GO:0006939

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Name smooth muscle contraction
Categary Process
Go Slim No
Go Link GO:0006939
Unique Molecular Interactions 363
Total Molecular Interactions 513
Total Single Events 4959
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
2 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
3 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
4 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
5 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
6 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
7 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
8 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
9 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
10 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
11 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
12 INT45423 Avp Positive_regulation of Localization of Prl 4 0.67 1.37 1.98
13 INT166947 Ngf Positive_regulation of KNG1 1 0.00 0.47 1.86
14 INT40239 Penk Regulation of Avp 1 0.07 0 1.84
15 INT117269 Binding of Avp and Prl 1 0.25 0.47 1.8
16 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
17 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
18 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
19 INT140009 Avp Positive_regulation of Gene_expression of Penk 1 0.40 0.77 1.64
20 INT140023 Avp Positive_regulation of Gene_expression of Kitl 1 0.00 0.76 1.62
21 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
22 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
23 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 0.07 0.85 1.52
24 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
25 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
26 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
27 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
28 INT61443 Binding of KNG1 and Tyr 1 0.00 0 1.46
29 INT45307 ENG Positive_regulation of Localization of Avp 1 0.00 0 1.45
30 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
31 INT5534 Binding of Oxt and Avp 7 0.04 0.6 1.43
32 INT142490 Avp Regulation of Oxt 1 0.09 0.74 1.4
33 INT140021 Avp Positive_regulation of Pag1 1 0.03 0.85 1.38
34 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 0.04 0.85 1.38
35 INT140020 Avp Positive_regulation of Localization of Pag1 1 0.03 0.85 1.38
36 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
37 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
38 INT121457 KNG1 Positive_regulation of Trpv1 1 0.16 0.91 1.33
39 INT140010 Avp Regulation of Gene_expression of Penk 1 0.25 0.58 1.19
40 INT75126 Pnoc Regulation of Localization of Avp 2 0.26 0.24 1.18
41 INT27621 Avp Positive_regulation of Protein_catabolism of Mbis1 1 0.00 0 1.18
42 INT140022 Avp Regulation of Localization of Pag1 1 0.01 0.57 1.17
43 INT43509 Avp Positive_regulation of Localization of POMC 2 0.13 1.26 1.16
44 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
45 INT164722 Avp Regulation of NT5C 1 0.06 0.88 1.15
46 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
47 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
48 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
49 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
50 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
51 INT73681 Regulation of KNG1 Positive_regulation of ALB 1 0.30 0.38 0.99
52 INT85320 Binding of Avp and Vas1 1 0.00 0.87 0.98
53 INT73680 KNG1 Positive_regulation of ALB 1 0.51 0.38 0.98
54 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
55 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
56 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
57 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
58 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96
59 INT93234 Negative_regulation of Pde4b Negative_regulation of Gene_expression of Fos 1 0.41 0.1 0.96
60 INT66714 Negative_regulation of Binding of BDKRB1 and KNG1 1 0.13 0.22 0.96
61 INT43454 Pomc Regulation of Localization of Avp 2 0.24 0.89 0.94
62 INT51542 Negative_regulation of Binding of Avp and Penk 1 0.46 0.05 0.94
63 INT51541 Positive_regulation of Binding of Avp and Penk 1 0.74 0.05 0.94
64 INT51545 Binding of Avp and Penk 1 0.51 0.05 0.94
65 INT64127 Igfbp2 Regulation of Localization of Avp 1 0.39 0.19 0.9
66 INT84369 Ngf Positive_regulation of KNG1 1 0.04 0.29 0.89
67 INT96008 Binding of KNG1 and EBP 1 0.01 0.15 0.88
68 INT96010 KNG1 Positive_regulation of Binding of MTG1 1 0.32 0.15 0.88
69 INT96009 KNG1 Positive_regulation of MTG1 1 0.32 0.15 0.88
70 INT121467 Binding of Avp and Ptafr 1 0.11 0.98 0.88
71 INT26529 Prl Regulation of Avp 1 0.08 0.26 0.85
72 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
73 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
74 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84
75 INT225690 KNG1 Positive_regulation of TRPV1 1 0.42 0.7 0.83
76 INT193322 KNG1 Positive_regulation of Prh1 1 0.00 0.51 0.83
77 INT16436 Ubqln1 Regulation of Localization of Avp 1 0.01 0 0.81
78 INT16439 Atp6v0d2 Regulation of Localization of Avp 1 0.02 0 0.81
79 INT78348 Binding of GALR1 and GAL 4 0.41 1.47 0.8
80 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
81 INT150636 Binding of KNG1 and CD177 1 0.10 0.37 0.79
82 INT9527 Avp Positive_regulation of Localization of Pomc 7 0.58 0.29 0.77
83 INT129415 KNG1 Positive_regulation of Trpv1 1 0.05 0.39 0.76
84 INT147251 Binding of Avp and Gal 1 0.15 0.19 0.76
85 INT107028 KNG1 Regulation of Des 1 0.01 1.7 0.76
86 INT12396 Binding of Avp and IGKV1-5 3 0.04 1.38 0.75
87 INT332699 Binding of KNG1 and TRGC1 1 0.16 3.37 0.75
88 INT45305 Pomc Positive_regulation of Localization of Avp 1 0.12 0 0.73
89 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
90 INT121458 KNG1 Positive_regulation of Localization of Trpv1 1 0.16 0.43 0.69
91 INT303691 KNG1 Positive_regulation of AHR 1 0.03 0.98 0.69
92 INT164713 Binding of Avp and Positive_regulation of Localization of Acot1 1 0.32 0.43 0.69
93 INT164715 Avp Positive_regulation of Localization of Acot1 1 0.28 0.43 0.69
94 INT303689 Regulation of KNG1 Positive_regulation of AHR 1 0.03 0.99 0.69
95 INT48032 Binding of Avp and Pebp1 1 0.00 0 0.68
96 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
97 INT11611 Cck Positive_regulation of Localization of Avp 1 0.09 0 0.67
98 INT11612 Cck Positive_regulation of Avp 1 0.10 0 0.67
99 INT164723 Binding of Avp and NT5C 1 0.07 0.45 0.65
100 INT95546 KNG1 Positive_regulation of Ptgir 1 0.02 0.93 0.64
101 INT164714 Binding of Avp and Acot1 1 0.26 0.45 0.64
102 INT48033 Binding of Avp and LH 1 0.08 0 0.64
103 INT96472 KNG1 Positive_regulation of Gene_expression of TRPV1 1 0.01 0.22 0.64
104 INT154263 NEUROD1 Positive_regulation of Gene_expression of GAL 1 0.50 0.06 0.63
105 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
106 INT34005 YY1 Regulation of KNG1 1 0.04 0.38 0.63
107 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
108 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
109 INT121460 KNG1 Positive_regulation of Bdkrb2 1 0.08 0.44 0.62
110 INT121459 Bdkrb2 Positive_regulation of KNG1 1 0.09 0.44 0.62
111 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
112 INT32747 Avp Positive_regulation of Localization of Pomc 4 0.16 1.92 0.61
113 INT27067 Crh Positive_regulation of Localization of Avp 3 0.18 0.46 0.61
114 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61
115 INT152766 TAT Positive_regulation of Positive_regulation of MYLK 1 0.44 0.67 0.61
116 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
117 INT37555 FDX1 Positive_regulation of Regulation of Avp 1 0.04 0 0.61
118 INT34840 Binding of KNG1 and PDYN 1 0.01 0 0.61
119 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
120 INT152765 TAT Regulation of Positive_regulation of MYLK 1 0.40 0.66 0.6
121 INT109803 Binding of Avp and Oprl1 1 0.07 0.1 0.59
122 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
123 INT120347 Binding of KNG1 and MYC 1 0.21 0.17 0.58
124 INT94506 Tnf Positive_regulation of Gene_expression of Avp 1 0.31 0.98 0.57
125 INT14387 GAL Regulation of TAC1 1 0.10 0 0.56
126 INT126641 Binding of KNG1 and Bdkrb2 1 0.11 0.42 0.55
127 INT255463 Binding of Avp and Avpr1a 1 0.06 0.67 0.54
128 INT75129 Pnoc Negative_regulation of Avp 1 0.13 0 0.54
129 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
130 INT303721 KNG1 Positive_regulation of Bdkrb1 1 0.05 0.75 0.52
131 INT172248 Binding of KNG1 and NCOR2 1 0.02 0.19 0.52
132 INT303722 KNG1 Positive_regulation of Bdkrb2 1 0.01 0.7 0.52
133 INT24869 GAL Regulation of Localization of Gh 1 0.19 0.4 0.51
134 INT33415 KNG1 Positive_regulation of GBP1 1 0.02 0.43 0.51
135 INT49150 GAL Regulation of Localization of Gnrhr 1 0.00 0.09 0.51
136 INT55553 Avp Regulation of Serpina6 1 0.02 0 0.49
137 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
138 INT47141 Creg2-ps1 Positive_regulation of Avp 1 0.01 0 0.48
139 INT47142 Negative_regulation of Creg2-ps1 Positive_regulation of Avp 1 0.01 0 0.48
140 INT66801 Oxt Regulation of Localization of Avp 1 0.08 0 0.48
141 INT61848 Npff Regulation of Localization of Avp 1 0.26 0.3 0.48
142 INT59546 Avp Positive_regulation of Localization of Crh 1 0.05 0.08 0.47
143 INT16677 Binding of Avp and Oprd1 1 0.02 0.8 0.47
144 INT58663 Binding of KNG1 and Ugt1a2 1 0.02 0.4 0.47
145 INT59548 Negative_regulation of Avp Positive_regulation of Crh 1 0.04 0.08 0.47
146 INT71839 Chrm3 Positive_regulation of Qrfp 1 0.09 0 0.47
147 INT175788 Il2 Positive_regulation of Localization of Avp 1 0.03 0.41 0.46
148 INT27065 Kndc1 Positive_regulation of Localization of Avp 1 0.00 0 0.46
149 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45
150 INT43453 Pomc Negative_regulation of Localization of Avp 1 0.38 0.82 0.45
151 INT96245 Negative_regulation of Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
152 INT349686 Nmu Positive_regulation of Nmur1 1 0.36 0.2 0.45
153 INT96246 Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
154 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
155 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
156 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
157 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
158 INT69173 Avp Positive_regulation of Oxt 1 0.18 0 0.42
159 INT201120 Binding of KNG1 and Par2 1 0.00 0.3 0.42
160 INT61345 Iapp Regulation of GAL 2 0.08 0.35 0.41
161 INT290269 KNG1 Positive_regulation of Binding of MID1 1 0.02 1.06 0.41
162 INT290270 KNG1 Positive_regulation of MID1 1 0.02 1.06 0.41
163 INT85511 Binding of KNG1 and Bdkrb2 1 0.54 0.51 0.4
164 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
165 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
166 INT152164 Binding of GALR3 and GAL 2 0.31 0.88 0.39
167 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39
168 INT24755 GAL Regulation of Regulation of Calca 1 0.16 0 0.38
169 INT40395 Ins1 Positive_regulation of Localization of Avp 1 0.16 0.09 0.38
170 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
171 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
172 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
173 INT26552 Gene_expression of Mras Positive_regulation of Gene_expression of KNG1 1 0.03 0.07 0.36
174 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
175 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35
176 INT84600 Binding of Avp and Aqp2 1 0.17 0 0.35
177 INT136008 Binding of BDKRB2 and INSRR 1 0.01 0.17 0.34
178 INT37552 Crh Regulation of Avp 1 0.22 0 0.34
179 INT37551 Positive_regulation of Crh Regulation of Avp 1 0.38 0 0.34
180 INT37554 Avp Regulation of FDX1 1 0.01 0 0.34
181 INT136007 Binding of INSRR and KNG1 1 0.00 0.17 0.34
182 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33
183 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
184 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
185 INT35216 Binding of KNG1 and Thop1 1 0.01 0 0.32
186 INT337327 KNG1 Positive_regulation of BDKRB2 1 0.21 0.4 0.32
187 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
188 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
189 INT196618 Binding of KNG1 and Positive_regulation of NA 1 0.01 0.19 0.32
190 INT196623 Binding of KNG1 and Positive_regulation of DNAH8 1 0.01 0.19 0.32
191 INT170994 KNG1 Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.32
192 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
193 INT66908 Il1b Positive_regulation of Localization of Avp 1 0.36 0.49 0.31
194 INT31275 Avp Negative_regulation of Cpe 1 0.00 0 0.31
195 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
196 INT15263 Gal Regulation of Localization of Avp 1 0.67 0 0.3
197 INT66243 KNG1 Positive_regulation of Ptgis 1 0.01 0 0.3
198 INT44984 KNG1 Regulation of Ltc4s 1 0.01 0.17 0.3
199 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
200 INT196641 Binding of KNG1 and Negative_regulation of DNAH8 1 0.01 0.19 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT477 Localization of Avp 813 0.81 131.58 300.4
2 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
3 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
4 INT4207 Regulation of Avp 267 0.62 63.72 115.33
5 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
6 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
7 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
8 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66
9 INT7134 Localization of KNG1 127 0.79 65.73 67.97
10 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
11 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74
12 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23
13 INT894 Binding of Avp 84 0.48 29.16 29.63
14 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02
15 INT3076 Regulation of KNG1 52 0.60 20.39 27.89
16 INT3167 Binding of KNG1 48 0.48 23.26 26.77
17 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
18 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
19 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96
20 INT5499 Transcription of Avp 52 0.72 7.98 19.87
21 INT4866 Positive_regulation of GAL 32 0.67 13.02 16.16
22 INT7587 Localization of GAL 27 0.78 4.79 14.29
23 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19
24 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
25 INT13743 Regulation of Gene_expression of Avp 30 0.62 6.9 11.66
26 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
27 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47
28 INT15262 Negative_regulation of Positive_regulation of Avp 22 0.58 3.28 10.81
29 INT4867 Positive_regulation of Gene_expression of GAL 17 0.70 6.65 8.28
30 INT13739 Positive_regulation of Positive_regulation of Avp 18 0.70 4.78 8.2
31 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98
32 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
33 INT89309 Negative_regulation of Pde4b 21 0.53 12.81 7.32
34 INT66811 Positive_regulation of Transcription of Avp 11 0.70 2.1 6.46
35 INT7138 Regulation of Regulation of Avp 10 0.36 1.99 6.37
36 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73
37 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5
38 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
39 INT21380 Regulation of Transcription of Avp 10 0.62 2.6 5.46
40 INT49149 Transcription of GAL 9 0.67 2.18 5.39
41 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39
42 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
43 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
44 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05
45 INT23638 Negative_regulation of GAL 17 0.42 5.68 5.04
46 INT58750 Binding of GAL 16 0.47 5.48 4.92
47 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9
48 INT49217 Positive_regulation of Positive_regulation of KNG1 7 0.41 3.64 4.18
49 INT14439 Regulation of GAL 12 0.61 2.25 4.02
50 INT105779 Gene_expression of Pde4b 7 0.73 3.33 3.91
51 INT220078 Positive_regulation of Negative_regulation of KNG1 3 0.13 5.03 3.41
52 INT53347 Localization of BDKRB2 5 0.75 4.96 3.39
53 INT18838 Positive_regulation of Regulation of Avp 3 0.47 0.48 3.32
54 INT30131 Positive_regulation of Negative_regulation of Avp 5 0.50 1.94 3.3
55 INT61347 Positive_regulation of Localization of GAL 4 0.49 1.06 3.15
56 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11
57 INT19553 Negative_regulation of Regulation of Avp 5 0.43 1.74 3.06
58 INT53348 Binding of BDKRB2 7 0.37 2.85 3
59 INT48651 Regulation of Gene_expression of GAL 7 0.61 2.95 2.63
60 INT48654 Negative_regulation of Gene_expression of GAL 5 0.42 2.14 2.56
61 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
62 INT1216 Negative_regulation of Pde4b 9 0.41 2.65 2.5
63 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
64 INT79402 Gene_expression of Pde4b 7 0.74 3 2.38
65 INT135925 Regulation of Pde4b 5 0.41 1.58 2.24
66 INT19286 Negative_regulation of Cacna1c 11 0.46 5.12 2.22
67 INT150640 Regulation of Binding of KNG1 3 0.35 1.31 2.2
68 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17
69 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
70 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
71 INT112368 Positive_regulation of Cacna1c 8 0.46 2.94 1.97
72 INT88375 Negative_regulation of Localization of KNG1 4 0.39 1.12 1.91
73 INT895 Negative_regulation of Binding of Avp 7 0.55 2.45 1.9
74 INT62349 Negative_regulation of Protein_catabolism of KNG1 8 0.42 6.47 1.86
75 INT135928 Positive_regulation of Binding of Pde4b 3 0.45 0.18 1.81
76 INT79401 Regulation of Gene_expression of Pde4b 4 0.59 1.26 1.8
77 INT106091 Negative_regulation of Transcription of Avp 4 0.59 0.23 1.72
78 INT135929 Positive_regulation of Pde4b 3 0.47 0.09 1.7
79 INT74818 Transcription of KNG1 6 0.67 2.71 1.59
80 INT91739 Positive_regulation of MYLK 9 0.54 2.89 1.58
81 INT123076 Gene_expression of Cacna1c 7 0.37 1.91 1.56
82 INT107132 Regulation of Localization of KNG1 2 0.22 0.96 1.55
83 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
84 INT15048 Regulation of Cacna1c 4 0.29 3.26 1.47
85 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44
86 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
87 INT135932 Regulation of Gene_expression of Pde4b 1 0.58 0 1.37
88 INT132915 Phosphorylation of GAL 1 0.61 0 1.36
89 INT37076 Negative_regulation of Binding of KNG1 3 0.14 1.77 1.32
90 INT77752 Binding of Cacna1c 3 0.22 0.22 1.31
91 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
92 INT120406 Positive_regulation of Positive_regulation of BDKRB2 2 0.27 1.48 1.28
93 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
94 INT135926 Binding of Pde4b 5 0.34 0.93 1.21
95 INT74849 Positive_regulation of Chrm3 5 0.64 1.71 1.2
96 INT40345 Positive_regulation of Pde4b 5 0.67 2.96 1.19
97 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13
98 INT79407 Positive_regulation of Gene_expression of Pde4b 1 0.67 0.38 1.13
99 INT105778 Negative_regulation of Gene_expression of Pde4b 3 0.38 1.05 1.1
100 INT66452 Positive_regulation of Cacna1c 6 0.19 2.56 1.08
101 INT150638 Positive_regulation of Binding of KNG1 1 0.39 0.24 1.07
102 INT10625 Regulation of Positive_regulation of Avp 4 0.44 1.06 1.04
103 INT25718 Negative_regulation of Negative_regulation of Avp 4 0.58 0.5 1.02
104 INT68844 Regulation of Positive_regulation of KNG1 2 0.44 2.22 1.02
105 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
106 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
107 INT78935 Localization of Cacna1c 3 0.48 1.25 0.97
108 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96
109 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
110 INT191530 Regulation of Gene_expression of KNG1 4 0.26 0.71 0.96
111 INT114340 Positive_regulation of Protein_catabolism of KNG1 5 0.07 2.42 0.92
112 INT148401 Regulation of Chrm3 3 0.19 1.19 0.91
113 INT1217 Regulation of Pde4b 1 0.06 0 0.9
114 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
115 INT73950 Negative_regulation of Chrm3 1 0.41 0 0.88
116 INT58753 Positive_regulation of Binding of GAL 1 0.49 0.57 0.85
117 INT239234 Regulation of Protein_catabolism of KNG1 2 0.09 1.06 0.82
118 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
119 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
120 INT48653 Positive_regulation of Positive_regulation of GAL 2 0.49 0.14 0.8
121 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
122 INT290271 Negative_regulation of Binding of BDKRB2 1 0.37 0.99 0.76
123 INT16676 Regulation of Negative_regulation of Avp 2 0.45 1.03 0.75
124 INT72756 Protein_catabolism of GAL 1 0.50 0.36 0.75
125 INT127487 Phosphorylation of KNG1 2 0.34 0.47 0.74
126 INT123075 Positive_regulation of Gene_expression of Cacna1c 1 0.05 0.73 0.73
127 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69
128 INT222919 Regulation of Negative_regulation of Pde4b 2 0.41 2.35 0.67
129 INT149689 Binding of Chrm3 3 0.24 1.54 0.65
130 INT50073 Negative_regulation of Negative_regulation of GAL 1 0.35 0.14 0.65
131 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
132 INT55662 Negative_regulation of Negative_regulation of KNG1 4 0.36 3.45 0.57
133 INT104335 Localization of Chrm3 2 0.62 0.58 0.57
134 INT79398 Transcription of Pde4b 1 0.51 0.18 0.57
135 INT79403 Positive_regulation of Transcription of Pde4b 1 0.45 0.18 0.57
136 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
137 INT172502 Binding of Chrm3 2 0.08 3.3 0.53
138 INT186686 Regulation of Positive_regulation of EDNRA 5 0.22 2.35 0.51
139 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
140 INT104336 Positive_regulation of Localization of Chrm3 1 0.38 0.14 0.5
141 INT159387 Binding of Nmur1 1 0.29 0.43 0.5
142 INT120405 Phosphorylation of EDNRA 1 0.61 0.38 0.48
143 INT158057 Positive_regulation of Positive_regulation of EDNRA 2 0.15 0 0.41
144 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
145 INT273326 Transcription of Pde4b 3 0.62 0.99 0.38
146 INT121073 Gene_expression of NMUR1 2 0.15 0.85 0.35
147 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
148 INT33569 Gene_expression of MYLK 6 0.25 2.56 0.34
149 INT111674 Phosphorylation of MYLK 3 0.81 0.35 0.33
150 INT41233 Regulation of Binding of Avp 1 0.24 0.33 0.32
151 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31
152 INT8449 Positive_regulation of Phosphorylation of Mylk 1 0.05 0.16 0.3
153 INT8448 Phosphorylation of Mylk 1 0.07 0.16 0.3
154 INT74817 Positive_regulation of Transcription of KNG1 1 0.49 0.18 0.3
155 INT185436 Gene_expression of ROCK1 5 0.52 6.85 0.29
156 INT350970 Negative_regulation of Binding of EDNRA 1 0.41 0.86 0.29
157 INT232444 Regulation of Localization of GAL 1 0.44 0.28 0.27
158 INT24992 Regulation of Mylk 2 0.20 0.4 0.26
159 INT78350 Negative_regulation of Binding of GAL 1 0.41 0.07 0.26
160 INT273339 Positive_regulation of Localization of Pde4b 1 0.45 0.7 0.25
161 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
162 INT273348 Localization of Pde4b 1 0.68 0.66 0.24
163 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
164 INT101742 Regulation of Cacna1c 3 0.22 1.35 0.23
165 INT258250 Positive_regulation of ROCK1 7 0.51 2.07 0.22
166 INT185443 Regulation of ROCK1 4 0.18 3.32 0.21
167 INT61348 Negative_regulation of Regulation of GAL 1 0.41 0 0.21
168 INT316230 Negative_regulation of Localization of BDKRB2 1 0.21 0.92 0.21
169 INT188310 Binding of Pde4b 2 0.06 0.77 0.18
170 INT72023 Positive_regulation of Localization of EDNRA 1 0.02 0.07 0.18
171 INT224030 Localization of Cacna1c 1 0.01 2.01 0.18
172 INT72025 Negative_regulation of Localization of EDNRA 1 0.01 0.07 0.18
173 INT101741 Binding of Cacna1c 3 0.28 1.49 0.17
174 INT173335 Negative_regulation of Gene_expression of EDNRA 2 0.19 0.71 0.17
175 INT273332 Positive_regulation of Negative_regulation of Pde4b 1 0.45 0.49 0.17
176 INT273346 Positive_regulation of Gene_expression of Pde4b 1 0.45 0.47 0.16
177 INT216261 Regulation of Gene_expression of Cacna1c 3 0.25 1.12 0.15
178 INT164831 Negative_regulation of Mylk 1 0.49 0.07 0.15
179 INT8094 Positive_regulation of Gene_expression of BDKRB2 1 0.12 1.02 0.15
180 INT172309 Binding of NMUR1 1 0.35 0 0.14
181 INT199810 Positive_regulation of Gene_expression of Cacna1c 2 0.43 0.81 0.13
182 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
183 INT61708 Positive_regulation of Regulation of GAL 1 0.06 0 0.13
184 INT48652 Regulation of Regulation of GAL 1 0.26 0 0.13
185 INT70908 Transcription of EDNRA 1 0.08 0.33 0.12
186 INT250736 Protein_catabolism of Cacna1c 1 0.14 0.06 0.12
187 INT70906 Negative_regulation of Transcription of EDNRA 1 0.05 0.33 0.12
188 INT172390 Negative_regulation of Gene_expression of Cacna1c 2 0.17 2.33 0.11
189 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
190 INT303728 Gene_expression of Chrm3 1 0.14 0.98 0.09
191 INT303727 Positive_regulation of Gene_expression of Chrm3 1 0.10 0.99 0.09
192 INT173322 Negative_regulation of Gene_expression of MYLK 1 0.14 0.14 0.09
193 INT307773 Regulation of Negative_regulation of KNG1 1 0.01 3.59 0.09
194 INT316232 Positive_regulation of Transcription of BDKRB2 1 0.23 0.7 0.09
195 INT316235 Transcription of BDKRB2 1 0.26 0.7 0.09
196 INT173327 Positive_regulation of Gene_expression of MYLK 1 0.22 0.24 0.07
197 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
198 INT348719 Positive_regulation of Mylk 1 0.20 0.4 0.05
199 INT170506 Positive_regulation of Positive_regulation of Cacna1c 1 0.04 0.09 0.05
200 INT207668 Binding of Chrnb4 1 0.27 0 0.05
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