GO:0006921

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Name cellular component disassembly involved in apoptosis
Categary Process
Go Slim No
Go Link GO:0006921
Unique Molecular Interactions 255
Total Molecular Interactions 327
Total Single Events 3101
Pain Genes Associated 27

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular component disassembly involved in apoptosis. They are ordered first by their pain relevance and then by number of times they were reported for cellular component disassembly involved in apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
2 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
3 INT1654 Pomc Regulation of DSP 1 0.03 0 0.94
4 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
5 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
6 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
7 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
8 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
9 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
10 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
11 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
12 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
13 INT162720 PEG3 Negative_regulation of Positive_regulation of CASP8 1 0.00 0.71 0.52
14 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
15 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
16 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
17 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
18 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
19 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
20 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
21 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
22 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
23 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
24 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
25 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
26 INT28081 POMC Regulation of Gene_expression of VIM 1 0.13 0.09 0.46
27 INT155085 CASP1 Negative_regulation of CASP8 1 0.29 1.25 0.44
28 INT121850 CASP8 Positive_regulation of Protein_catabolism of BID 2 0.21 1.81 0.43
29 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
30 INT121855 CASP8 Regulation of ROS1 1 0.05 0.52 0.41
31 INT121849 CASP8 Positive_regulation of CYCS 1 0.35 0.48 0.4
32 INT121852 CASP8 Positive_regulation of Localization of CYCS 1 0.32 0.48 0.4
33 INT345006 CSF2 Regulation of GSN 1 0.16 0.82 0.39
34 INT266419 HMGB1 Positive_regulation of Ager 1 0.01 1.37 0.37
35 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
36 INT345012 GSN Regulation of CCBE1 1 0.00 0.82 0.36
37 INT345010 GSN Regulation of DBP 1 0.26 0.81 0.36
38 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36
39 INT107726 BIRC2 Regulation of ASIP 1 0.03 0.24 0.35
40 INT254391 Binding of F13A1 and GSN 1 0.00 1.08 0.34
41 INT228446 PMAIP1 Regulation of Transcription of Mtpn 1 0.00 0 0.34
42 INT254393 Binding of FN1 and GSN 1 0.01 1.08 0.34
43 INT329954 Binding of PRKCQ and SNRNP70 1 0.07 0.65 0.33
44 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
45 INT259132 KLK7 Positive_regulation of Binding of DSG2 1 0.51 0.91 0.31
46 INT259130 KLK7 Positive_regulation of Binding of DSG1 1 0.51 0.91 0.31
47 INT259133 KLK7 Positive_regulation of DSG2 1 0.51 0.91 0.31
48 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
49 INT259131 KLK7 Positive_regulation of DSG1 1 0.51 0.91 0.31
50 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
51 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
52 INT222975 PTPRC Positive_regulation of VIM 1 0.05 0.46 0.26
53 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
54 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
55 INT245091 CCL1 Negative_regulation of Localization of VIM 1 0.02 1.08 0.25
56 INT328204 Binding of DSG3 and PSORS4 1 0.00 0.5 0.25
57 INT245092 TNF Negative_regulation of Localization of VIM 1 0.03 1.1 0.25
58 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
59 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
60 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
61 INT193031 CHRM2 Positive_regulation of ROCK1 1 0.00 0.12 0.24
62 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
63 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
64 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
65 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
66 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
67 INT266418 Binding of HMGB1 and Tlr4 1 0.09 0.37 0.23
68 INT169614 Binding of KPNA1 and OGFR 1 0.06 0.18 0.23
69 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
70 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
71 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
72 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
73 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
74 INT266423 Binding of HMGB1 and Mapk3 1 0.04 0.9 0.2
75 INT266410 Binding of HMGB1 and Mapk14 1 0.03 0.91 0.2
76 INT266416 Binding of HMGB1 and Mapk1 1 0.06 0.9 0.2
77 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2
78 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
79 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
80 INT266404 Binding of HMGB1 and Thbd 1 0.06 0.3 0.2
81 INT175948 TNF Positive_regulation of Positive_regulation of CASP8 1 0.02 1.12 0.2
82 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
83 INT175947 TNFSF10 Positive_regulation of Positive_regulation of CASP8 1 0.01 1.12 0.2
84 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
85 INT198700 Binding of DSG3 and Pv 1 0.15 1.45 0.18
86 INT193080 ROCK1 Positive_regulation of Ppp1r14a 1 0.00 0.13 0.18
87 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
88 INT247084 Binding of F7 and H1F0 1 0.00 0.38 0.17
89 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
90 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
91 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
92 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
93 INT149281 Binding of MAPT and Dbp 1 0.00 0.4 0.17
94 INT266422 HMGB1 Positive_regulation of Binding of Ager 1 0.01 0.92 0.16
95 INT254392 Binding of CRP and GSN 1 0.12 0.33 0.16
96 INT259135 Gene_expression of KLK7 Positive_regulation of DSG2 1 0.47 1.21 0.16
97 INT282708 Binding of MAPT and Y301C7L 1 0.00 0.54 0.16
98 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
99 INT130923 HMHA1 Positive_regulation of Protein_catabolism of CASP8 1 0.04 1.37 0.14
100 INT266413 Positive_regulation of Binding of HMGB1 and Col4a1 1 0.02 1.05 0.14
101 INT117913 CREM Positive_regulation of Negative_regulation of BIRC2 1 0.15 0.81 0.14
102 INT266411 Binding of HMGB1 and Col4a1 1 0.01 1.05 0.14
103 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
104 INT130920 HMHA1 Positive_regulation of CASP8 1 0.04 1.36 0.14
105 INT254133 PLEC Regulation of MCRS1 1 0.03 0.33 0.13
106 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
107 INT238805 Binding of DSP and HSPB2 1 0.09 4.2 0.13
108 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
109 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
110 INT345011 Binding of GSN and PTAFR 1 0.09 0.83 0.12
111 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
112 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
113 INT117911 MAPK1 Regulation of Positive_regulation of BIRC2 1 0.04 0.9 0.12
114 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
115 INT255811 Binding of GNAS and MAPT 1 0.00 0.67 0.11
116 INT148102 AGT Positive_regulation of Gene_expression of STK24 1 0.37 0.96 0.1
117 INT322019 CASP8 Regulation of Gene_expression of IL1B 1 0.02 0 0.1
118 INT262255 Binding of APC and F2R 1 0.05 3 0.1
119 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
120 INT259129 KLK7 Regulation of DSG2 1 0.24 0.61 0.09
121 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
122 INT137254 BCL2L11 Regulation of VIM 1 0.17 0.99 0.08
123 INT137251 BCL2L11 Regulation of CDH1 1 0.17 0.99 0.08
124 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
125 INT250662 FNTA Positive_regulation of Positive_regulation of RASGRP1 1 0.00 0.79 0.07
126 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06
127 INT352297 Regulation of Binding of CD99 and VIM 1 0.19 1.07 0.06
128 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
129 INT352296 Binding of CD99 and VIM 1 0.16 1.06 0.06
130 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
131 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06
132 INT269210 CDH1 Positive_regulation of Positive_regulation of ITK 1 0.06 0.84 0.06
133 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06
134 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
135 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
136 INT302162 CASP8 Positive_regulation of CASP3 2 0.01 2.07 0.04
137 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
138 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
139 INT269214 SNAI1 Positive_regulation of Positive_regulation of CDH1 1 0.35 0.71 0.04
140 INT269211 SNAI1 Positive_regulation of Gene_expression of CDH1 1 0.40 0.73 0.04
141 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03
142 INT269584 Binding of CFL1 and ROCK1 1 0.03 0.05 0.03
143 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03
144 INT332438 CASP8 Positive_regulation of Gene_expression of BID 1 0.02 1.33 0.03
145 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
146 INT175946 RSF1 Positive_regulation of Positive_regulation of CASP3 1 0.01 0.41 0.03
147 INT343537 ROCK1 Regulation of Gene_expression of PTHLH 1 0.08 0.09 0.03
148 INT327981 CASP9 Positive_regulation of CASP3 2 0.29 1.34 0
149 INT192044 Binding of DSP and Jup 2 0.24 2.39 0
150 INT235004 Binding of PKP1 and Dsp 1 0.00 0.14 0
151 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
152 INT259136 DSG2 Regulation of Gene_expression of KLK7 1 0.27 0.24 0
153 INT292464 Binding of PTK2 and MMRN1 1 0.03 0.26 0
154 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
155 INT279798 APAF1 Positive_regulation of CASP3 1 0.01 1 0
156 INT235002 Negative_regulation of Binding of DSG1 and Dsg3 1 0.13 1.08 0
157 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0
158 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
159 INT298450 Binding of CDH1 and Efs 1 0.03 0.96 0
160 INT292463 LAMB2 Positive_regulation of Phosphorylation of PTK2 1 0.01 0.7 0
161 INT301246 Binding of HMGB1 and Hbp1 1 0.03 0.74 0
162 INT355588 Binding of CDH1 and CTNNA1 1 0.00 1.12 0
163 INT349220 Binding of CASP3 and CD8A 1 0.00 0.18 0
164 INT249169 PMAIP1 Positive_regulation of PRKDC 1 0.00 0 0
165 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0
166 INT175624 Gene_expression of CDH2 Positive_regulation of CDH1 1 0.00 1.12 0
167 INT258209 ROCK1 Regulation of ARR3 1 0.00 0.2 0
168 INT186096 EGF Regulation of Positive_regulation of CASP3 1 0.01 0.28 0
169 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
170 INT268520 MIR19B1 Regulation of CASP8 1 0.14 1 0
171 INT355587 Binding of occludin and TJP1 1 0.01 1.12 0
172 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
173 INT258202 ROCK1 Positive_regulation of MYL2 1 0.14 0.2 0
174 INT235007 Binding of DSG1 and Jup 1 0.08 0.36 0
175 INT243373 Binding of CASP8 and SERPINH1 1 0.28 1.49 0
176 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
177 INT235005 Positive_regulation of Binding of DSG1 and Jup 1 0.08 0.36 0
178 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0
179 INT336035 Positive_regulation of CASP8 Positive_regulation of BID 1 0.03 0.5 0
180 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
181 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
182 INT292452 Gene_expression of PTK2 Negative_regulation of Positive_regulation of AKT1 1 0.14 0.6 0
183 INT263248 Binding of ADD1 and RAPGEF5 1 0.01 0.84 0
184 INT235182 IRF6 Positive_regulation of VIM 1 0.05 0.08 0
185 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0
186 INT322553 TNFSF10 Positive_regulation of CASP8 1 0.05 1.79 0
187 INT292453 PTK2 Regulation of Gene_expression of GEM 1 0.16 0.42 0
188 INT327982 PNLIP Regulation of Gene_expression of CASP3 1 0.13 0.58 0
189 INT283863 Binding of MAPK1 and PTK2 1 0.12 0.97 0
190 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
191 INT287891 Binding of CDH1 and KRT20 1 0.00 0.5 0
192 INT328906 Binding of LMNA and CSAD 1 0.11 0 0
193 INT167401 Ros1 Positive_regulation of CASP3 1 0.15 0.71 0
194 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
195 INT301674 Binding of APC and CD80 1 0.01 0.53 0
196 INT348537 TNF Positive_regulation of Gene_expression of BIRC2 1 0.03 0.23 0
197 INT235019 Binding of DSC1 and DSP 1 0.39 0.07 0
198 INT195661 Binding of APC and PROC 1 0.23 0.89 0
199 INT235018 Binding of DSP and GOPC 1 0.02 0.19 0
200 INT234997 Binding of DSG1 and Car2 1 0.03 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular component disassembly involved in apoptosis. They are ordered first by their pain relevance and then by number of times they were reported in cellular component disassembly involved in apoptosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
2 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29
3 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
4 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
5 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
6 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77
7 INT189230 Gene_expression of GSN 12 0.75 25.04 7.6
8 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
9 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
10 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
11 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
12 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
13 INT254400 Negative_regulation of GSN 22 0.57 18.15 5.89
14 INT15542 Negative_regulation of CASP8 20 0.41 17.3 5.63
15 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15
16 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
17 INT184269 Gene_expression of HMGB1 51 0.77 42.96 4.55
18 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
19 INT184288 Localization of HMGB1 20 0.61 14.5 3.84
20 INT63121 Binding of APC 29 0.41 23.02 3.8
21 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
22 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
23 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93
24 INT15543 Gene_expression of CASP8 32 0.75 25.6 2.61
25 INT184272 Binding of HMGB1 14 0.37 8.78 2.49
26 INT100620 Localization of VIM 8 0.76 5.47 2.16
27 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
28 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01
29 INT152771 Gene_expression of TJP1 19 0.75 14.95 1.98
30 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98
31 INT189239 Binding of GSN 11 0.36 9.34 1.93
32 INT111603 Positive_regulation of Gene_expression of CDH1 14 0.49 11.17 1.72
33 INT189226 Protein_catabolism of GSN 3 0.54 7.1 1.7
34 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
35 INT15544 Regulation of CASP8 6 0.41 5.83 1.63
36 INT107341 Phosphorylation of MAPT 19 0.80 14 1.61
37 INT117915 Gene_expression of BIRC2 8 0.63 6.74 1.59
38 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58
39 INT25771 Regulation of DSP 8 0.10 3.67 1.55
40 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
41 INT118430 Positive_regulation of Gene_expression of VIM 8 0.47 2.14 1.53
42 INT184271 Positive_regulation of Gene_expression of HMGB1 7 0.41 6.17 1.53
43 INT345015 Positive_regulation of Gene_expression of GSN 1 0.49 3.58 1.5
44 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33
45 INT15541 Positive_regulation of Negative_regulation of CASP8 2 0.31 1.23 1.31
46 INT61999 Gene_expression of MAPT 19 0.75 15.4 1.3
47 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28
48 INT254397 Negative_regulation of Gene_expression of GSN 2 0.41 3.56 1.28
49 INT9205 Binding of DSP 12 0.44 9.9 1.21
50 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
51 INT87346 Binding of PTK2 6 0.37 4.03 1.18
52 INT28083 Negative_regulation of Gene_expression of VIM 9 0.41 7.23 1.17
53 INT34734 Binding of DSG3 4 0.48 2.91 1.17
54 INT219168 Positive_regulation of Localization of HMGB1 5 0.36 4 1.16
55 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15
56 INT111605 Positive_regulation of CDH1 12 0.50 7.95 1.15
57 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
58 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13
59 INT345013 Regulation of GSN 4 0.51 3.49 1.11
60 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
61 INT102845 Localization of CASP3 7 0.81 2.81 1.06
62 INT238495 Negative_regulation of Gene_expression of TJP1 5 0.18 9.51 1.05
63 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
64 INT101889 Negative_regulation of DSP 3 0.42 1.61 1.05
65 INT234952 Protein_catabolism of DSG1 3 0.96 5.86 0.98
66 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
67 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
68 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
69 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
70 INT259149 Gene_expression of DSG2 13 0.74 9.73 0.82
71 INT80498 Gene_expression of DSP 15 0.75 7.06 0.79
72 INT254401 Positive_regulation of GSN 4 0.38 2 0.79
73 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
74 INT68297 Binding of MAPT 9 0.47 4.45 0.75
75 INT259142 Negative_regulation of DSG2 1 0.41 3.74 0.72
76 INT25663 Localization of PMAIP1 3 0.38 2.47 0.71
77 INT57062 Regulation of APC 24 0.58 14.3 0.7
78 INT86370 Regulation of CDH1 10 0.54 13.89 0.7
79 INT234950 Binding of DSG1 29 0.36 23.67 0.69
80 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
81 INT87445 Localization of TJP1 2 0.45 0.55 0.68
82 INT152775 Regulation of Gene_expression of TJP1 1 0.44 2.05 0.67
83 INT25664 Negative_regulation of Localization of PMAIP1 1 0.09 0.09 0.66
84 INT34187 Localization of MAPT 1 0.78 0 0.65
85 INT34186 Positive_regulation of Localization of MAPT 1 0.49 0 0.65
86 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
87 INT254402 Localization of GSN 2 0.78 2.73 0.63
88 INT25961 Positive_regulation of Positive_regulation of DSP 1 0.04 0.28 0.63
89 INT234954 Negative_regulation of DSG1 22 0.42 19.5 0.62
90 INT164585 Regulation of PMAIP1 2 0.20 2.07 0.61
91 INT14318 Negative_regulation of MAPT 3 0.57 2.05 0.59
92 INT259151 Protein_catabolism of DSG2 1 0.95 2.74 0.58
93 INT184277 Regulation of Localization of HMGB1 1 0.37 1.15 0.58
94 INT125867 Protein_catabolism of CASP8 9 0.65 8.5 0.57
95 INT100065 Negative_regulation of LMNA 12 0.49 0.12 0.56
96 INT14317 Negative_regulation of Negative_regulation of MAPT 1 0.41 0.28 0.56
97 INT118716 Positive_regulation of MAPT 4 0.49 7.25 0.54
98 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
99 INT91209 Binding of VIM 15 0.36 12.02 0.53
100 INT140645 Gene_expression of DSG3 6 0.78 4.48 0.52
101 INT211714 Regulation of Gene_expression of VIM 4 0.43 3.77 0.52
102 INT162721 Negative_regulation of Positive_regulation of CASP8 3 0.12 3.17 0.52
103 INT192946 Gene_expression of PMAIP1 2 0.27 1.77 0.52
104 INT164584 Positive_regulation of Positive_regulation of PMAIP1 1 0.20 0.9 0.52
105 INT117926 Positive_regulation of Gene_expression of BIRC2 1 0.48 3.25 0.52
106 INT343799 Negative_regulation of Transcription of HMGB1 1 0.32 0.37 0.5
107 INT220339 Transcription of HMGB1 2 0.53 2.03 0.49
108 INT28085 Regulation of Positive_regulation of VIM 1 0.31 0.08 0.49
109 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
110 INT117919 Negative_regulation of BIRC2 4 0.30 3.72 0.45
111 INT219178 Negative_regulation of Localization of HMGB1 1 0.22 1.26 0.45
112 INT259152 Positive_regulation of Protein_catabolism of DSG1 1 0.48 1.6 0.44
113 INT132496 Regulation of Gene_expression of CASP3 6 0.20 4.59 0.42
114 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
115 INT259138 Negative_regulation of Gene_expression of DSG2 1 0.41 1.39 0.39
116 INT117923 Positive_regulation of BIRC2 1 0.48 2.5 0.38
117 INT234962 Positive_regulation of Gene_expression of DSG1 5 0.48 5.41 0.37
118 INT323313 Transcription of MAPT 1 0.69 0.45 0.37
119 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36
120 INT163489 Binding of CDH1 13 0.19 8.63 0.35
121 INT107340 Negative_regulation of Phosphorylation of MAPT 3 0.57 2.64 0.35
122 INT247094 Binding of H1F0 1 0.00 0.89 0.35
123 INT345016 Regulation of Gene_expression of GSN 1 0.38 0.78 0.35
124 INT127871 Regulation of Gene_expression of CDH1 4 0.44 2.34 0.34
125 INT259144 Binding of DSG2 3 0.35 3.69 0.34
126 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
127 INT118243 Transcription of APC 4 0.45 3.33 0.33
128 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
129 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
130 INT68338 Gene_expression of PLEC 4 0.75 0.44 0.32
131 INT214842 Positive_regulation of LMNA 14 0.45 2.98 0.31
132 INT195672 Localization of APC 7 0.74 3.76 0.3
133 INT259154 Transcription of DSG1 1 0.67 1.53 0.3
134 INT185436 Gene_expression of ROCK1 5 0.52 6.85 0.29
135 INT135546 Positive_regulation of Positive_regulation of CASP8 13 0.31 10.97 0.28
136 INT148104 Gene_expression of STK24 1 0.77 2.85 0.28
137 INT148105 Positive_regulation of Gene_expression of STK24 1 0.69 2.86 0.28
138 INT176260 Binding of CASP8 5 0.36 2.73 0.27
139 INT159320 Negative_regulation of Protein_catabolism of CASP3 1 0.21 0.59 0.27
140 INT159323 Negative_regulation of Protein_catabolism of CASP8 1 0.31 0.59 0.27
141 INT145070 Regulation of MAPT 2 0.44 0.72 0.25
142 INT264513 Positive_regulation of Positive_regulation of VIM 1 0.09 0.34 0.24
143 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
144 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22
145 INT259150 Localization of DSG2 3 0.67 1.32 0.22
146 INT279230 Regulation of Gene_expression of LMNA 1 0.02 0.22 0.22
147 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
148 INT185443 Regulation of ROCK1 4 0.18 3.32 0.21
149 INT220336 Negative_regulation of HMGB1 3 0.43 0.97 0.21
150 INT259139 Positive_regulation of Gene_expression of DSG2 2 0.44 1.89 0.21
151 INT308636 Positive_regulation of Phosphorylation of MAPT 1 0.67 2.31 0.21
152 INT266367 Positive_regulation of Binding of HMGB1 1 0.26 0.31 0.21
153 INT136488 Regulation of LMNA 13 0.60 3.53 0.2
154 INT151413 Negative_regulation of FNTA 3 0.10 1.33 0.19
155 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
156 INT266364 Protein_catabolism of HMGB1 1 0.34 0.29 0.19
157 INT254396 Negative_regulation of Transcription of GSN 1 0.36 0.78 0.19
158 INT254398 Transcription of GSN 1 0.44 0.78 0.19
159 INT188239 Binding of LMNA 20 0.47 6.58 0.18
160 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
161 INT254701 Transcription of CDH1 6 0.67 2.5 0.17
162 INT235196 Protein_catabolism of VIM 5 0.62 2.68 0.17
163 INT151742 Positive_regulation of PLEC 3 0.41 0.89 0.17
164 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
165 INT164682 Gene_expression of PKP1 3 0.78 3.04 0.17
166 INT308526 Protein_catabolism of TJP1 1 0.07 1.18 0.17
167 INT318208 Transcription of TJP1 1 0.02 0.38 0.17
168 INT149276 Positive_regulation of Binding of MAPT 1 0.49 0.41 0.17
169 INT266353 Negative_regulation of Binding of HMGB1 1 0.22 0.22 0.17
170 INT164683 Negative_regulation of Gene_expression of PKP1 1 0.59 1.5 0.17
171 INT178607 Binding of CASP3 5 0.19 1.06 0.16
172 INT134952 Localization of DSG3 3 0.81 3.23 0.16
173 INT259141 Transcription of DSG3 1 0.49 0.75 0.16
174 INT259145 Positive_regulation of DSG2 1 0.44 1.53 0.16
175 INT63101 Gene_expression of FNTA 1 0.07 0.52 0.16
176 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
177 INT164160 Localization of CDH1 8 0.66 3.39 0.14
178 INT137827 Negative_regulation of Gene_expression of MAPT 2 0.57 1.39 0.13
179 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
180 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
181 INT164684 Transcription of PKP1 1 0.69 0.75 0.13
182 INT254136 Regulation of PLEC 1 0.23 0.33 0.13
183 INT230645 Binding of PLEC 3 0.47 0.8 0.12
184 INT101395 Regulation of FNTA 1 0.01 0.69 0.12
185 INT209698 Gene_expression of PRKCD 1 0.33 1.78 0.12
186 INT228409 Localization of DSP 5 0.73 2.39 0.11
187 INT84750 Negative_regulation of Gene_expression of DSP 2 0.42 0.41 0.11
188 INT189876 Binding of TJP1 3 0.14 0.29 0.1
189 INT255827 Positive_regulation of Gene_expression of MAPT 3 0.49 2.63 0.1
190 INT154235 Gene_expression of KPNA1 2 0.78 1.77 0.1
191 INT190821 Positive_regulation of Negative_regulation of CASP3 1 0.06 0.51 0.1
192 INT259140 Negative_regulation of Gene_expression of DSG1 1 0.42 0.68 0.1
193 INT345504 Binding of PMAIP1 1 0.15 1.7 0.1
194 INT115817 Protein_catabolism of MAPT 1 0.64 1.21 0.1
195 INT185901 Localization of CASP8 7 0.55 5.38 0.09
196 INT206737 Negative_regulation of Gene_expression of HMGB1 3 0.32 3.48 0.09
197 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
198 INT259155 Positive_regulation of Localization of DSG2 1 0.44 0.71 0.09
199 INT209688 Negative_regulation of Positive_regulation of PRKCD 1 0.18 1.1 0.08
200 INT264170 Binding of BIRC2 1 0.01 1.19 0.08
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