GO:0006958

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Name complement activation, classical pathway
Categary Process
Go Slim No
Go Link GO:0006958
Unique Molecular Interactions 568
Total Molecular Interactions 876
Total Single Events 9511
Pain Genes Associated 52

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for complement activation, classical pathway. They are ordered first by their pain relevance and then by number of times they were reported for complement activation, classical pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
2 INT130085 Crp Positive_regulation of Gene_expression of Vcam1 1 0.23 4.34 2.84
3 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
4 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
5 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
6 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
7 INT165200 Binding of CTLA4 and Crp 1 0.09 1.64 1.91
8 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
9 INT167169 Nfkb1 Regulation of Gene_expression of Crp 1 0.09 1.76 1.38
10 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
11 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22
12 INT224410 Binding of CRP and CIMT 3 0.42 10.46 1.2
13 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
14 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17
15 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
16 INT83427 Binding of IGHG3 and FRTS 3 0.03 1.92 1.12
17 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
18 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
19 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
20 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
21 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
22 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
23 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
24 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
25 INT188805 TNF Positive_regulation of Gene_expression of Crp 1 0.15 2.96 0.95
26 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94
27 INT134782 Il2rb Regulation of Gene_expression of Crp 1 0.00 1.16 0.92
28 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
29 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 0.10 4.58 0.84
30 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
31 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
32 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
33 INT239064 Binding of Mbl1 and IgG 1 0.03 2.59 0.78
34 INT16507 Binding of LPA and Crp 1 0.00 0.78 0.78
35 INT16488 Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
36 INT16506 Positive_regulation of Binding of LPA and Crp 1 0.00 0.78 0.78
37 INT16489 Positive_regulation of Binding of Serpinf2 and Crp 1 0.00 0.78 0.78
38 INT12396 Binding of Avp and IGKV1-5 3 0.04 1.38 0.75
39 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74
40 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
41 INT240729 Binding of CRP and HLA-A 1 0.11 2.18 0.71
42 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 0.13 0.23 0.71
43 INT82759 Binding of IGHG3 and OPRM1 2 0.06 0 0.7
44 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7
45 INT202037 Binding of CRP and URB1 1 0.01 1.26 0.68
46 INT251171 Clu Positive_regulation of C6 1 0.05 0.75 0.67
47 INT46964 C3 Positive_regulation of Tcm 1 0.00 1.26 0.66
48 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
49 INT153750 Binding of CCL2 and Crp 1 0.02 1.8 0.65
50 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
51 INT153751 Regulation of Binding of CCL2 and Crp 1 0.03 1.8 0.65
52 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63
53 INT172825 Binding of Crp and T2dm2 1 0.00 4.5 0.62
54 INT30129 Binding of C3 and Gast 1 0.06 0.09 0.62
55 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61
56 INT177899 Crp Positive_regulation of Positive_regulation of Crp 1 0.01 1.69 0.6
57 INT327165 RETNLB Regulation of Gene_expression of CRP 1 0.01 2.25 0.59
58 INT316674 Binding of CRP and SFTPD 1 0.16 2.02 0.59
59 INT149479 CEBPD Positive_regulation of C3 1 0.30 0.14 0.57
60 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56
61 INT182348 Binding of Cd3e and Crp 1 0.15 2.33 0.56
62 INT225082 Binding of IGHG3 and fc 6 0.01 3.6 0.55
63 INT169648 IGHG3 Regulation of AQP4 3 0.02 4.63 0.55
64 INT270984 Slc6a3 Regulation of IGKC 1 0.02 0 0.53
65 INT125699 CR1 Negative_regulation of Positive_regulation of ABCA1 1 0.03 0.64 0.53
66 INT59945 Binding of C2 and Srms 1 0.00 0 0.53
67 INT263738 Binding of C1ra and Neto1 1 0.42 0.11 0.53
68 INT119030 Binding of POMC and Ighg1 1 0.06 0 0.52
69 INT187333 Binding of C4bpa and Car1 1 0.08 0 0.52
70 INT106744 Binding of CRP and EGFL7 2 0.07 2.35 0.51
71 INT269057 Il6 Positive_regulation of Crp 1 0.37 1.83 0.51
72 INT334901 LDLR Positive_regulation of Crp 1 0.00 1.48 0.51
73 INT348322 Il6 Positive_regulation of Localization of Crp 1 0.06 3.51 0.51
74 INT163391 Il17a Positive_regulation of Gene_expression of Crp 1 0.02 0.6 0.51
75 INT313650 Binding of C8A and TRGC1 1 0.01 0.49 0.5
76 INT184405 CRP Positive_regulation of Gene_expression of ASF1A 1 0.03 1.17 0.49
77 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48
78 INT351771 Il6 Positive_regulation of Localization of Crp 1 0.01 0.94 0.48
79 INT277063 CRP Positive_regulation of Gene_expression of MMP10 1 0.39 1.53 0.48
80 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47
81 INT277065 CRP Positive_regulation of Gene_expression of MMP1 1 0.41 1.52 0.47
82 INT203150 Binding of Ighg2b and IgG2a 1 0.11 1.35 0.47
83 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
84 INT331731 Binding of C3 and CD79A 1 0.02 0.85 0.46
85 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
86 INT184291 Binding of AGER and Crp 1 0.01 1.23 0.46
87 INT168445 Positive_regulation of C2 Positive_regulation of Positive_regulation of Dcn 1 0.14 0.66 0.46
88 INT277064 CRP Positive_regulation of Gene_expression of TIMP1 1 0.15 1.47 0.45
89 INT68252 Penk Positive_regulation of Transcription of Ighg1 1 0.44 0 0.44
90 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
91 INT104987 Binding of CLs and Crp 1 0.07 0.59 0.43
92 INT231225 Binding of C1S and SFTPC 1 0.39 1.51 0.43
93 INT323702 HGF Regulation of Gene_expression of CRP 1 0.01 0.81 0.43
94 INT226070 Binding of CRP and MMP9 1 0.51 1.13 0.42
95 INT329960 Binding of C5 and TRAF1 1 0.32 1.04 0.42
96 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
97 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
98 INT329958 Binding of C5 and STAT4 1 0.33 0.93 0.41
99 INT326303 Binding of CRP and FKBP4 1 0.15 1.22 0.41
100 INT328934 Binding of C2 and KIR2DS4 1 0.11 0.76 0.41
101 INT58481 Crp Regulation of TF 1 0.01 0.46 0.4
102 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39
103 INT203140 Binding of C5ar1 and C5 1 0.39 0.81 0.38
104 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
105 INT242025 Binding of CRP and CHDH 7 0.18 15.72 0.36
106 INT112020 Binding of Ighg1 and IgG2a 2 0.25 0.36 0.36
107 INT270789 CRP Negative_regulation of Gene_expression of TNF 1 0.34 0.87 0.36
108 INT114755 Il6 Positive_regulation of Crp 1 0.08 0.41 0.35
109 INT93202 Binding of IGHG3 and Oprm1 1 0.02 0 0.35
110 INT112455 Binding of IGHG3 and UGT2B7 1 0.07 0 0.35
111 INT93201 Positive_regulation of Binding of IGHG3 and OPRM1 1 0.02 0 0.35
112 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
113 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
114 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34
115 INT155166 Binding of C2 and C3 1 0.40 0 0.34
116 INT320696 C5 Regulation of Gene_expression of TNF 1 0.34 2.15 0.34
117 INT240130 Il6 Positive_regulation of Crp 1 0.01 1.57 0.34
118 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34
119 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
120 INT112019 Binding of Ifng and Ighg1 1 0.10 0.3 0.33
121 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
122 INT240129 Binding of Nppb and Crp 1 0.21 1.02 0.32
123 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
124 INT277011 CRP Positive_regulation of Gene_expression of F3 1 0.06 1.03 0.32
125 INT108771 Phb2 Positive_regulation of Crp 1 0.02 0.15 0.32
126 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
127 INT328932 TRGC1 Regulation of C2 1 0.03 0.92 0.31
128 INT284047 Vtcn1 Negative_regulation of Gene_expression of Ighg2b 1 0.05 0.68 0.3
129 INT118300 Vwf Positive_regulation of Crp 1 0.00 0.87 0.3
130 INT315369 Binding of IL6 and Crp 1 0.10 2.09 0.3
131 INT132115 Binding of Crp and Nfkb1 1 0.06 1.04 0.3
132 INT235958 Binding of Ighg1 and Aqp4 1 0.14 1.32 0.3
133 INT235977 Binding of AQP4 and Ighg1 1 0.03 1.31 0.3
134 INT187113 Binding of IGHG3 and MMP9 1 0.01 0.63 0.3
135 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
136 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
137 INT272866 TNF Regulation of Crp 1 0.01 0.05 0.28
138 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28
139 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28
140 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28
141 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27
142 INT285241 Binding of Crp and Il6 1 0.00 1.78 0.27
143 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27
144 INT293900 TYRP1 Regulation of IGKC 1 0.01 0.11 0.27
145 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
146 INT194045 Binding of CRP and PM20D2 1 0.01 1.64 0.27
147 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26
148 INT24222 Ifng Positive_regulation of Gene_expression of Serping1 1 0.00 0 0.26
149 INT346196 AMELX Negative_regulation of CRP 1 0.04 0.36 0.26
150 INT24223 Ifng Negative_regulation of Gene_expression of C3 1 0.01 0 0.26
151 INT300779 STAT3 Positive_regulation of CRP 1 0.41 0.62 0.26
152 INT300778 STAT3 Positive_regulation of Transcription of CRP 1 0.38 0.62 0.26
153 INT182350 Binding of Ms4a1 and Crp 1 0.10 1.25 0.25
154 INT341541 Binding of C1R and C1QL1 1 0.09 0.21 0.25
155 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
156 INT341532 Binding of C1R and TRGC1 1 0.04 0.21 0.25
157 INT322018 CR1 Negative_regulation of IL1B 1 0.00 0.17 0.25
158 INT226073 Binding of CRP and SHBG 2 0.10 2.14 0.24
159 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24
160 INT184404 CRP Regulation of Gene_expression of KRT20 1 0.02 1.21 0.24
161 INT267623 IL6 Positive_regulation of Crp 1 0.00 1.6 0.24
162 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23
163 INT194047 Negative_regulation of Binding of CRP and PM20D2 1 0.02 1.57 0.23
164 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22
165 INT265360 Binding of Car2 and Daf2 1 0.18 0.09 0.22
166 INT318174 Binding of Crp and Xcl1 1 0.03 1.9 0.22
167 INT284589 Binding of ICAM1 and Crp 1 0.00 1.08 0.22
168 INT177895 Binding of Crp and Wbc1 1 0.00 0.45 0.22
169 INT20392 FPR1 Positive_regulation of CR1 1 0.04 0.22 0.22
170 INT58306 C4A Regulation of Gene_expression of IL1B 1 0.00 0.15 0.21
171 INT332013 Hc Regulation of Binding of C3ar1 1 0.12 1.11 0.21
172 INT332018 Binding of C1qa and Gopc 1 0.23 0.87 0.21
173 INT58304 C4A Regulation of Localization of TNF 1 0.00 0.15 0.21
174 INT182816 EEF1A2 Negative_regulation of CRP 1 0.28 1.84 0.21
175 INT141625 Crp Positive_regulation of Gene_expression of TF 1 0.11 1.39 0.21
176 INT332016 C3ar1 Regulation of Binding of Hc 1 0.12 1.11 0.21
177 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
178 INT228703 MPO Regulation of Positive_regulation of CRP 1 0.40 1.63 0.2
179 INT344399 IL8 Regulation of Gene_expression of Crp 1 0.03 0.59 0.2
180 INT142579 Binding of IL3 and Crp 1 0.03 1.2 0.2
181 INT218510 Binding of C3 and Cfb 1 0.02 0.53 0.2
182 INT142578 Binding of CSF1 and Crp 1 0.01 1.2 0.2
183 INT264298 NOL3 Negative_regulation of CRP 1 0.39 0.49 0.2
184 INT244093 Binding of C2 and Arhgap4 3 0.23 0.38 0.19
185 INT242037 Binding of CRP and SNRNP70 3 0.07 4.62 0.19
186 INT240625 Binding of CRP and Hdlcl1 1 0.01 2.56 0.19
187 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
188 INT139302 Binding of CRP and TLR4 1 0.38 1.18 0.19
189 INT181082 Binding of C3 and C3ar1 1 0.03 1.31 0.19
190 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19
191 INT183443 C7 Positive_regulation of POSTN 1 0.00 0 0.19
192 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19
193 INT139502 Binding of Crp and Tnf 1 0.03 0.48 0.19
194 INT326464 KNG1 Positive_regulation of SERPING1 1 0.19 1.53 0.18
195 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
196 INT228984 CRP Positive_regulation of IL6 2 0.63 0.99 0.17
197 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17
198 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17
199 INT238264 pma Negative_regulation of Gene_expression of Cr1l 1 0.02 0.26 0.16
200 INT244840 Lbx1 Negative_regulation of C9 1 0.13 0.09 0.16

Single Events

The table below shows the top 100 pain related interactions that have been reported for complement activation, classical pathway. They are ordered first by their pain relevance and then by number of times they were reported in complement activation, classical pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09
2 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15
3 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03
4 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74
5 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86
6 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35
7 INT22454 Regulation of Crp 213 0.62 160.67 49.24
8 INT2774 Binding of Crp 241 0.48 195.89 44.39
9 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33
10 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33
11 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07
12 INT100861 Binding of CRP 179 0.48 175.2 26.45
13 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9
14 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7
15 INT23257 Regulation of CRP 127 0.62 100.05 21.87
16 INT756 Gene_expression of C3 138 0.75 100.6 19.2
17 INT38056 Localization of Crp 71 0.78 53.14 17.03
18 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92
19 INT106745 Localization of CRP 65 0.81 66.44 15.21
20 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18
21 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63
22 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89
23 INT37390 Regulation of Crp 39 0.46 28.74 11.45
24 INT16449 Binding of IGHG3 67 0.48 39.55 10.59
25 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05
26 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83
27 INT17996 Binding of Crp 40 0.37 31.4 7.8
28 INT32579 Binding of C4B 14 0.36 14.99 7.79
29 INT573 Negative_regulation of C3 60 0.59 41.37 7.78
30 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75
31 INT178198 Gene_expression of C3 62 0.78 39.5 7.69
32 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58
33 INT1120 Gene_expression of C3 33 0.67 22.86 7.56
34 INT65489 Regulation of Gene_expression of Crp 28 0.59 29.17 7.56
35 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5
36 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37
37 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17
38 INT57720 Localization of IGHG3 33 0.74 20.24 6.25
39 INT195 Gene_expression of C4a 16 0.48 15.55 6.1
40 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92
41 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61
42 INT116229 Gene_expression of C1qa 28 0.77 18.53 5.35
43 INT44608 Gene_expression of C2 45 0.75 15.84 5.05
44 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01
45 INT131152 Gene_expression of Cr1l 17 0.75 10.83 4.88
46 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75
47 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75
48 INT140350 Binding of C2 17 0.36 3.97 4.69
49 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64
50 INT239050 Negative_regulation of Mbl1 1 0.45 15 4.24
51 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07
52 INT6507 Binding of C5 23 0.48 15.35 3.91
53 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83
54 INT69904 Binding of Hc 11 0.35 7.79 3.69
55 INT9223 Localization of Ighg1 22 0.78 11.03 3.67
56 INT182676 Transcription of C4B 1 0.31 4.82 3.66
57 INT107074 Gene_expression of C5 14 0.75 9.87 3.64
58 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63
59 INT62386 Negative_regulation of Gene_expression of IGHG3 12 0.20 7.94 3.62
60 INT22270 Regulation of IGKV1-5 13 0.39 3.56 3.54
61 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52
62 INT52021 Regulation of IGHG3 34 0.39 22.43 3.3
63 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16
64 INT146693 Gene_expression of Mbl1 17 0.59 10.99 3.13
65 INT116228 Binding of C1qa 26 0.47 15.72 3
66 INT62568 Positive_regulation of Positive_regulation of Crp 9 0.68 8.61 2.98
67 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89
68 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85
69 INT9460 Positive_regulation of C3 6 0.69 3.96 2.81
70 INT145774 Positive_regulation of C5 7 0.67 4.88 2.79
71 INT64147 Gene_expression of C5 15 0.60 16.8 2.78
72 INT114753 Negative_regulation of Gene_expression of Crp 7 0.42 4.79 2.77
73 INT26996 Positive_regulation of Gene_expression of Crp 21 0.68 21.55 2.75
74 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72
75 INT204124 Transcription of CRP 14 0.69 20.79 2.71
76 INT121683 Gene_expression of Hc 23 0.75 7.15 2.7
77 INT155160 Binding of C3 20 0.47 7.77 2.61
78 INT82966 Transcription of Crp 14 0.70 9.91 2.61
79 INT35407 Positive_regulation of C2 25 0.69 7.74 2.59
80 INT156130 Binding of SERPING1 29 0.42 26.16 2.52
81 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44
82 INT49930 Binding of Ighg1 21 0.37 13.27 2.43
83 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42
84 INT173504 Positive_regulation of Gene_expression of Ighg1 16 0.47 7.2 2.36
85 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35
86 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29
87 INT163064 Positive_regulation of Gene_expression of C1qa 9 0.67 6.51 2.29
88 INT29094 Binding of C3 39 0.37 12.65 2.27
89 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23
90 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14
91 INT55897 Positive_regulation of C4a 8 0.29 3.81 2.07
92 INT186872 Gene_expression of C4bpa 6 0.24 1.33 2.07
93 INT33848 Binding of C6 6 0.36 0.88 2.04
94 INT55810 Negative_regulation of Positive_regulation of Crp 10 0.41 4.95 2.02
95 INT67033 Localization of Crp 14 0.54 10.35 2.01
96 INT216065 Localization of C4B 2 0.21 2.86 2.01
97 INT30531 Gene_expression of C2 15 0.66 5.5 1.99
98 INT35689 Localization of C3 17 0.75 5.3 1.98
99 INT22269 Gene_expression of IGKV1-5 32 0.50 1.71 1.95
100 INT16385 Regulation of C3 20 0.41 9.98 1.92
101 INT40954 Regulation of Serping1 5 0.32 3.71 1.88
102 INT135961 Positive_regulation of Hc 8 0.67 3.67 1.87
103 INT184006 Gene_expression of Ighg2b 21 0.71 7.97 1.86
104 INT163065 Transcription of C1qa 5 0.69 2.5 1.86
105 INT9261 Gene_expression of CR1 15 0.73 15.58 1.85
106 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84
107 INT62718 Gene_expression of CFI 7 0.75 2.06 1.84
108 INT153743 Negative_regulation of Localization of Crp 2 0.14 1.83 1.84
109 INT53493 Negative_regulation of C6 3 0.53 2.68 1.77
110 INT157719 Gene_expression of C6 8 0.67 3.41 1.74
111 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73
112 INT130730 Negative_regulation of C2 11 0.57 3.81 1.7
113 INT4217 Negative_regulation of Negative_regulation of IGHG3 3 0.11 0.69 1.7
114 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62
115 INT26426 Localization of C5 5 0.78 3.87 1.61
116 INT212790 Regulation of C5 6 0.24 6.04 1.59
117 INT102428 Binding of C2 17 0.32 5.12 1.58
118 INT75230 Transcription of Crp 4 0.55 3.15 1.57
119 INT68250 Regulation of Gene_expression of Ighg1 7 0.40 2.99 1.56
120 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54
121 INT247102 Binding of MBL2 16 0.38 14.18 1.54
122 INT182037 Localization of C3 10 0.68 6.69 1.54
123 INT279572 Gene_expression of MBL2 27 0.64 20.88 1.51
124 INT102711 Regulation of Gene_expression of Crp 3 0.44 1.63 1.47
125 INT145770 Regulation of C1qa 5 0.26 2.67 1.46
126 INT112013 Negative_regulation of Gene_expression of Ighg1 7 0.38 3.57 1.42
127 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41
128 INT134338 Gene_expression of CD55 23 0.65 13.01 1.38
129 INT10885 Negative_regulation of C3 9 0.38 11.86 1.35
130 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32
131 INT239060 Binding of Mbl1 5 0.32 4.89 1.27
132 INT12148 Positive_regulation of IGKV1-5 24 0.57 3.13 1.25
133 INT156672 Localization of SERPING1 10 0.74 12.15 1.25
134 INT68248 Transcription of Ighg1 3 0.61 3.02 1.25
135 INT101362 Regulation of CFI 5 0.27 2.46 1.24
136 INT148212 Negative_regulation of Gene_expression of C3 2 0.43 5.47 1.24
137 INT171576 Phosphorylation of CRP 6 0.80 5.55 1.22
138 INT122988 Gene_expression of CLU 28 0.75 24.07 1.21
139 INT111277 Negative_regulation of Gene_expression of C2 7 0.42 2.44 1.2
140 INT107942 Positive_regulation of C5 9 0.50 6.86 1.19
141 INT12150 Negative_regulation of IGKV1-5 24 0.55 1.91 1.17
142 INT160553 Regulation of C4B 3 0.14 1.54 1.16
143 INT185943 Gene_expression of C8A 3 0.06 3.14 1.16
144 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15
145 INT93055 Regulation of C3 4 0.40 1.81 1.12
146 INT139679 Positive_regulation of Ighg2b 11 0.55 10.57 1.1
147 INT59010 Positive_regulation of Regulation of Crp 2 0.27 2.11 1.09
148 INT182645 Localization of C2 6 0.74 3.02 1.08
149 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06
150 INT131116 Localization of IGKV1-5 10 0.36 2.13 1.06
151 INT145773 Positive_regulation of Localization of C5 1 0.49 1.15 1.06
152 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05
153 INT49115 Binding of CFI 3 0.04 2.28 1.04
154 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03
155 INT179535 Negative_regulation of C1qa 10 0.57 4.7 1.03
156 INT152503 Binding of CR1 3 0.45 8.64 1.03
157 INT125422 Protein_catabolism of IGKV1-5 2 0.85 0.27 1.03
158 INT130233 Positive_regulation of Binding of Crp 5 0.49 2.54 1.01
159 INT198406 Localization of C2 5 0.65 1.42 1.01
160 INT116360 Protein_catabolism of C3 19 0.64 4.4 1
161 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98
162 INT238250 Regulation of Gene_expression of C3 2 0.27 2.16 0.98
163 INT183466 Positive_regulation of Localization of IGHG3 1 0.03 1.55 0.97
164 INT171113 Binding of Ighg2b 3 0.47 2.85 0.96
165 INT110076 Regulation of C6 2 0.22 1.14 0.96
166 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95
167 INT138683 Regulation of Ighg1 15 0.30 7.95 0.94
168 INT111279 Positive_regulation of Gene_expression of C2 8 0.49 1.06 0.94
169 INT145772 Regulation of C4a 3 0.38 1.99 0.92
170 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9
171 INT41873 Positive_regulation of Mbl1 4 0.39 2.1 0.9
172 INT144482 Negative_regulation of Gene_expression of SERPING1 8 0.43 6.06 0.89
173 INT157115 Positive_regulation of Localization of Crp 4 0.59 1.96 0.88
174 INT20401 Positive_regulation of CR1 10 0.49 3.77 0.87
175 INT111668 Binding of C3 4 0.36 3.84 0.87
176 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86
177 INT57059 Negative_regulation of IGKC 4 0.24 1.34 0.86
178 INT79956 Positive_regulation of Positive_regulation of C3 4 0.35 4.17 0.86
179 INT131066 Binding of C6 4 0.31 1.81 0.86
180 INT28689 Negative_regulation of Positive_regulation of C3 4 0.23 1.28 0.85
181 INT168444 Positive_regulation of Positive_regulation of C2 2 0.43 0.93 0.85
182 INT23621 Regulation of C4A 10 0.44 5.07 0.84
183 INT221967 Protein_catabolism of C2 2 0.08 1.06 0.83
184 INT184351 Localization of Hc 2 0.20 2.33 0.83
185 INT269693 Regulation of Negative_regulation of Hc 1 0.00 0.09 0.83
186 INT328943 Negative_regulation of Localization of C2 1 0.12 2.02 0.82
187 INT313673 Negative_regulation of C8A 1 0.04 0.85 0.82
188 INT130727 Regulation of C2 12 0.32 5.95 0.81
189 INT119962 Negative_regulation of Negative_regulation of Crp 2 0.45 3.24 0.81
190 INT329967 Positive_regulation of Gene_expression of C5 1 0.42 1.63 0.81
191 INT116230 Localization of C1qa 5 0.80 3.98 0.8
192 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8
193 INT163360 Positive_regulation of Cr1l 2 0.49 0.89 0.8
194 INT23350 Negative_regulation of CFI 9 0.05 3.48 0.78
195 INT184415 Regulation of Positive_regulation of CRP 3 0.43 4.32 0.77
196 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75
197 INT149485 Regulation of Gene_expression of C3 5 0.60 3.39 0.75
198 INT70666 Positive_regulation of CLU 16 0.45 12.95 0.74
199 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73
200 INT39819 Localization of C4A 4 0.62 3.1 0.72
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