 0.35
199 INT122755 Helt Positive_regulation of Pik3cb 1 0.00 0.19 0.35
200 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35

Single Events

The table below shows the top 100 pain related interactions that have been reported for endocytosis. They are ordered first by their pain relevance and then by number of times they were reported in endocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24
3 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
4 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
5 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
6 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
7 INT4459 Positive_regulation of Arc 74 0.69 33.61 28.29
8 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44
9 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
10 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
11 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
12 INT11625 Localization of App 98 0.78 55.46 20.86
13 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
14 INT16794 Binding of App 103 0.48 64.87 19.79
15 INT65502 Regulation of App 77 0.62 52.05 19.44
16 INT62564 Gene_expression of Syp 40 0.76 15.56 17
17 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
18 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59
19 INT20966 Positive_regulation of Arc 30 0.70 24.38 15.62
20 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4
21 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
22 INT54052 Gene_expression of App 33 0.78 25.08 14.7
23 INT27627 Binding of Rac1 41 0.41 22.88 13.68
24 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
25 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
26 INT121783 Positive_regulation of Gene_expression of Arc 30 0.70 29.22 13.02
27 INT29745 Binding of APP 47 0.48 26.49 12.4
28 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
29 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05
30 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
31 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
32 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27
33 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
34 INT91357 Regulation of Dnm2 5 0.61 0 11.06
35 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
36 INT1087 Negative_regulation of Msr1 32 0.57 8.35 10.72
37 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68
38 INT106477 Positive_regulation of Syp 21 0.68 8.69 10.3
39 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
40 INT41569 Regulation of APP 32 0.62 17.15 9.4
41 INT106595 Negative_regulation of Dnm2 10 0.58 0.15 9.29
42 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
43 INT168096 Transcription of Cav3 1 0.72 7.23 8.58
44 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
45 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
46 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87
47 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85
48 INT4457 Regulation of Arc 27 0.60 14.96 7.83
49 INT14207 Gene_expression of DNM2 20 0.67 5.76 7.64
50 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53
51 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
52 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
53 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05
54 INT106599 Positive_regulation of Dnm2 8 0.69 0.28 7.01
55 INT90545 Phosphorylation of Siglec1 53 0.11 12.09 6.81
56 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
57 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48
58 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
59 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
60 INT115677 Positive_regulation of Gene_expression of Syp 15 0.63 4.69 6.25
61 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
62 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21
63 INT4282 Regulation of Msr1 11 0.45 2.51 5.75
64 INT9895 Binding of GHR 18 0.36 4.8 5.65
65 INT102836 Binding of LRP2 12 0.38 11.27 5.58
66 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31
67 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
68 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
69 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
70 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
71 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
72 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5
73 INT57125 Gene_expression of AP1B1 8 0.18 3.8 4.91
74 INT201653 Gene_expression of Sort1 6 0.75 6.29 4.89
75 INT3476 Phosphorylation of Npc1 7 0.48 0 4.84
76 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
77 INT255981 Localization of RAB5A 3 0.68 0.88 4.76
78 INT269476 Binding of RAB5A 1 0.41 0 4.76
79 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
80 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
81 INT88909 Positive_regulation of Gene_expression of Dnm1 6 0.70 3.43 4.59
82 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55
83 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
84 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
85 INT106596 Transcription of Dnm2 4 0.69 0 4.5
86 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
87 INT148901 Binding of Sort1 2 0.39 3.65 4.32
88 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
89 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
90 INT20981 Binding of HRAS 42 0.48 24.49 4.23
91 INT58003 Localization of APP 32 0.80 13.75 4.2
92 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
93 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
94 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
95 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
96 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
97 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
98 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
99 INT169475 Localization of HRAS 14 0.73 9.02 3.9
100 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87
101 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
102 INT112928 Localization of Dnm2 3 0.74 0 3.81
103 INT106095 Localization of Arc 17 0.80 7.61 3.74
104 INT129746 Positive_regulation of Gene_expression of Tfrc 4 0.18 2.15 3.74
105 INT88906 Gene_expression of Dnm1 5 0.78 10.48 3.7
106 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
107 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
108 INT32905 Gene_expression of Mrc1 18 0.58 11.07 3.54
109 INT10106 Positive_regulation of Msr1 16 0.50 5.86 3.52
110 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
111 INT61875 Negative_regulation of Arc 4 0.34 5.61 3.49
112 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
113 INT57728 Regulation of LDLR 25 0.41 13.18 3.46
114 INT148899 Regulation of Sort1 2 0.50 2.72 3.46
115 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
116 INT116645 Regulation of Pik3cb 11 0.41 3.78 3.43
117 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
118 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32
119 INT5166 Binding of Ldlr 14 0.48 11.95 3.32
120 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3
121 INT58475 Localization of Rac1 12 0.75 5.94 3.2
122 INT68846 Gene_expression of Tfrc 22 0.32 10.1 3.06
123 INT81734 Regulation of Gene_expression of Arc 12 0.43 7.77 3.06
124 INT10057 Gene_expression of Ldlr 35 0.67 23.99 3.05
125 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
126 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04
127 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
128 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
129 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
130 INT57123 Localization of AP1B1 5 0.24 1.29 2.91
131 INT292058 Positive_regulation of Cav2 7 0.67 3.43 2.89
132 INT121759 Localization of Syp 8 0.73 1.78 2.84
133 INT130784 Regulation of Gene_expression of Arc 4 0.54 4.9 2.84
134 INT178772 Transcription of App 17 0.70 10.79 2.79
135 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79
136 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
137 INT54054 Binding of App 4 0.48 10.89 2.78
138 INT13943 Localization of DNM2 4 0.52 0.07 2.75
139 INT194465 Gene_expression of Ldlr 27 0.76 31.36 2.73
140 INT282270 Gene_expression of Cav2 11 0.57 3.53 2.72
141 INT121463 Regulation of Localization of Dnm2 2 0.45 0 2.72
142 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71
143 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
144 INT51753 Negative_regulation of Tfrc 7 0.41 3.47 2.62
145 INT82284 Negative_regulation of Gene_expression of Arc 10 0.41 4.26 2.58
146 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5
147 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48
148 INT144274 Gene_expression of Cav3 28 0.78 3.21 2.47
149 INT3475 Regulation of Phosphorylation of Npc1 3 0.36 0 2.45
150 INT69147 Localization of AMPH 4 0.61 0 2.44
151 INT65732 Binding of Msr1 9 0.47 7.28 2.42
152 INT237875 Gene_expression of Epn1 1 0.10 1.26 2.4
153 INT22019 Regulation of GHR 9 0.62 2.56 2.39
154 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36
155 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
156 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
157 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
158 INT56030 Regulation of App 8 0.62 4.06 2.32
159 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
160 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
161 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
162 INT106476 Regulation of Gene_expression of Syp 3 0.60 2.32 2.3
163 INT110304 Negative_regulation of Gene_expression of NOSTRIN 6 0.55 2.22 2.27
164 INT190028 Positive_regulation of Mrc1 10 0.22 2.94 2.26
165 INT128745 Positive_regulation of Positive_regulation of Pik3cb 4 0.56 0.95 2.24
166 INT264600 Negative_regulation of Gene_expression of Syp 8 0.31 2.88 2.23
167 INT24890 Localization of SYP 5 0.73 2.22 2.23
168 INT130785 Regulation of Arc 9 0.62 5.56 2.2
169 INT168959 Gene_expression of CAV3 5 0.65 0.7 2.2
170 INT96856 Localization of NOSTRIN 8 0.49 6.39 2.19
171 INT66881 Positive_regulation of Sort1 2 0.57 0.99 2.16
172 INT70384 Positive_regulation of Rabep2 10 0.67 1.56 2.13
173 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
174 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
175 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
176 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
177 INT39008 Localization of App 13 0.77 9.07 2.05
178 INT82543 Negative_regulation of Gene_expression of TFRC 4 0.57 1.27 2.03
179 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
180 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99
181 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
182 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97
183 INT66882 Gene_expression of Sort1 3 0.73 0.64 1.97
184 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
185 INT110242 Regulation of Syp 4 0.32 1.72 1.96
186 INT54477 Gene_expression of Rabep2 13 0.75 0.56 1.95
187 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
188 INT57122 Positive_regulation of Localization of AP1B1 3 0.16 0.39 1.93
189 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
190 INT246723 Localization of Arc 10 0.63 7.27 1.92
191 INT198885 Gene_expression of Lrp1 33 0.57 10.2 1.91
192 INT237873 Regulation of Epn1 1 0.07 2.12 1.91
193 INT292051 Negative_regulation of Cav2 6 0.41 2.52 1.9
194 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
195 INT245663 Phosphorylation of Syp 2 0.76 7.4 1.88
196 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
197 INT149335 Gene_expression of Pik3cb 10 0.57 2.93 1.82
198 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
199 INT323912 Regulation of ARC 1 0.01 1.06 1.78
200 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
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