GO:0006953

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Name acute-phase response
Categary Process
Go Slim No
Go Link GO:0006953
Unique Molecular Interactions 1792
Total Molecular Interactions 2639
Total Single Events 26297
Pain Genes Associated 58

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for acute-phase response. They are ordered first by their pain relevance and then by number of times they were reported for acute-phase response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
2 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
3 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
4 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
5 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
6 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
7 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
8 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
9 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
10 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
11 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
12 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
13 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
14 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
15 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
16 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
17 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
18 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24
19 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
20 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
21 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
22 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
23 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
24 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
25 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
26 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
27 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
28 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
29 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
30 INT113550 Binding of FN1 and VTN 6 0.30 5.24 1.91
31 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
32 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
33 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
34 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
35 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
36 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
37 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
38 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
39 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
40 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
41 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
42 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
43 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
44 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
45 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
46 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
47 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
48 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
49 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
50 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
51 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
52 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
53 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
54 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
55 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
56 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
57 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
58 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
59 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
60 INT351205 VEGFA Positive_regulation of Binding of MRGPRX1 1 0.08 0.65 1.35
61 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
62 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
63 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
64 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
65 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
66 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
67 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
68 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
69 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
70 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
71 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
72 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2
73 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
74 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
75 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
76 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
77 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
78 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
79 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
80 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
81 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
82 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
83 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
84 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
85 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
86 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
87 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
88 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
89 INT116777 Psma5 Positive_regulation of Binding of Fn1 1 0.01 1.24 1.06
90 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
91 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
92 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
93 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
94 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
95 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
96 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
97 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
98 INT106706 POMC Negative_regulation of Binding of FN1 1 0.19 0.79 1.02
99 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
100 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
101 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
102 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
103 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
104 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
105 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99
106 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
107 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
108 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
109 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
110 INT275406 Binding of ITIH4 and Ccr5 1 0.09 2.88 0.97
111 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
112 INT275409 Binding of ITIH4 and Cxcr4 1 0.09 2.87 0.97
113 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
114 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
115 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
116 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
117 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
118 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
119 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
120 INT222979 Negative_regulation of Binding of COL1A1 and FN1 1 0.01 1.64 0.93
121 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
122 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
123 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
124 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92
125 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
126 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
127 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
128 INT222978 Binding of COL1A1 and FN1 1 0.01 1.64 0.92
129 INT128653 ITIH4 Regulation of Gene_expression of MIP 1 0.23 1.44 0.92
130 INT82120 IK Positive_regulation of CEBPB 1 0.00 0 0.92
131 INT134782 Il2rb Regulation of Gene_expression of Crp 1 0.00 1.16 0.92
132 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 0.00 0.67 0.92
133 INT138601 BCL2L2 Positive_regulation of F2 1 0.00 0.66 0.91
134 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
135 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
136 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
137 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
138 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
139 INT116771 Binding of MAVS and MRGPRX1 1 0.00 0.51 0.89
140 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89
141 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
142 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
143 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
144 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
145 INT224583 CSF2 Positive_regulation of IL1RN 1 0.02 1.3 0.88
146 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
147 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
148 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
149 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
150 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
151 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
152 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
153 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
154 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
155 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
156 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
157 INT107698 FN1 Positive_regulation of Gene_expression of CPOX 1 0.13 0.26 0.84
158 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
159 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
160 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
161 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
162 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
163 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
164 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
165 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
166 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
167 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
168 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
169 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
170 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
171 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
172 INT16507 Binding of LPA and Crp 1 0.00 0.78 0.78
173 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
174 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
175 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
176 INT16494 Binding of LPA and Serpinf2 1 0.00 0.78 0.78
177 INT16492 Positive_regulation of Binding of LPA and Serpinf2 1 0.00 0.78 0.78
178 INT16506 Positive_regulation of Binding of LPA and Crp 1 0.00 0.78 0.78
179 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
180 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
181 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
182 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
183 INT113546 Binding of FN1 and ITGA3 1 0.03 2.12 0.77
184 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
185 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
186 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
187 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
188 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
189 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
190 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
191 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
192 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
193 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
194 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73
195 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
196 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
197 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
198 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
199 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
200 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73

Single Events

The table below shows the top 100 pain related interactions that have been reported for acute-phase response. They are ordered first by their pain relevance and then by number of times they were reported in acute-phase response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT812 Localization of INS 1026 0.81 515.6 145.31
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
8 INT1026 Binding of Lbp 207 0.48 150.96 119.16
9 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03
10 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
11 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
12 INT12082 Localization of IL6 365 0.81 241.78 105.78
13 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74
14 INT19511 Localization of Il6 212 0.81 118.17 67.67
15 INT11937 Localization of Il6 228 0.81 139.83 64.39
16 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
17 INT9664 Binding of LBP 127 0.48 94.9 63.42
18 INT10706 Regulation of Il6 150 0.62 93.23 62.34
19 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62
20 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
21 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35
22 INT251 Regulation of INS 398 0.62 232.47 55.04
23 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
24 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
25 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
26 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
27 INT9210 Regulation of IL6 166 0.62 125.61 49.95
28 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
29 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
30 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
31 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
32 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
33 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33
34 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
35 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
36 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
37 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
38 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07
39 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
40 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
41 INT9655 Regulation of Il6 98 0.62 70.92 31.95
42 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
43 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
44 INT86437 Binding of IL6 154 0.48 121.22 29.3
45 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
46 INT100861 Binding of CRP 179 0.48 175.2 26.45
47 INT53482 Gene_expression of ITIH4 75 0.77 58.87 26.05
48 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9
49 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
50 INT1030 Localization of Lbp 52 0.74 38.92 24.91
51 INT23257 Regulation of CRP 127 0.62 100.05 21.87
52 INT51474 Binding of Il6 55 0.48 44.99 20.52
53 INT49985 Transcription of Il6 62 0.72 40.13 20.29
54 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99
55 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
56 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
57 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
58 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
59 INT61626 Transcription of IL6 73 0.72 42.04 17.86
60 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
61 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
62 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66
63 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
64 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
65 INT4977 Binding of ITIH4 60 0.46 42.48 15.65
66 INT106745 Localization of CRP 65 0.81 66.44 15.21
67 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
68 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
69 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
70 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
71 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
72 INT14572 Binding of INS 205 0.48 175.43 13.38
73 INT72565 Localization of IL1RN 45 0.80 23.59 13.17
74 INT54763 Binding of Il6 82 0.48 63.27 12.89
75 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
76 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
77 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
78 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63
79 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
80 INT87844 Binding of IL1RN 40 0.41 24.37 11.92
81 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89
82 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64
83 INT50933 Transcription of Il6 38 0.72 24.31 11.58
84 INT37390 Regulation of Crp 39 0.46 28.74 11.45
85 INT52625 Regulation of IL1RN 30 0.61 19.12 11.31
86 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
87 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99
88 INT4498 Gene_expression of F2 83 0.65 57.4 10.8
89 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
90 INT82854 Gene_expression of MRGPRX1 61 0.75 10.14 10.65
91 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
92 INT35612 Gene_expression of REG3A 37 0.78 33.33 10.13
93 INT57000 Localization of LBP 21 0.78 11.01 10.01
94 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93
95 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7
96 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
97 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
98 INT32624 Regulation of LBP 15 0.60 11.48 8.71
99 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
100 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56
101 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
102 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51
103 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
104 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
105 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07
106 INT15725 Positive_regulation of Fn1 17 0.67 14.93 8.03
107 INT2271 Gene_expression of F2 51 0.76 30.21 7.97
108 INT17996 Binding of Crp 40 0.37 31.4 7.8
109 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
110 INT80822 Positive_regulation of MRGPRX1 30 0.67 3.66 7.73
111 INT10284 Binding of ORM1 16 0.48 0.98 7.73
112 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58
113 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
114 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51
115 INT92755 Regulation of MRGPRX1 26 0.27 3.63 7.37
116 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33
117 INT717 Regulation of F2 29 0.61 17.46 6.99
118 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75
119 INT612 Positive_regulation of Orm1 15 0.68 5.24 6.73
120 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
121 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28
122 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
123 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
124 INT73902 Regulation of Gene_expression of IL1RN 6 0.61 4.59 6.14
125 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
126 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
127 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
128 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85
129 INT190298 Binding of MRGPRX1 61 0.46 2.66 5.75
130 INT29821 Gene_expression of Serpina1 18 0.60 2.98 5.75
131 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61
132 INT22839 Gene_expression of F2 31 0.74 15.53 5.56
133 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
134 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
135 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
136 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18
137 INT246031 Gene_expression of IL22 10 0.40 9.48 5.11
138 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1
139 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08
140 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
141 INT10889 Gene_expression of F8 60 0.78 41.36 5.06
142 INT73905 Transcription of IL1RN 10 0.71 9.16 5.04
143 INT84057 Positive_regulation of Gene_expression of ITIH4 12 0.50 10.5 4.92
144 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
145 INT92199 Negative_regulation of Gene_expression of IL1RN 14 0.58 10.11 4.71
146 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69
147 INT164171 Gene_expression of Cd163 18 0.49 12.45 4.63
148 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
149 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59
150 INT11106 Gene_expression of Lbp 10 0.67 10.29 4.52
151 INT47044 Positive_regulation of ORM1 5 0.68 0.58 4.46
152 INT9842 Binding of F2 36 0.47 22.79 4.42
153 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
154 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
155 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
156 INT57273 Positive_regulation of Gene_expression of FN1 26 0.47 17.83 4.2
157 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15
158 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
159 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07
160 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06
161 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
162 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
163 INT44323 Positive_regulation of F8 32 0.60 24.88 3.89
164 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87
165 INT51312 Positive_regulation of Gene_expression of SERPINA1 4 0.46 9.41 3.84
166 INT25464 Binding of SAA1 11 0.42 6.89 3.72
167 INT121818 Binding of STAT3 25 0.47 11.16 3.67
168 INT90406 Gene_expression of IL6R 27 0.38 15.74 3.64
169 INT174816 Binding of IL6R 14 0.09 11.26 3.63
170 INT133733 Positive_regulation of Localization of Lbp 6 0.43 9.19 3.61
171 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
172 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
173 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
174 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49
175 INT28802 Binding of F2 15 0.47 8.8 3.47
176 INT15827 Regulation of Fn1 8 0.54 4.67 3.47
177 INT63506 Localization of F2 21 0.77 7.53 3.41
178 INT11107 Binding of Lbp 12 0.42 4.42 3.41
179 INT8539 Negative_regulation of Serpina1a 21 0.58 12.65 3.39
180 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
181 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
182 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
183 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3
184 INT22092 Gene_expression of SERPINA3 17 0.75 11.57 3.16
185 INT61500 Binding of FN1 39 0.48 27.33 3.13
186 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
187 INT84354 Transcription of REG3A 6 0.53 5.05 3.1
188 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
189 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
190 INT97393 Localization of Stat3 11 0.75 7.33 3.01
191 INT68675 Regulation of APCS 10 0.62 7.61 3.01
192 INT62568 Positive_regulation of Positive_regulation of Crp 9 0.68 8.61 2.98
193 INT19293 Protein_catabolism of FN1 7 0.95 5.15 2.97
194 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
195 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
196 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
197 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
198 INT144524 Gene_expression of Mrgpra3 3 0.64 1.05 2.81
199 INT114753 Negative_regulation of Gene_expression of Crp 7 0.42 4.79 2.77
200 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75
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