GO:0006971

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Name hypotonic response
Categary Process
Go Slim No
Go Link GO:0006971
Unique Molecular Interactions 50
Total Molecular Interactions 75
Total Single Events 637
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hypotonic response. They are ordered first by their pain relevance and then by number of times they were reported for hypotonic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
2 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
3 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
4 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
5 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
6 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
7 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
8 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
9 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
10 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
11 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
12 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
13 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
14 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
15 INT171792 GPER Regulation of Gene_expression of Itga2 1 0.00 0.54 0.12
16 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
17 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
18 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
19 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
20 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
21 INT196134 Gopc Negative_regulation of Trpv4 1 0.07 0.08 0.06
22 INT196126 Gopc Negative_regulation of Gene_expression of Trpv4 1 0.15 0.08 0.06
23 INT196131 Trpm7 Negative_regulation of Trpv4 1 0.14 0.08 0.06
24 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
25 INT196129 Trpm7 Negative_regulation of Gene_expression of Trpv4 1 0.32 0.08 0.06
26 INT322130 Trpv1 Positive_regulation of Positive_regulation of Trpv4 1 0.15 0.1 0.05
27 INT333034 Trpv4 Positive_regulation of Localization of Car2 1 0.06 0 0.05
28 INT169403 Binding of TRPV1 and Trpv4 1 0.23 0.94 0.05
29 INT333032 Binding of Trpv4 and Gopc 1 0.05 0 0.04
30 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03
31 INT333037 Binding of Agt and Trpv4 1 0.09 0 0.03
32 INT322126 Binding of Trpv4 and Fig4 1 0.02 0 0
33 INT331089 Binding of Cd3e and Itga2 1 0.09 0.2 0
34 INT333035 Positive_regulation of Binding of Agt and Trpv4 1 0.11 0 0
35 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
36 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
37 INT333036 Trpv4 Positive_regulation of Gene_expression of Agt 1 0.12 0 0
38 INT331088 Binding of Itga2 and Klrb1c 1 0.11 0.2 0
39 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0
40 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0
41 INT169448 Binding of Prkce and Trpv4 1 0.04 0.08 0
42 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0
43 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0
44 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
45 INT164929 Binding of Calca and Trpv4 1 0.32 0 0
46 INT275972 Binding of Itga2 and Gp6 1 0.05 0 0
47 INT331090 Binding of Ctsl and Itga2 1 0.10 0.2 0
48 INT333038 Agt Positive_regulation of Positive_regulation of Trpv4 1 0.12 0 0
49 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
50 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hypotonic response. They are ordered first by their pain relevance and then by number of times they were reported in hypotonic response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
2 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
3 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
4 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
5 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
6 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
7 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
8 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
9 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
10 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
11 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
12 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
13 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
14 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
15 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
16 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
17 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
18 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
19 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
20 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
21 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
22 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
23 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
24 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
25 INT156303 Regulation of Regulation of Trpv4 2 0.27 0.26 0.63
26 INT158548 Regulation of Gene_expression of Trpv4 3 0.61 1.03 0.57
27 INT125188 Negative_regulation of Transcription of Trpv4 3 0.42 0.44 0.56
28 INT118891 Transcription of Itga2 1 0.03 0 0.54
29 INT263224 Phosphorylation of Trpv4 2 0.76 0.73 0.49
30 INT137671 Negative_regulation of Positive_regulation of Trpv4 3 0.58 0.25 0.48
31 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39
32 INT239861 Gene_expression of Itga2 5 0.65 1.32 0.32
33 INT140187 Positive_regulation of Itga2 1 0.18 0.34 0.3
34 INT239863 Negative_regulation of Gene_expression of Itga2 1 0.03 0.8 0.29
35 INT171788 Positive_regulation of Binding of Itga2 1 0.02 0.94 0.28
36 INT171790 Regulation of Binding of Itga2 1 0.01 0.93 0.28
37 INT171789 Binding of Itga2 1 0.02 0.92 0.27
38 INT156172 Transcription of Trpv4 3 0.72 1.19 0.19
39 INT322153 Positive_regulation of Binding of Trpv4 1 0.49 0 0.18
40 INT333015 Regulation of Binding of Trpv4 1 0.42 0.43 0.13
41 INT115521 Gene_expression of Itga2 1 0.04 0.62 0.12
42 INT115520 Regulation of Itga2 2 0.01 0.46 0.1
43 INT156173 Positive_regulation of Transcription of Trpv4 1 0.61 0.43 0.1
44 INT333013 Positive_regulation of Protein_catabolism of Trpv4 1 0.43 0 0
45 INT333010 Positive_regulation of Binding of Trpv4 1 0.47 0 0
46 INT158549 Negative_regulation of Transcription of Trpv4 1 0.42 0 0
47 INT156298 Negative_regulation of Phosphorylation of Trpv4 1 0.43 0.14 0
48 INT322151 Positive_regulation of Localization of Trpv4 1 0.49 0.31 0
49 INT333022 Positive_regulation of Phosphorylation of Trpv4 1 0.47 0 0
50 INT333018 Positive_regulation of Negative_regulation of Trpv4 1 0.43 0 0
51 INT333016 Protein_catabolism of Trpv4 1 0.93 0 0
52 INT331077 Binding of Itga2 1 0.19 0.2 0
53 INT333026 Regulation of Localization of Trpv4 1 0.42 0 0
54 INT333027 Negative_regulation of Binding of Trpv4 1 0.40 0 0
55 INT158546 Regulation of Transcription of Trpv4 1 0.45 0.17 0
56 INT333017 Negative_regulation of Localization of Trpv4 1 0.40 0 0
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