GO:0006917

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Name induction of apoptosis
Categary Process
Go Slim No
Go Link GO:0006917
Unique Molecular Interactions 4534
Total Molecular Interactions 6051
Total Single Events 54670
Pain Genes Associated 205

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
4 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
5 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
8 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
9 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
10 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
11 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
12 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
13 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
14 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
15 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
16 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
17 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
18 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
19 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
20 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
21 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
22 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
23 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
24 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
25 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
26 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
27 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
28 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
29 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
30 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
31 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
32 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
33 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
34 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
35 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
36 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
37 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
38 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
39 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
40 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
41 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
42 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
43 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
44 INT165183 Ifnb1 Positive_regulation of P2rx4 1 0.04 1.73 1.73
45 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
46 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
47 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
48 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
49 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
50 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
51 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
52 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
53 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
54 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 0.03 0 1.63
55 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
56 INT167202 TNF Regulation of Gene_expression of Ngf 1 0.10 1.47 1.6
57 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
58 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 0.01 1.69 1.59
59 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
60 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
61 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
62 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
63 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
64 INT167201 Gtf3a Regulation of TNF 1 0.01 1.39 1.52
65 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
66 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
67 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
68 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
69 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
70 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
71 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
72 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
73 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
74 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42
75 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
76 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
77 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
78 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
79 INT158144 Binding of Gpx1 and Glyat 2 0.31 0 1.29
80 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
81 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
82 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
83 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
84 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
85 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
86 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
87 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
88 INT296796 Tbrs1 Positive_regulation of Gene_expression of TNF 1 0.00 1.58 1.26
89 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
90 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
91 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
92 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22
93 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
94 INT298260 Binding of Runx3 and Pou4f1 1 0.52 2.08 1.22
95 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
96 INT70028 LTA Regulation of PRF1 1 0.02 1.42 1.21
97 INT70036 LTA Regulation of Negative_regulation of IL10 1 0.03 1.42 1.21
98 INT70035 TNF Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
99 INT70032 TNF Regulation of PRF1 1 0.05 1.42 1.21
100 INT70042 LTA Regulation of Negative_regulation of PRF1 1 0.02 1.42 1.21
101 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
102 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
103 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21
104 INT70041 LTA Regulation of IL10 1 0.03 1.42 1.21
105 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2
106 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
107 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
108 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
109 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
110 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
111 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
112 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
113 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
114 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
115 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
116 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
117 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
118 INT139188 Binding of Daxx and Fas 1 0.03 0.55 1.14
119 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
120 INT72754 Adamts7 Negative_regulation of TNF 1 0.28 1.64 1.13
121 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
122 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
123 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
124 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
125 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
126 INT107264 Binding of TNF and NCR3 1 0.30 1.42 1.1
127 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
128 INT107266 Binding of HLA-DRB1 and TNF 1 0.29 1.41 1.1
129 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
130 INT107267 Binding of HLA-A and TNF 1 0.34 1.41 1.1
131 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
132 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
133 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
134 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
135 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
136 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
137 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
138 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
139 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
140 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
141 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07
142 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
143 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
144 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
145 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06
146 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
147 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
148 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
149 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
150 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
151 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
152 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
153 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
154 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
155 INT69011 Binding of Cebpb and Nfkb1 1 0.19 0.75 1.04
156 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
157 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
158 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
159 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
160 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
161 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
162 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
163 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
164 INT338892 TNFSF14 Regulation of Abat 1 0.00 0.61 1.01
165 INT338895 TNFSF14 Regulation of Regulation of Abat 1 0.00 0.62 1.01
166 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
167 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
168 INT308804 Pld1 Positive_regulation of TNF 1 0.05 2.42 0.99
169 INT274895 Positive_regulation of Cbr2 Negative_regulation of Gene_expression of TNF 1 0.06 1.21 0.99
170 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
171 INT182022 TNF Positive_regulation of Gene_expression of Tnfrsf11b 1 0.06 1.56 0.98
172 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
173 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
174 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98
175 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
176 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
177 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
178 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
179 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
180 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
181 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
182 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
183 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
184 INT171264 TNF Positive_regulation of MMP1 2 0.10 2.05 0.95
185 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
186 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
187 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
188 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
189 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
190 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
191 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
192 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94
193 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
194 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
195 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
196 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
197 INT153685 Binding of Bcl2l11 and Gtpbp4 1 0.08 0.76 0.93
198 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
199 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
200 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93

Single Events

The table below shows the top 100 pain related interactions that have been reported for induction of apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in induction of apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
4 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
5 INT6852 Localization of TNF 883 0.81 705.95 270.84
6 INT6481 Binding of TNF 624 0.48 510.2 214.82
7 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
8 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
9 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
10 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
11 INT9660 Regulation of TNF 363 0.62 312.94 139.99
12 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
13 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
14 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
15 INT65500 Gene_expression of App 605 0.78 429.94 98.31
16 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
17 INT10166 Localization of Tnf 237 0.81 153.95 88.64
18 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
19 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
20 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
21 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
22 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
23 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
24 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
25 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
26 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
27 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
28 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
29 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
30 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
31 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
32 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
33 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
34 INT13354 Transcription of TNF 108 0.72 85.81 42.32
35 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
36 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
37 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
38 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
39 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
40 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
41 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
42 INT35406 Localization of Tnf 94 0.81 64.63 31.65
43 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
44 INT1158 Regulation of Agt 106 0.61 29.4 30.29
45 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
46 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
47 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
48 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
49 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
50 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
51 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
52 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
53 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
54 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
55 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
56 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2
57 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
58 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
59 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
60 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
61 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
62 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
63 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
64 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
65 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
66 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
67 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
68 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
69 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
70 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
71 INT11625 Localization of App 98 0.78 55.46 20.86
72 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
73 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
74 INT16794 Binding of App 103 0.48 64.87 19.79
75 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
76 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
77 INT67608 Gene_expression of Pparg 41 0.78 25.09 19.53
78 INT65502 Regulation of App 77 0.62 52.05 19.44
79 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
80 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
81 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
82 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
83 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
84 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
85 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07
86 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
87 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
88 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
89 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
90 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
91 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
92 INT164366 Localization of NLRP1 26 0.71 5.9 16.54
93 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51
94 INT2066 Localization of Agt 56 0.80 9.95 16.25
95 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
96 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
97 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
98 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
99 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
100 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
101 INT114395 Positive_regulation of Nlrp1a 15 0.45 4.61 15.37
102 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17
103 INT54052 Gene_expression of App 33 0.78 25.08 14.7
104 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
105 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
106 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
107 INT10173 Binding of Tnf 45 0.48 35.6 14.32
108 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
109 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
110 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
111 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
112 INT47708 Gene_expression of Nr4a1 30 0.78 5.12 13.59
113 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31
114 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
115 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
116 INT3962 Regulation of AGT 50 0.62 20.96 13.01
117 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71
118 INT4199 Binding of Agt 76 0.48 21.06 12.66
119 INT203490 Gene_expression of Runx3 19 0.76 27.56 12.57
120 INT29745 Binding of APP 47 0.48 26.49 12.4
121 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
122 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
123 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09
124 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77
125 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
126 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
127 INT398 Localization of AGT 45 0.78 16.97 11.54
128 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
129 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
130 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
131 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
132 INT79685 Positive_regulation of Gene_expression of Pparg 17 0.70 14.63 11.03
133 INT8065 Binding of AGT 54 0.48 20.54 10.85
134 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75
135 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
136 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
137 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
138 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
139 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
140 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
141 INT150540 Binding of TLR2 50 0.45 35.86 10.43
142 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
143 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
144 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
145 INT80110 Regulation of Positive_regulation of TNF 34 0.44 25.79 9.78
146 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
147 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
148 INT41569 Regulation of APP 32 0.62 17.15 9.4
149 INT35707 Gene_expression of Nlrp1a 20 0.75 9.61 9.32
150 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
151 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
152 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
153 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
154 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
155 INT67612 Binding of PPARG 38 0.48 22.67 8.94
156 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83
157 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
158 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
159 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68
160 INT47701 Positive_regulation of Nr4a1 26 0.70 4.45 8.64
161 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
162 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
163 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
164 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
165 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
166 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
167 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
168 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
169 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07
170 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89
171 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
172 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
173 INT98178 Localization of Casp3 32 0.65 21.01 7.77
174 INT49490 Positive_regulation of Transcription of TNF 19 0.70 14.76 7.58
175 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
176 INT95133 Gene_expression of FASLG 38 0.75 44.09 7.51
177 INT68299 Binding of Tnf 17 0.39 12.55 7.49
178 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
179 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
180 INT10145 Gene_expression of Plg 28 0.62 12.68 7.46
181 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
182 INT114394 Negative_regulation of Positive_regulation of Nlrp1a 4 0.42 1.09 7.37
183 INT103399 Positive_regulation of Positive_regulation of Pparg 11 0.66 7 7.36
184 INT152347 Binding of GCH1 8 0.37 6.13 7.36
185 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
186 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
187 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
188 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
189 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2
190 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
191 INT7607 Localization of Nacc1 7 0.81 0 7.09
192 INT197493 Localization of Apoe 61 0.79 27.48 7.06
193 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
194 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
195 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
196 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
197 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
198 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86
199 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
200 INT16344 Gene_expression of CASP4 11 0.74 4.64 6.75
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