GO:0006970

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Name response to osmotic stress
Categary Process
Go Slim No
Go Link GO:0006970
Unique Molecular Interactions 331
Total Molecular Interactions 444
Total Single Events 3341
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to osmotic stress. They are ordered first by their pain relevance and then by number of times they were reported for response to osmotic stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
2 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
3 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
4 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
5 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
6 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
7 INT305408 Binding of KCNMA1 and ST8SIA2 1 0.01 0.09 1.24
8 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
9 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
10 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
11 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
12 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
13 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
14 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
15 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
16 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
17 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
18 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
19 INT83987 Ngf Regulation of Atf2 1 0.52 0.49 1
20 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
21 INT128602 Binding of Kcnma1 and Gtf2ird2 1 0.00 0 0.97
22 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
23 INT112642 Positive_regulation of Kcnma1 Positive_regulation of Nav1 1 0.02 0 0.89
24 INT306831 Positive_regulation of Binding of E2F4 and NOLC1 1 0.10 0.46 0.85
25 INT306826 Binding of E2F4 and NOLC1 1 0.08 0.41 0.84
26 INT54559 KCNMA1 Positive_regulation of Localization of TBXA2R 1 0.01 0.07 0.81
27 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
28 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
29 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
30 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
31 INT16933 Tsc22d3 Positive_regulation of Localization of Penk 2 0.24 0 0.76
32 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
33 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
34 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
35 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
36 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
37 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
38 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
39 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
40 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
41 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
42 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
43 INT233671 gr Positive_regulation of Transcription of Tsc22d3 1 0.44 0.33 0.64
44 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
45 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
46 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
47 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
48 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
49 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
50 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
51 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
52 INT38875 Penk Regulation of Localization of Tsc22d3 1 0.20 0 0.48
53 INT38874 Penk Regulation of Tsc22d3 1 0.20 0 0.47
54 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
55 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
56 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
57 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
58 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
59 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
60 INT210784 Bst2 Positive_regulation of Tsc22d3 1 0.29 0.27 0.45
61 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
62 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
63 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
64 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
65 INT305405 Binding of KCNMA1 and ANTXR1 1 0.00 0.09 0.38
66 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
67 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
68 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
69 INT151546 Adcy1 Positive_regulation of Atf2 1 0.36 0.37 0.37
70 INT151549 Regulation of Adcy1 Positive_regulation of Atf2 1 0.33 0.37 0.37
71 INT151551 Regulation of Camk4 Positive_regulation of Atf2 1 0.34 0.36 0.37
72 INT151547 Camk4 Positive_regulation of Atf2 1 0.38 0.36 0.37
73 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
74 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
75 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
76 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
77 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
78 INT337412 AKT3 Negative_regulation of Localization of AKT2 1 0.09 0.5 0.32
79 INT110464 Cpe Regulation of Phosphorylation of Atf2 1 0.02 0 0.32
80 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
81 INT337418 AKT2 Negative_regulation of Localization of AKT3 1 0.09 0.5 0.32
82 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
83 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
84 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
85 INT110461 Binding of Mapk8 and Gtf3a 1 0.03 0 0.32
86 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
87 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
88 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31
89 INT167983 Mapk8 Negative_regulation of gr 1 0.02 0.5 0.31
90 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31
91 INT110459 Binding of Atf2 and Jun 1 0.32 0 0.31
92 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
93 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
94 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
95 INT309122 Edc4 Positive_regulation of Phosphorylation of Mapk8 1 0.02 0.73 0.28
96 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
97 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
98 INT132368 Mapk8 Positive_regulation of Nfkb1 1 0.17 0.11 0.27
99 INT132369 Mapk8 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.27
100 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
101 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
102 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
103 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
104 INT165478 Prok2 Positive_regulation of Positive_regulation of Kcnma1 1 0.02 0 0.25
105 INT169048 Positive_regulation of Binding of Atf2 and Sult4a1 1 0.38 0.11 0.24
106 INT169054 Binding of Atf2 and Sult4a1 1 0.37 0.11 0.24
107 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
108 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
109 INT255942 Elk1 Regulation of Binding of ATF2 1 0.07 0.12 0.22
110 INT255842 CREB1 Regulation of Binding of ATF2 1 0.03 0.12 0.22
111 INT255837 ATF2 Regulation of Binding of CREB1 1 0.03 0.12 0.22
112 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
113 INT255941 ATF2 Regulation of Transcription of Elk1 1 0.07 0.12 0.22
114 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
115 INT255835 ATF2 Regulation of Transcription of CREB1 1 0.03 0.12 0.22
116 INT255839 CREB1 Regulation of Transcription of ATF2 1 0.03 0.12 0.22
117 INT255937 ATF2 Regulation of Binding of Elk1 1 0.07 0.12 0.22
118 INT309116 Edc4 Negative_regulation of Mapk8 1 0.01 0.43 0.22
119 INT255939 Elk1 Regulation of Transcription of ATF2 1 0.07 0.12 0.22
120 INT330051 Mapk8 Positive_regulation of Bcl2l11 1 0.13 0.46 0.21
121 INT131718 Mapk8 Regulation of Penk 1 0.46 0.16 0.2
122 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
123 INT210990 Binding of KCNMA1 and PKDREJ 1 0.00 0.6 0.19
124 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19
125 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
126 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18
127 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
128 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17
129 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
130 INT284445 Dep1 Positive_regulation of Mapk8 1 0.00 0.58 0.17
131 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
132 INT216487 Ca2 Negative_regulation of Kcnma1 1 0.00 0.1 0.17
133 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
134 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
135 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
136 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15
137 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
138 INT266531 Mapk8 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0.13
139 INT182886 Ros1 Positive_regulation of Mapk8 3 0.09 2.3 0.12
140 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
141 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
142 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
143 INT348786 Tlr4 Positive_regulation of Mapk8 1 0.33 1.09 0.11
144 INT143648 Negative_regulation of Mapk8 Negative_regulation of Gene_expression of Fas 1 0.39 0.21 0.11
145 INT266904 Plat Positive_regulation of Positive_regulation of Mapk8 1 0.03 0.6 0.11
146 INT181076 Map4k4 Positive_regulation of Mapk8 1 0.11 0.47 0.11
147 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1
148 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1
149 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
150 INT210992 Binding of KCNMA1 and SP3 1 0.00 0.17 0.1
151 INT153028 Binding of INSRR and KCNMA1 1 0.06 0.29 0.1
152 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
153 INT153027 Binding of HTR3A and KCNMA1 1 0.18 0.29 0.1
154 INT348042 Positive_regulation of Mapk8 Regulation of Gene_expression of VEGFA 1 0.03 0.85 0.1
155 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
156 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
157 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
158 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
159 INT348025 Mapk8 Regulation of Gene_expression of Proc 1 0.00 0.58 0.08
160 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
161 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
162 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08
163 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
164 INT147675 Positive_regulation of Atf2 Positive_regulation of GRP 1 0.04 0 0.07
165 INT325274 IL1RAP Positive_regulation of Mapk8 1 0.14 0 0.07
166 INT333051 Binding of HIVEP1 and NOLC1 1 0.00 4.11 0.07
167 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
168 INT216570 Gene_expression of cx Positive_regulation of Kcnma1 1 0.00 0.25 0.06
169 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
170 INT266388 S100a6 Negative_regulation of Mapk8 1 0.03 0.49 0.06
171 INT196134 Gopc Negative_regulation of Trpv4 1 0.07 0.08 0.06
172 INT216545 Gene_expression of Cftr Negative_regulation of Kcnma1 1 0.00 0.59 0.06
173 INT196126 Gopc Negative_regulation of Gene_expression of Trpv4 1 0.15 0.08 0.06
174 INT178438 Mapk8 Positive_regulation of Plau 1 0.06 0.52 0.06
175 INT348030 Mapk8 Regulation of Re 1 0.17 0.95 0.06
176 INT196131 Trpm7 Negative_regulation of Trpv4 1 0.14 0.08 0.06
177 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
178 INT196129 Trpm7 Negative_regulation of Gene_expression of Trpv4 1 0.32 0.08 0.06
179 INT218676 Mapk8 Regulation of Mapk14 1 0.00 0.33 0.05
180 INT181571 Binding of Mapk8 and Mapk1 1 0.04 1.24 0.05
181 INT322130 Trpv1 Positive_regulation of Positive_regulation of Trpv4 1 0.15 0.1 0.05
182 INT333034 Trpv4 Positive_regulation of Localization of Car2 1 0.06 0 0.05
183 INT218703 Mapk8 Regulation of EPHB2 1 0.04 0.33 0.05
184 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
185 INT169403 Binding of TRPV1 and Trpv4 1 0.23 0.94 0.05
186 INT218667 Olr811 Regulation of Mapk8 1 0.00 0.33 0.05
187 INT267046 Binding of SLC2A1 and SV2A 1 0.12 0 0.05
188 INT333032 Binding of Trpv4 and Gopc 1 0.05 0 0.04
189 INT178443 Negative_regulation of Mapk8 Positive_regulation of Negative_regulation of Mapk14 1 0.13 0.76 0.04
190 INT274078 Binding of Mapk8 and Gmcl1 1 0.05 0.68 0.04
191 INT248703 Mapk8 Positive_regulation of Phosphorylation of Rxrb 1 0.01 0.25 0.04
192 INT288595 Binding of CYTIP and Kcnma1 1 0.00 0 0.04
193 INT323286 CYP4A11 Positive_regulation of Kcnma1 1 0.01 0.45 0.04
194 INT179927 Litaf Positive_regulation of Mapk8 1 0.02 0.39 0.04
195 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04
196 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04
197 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
198 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
199 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 0.15 0.59 0.04
200 INT348220 Glp1r Regulation of Slc2a1 1 0.12 0.66 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to osmotic stress. They are ordered first by their pain relevance and then by number of times they were reported in response to osmotic stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
2 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
3 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
4 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
5 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
6 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
7 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
8 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
9 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
10 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
11 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
12 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55
13 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
14 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
15 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
16 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82
17 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4
18 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
19 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
20 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
21 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
22 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
23 INT233645 Transcription of Tsc22d3 11 0.71 5.83 7.97
24 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58
25 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
26 INT28042 Gene_expression of Tsc22d3 14 0.77 6.54 6.4
27 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
28 INT88286 Phosphorylation of Atf2 11 0.66 1.93 5.69
29 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
30 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
31 INT13051 Regulation of Kcnma1 12 0.12 2.09 5.06
32 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
33 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
34 INT88282 Positive_regulation of Phosphorylation of Atf2 8 0.44 1.77 4.85
35 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3
36 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
37 INT233605 Positive_regulation of Transcription of Tsc22d3 5 0.69 2.05 3.98
38 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
39 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
40 INT77251 Positive_regulation of Atf2 8 0.70 2.45 3.62
41 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
42 INT210761 Positive_regulation of Tsc22d3 5 0.69 1.46 3.42
43 INT11490 Binding of KCNMA1 13 0.37 3.61 3.32
44 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
45 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
46 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
47 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
48 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
49 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
50 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
51 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
52 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
53 INT88285 Transcription of Atf2 4 0.36 1.56 2.62
54 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
55 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
56 INT11485 Localization of KCNMA1 7 0.09 1.81 2.6
57 INT91471 Positive_regulation of Gene_expression of Kcnma1 4 0.22 2.88 2.56
58 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
59 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
60 INT52326 Negative_regulation of Atf2 7 0.45 0.94 2.5
61 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
62 INT31573 Gene_expression of Tsc22d3 3 0.65 0.61 2.39
63 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
64 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
65 INT11487 Positive_regulation of Localization of KCNMA1 4 0.06 1.5 2.31
66 INT14010 Gene_expression of SLC2A1 19 0.78 15.22 2.12
67 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
68 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
69 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
70 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
71 INT64075 Positive_regulation of Positive_regulation of Kcnma1 2 0.02 0.55 1.96
72 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
73 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
74 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
75 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
76 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
77 INT157366 Positive_regulation of Positive_regulation of KCNMA1 2 0.05 2.43 1.74
78 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
79 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
80 INT115309 Gene_expression of Slc2a1 6 0.75 2.85 1.64
81 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
82 INT7119 Localization of Tsc22d3 4 0.73 0.62 1.56
83 INT233637 Regulation of Transcription of Tsc22d3 1 0.61 0.64 1.56
84 INT233643 Localization of Tsc22d3 4 0.74 2.19 1.53
85 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
86 INT66487 Binding of Tsc22d3 2 0.48 1.46 1.52
87 INT110444 Positive_regulation of Atf2 7 0.50 2 1.48
88 INT28043 Negative_regulation of Tsc22d3 2 0.42 0.09 1.44
89 INT179309 Regulation of Gene_expression of KCNMA1 8 0.39 2.36 1.36
90 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
91 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
92 INT28044 Regulation of Gene_expression of Tsc22d3 2 0.61 0 1.26
93 INT162361 Positive_regulation of Gene_expression of KCNMA1 6 0.46 2.44 1.25
94 INT130207 Phosphorylation of ATF2 5 0.60 1.34 1.25
95 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
96 INT160054 Localization of AKT2 4 0.73 1.93 1.18
97 INT162357 Protein_catabolism of KCNMA1 3 0.77 1.19 1.18
98 INT233620 Positive_regulation of Gene_expression of Tsc22d3 3 0.69 1.46 1.17
99 INT154437 Positive_regulation of Slc2a1 4 0.26 2.67 1.08
100 INT49556 Gene_expression of NOLC1 11 0.49 29.44 1.07
101 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
102 INT130209 Positive_regulation of Phosphorylation of ATF2 3 0.36 1.15 1.03
103 INT72255 Binding of Kcnma1 4 0.02 0.2 0.99
104 INT83983 Phosphorylation of Atf2 6 0.63 2 0.95
105 INT106746 Gene_expression of Mtap7 1 0.39 2.09 0.95
106 INT205497 Binding of NOLC1 13 0.35 15.91 0.91
107 INT233623 Regulation of Tsc22d3 3 0.44 1.68 0.9
108 INT83984 Positive_regulation of Positive_regulation of Atf2 1 0.44 0.48 0.89
109 INT160056 Positive_regulation of AKT2 3 0.48 1.43 0.88
110 INT271605 Regulation of Gene_expression of AKT2 1 0.44 0.81 0.87
111 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
112 INT7457 Localization of Kcnma1 3 0.60 2.75 0.85
113 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
114 INT139928 Negative_regulation of Kcnma1 6 0.37 1.19 0.84
115 INT69913 Binding of ATF2 6 0.13 0.83 0.84
116 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
117 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
118 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
119 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
120 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
121 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
122 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
123 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
124 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
125 INT69771 Positive_regulation of Kcnma1 6 0.52 0.31 0.74
126 INT69922 Positive_regulation of ATF2 3 0.05 1.28 0.74
127 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
128 INT200669 Negative_regulation of AKT2 2 0.42 0.94 0.72
129 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
130 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
131 INT13654 Regulation of SLC2A1 1 0.44 0.44 0.68
132 INT215809 Gene_expression of Kcnma1 11 0.58 0.53 0.66
133 INT288019 Regulation of Gene_expression of Kcnma1 3 0.00 0.7 0.63
134 INT156303 Regulation of Regulation of Trpv4 2 0.27 0.26 0.63
135 INT104095 Positive_regulation of Negative_regulation of KCNMA1 1 0.02 0 0.61
136 INT121195 Phosphorylation of KCNMA1 5 0.63 0.49 0.6
137 INT162362 Positive_regulation of Protein_catabolism of KCNMA1 1 0.05 0.61 0.6
138 INT103888 Gene_expression of Atf2 7 0.58 1.69 0.59
139 INT101705 Negative_regulation of Positive_regulation of Kcnma1 2 0.03 0 0.59
140 INT162355 Regulation of Protein_catabolism of KCNMA1 1 0.05 0.59 0.59
141 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
142 INT158548 Regulation of Gene_expression of Trpv4 3 0.61 1.03 0.57
143 INT320644 Binding of Egfr 7 0.34 5.9 0.56
144 INT7630 Negative_regulation of SLC2A1 4 0.45 0.73 0.56
145 INT125188 Negative_regulation of Transcription of Trpv4 3 0.42 0.44 0.56
146 INT88290 Positive_regulation of Transcription of Atf2 1 0.31 0.09 0.56
147 INT88291 Regulation of Transcription of Atf2 1 0.18 0.1 0.55
148 INT306880 Localization of NOLC1 2 0.19 6.32 0.54
149 INT307752 Negative_regulation of Regulation of Kcnma1 1 0.01 0.18 0.52
150 INT212596 Positive_regulation of NOLC1 3 0.37 4.7 0.51
151 INT309304 Regulation of Negative_regulation of KCNMA1 2 0.04 0.06 0.5
152 INT263224 Phosphorylation of Trpv4 2 0.76 0.73 0.49
153 INT320019 Regulation of Positive_regulation of Kcnma1 1 0.01 0.05 0.49
154 INT137671 Negative_regulation of Positive_regulation of Trpv4 3 0.58 0.25 0.48
155 INT271604 Positive_regulation of Gene_expression of AKT2 2 0.49 0.22 0.47
156 INT319542 Positive_regulation of Positive_regulation of Tsc22d3 1 0.49 0 0.46
157 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
158 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
159 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
160 INT301056 Transcription of Mapk8 1 0.06 1.22 0.45
161 INT93214 Positive_regulation of Phosphorylation of Atf2 2 0.38 0.99 0.44
162 INT109920 Positive_regulation of PTK2B 5 0.43 2.21 0.43
163 INT147482 Regulation of Phosphorylation of Atf2 1 0.22 0.56 0.43
164 INT69915 Regulation of ATF2 2 0.34 0.81 0.42
165 INT83985 Negative_regulation of Positive_regulation of Atf2 1 0.43 0.26 0.42
166 INT98419 Positive_regulation of Mtap7 3 0.38 2.66 0.41
167 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39
168 INT109922 Negative_regulation of PTK2B 3 0.26 1.63 0.39
169 INT231553 Localization of Slc2a1 2 0.48 3.96 0.39
170 INT187209 Negative_regulation of Localization of Mapk8 1 0.22 0.93 0.39
171 INT49557 Transcription of NOLC1 4 0.02 16.54 0.38
172 INT301047 Negative_regulation of Transcription of Mapk8 1 0.12 0.65 0.36
173 INT109919 Positive_regulation of Positive_regulation of PTK2B 1 0.31 0.09 0.35
174 INT123420 Negative_regulation of Gene_expression of KCNMA1 7 0.58 0.25 0.33
175 INT255920 Gene_expression of ATF2 3 0.75 1.52 0.33
176 INT260463 Regulation of Slc2a1 2 0.27 1.58 0.33
177 INT347246 Positive_regulation of Gene_expression of SLC2A1 1 0.21 0.28 0.32
178 INT347245 Regulation of Gene_expression of SLC2A1 1 0.14 0.28 0.32
179 INT323118 Positive_regulation of Localization of AKT2 2 0.49 0.48 0.31
180 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
181 INT99793 Regulation of Negative_regulation of Kcnma1 1 0.01 0.1 0.3
182 INT83986 Localization of Atf2 1 0.81 0.27 0.28
183 INT288561 Regulation of Kcnma1 5 0.21 0.49 0.26
184 INT93217 Negative_regulation of Phosphorylation of Atf2 1 0.12 0.08 0.26
185 INT291227 Protein_catabolism of Mapk8 1 0.64 0.26 0.26
186 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
187 INT178399 Regulation of Positive_regulation of Mapk8 4 0.44 3.4 0.23
188 INT136401 Binding of SLC2A1 2 0.36 1.75 0.22
189 INT299366 Positive_regulation of Transcription of Mapk8 2 0.70 1.29 0.22
190 INT255901 Transcription of ATF2 1 0.25 0.12 0.22
191 INT72207 Positive_regulation of Mapk13 2 0.03 0.81 0.21
192 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
193 INT89400 Phosphorylation of PTK2B 4 0.38 1.16 0.19
194 INT156172 Transcription of Trpv4 3 0.72 1.19 0.19
195 INT200676 Phosphorylation of AKT2 1 0.53 1.01 0.19
196 INT169047 Positive_regulation of Gene_expression of Atf2 1 0.36 0.31 0.19
197 INT322153 Positive_regulation of Binding of Trpv4 1 0.49 0 0.18
198 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
199 INT179260 Binding of AKT2 2 0.27 1.8 0.15
200 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
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