GO:0006941

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Name striated muscle contraction
Categary Process
Go Slim No
Go Link GO:0006941
Unique Molecular Interactions 112
Total Molecular Interactions 143
Total Single Events 1873
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for striated muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for striated muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
3 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
4 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
5 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
6 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
7 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
8 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
9 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
10 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
11 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
12 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
13 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
14 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
15 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
16 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
17 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
18 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
19 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
20 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
21 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
22 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
23 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
24 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
25 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
26 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
27 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
28 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
29 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
30 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
31 INT89875 Pdyn Positive_regulation of Localization of Myh6 1 0.09 0 0.66
32 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
33 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
34 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
35 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
36 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
37 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
38 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
39 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
40 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
41 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
42 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
43 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
44 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
45 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
46 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
47 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
48 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
49 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
50 INT304497 Mknk1 Positive_regulation of Nos1 1 0.19 0.53 0.3
51 INT304504 Mapk1 Positive_regulation of Nos1 1 0.29 0.93 0.3
52 INT77753 Abnormal Regulation of CACNA1S 1 0.00 0.78 0.28
53 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
54 INT311533 ROS1 Positive_regulation of Positive_regulation of RYR3 1 0.28 0.18 0.26
55 INT242763 Olr1746 Negative_regulation of Nos1 1 0.02 0.97 0.26
56 INT311532 ROS1 Regulation of RYR3 1 0.43 0.18 0.25
57 INT126227 Hsp90aa1 Positive_regulation of Nos1 1 0.03 0.73 0.25
58 INT328707 Trat1 Negative_regulation of Nos1 1 0.02 2.32 0.24
59 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 0.03 0.07 0.24
60 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
61 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
62 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
63 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2
64 INT257218 Camk1 Negative_regulation of Nos1 1 0.04 0.09 0.19
65 INT291788 ALDOA Positive_regulation of Gnat3 2 0.02 0.52 0.18
66 INT222661 IFNA1 Positive_regulation of Gene_expression of Nos1 1 0.01 0.25 0.18
67 INT330433 ALDOA Positive_regulation of esterase 1 0.00 0.46 0.17
68 INT330430 ALDOA Positive_regulation of Pcyt2 1 0.01 0.47 0.17
69 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16
70 INT304503 Map2k1 Positive_regulation of Nos1 1 0.07 0.66 0.16
71 INT71383 Vip Positive_regulation of Nos1 1 0.01 0.09 0.16
72 INT257230 Binding of CALM1 and Nos1 1 0.00 0 0.15
73 INT304496 Mknk1 Positive_regulation of Gene_expression of Nos1 1 0.19 0.18 0.15
74 INT78662 Dlst Positive_regulation of Gene_expression of Nos1 1 0.20 0.17 0.14
75 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
76 INT304502 Mknk1 Positive_regulation of Phosphorylation of Nos1 1 0.19 0.16 0.11
77 INT301144 Nos1 Regulation of Gene_expression of TNF 1 0.11 0.55 0.09
78 INT267998 Binding of XDH and Nos1 1 0.02 0.46 0.06
79 INT269501 Nos1 Regulation of Lta 1 0.28 0.26 0.05
80 INT291749 ALDOA Regulation of ALDH2 1 0.04 0 0.05
81 INT291750 ALDOA Positive_regulation of ALDH2 1 0.08 0 0.05
82 INT291757 ALDOA Negative_regulation of Positive_regulation of SGCB 1 0.01 0 0.04
83 INT291751 ALDOA Positive_regulation of PON1 1 0.01 0 0.04
84 INT291792 Regulation of Binding of ALDOA and Gnat3 1 0.02 0 0.04
85 INT291789 Binding of ALDOA and Gnat3 1 0.01 0 0.04
86 INT239338 Arg2 Positive_regulation of RCT 1 0.01 1.15 0.03
87 INT291756 ALDH2 Positive_regulation of ALDOA 1 0.06 0 0.03
88 INT291783 ALDOA Regulation of Gnat3 1 0.01 0 0
89 INT330432 ALDOA Positive_regulation of Binding of Aldh2 1 0.03 0.43 0
90 INT291753 ALDOA Positive_regulation of ALDH1A1 1 0.00 0 0
91 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
92 INT117647 Agt Regulation of Nos1 1 0.19 0.13 0
93 INT322246 Binding of Hcm and Tnni3 1 0.11 0.86 0
94 INT278761 Binding of KBTBD10 and GOPC 1 0.14 0 0
95 INT291754 ALDOA Negative_regulation of ALDH2 1 0.07 0 0
96 INT315669 Binding of Nes and Nos1 1 0.20 0 0
97 INT249937 Nos1 Regulation of Nos3 1 0.23 0.19 0
98 INT278753 NUP98 Positive_regulation of KBTBD10 1 0.45 0 0
99 INT314986 Ins1 Negative_regulation of CACNA1S 1 0.00 0.08 0
100 INT278758 OR51S1 Positive_regulation of KBTBD10 1 0.01 0 0
101 INT278770 Binding of NUP98 and KBTBD10 1 0.35 0 0
102 INT231168 Binding of Dmd and Nos1 1 0.11 0.06 0
103 INT323279 Binding of Nos3 and Arg2 1 0.01 0.67 0
104 INT330434 ALDOA Positive_regulation of Aldh2 1 0.03 0.38 0
105 INT269500 Lta Positive_regulation of Protein_catabolism of Nos1 1 0.29 0.65 0
106 INT330431 Binding of ALDOA and Aldh2 1 0.03 0 0
107 INT249934 Nos1 Regulation of Nos2 1 0.20 0.19 0
108 INT278757 HOXA9 Positive_regulation of KBTBD10 1 0.42 0 0
109 INT291755 ALDOA Negative_regulation of PON1 1 0.00 0 0
110 INT278764 Binding of HOXA9 and KBTBD10 1 0.34 0 0
111 INT269503 Lta Regulation of Nos1 1 0.44 1.3 0
112 INT168246 Pomgnt1 Positive_regulation of Transcription of Nos1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for striated muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in striated muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
3 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
4 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
5 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
6 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
7 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
8 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
9 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
10 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
11 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
12 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
13 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
14 INT80251 Binding of Nos1 21 0.30 8.24 11.31
15 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
16 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
17 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
18 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
19 INT71381 Localization of Nos1 33 0.79 11.46 8.05
20 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
21 INT69499 Binding of Nos1 15 0.36 2.56 6.23
22 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
23 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
24 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
25 INT84673 Localization of Nos1 19 0.80 5.01 5.62
26 INT16923 Positive_regulation of Tnni3 32 0.50 25.01 5.44
27 INT50872 Positive_regulation of Tnni3 24 0.64 13.51 3.95
28 INT137702 Binding of TTN 7 0.35 4.48 3.62
29 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
30 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
31 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
32 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
33 INT89146 Localization of Tnni3 7 0.51 4.31 2.38
34 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
35 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
36 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
37 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
38 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
39 INT63959 Regulation of Tnni3 11 0.21 4.69 1.57
40 INT77383 Gene_expression of Tnni3 8 0.65 4.14 1.55
41 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
42 INT104636 Regulation of TTN 2 0.33 0 1.29
43 INT65324 Gene_expression of Tnni3 12 0.66 7.97 1.25
44 INT50873 Regulation of Tnni3 4 0.13 2.36 1.22
45 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
46 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
47 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
48 INT76471 Negative_regulation of Tnni3 5 0.09 1.51 0.98
49 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97
50 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
51 INT161775 Negative_regulation of Localization of Tnni3 1 0.23 0.85 0.86
52 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
53 INT68650 Negative_regulation of Tnni3 8 0.37 1.01 0.73
54 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
55 INT70104 Positive_regulation of CACNA1S 6 0.47 5.92 0.68
56 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
57 INT89870 Localization of Myh6 1 0.26 0 0.65
58 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
59 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
60 INT287853 Phosphorylation of Tnni3 1 0.63 0.87 0.56
61 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
62 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
63 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
64 INT65323 Positive_regulation of Positive_regulation of Tnni3 5 0.36 1.93 0.46
65 INT104414 Negative_regulation of Transcription of Nos1 1 0.42 0.96 0.38
66 INT133717 Positive_regulation of Gene_expression of Tnni3 1 0.11 0.54 0.36
67 INT133718 Negative_regulation of Positive_regulation of Tnni3 1 0.09 0.38 0.36
68 INT158967 Positive_regulation of Gene_expression of Tnni3 2 0.49 1.31 0.34
69 INT120320 Positive_regulation of Transcription of Nos1 3 0.46 0.58 0.29
70 INT239293 Gene_expression of Arg2 1 0.10 3.26 0.29
71 INT81901 Binding of Tnni3 2 0.07 0.62 0.27
72 INT107757 Regulation of Negative_regulation of Nos1 2 0.39 0 0.27
73 INT311550 Positive_regulation of Positive_regulation of RYR3 1 0.33 0.18 0.26
74 INT311547 Positive_regulation of RYR3 1 0.45 0.17 0.26
75 INT112278 Positive_regulation of Regulation of Nos1 4 0.38 0.99 0.25
76 INT105900 Regulation of Binding of Nos1 1 0.35 0.52 0.22
77 INT133634 Positive_regulation of Negative_regulation of Nos1 1 0.47 0.57 0.2
78 INT85574 Negative_regulation of Negative_regulation of Tnni3 1 0.29 0.1 0.19
79 INT68735 Binding of Arg2 2 0.05 0.22 0.17
80 INT50871 Positive_regulation of Positive_regulation of Tnni3 1 0.05 0.53 0.17
81 INT257203 Regulation of Phosphorylation of Nos1 1 0.15 0 0.17
82 INT91650 Binding of Tnni3 2 0.36 0.73 0.15
83 INT101021 Regulation of Positive_regulation of Tnni3 2 0.12 0.88 0.14
84 INT287860 Regulation of Phosphorylation of Tnni3 1 0.21 0.16 0.12
85 INT287850 Positive_regulation of Phosphorylation of Tnni3 1 0.54 0.09 0.11
86 INT355176 Regulation of Binding of TTN 1 0.29 0.78 0.09
87 INT100628 Localization of Tnni3 1 0.18 0.73 0.09
88 INT197520 Positive_regulation of Gene_expression of TTN 1 0.09 0 0.08
89 INT123164 Positive_regulation of Arg2 2 0.04 0.34 0.05
90 INT108117 Regulation of CACNA1S 1 0.39 0.25 0.05
91 INT123165 Positive_regulation of Positive_regulation of Arg2 1 0.01 0.34 0.05
92 INT291770 Gene_expression of ALDOA 6 0.10 1.49 0.04
93 INT291767 Positive_regulation of Gene_expression of ALDOA 2 0.07 1.5 0.04
94 INT100487 Negative_regulation of Binding of Nos1 1 0.28 0 0.04
95 INT207781 Gene_expression of CACNA1S 3 0.63 0.9 0.03
96 INT134689 Positive_regulation of ALDOA 3 0.26 0.07 0.03
97 INT265497 Positive_regulation of TTN 2 0.04 0 0.03
98 INT239276 Positive_regulation of Gene_expression of Arg2 1 0.09 1.1 0.03
99 INT291766 Negative_regulation of ALDOA 1 0.05 0 0.03
100 INT112277 Negative_regulation of Regulation of Nos1 1 0.35 0.33 0.03
101 INT207782 Binding of CACNA1S 1 0.30 0.53 0.03
102 INT109984 Positive_regulation of Localization of Nos1 2 0.39 0.86 0
103 INT239989 Gene_expression of Myh6 2 0.55 0 0
104 INT278782 Binding of KBTBD10 1 0.44 0 0
105 INT144505 Negative_regulation of Arg2 1 0.35 0 0
106 INT68274 Positive_regulation of Arg2 1 0.01 0 0
107 INT239982 Positive_regulation of Positive_regulation of Myh6 1 0.46 0 0
108 INT287835 Negative_regulation of Phosphorylation of Tnni3 1 0.33 0 0
109 INT197519 Positive_regulation of Regulation of TTN 1 0.09 0 0
110 INT239981 Positive_regulation of Myh6 1 0.46 0 0
111 INT139479 Protein_catabolism of Nos1 1 0.58 0.05 0
112 INT239986 Regulation of Myh6 1 0.25 0 0
113 INT323259 Gene_expression of Arg2 1 0.03 0.59 0
114 INT269497 Protein_catabolism of Nos1 1 0.57 0.64 0
115 INT330421 Binding of ALDOA 1 0.02 0 0
116 INT197522 Localization of TTN 1 0.14 0 0
117 INT278809 Positive_regulation of KBTBD10 1 0.63 0 0
118 INT291775 Localization of ALDOA 1 0.11 0 0
119 INT278804 Positive_regulation of Binding of KBTBD10 1 0.45 0 0
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