GO:0006956

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Name complement activation
Categary Process
Go Slim No
Go Link GO:0006956
Unique Molecular Interactions 380
Total Molecular Interactions 548
Total Single Events 4128
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for complement activation. They are ordered first by their pain relevance and then by number of times they were reported for complement activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
2 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
3 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
4 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
5 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22
6 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
7 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17
8 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
9 INT83427 Binding of IGHG3 and FRTS 3 0.03 1.92 1.12
10 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
11 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
12 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
13 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
14 INT12396 Binding of Avp and IGKV1-5 3 0.04 1.38 0.75
15 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74
16 INT82759 Binding of IGHG3 and OPRM1 2 0.06 0 0.7
17 INT46964 C3 Positive_regulation of Tcm 1 0.00 1.26 0.66
18 INT30129 Binding of C3 and Gast 1 0.06 0.09 0.62
19 INT149479 CEBPD Positive_regulation of C3 1 0.30 0.14 0.57
20 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55
21 INT169648 IGHG3 Regulation of AQP4 3 0.02 4.63 0.55
22 INT270984 Slc6a3 Regulation of IGKC 1 0.02 0 0.53
23 INT125699 CR1 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0.64 0.53
24 INT59945 Binding of C2 and Srms 1 0.00 0 0.53
25 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53
26 INT313650 Binding of C8A and TRGC1 1 0.01 0.49 0.5
27 INT135378 Binding of Cfb and Oprk1 1 0.01 0.31 0.49
28 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
29 INT331731 Binding of C3 and CD79A 1 0.02 0.85 0.46
30 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
31 INT352387 Binding of CFP and HPSE 1 0.01 1.25 0.46
32 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46
33 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
34 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43
35 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
36 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
37 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41
38 INT328934 Binding of C2 and KIR2DS4 1 0.11 0.76 0.41
39 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38
40 INT93202 Binding of IGHG3 and Oprm1 1 0.02 0 0.35
41 INT112455 Binding of IGHG3 and UGT2B7 1 0.07 0 0.35
42 INT93201 Positive_regulation of Binding of IGHG3 and OPRM1 1 0.02 0 0.35
43 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
44 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
45 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34
46 INT155166 Binding of C2 and C3 1 0.40 0 0.34
47 INT320696 C5 Regulation of Gene_expression of TNF 1 0.34 2.15 0.34
48 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34
49 INT328932 TRGC1 Regulation of C2 1 0.03 0.92 0.31
50 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3
51 INT187113 Binding of IGHG3 and MMP9 1 0.01 0.63 0.3
52 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
53 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
54 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
55 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27
56 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27
57 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27
58 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
59 INT299745 Binding of Masp1 and IgG 1 0.03 0.69 0.26
60 INT341541 Binding of C1R and C1QL1 1 0.09 0.21 0.25
61 INT341532 Binding of C1R and TRGC1 1 0.04 0.21 0.25
62 INT322018 CR1 Negative_regulation of IL1B 1 0.00 0.17 0.25
63 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24
64 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
65 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23
66 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22
67 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
68 INT20392 FPR1 Positive_regulation of CR1 1 0.04 0.22 0.22
69 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
70 INT58306 C4A Regulation of Gene_expression of IL1B 1 0.00 0.15 0.21
71 INT58304 C4A Regulation of Localization of TNF 1 0.00 0.15 0.21
72 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
73 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2
74 INT244093 Binding of C2 and Arhgap4 3 0.23 0.38 0.19
75 INT181082 Binding of C3 and C3ar1 1 0.03 1.31 0.19
76 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19
77 INT183443 C7 Positive_regulation of POSTN 1 0.00 0 0.19
78 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19
79 INT277112 Binding of AMD1 and CFH 1 0.16 2.45 0.18
80 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17
81 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17
82 INT258340 Binding of Ms4a1 and Cfb 1 0.04 0.32 0.16
83 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16
84 INT344590 Binding of IFN1@ and C3 1 0.32 0.3 0.16
85 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15
86 INT37659 IGHG3 Negative_regulation of F2 1 0.06 0.79 0.15
87 INT116359 Positive_regulation of Binding of C4A and ELANE 1 0.14 0 0.15
88 INT293901 Positive_regulation of TYRP1 Regulation of IGKC 1 0.02 0.06 0.15
89 INT116357 Binding of C4A and ELANE 1 0.11 0 0.14
90 INT272776 CD40 Positive_regulation of Gene_expression of IGHG3 1 0.01 0.18 0.14
91 INT218499 Cfb Negative_regulation of ap 1 0.00 0.74 0.13
92 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13
93 INT185454 IGHG1 Negative_regulation of Timp1 1 0.04 0.85 0.13
94 INT185418 IGHG1 Negative_regulation of TIMP1 1 0.11 0.84 0.13
95 INT284215 Binding of C2 and Eclc 1 0.01 0.37 0.12
96 INT334870 Binding of C4b and Mpz 1 0.10 0 0.11
97 INT220905 Cfb Positive_regulation of C3 1 0.06 0.91 0.11
98 INT309662 C5 Positive_regulation of Akt1 1 0.30 0.43 0.11
99 INT334861 Positive_regulation of Binding of C4b and Mpz 1 0.13 0 0.11
100 INT281042 Serping1 Regulation of MBL2 1 0.01 0.74 0.11
101 INT279511 Binding of Serping1 and C1ra 1 0.01 0.3 0.11
102 INT306452 Binding of MBL2 and TLR4 1 0.38 0.37 0.1
103 INT306453 MBL2 Regulation of Binding of TLR4 1 0.48 0.37 0.1
104 INT281029 MASP2 Positive_regulation of C4A 1 0.00 0.72 0.1
105 INT332014 Binding of Cfi and Cfb 1 0.00 0.29 0.09
106 INT303759 IGHG3 Regulation of Localization of ROS1 1 0.07 0 0.09
107 INT16444 IGHG3 Negative_regulation of Binding of IL1A 1 0.11 0.42 0.09
108 INT35691 IGHG3 Positive_regulation of Gene_expression of SUPT7L 1 0.26 0.18 0.09
109 INT332019 Binding of C3ar1 and Cfb 1 0.03 0.29 0.09
110 INT189195 Binding of C4A and C4B 1 0.14 2.45 0.09
111 INT45452 Binding of C2 and C3 1 0.34 0.08 0.08
112 INT41832 Binding of ALB and C5 1 0.41 0.07 0.08
113 INT41831 Binding of ALB and C3 1 0.22 0.07 0.08
114 INT269508 Binding of HTN1 and CFP 1 0.00 0 0.08
115 INT291040 Binding of CFH and INS 1 0.25 1.32 0.08
116 INT37660 IGHG3 Negative_regulation of ANGPTL5 1 0.01 0.45 0.08
117 INT201227 C2 Regulation of CEBPZ 2 0.06 1.19 0.07
118 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07
119 INT266389 Binding of C2 and S100a6 1 0.04 0.5 0.07
120 INT279767 Binding of IGHG3 and KRT19 1 0.01 0.84 0.07
121 INT20393 Negative_regulation of FPR1 Positive_regulation of CR1 1 0.03 0.07 0.07
122 INT284210 Binding of C2 and Cd4 1 0.03 0.32 0.07
123 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07
124 INT225068 Binding of FCAR and IGHG3 1 0.02 0.27 0.07
125 INT249131 Positive_regulation of C2 Positive_regulation of CEBPZ 1 0.05 0.43 0.07
126 INT319001 Binding of IGHG3 and ACCS 1 0.00 1.76 0.07
127 INT187104 Binding of IGHG3 and TIMP1 1 0.01 0.22 0.07
128 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
129 INT262637 Binding of C2 and HLA-DOA 1 0.01 0.5 0.07
130 INT225064 Binding of IGHA1 and IGHG3 1 0.01 1.54 0.07
131 INT74033 Binding of IGHG3 and Ighg1 2 0.08 0.87 0.06
132 INT322013 Negative_regulation of CR1 Negative_regulation of IL1B 1 0.00 0 0.06
133 INT313649 C8A Regulation of ISYNA1 1 0.00 0.12 0.06
134 INT36476 C2 Negative_regulation of Positive_regulation of DPP3 1 0.46 0 0.06
135 INT320160 Binding of FCER2 and IGHG3 1 0.00 0.35 0.06
136 INT218511 Cfb Positive_regulation of C5 1 0.01 0.29 0.06
137 INT218503 Cfb Positive_regulation of C3 1 0.01 0.29 0.06
138 INT313652 C8A Regulation of CPOX 1 0.00 0.11 0.06
139 INT299703 ECB2 Negative_regulation of Binding of C5 1 0.00 0.39 0.06
140 INT229977 Binding of amd and Cfb 1 0.03 2.78 0.06
141 INT320161 Binding of IGHE and IGHG3 1 0.02 0.35 0.06
142 INT334868 Binding of C4b and Nfatc1 1 0.01 0 0.06
143 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06
144 INT229985 Binding of C2 and amd 1 0.01 1.89 0.06
145 INT278984 Binding of CFH and NCS1 1 0.02 0.63 0.05
146 INT275126 Binding of CSTB and IGHG3 1 0.00 0.49 0.05
147 INT189202 Binding of C4B and HAS2 1 0.02 1.25 0.05
148 INT136096 Binding of CFH and CFI 1 0.04 2.28 0.05
149 INT171543 IL4 Positive_regulation of Transcription of C3 1 0.28 0 0.05
150 INT171542 IL4 Positive_regulation of Gene_expression of C3 1 0.19 0 0.05
151 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05
152 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05
153 INT328668 Binding of CSF2 and IGHG3 1 0.03 0.59 0.05
154 INT16442 Binding of IGHG3 and IL1A 1 0.10 0.36 0.05
155 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04
156 INT209644 Binding of AR and C4B 1 0.00 0.32 0.04
157 INT279763 Binding of IGHG3 and KRT18 1 0.00 0.43 0.04
158 INT279764 Binding of IGHG3 and BTG3 1 0.00 0.3 0.04
159 INT189198 Binding of C4A and SERPINF1 1 0.12 1.17 0.04
160 INT232013 SERPING1 Negative_regulation of C1S 1 0.24 0.72 0.04
161 INT232012 SERPING1 Negative_regulation of C1R 1 0.18 0.72 0.04
162 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04
163 INT334497 Positive_regulation of IGHG3 Positive_regulation of IGHE 1 0.01 0.81 0.04
164 INT279536 Binding of C1QC and CRP 1 0.01 0.59 0.04
165 INT279531 Binding of LPA and MBL2 1 0.02 0.54 0.04
166 INT245216 Binding of C3 and C3AR1 1 0.19 1.21 0.04
167 INT334496 IGHG3 Positive_regulation of IGHE 1 0.01 0.75 0.04
168 INT279765 Binding of IGHG3 and KRT8 1 0.01 0.42 0.04
169 INT317417 Binding of CFH and MMP9 1 0.10 1.27 0.04
170 INT309727 Binding of C2 and GOPC 1 0.03 0 0.04
171 INT281652 GOPC Positive_regulation of C3 1 0.22 0.22 0.04
172 INT268909 Binding of TRGV9 and IGKV1-5 1 0.18 0.06 0.04
173 INT198595 Binding of CFH and CFHR1 3 0.41 1.36 0.03
174 INT334867 Binding of C4b and Sox10 1 0.04 0 0.03
175 INT320991 C5AR1 Regulation of C5 1 0.05 0 0.03
176 INT279538 Binding of C4B and Positive_regulation of ENPEP 1 0.00 0.48 0.03
177 INT313656 C8A Regulation of Gene_expression of ISYNA1 1 0.00 0.06 0.03
178 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
179 INT334872 Positive_regulation of Binding of C4b and Sox10 1 0.04 0 0.03
180 INT315437 Binding of IGHG3 and SEMA4B 1 0.19 0.12 0.03
181 INT279593 Binding of C4B and Cfb 1 0.00 1.18 0.03
182 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
183 INT289410 Binding of C3 and Cfb 1 0.01 0.36 0.03
184 INT315435 Negative_regulation of Binding of IGHG3 and SEMA4B 1 0.22 0.12 0.03
185 INT229983 Binding of CFH and Crp 2 0.14 1.48 0
186 INT336576 Binding of HCRTR1 and IGHG3 1 0.01 5.01 0
187 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0
188 INT279533 CFH Positive_regulation of C3 1 0.07 1.8 0
189 INT215432 Binding of IGHG3 and MSMB 1 0.01 0.96 0
190 INT232016 SERPING1 Regulation of C1S 1 0.15 0.57 0
191 INT229934 Binding of C3 and GPI 1 0.01 0 0
192 INT218506 Binding of LCN1 and Cfb 1 0.04 0.25 0
193 INT316354 Binding of CR1 and Gypa 1 0.05 0.43 0
194 INT300195 Binding of C1S and CHDH 1 0.23 2.51 0
195 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0
196 INT197761 Binding of KRT5 and C4a 1 0.02 2.29 0
197 INT194226 Binding of IGHG3 and SFSWAP 1 0.03 0.93 0
198 INT229921 CD55 Negative_regulation of C4B 1 0.11 0 0
199 INT299709 S100A12 Regulation of CFB 1 0.00 0.05 0
200 INT289413 Binding of C4A and Cfb 1 0.02 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for complement activation. They are ordered first by their pain relevance and then by number of times they were reported in complement activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33
2 INT756 Gene_expression of C3 138 0.75 100.6 19.2
3 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87
4 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18
5 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63
6 INT16449 Binding of IGHG3 67 0.48 39.55 10.59
7 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29
8 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05
9 INT32579 Binding of C4B 14 0.36 14.99 7.79
10 INT573 Negative_regulation of C3 60 0.59 41.37 7.78
11 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75
12 INT178198 Gene_expression of C3 62 0.78 39.5 7.69
13 INT1120 Gene_expression of C3 33 0.67 22.86 7.56
14 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37
15 INT57720 Localization of IGHG3 33 0.74 20.24 6.25
16 INT195 Gene_expression of C4a 16 0.48 15.55 6.1
17 INT44608 Gene_expression of C2 45 0.75 15.84 5.05
18 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74
19 INT140350 Binding of C2 17 0.36 3.97 4.69
20 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64
21 INT68789 Regulation of CFP 17 0.51 4.76 3.98
22 INT43931 Binding of CFH 49 0.48 31.85 3.96
23 INT6507 Binding of C5 23 0.48 15.35 3.91
24 INT7437 Gene_expression of CFP 21 0.65 4.93 3.89
25 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83
26 INT182676 Transcription of C4B 1 0.31 4.82 3.66
27 INT107074 Gene_expression of C5 14 0.75 9.87 3.64
28 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62
29 INT22270 Regulation of IGKV1-5 13 0.39 3.56 3.54
30 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52
31 INT27660 Binding of CFP 21 0.40 12.47 3.51
32 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36
33 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33
34 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3
35 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16
36 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89
37 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85
38 INT9460 Positive_regulation of C3 6 0.69 3.96 2.81
39 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79
40 INT64147 Gene_expression of C5 15 0.60 16.8 2.78
41 INT155160 Binding of C3 20 0.47 7.77 2.61
42 INT35407 Positive_regulation of C2 25 0.69 7.74 2.59
43 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49
44 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44
45 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42
46 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38
47 INT184378 Binding of Cfb 54 0.20 12.49 2.36
48 INT29094 Binding of C3 39 0.37 12.65 2.27
49 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23
50 INT3810 Regulation of CFHR1 7 0.38 1.19 2.13
51 INT55897 Positive_regulation of C4a 8 0.29 3.81 2.07
52 INT216065 Localization of C4B 2 0.21 2.86 2.01
53 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99
54 INT30531 Gene_expression of C2 15 0.66 5.5 1.99
55 INT35689 Localization of C3 17 0.75 5.3 1.98
56 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95
57 INT16385 Regulation of C3 20 0.41 9.98 1.92
58 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85
59 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84
60 INT53493 Negative_regulation of C6 3 0.53 2.68 1.77
61 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73
62 INT207035 Gene_expression of CFB 4 0.63 18.4 1.72
63 INT130730 Negative_regulation of C2 11 0.57 3.81 1.7
64 INT4217 Negative_regulation of Negative_regulation of IGHG3 3 0.11 0.69 1.7
65 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69
66 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62
67 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61
68 INT26426 Localization of C5 5 0.78 3.87 1.61
69 INT212790 Regulation of C5 6 0.24 6.04 1.59
70 INT102428 Binding of C2 17 0.32 5.12 1.58
71 INT247102 Binding of MBL2 16 0.38 14.18 1.54
72 INT182037 Localization of C3 10 0.68 6.69 1.54
73 INT279572 Gene_expression of MBL2 27 0.64 20.88 1.51
74 INT46389 Positive_regulation of Cfb 20 0.23 8.29 1.49
75 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41
76 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41
77 INT25621 Localization of Cfb 8 0.20 2.23 1.4
78 INT125980 Binding of CFD 8 0.42 10.96 1.39
79 INT10885 Negative_regulation of C3 9 0.38 11.86 1.35
80 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32
81 INT242105 Positive_regulation of Positive_regulation of CFP 5 0.49 1.93 1.32
82 INT12148 Positive_regulation of IGKV1-5 24 0.57 3.13 1.25
83 INT148212 Negative_regulation of Gene_expression of C3 2 0.43 5.47 1.24
84 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
85 INT111277 Negative_regulation of Gene_expression of C2 7 0.42 2.44 1.2
86 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19
87 INT12150 Negative_regulation of IGKV1-5 24 0.55 1.91 1.17
88 INT160553 Regulation of C4B 3 0.14 1.54 1.16
89 INT185943 Gene_expression of C8A 3 0.06 3.14 1.16
90 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15
91 INT93055 Regulation of C3 4 0.40 1.81 1.12
92 INT227492 Negative_regulation of Regulation of CFP 1 0.03 1.25 1.11
93 INT182645 Localization of C2 6 0.74 3.02 1.08
94 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06
95 INT131116 Localization of IGKV1-5 10 0.36 2.13 1.06
96 INT165275 Regulation of Cfb 5 0.06 0.83 1.06
97 INT145773 Positive_regulation of Localization of C5 1 0.49 1.15 1.06
98 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05
99 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03
100 INT152503 Binding of CR1 3 0.45 8.64 1.03
101 INT125422 Protein_catabolism of IGKV1-5 2 0.85 0.27 1.03
102 INT198406 Localization of C2 5 0.65 1.42 1.01
103 INT116360 Protein_catabolism of C3 19 0.64 4.4 1
104 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98
105 INT238250 Regulation of Gene_expression of C3 2 0.27 2.16 0.98
106 INT183466 Positive_regulation of Localization of IGHG3 1 0.03 1.55 0.97
107 INT111279 Positive_regulation of Gene_expression of C2 8 0.49 1.06 0.94
108 INT68788 Localization of CFP 7 0.63 1.07 0.93
109 INT145772 Regulation of C4a 3 0.38 1.99 0.92
110 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9
111 INT20401 Positive_regulation of CR1 10 0.49 3.77 0.87
112 INT111668 Binding of C3 4 0.36 3.84 0.87
113 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86
114 INT57059 Negative_regulation of IGKC 4 0.24 1.34 0.86
115 INT79956 Positive_regulation of Positive_regulation of C3 4 0.35 4.17 0.86
116 INT131066 Binding of C6 4 0.31 1.81 0.86
117 INT28689 Negative_regulation of Positive_regulation of C3 4 0.23 1.28 0.85
118 INT17597 Positive_regulation of Gene_expression of CFHR1 3 0.50 0 0.85
119 INT168444 Positive_regulation of Positive_regulation of C2 2 0.43 0.93 0.85
120 INT23621 Regulation of C4A 10 0.44 5.07 0.84
121 INT126030 Regulation of CFD 4 0.21 3.92 0.83
122 INT221967 Protein_catabolism of C2 2 0.08 1.06 0.83
123 INT328943 Negative_regulation of Localization of C2 1 0.12 2.02 0.82
124 INT313673 Negative_regulation of C8A 1 0.04 0.85 0.82
125 INT130727 Regulation of C2 12 0.32 5.95 0.81
126 INT329967 Positive_regulation of Gene_expression of C5 1 0.42 1.63 0.81
127 INT70744 Regulation of CFH 12 0.41 7.38 0.8
128 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78
129 INT248227 Protein_catabolism of CFD 4 0.46 2.48 0.77
130 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75
131 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75
132 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
133 INT39819 Localization of C4A 4 0.62 3.1 0.72
134 INT179530 Transcription of C3 4 0.69 2.59 0.7
135 INT47048 Regulation of Positive_regulation of CFH 1 0.29 0.27 0.7
136 INT116361 Positive_regulation of Protein_catabolism of C3 6 0.45 1.86 0.69
137 INT161201 Localization of C5 2 0.75 0.93 0.69
138 INT16386 Regulation of C1S 2 0.44 1.49 0.68
139 INT252856 Positive_regulation of Positive_regulation of C5 1 0.02 0.95 0.67
140 INT87931 Binding of IGKV1-5 13 0.06 2.03 0.65
141 INT203146 Protein_catabolism of C5 1 0.64 1.62 0.64
142 INT61816 Negative_regulation of Binding of IGHG3 4 0.28 0.92 0.63
143 INT166437 Binding of C5 4 0.36 3.28 0.63
144 INT11437 Positive_regulation of IGKC 3 0.20 0.5 0.59
145 INT107652 Gene_expression of C7 4 0.60 2.06 0.56
146 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54
147 INT46173 Transcription of C3 4 0.61 3.54 0.53
148 INT281033 Regulation of MBL2 6 0.34 4.96 0.52
149 INT149027 Positive_regulation of C1s 8 0.36 4.27 0.51
150 INT85081 Protein_catabolism of C5 5 0.19 1.34 0.5
151 INT179549 Positive_regulation of Gene_expression of C4b 2 0.19 1.36 0.49
152 INT45447 Positive_regulation of Gene_expression of C3 2 0.42 0.9 0.49
153 INT20402 Negative_regulation of Positive_regulation of CR1 1 0.18 0.47 0.46
154 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45
155 INT220886 Regulation of C3 2 0.36 1.04 0.43
156 INT241407 Phosphorylation of C3 2 0.24 0.16 0.42
157 INT229119 Negative_regulation of Localization of CFP 1 0.12 0.42 0.42
158 INT55898 Localization of C4a 2 0.40 1.29 0.41
159 INT238253 Localization of C3 1 0.37 1.76 0.41
160 INT55050 Phosphorylation of C1S 1 0.61 0 0.4
161 INT196594 Localization of CFD 4 0.65 4.36 0.39
162 INT54101 Phosphorylation of IGHG3 1 0.13 1.09 0.36
163 INT179545 Transcription of C4b 2 0.40 0.59 0.35
164 INT27059 Negative_regulation of C5 2 0.42 1.87 0.35
165 INT35901 Positive_regulation of Masp1 1 0.00 0.53 0.35
166 INT179541 Positive_regulation of Transcription of C4b 1 0.10 0.59 0.35
167 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34
168 INT235306 Gene_expression of IGKC 5 0.38 3.18 0.34
169 INT1121 Protein_catabolism of C3 1 0.96 1.8 0.34
170 INT183446 Positive_regulation of C6 4 0.30 0.77 0.33
171 INT207775 Negative_regulation of Gene_expression of C5 4 0.42 2.08 0.33
172 INT242104 Transcription of CFP 2 0.44 0.86 0.32
173 INT4218 Transcription of IGHG3 7 0.63 2.76 0.31
174 INT279571 Regulation of Gene_expression of CFD 2 0.21 2.86 0.31
175 INT116867 Positive_regulation of Gene_expression of CFH 11 0.67 11.42 0.3
176 INT23453 Negative_regulation of Gene_expression of CFP 2 0.31 0.5 0.3
177 INT46174 Positive_regulation of Transcription of C3 1 0.13 0.25 0.3
178 INT244267 Negative_regulation of Positive_regulation of CFP 1 0.05 0.87 0.3
179 INT36594 Binding of C4a 4 0.09 2.29 0.29
180 INT174519 Gene_expression of C1R 4 0.35 0.51 0.29
181 INT126999 Positive_regulation of Gene_expression of Cfb 4 0.28 2.37 0.29
182 INT334853 Phosphorylation of C4b 1 0.22 0 0.29
183 INT306469 Negative_regulation of Gene_expression of MBL2 1 0.40 1.72 0.29
184 INT218463 Negative_regulation of Binding of Cfb 7 0.08 2.31 0.28
185 INT44679 Binding of CFHR1 3 0.34 3.39 0.28
186 INT229971 Localization of C1S 3 0.68 2.91 0.28
187 INT184346 Positive_regulation of Binding of Cfb 2 0.10 0.83 0.28
188 INT79959 Positive_regulation of Positive_regulation of C4a 1 0.05 0.34 0.28
189 INT180536 Positive_regulation of Gene_expression of CR1 1 0.45 1.13 0.28
190 INT122985 Negative_regulation of Gene_expression of CLU 4 0.57 4.58 0.27
191 INT145259 Binding of CLU 1 0.03 0.84 0.27
192 INT289396 Binding of Masp1 3 0.19 0.8 0.26
193 INT54883 Positive_regulation of Gene_expression of CFP 2 0.49 0.61 0.26
194 INT263705 Binding of C1ra 2 0.36 0.62 0.26
195 INT225076 Positive_regulation of Binding of IGHG3 2 0.50 0.92 0.26
196 INT97897 Regulation of CR1 2 0.22 0.51 0.26
197 INT299742 Gene_expression of Masp1 1 0.12 0.68 0.26
198 INT313683 Binding of C8A 1 0.03 0.07 0.26
199 INT283996 Negative_regulation of Positive_regulation of IGHG3 2 0.20 1.15 0.25
200 INT185450 Localization of IGHG1 1 0.33 1.56 0.25
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