GO:0006974

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Name response to DNA damage stimulus
Categary Process
Go Slim No
Go Link GO:0006974
Unique Molecular Interactions 2331
Total Molecular Interactions 3099
Total Single Events 25176
Pain Genes Associated 154

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to DNA damage stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to DNA damage stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
3 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
4 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
5 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
6 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
7 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
8 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
9 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47
10 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
11 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
12 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
13 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
14 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
15 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
16 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
17 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
18 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
19 INT165200 Binding of CTLA4 and Crp 1 0.09 1.64 1.91
20 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76
21 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
22 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
23 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
24 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
25 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
26 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
27 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
28 INT30042 Binding of YY1 and Gnrhr 1 0.18 0 1.47
29 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
30 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
31 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
32 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
33 INT154114 PENK Positive_regulation of YY1 1 0.50 0.06 1.41
34 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
35 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
36 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
37 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
38 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
39 INT265213 Binding of Ctla4 and Cd86 2 0.13 1.93 1.31
40 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
41 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
42 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
43 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
44 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
45 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
46 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
47 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
48 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
49 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
50 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
51 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
52 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
53 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
54 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
55 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
56 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
57 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
58 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
59 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
60 INT56882 Binding of YY1 and Ppbp 1 0.01 0 1.11
61 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
62 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
63 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
64 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
65 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
66 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
67 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
68 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
69 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
70 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
71 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
72 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
73 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
74 INT59518 YY1 Positive_regulation of SGCG 1 0.50 0.32 0.99
75 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
76 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
77 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
78 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
79 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
80 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
81 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
82 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
83 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
84 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93
85 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
86 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
87 INT118204 ST14 Regulation of YY1 1 0.04 0 0.93
88 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
89 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
90 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
91 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
92 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
93 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
94 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
95 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
96 INT161915 Negative_regulation of Binding of POMC and YY1 1 0.33 0 0.88
97 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
98 INT30955 YY1 Negative_regulation of Negative_regulation of LH 1 0.23 0.47 0.87
99 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
100 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
101 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
102 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
103 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
104 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
105 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
106 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
107 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
108 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
109 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
110 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
111 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
112 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
113 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
114 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
115 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
116 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
117 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
118 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
119 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
120 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
121 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
122 INT170369 Binding of Car2 and Nono 1 0.01 0 0.76
123 INT166672 YY1 Regulation of Binding of UGT1A6 1 0.48 0 0.76
124 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
125 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
126 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
127 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
128 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74
129 INT150997 Sfpq Positive_regulation of Gene_expression of Il10 1 0.09 0.71 0.74
130 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
131 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
132 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
133 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
134 INT7049 Binding of YY1 and Oprd1 1 0.01 0 0.73
135 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
136 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
137 INT145121 Msh3 Positive_regulation of Oprm1 1 0.06 0.15 0.72
138 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
139 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
140 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
141 INT145120 Msh3 Negative_regulation of Positive_regulation of Oprm1 1 0.05 0.15 0.72
142 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
143 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7
144 INT166671 YY1 Regulation of Positive_regulation of UGT1A6 1 0.48 0 0.7
145 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
146 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
147 INT106601 ZNF398 Negative_regulation of Protein_catabolism of CIB1 1 0.02 0.21 0.7
148 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
149 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
150 INT133942 Binding of YY1 and ARFGEF1 1 0.05 0 0.69
151 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
152 INT133936 Binding of DNM2 and YY1 1 0.29 0 0.69
153 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
154 INT223868 Mapk1 Positive_regulation of Creb1 2 0.17 0.34 0.68
155 INT223876 Mapk1 Positive_regulation of Atf6b 1 0.10 0 0.68
156 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
157 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
158 INT314560 RYBP Positive_regulation of Gene_expression of MYC 1 0.02 0.06 0.67
159 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
160 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
161 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
162 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
163 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66
164 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
165 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
166 INT114947 YY1 Positive_regulation of Gene_expression of RXRA 1 0.33 0.25 0.65
167 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
168 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
169 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
170 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
171 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
172 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
173 INT114950 YY1 Positive_regulation of Positive_regulation of PPARA 1 0.52 0.25 0.64
174 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
175 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
176 INT145122 Oprm1 Negative_regulation of Msh3 1 0.06 0.15 0.63
177 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63
178 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63
179 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
180 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
181 INT281092 Adcy1 Positive_regulation of Mapk1 1 0.21 0 0.63
182 INT34005 YY1 Regulation of KNG1 1 0.04 0.38 0.63
183 INT135498 Binding of YY1 and MRGPRX4 1 0.00 0.2 0.62
184 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
185 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
186 INT96945 Hrh1 Negative_regulation of Spdya 1 0.00 0.32 0.62
187 INT172048 Binding of TNF and MICA 1 0.29 1.63 0.62
188 INT148352 Binding of MC1R and XRCC3 1 0.36 0.34 0.62
189 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
190 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
191 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
192 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
193 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
194 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
195 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
196 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
197 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
198 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
199 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
200 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to DNA damage stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to DNA damage stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
2 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
3 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
4 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
5 INT6437 Binding of YY1 154 0.47 26.3 90.46
6 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
7 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
8 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16
9 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
10 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
11 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
12 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
13 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06
14 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
15 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
16 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
17 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
18 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
19 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
20 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
21 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
22 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
23 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
24 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
25 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
26 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
27 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
28 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
29 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
30 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
31 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
32 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
33 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8
34 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
35 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
36 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
37 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
38 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
39 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
40 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
41 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
42 INT3359 Regulation of YY1 32 0.60 8.19 19.2
43 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
44 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
45 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
46 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
47 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
48 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
49 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
50 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
51 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
52 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
53 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
54 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
55 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
56 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
57 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
58 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
59 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
60 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
61 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
62 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
63 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
64 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
65 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
66 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
67 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
68 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
69 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07
70 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
71 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
72 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
73 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
74 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
75 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
76 INT149818 Gene_expression of Clock 81 0.70 14.15 10.04
77 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
78 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
79 INT18647 Localization of YY1 16 0.78 4.04 9.77
80 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
81 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
82 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
83 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
84 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
85 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
86 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
87 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
88 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
89 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
90 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
91 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
92 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
93 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
94 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
95 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
96 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
97 INT132278 Binding of CTLA4 32 0.39 18.69 8.17
98 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
99 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
100 INT98178 Localization of Casp3 32 0.65 21.01 7.77
101 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
102 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
103 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
104 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
105 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
106 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34
107 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
108 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
109 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
110 INT33419 Positive_regulation of Gene_expression of YY1 10 0.67 4.15 7.08
111 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
112 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
113 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
114 INT25647 Negative_regulation of Binding of YY1 10 0.57 1.47 6.77
115 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
116 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
117 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
118 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
119 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
120 INT170385 Regulation of Clock 29 0.49 4.95 6.39
121 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
122 INT57232 Binding of Casp3 22 0.36 9.42 6.2
123 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
124 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
125 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
126 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
127 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
128 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93
129 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
130 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
131 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
132 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
133 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
134 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
135 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
136 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
137 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
138 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
139 INT145929 Regulation of Bax 20 0.60 18.12 5.35
140 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
141 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
142 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
143 INT60585 Regulation of TP53 59 0.59 54.55 5.21
144 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17
145 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
146 INT61312 Positive_regulation of Spdya 3 0.10 0.74 5.12
147 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
148 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
149 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
150 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
151 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
152 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
153 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
154 INT131808 Localization of Apex1 2 0.16 13.46 4.61
155 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
156 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
157 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
158 INT168151 Gene_expression of Sgk1 10 0.76 5.58 4.35
159 INT111535 Negative_regulation of Phosphorylation of Mapk3 9 0.57 6.39 4.31
160 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
161 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
162 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
163 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
164 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
165 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
166 INT123752 Regulation of Bax 19 0.60 16.45 4
167 INT112692 Localization of Bax 31 0.80 20.97 3.98
168 INT112782 Localization of Mapk3 8 0.78 1.87 3.98
169 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
170 INT73750 Regulation of Gene_expression of YY1 7 0.44 0.28 3.91
171 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
172 INT123827 Positive_regulation of Phosphorylation of Mapk3 10 0.67 5.22 3.82
173 INT63121 Binding of APC 29 0.41 23.02 3.8
174 INT94291 Regulation of Gene_expression of Mapk3 4 0.40 3.05 3.8
175 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
176 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
177 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
178 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
179 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68
180 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65
181 INT53891 Positive_regulation of Positive_regulation of YY1 5 0.49 0.24 3.65
182 INT106618 Positive_regulation of CIB1 9 0.63 3.38 3.63
183 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
184 INT223134 Positive_regulation of Cib1 1 0.02 1.94 3.55
185 INT104705 Regulation of Msh3 4 0.28 0.1 3.51
186 INT29356 Positive_regulation of Binding of YY1 8 0.67 0.22 3.49
187 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
188 INT191667 Positive_regulation of Sgk1 6 0.68 4.59 3.45
189 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
190 INT129751 Regulation of Phosphorylation of Mapk3 11 0.55 3.91 3.35
191 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
192 INT97737 Negative_regulation of Phosphorylation of Mapk3 9 0.57 5.64 3.3
193 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29
194 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
195 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
196 INT75500 Negative_regulation of Gene_expression of CCND1 21 0.57 11.59 3.24
197 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2
198 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
199 INT104708 Gene_expression of Msh3 6 0.72 0.07 3.17
200 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
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