GO:0006975

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Name DNA damage induced protein phosphorylation
Categary Process
Go Slim No
Go Link GO:0006975
Unique Molecular Interactions 65
Total Molecular Interactions 86
Total Single Events 622
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage induced protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage induced protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
2 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
3 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
4 INT346237 MAP2K6 Positive_regulation of MAP2K3 1 0.49 1 0.44
5 INT263433 Abl1 Regulation of Abl1 1 0.04 0.28 0.38
6 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
7 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
8 INT263383 Abl1 Regulation of Trib3 1 0.01 0.28 0.35
9 INT346228 MAP2K6 Positive_regulation of Positive_regulation of MAPK14 1 0.44 0.68 0.34
10 INT346236 Binding of MAPK14 and MAP2K6 1 0.32 0.65 0.33
11 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21
12 INT274578 Binding of ABL1 and PSTPIP1 1 0.07 1.55 0.21
13 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
14 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
15 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
16 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
17 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
18 INT246365 CALM1 Regulation of MAP2K6 1 0.00 0.34 0.15
19 INT143661 Abl1 Regulation of Gpx1 1 0.19 0.56 0.12
20 INT263429 Pdgfb Positive_regulation of Localization of Abl1 1 0.01 0 0.12
21 INT274583 Binding of ABL1 and PSTPIP2 1 0.06 0.79 0.11
22 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09
23 INT194727 MAP3K4 Positive_regulation of MAP2K6 1 0.06 0 0.04
24 INT194703 MAP2K1 Positive_regulation of MAP2K6 1 0.21 0 0.04
25 INT263377 Abl1 Regulation of Src 1 0.15 0 0.04
26 INT263428 Abl1 Regulation of Pdgfra 1 0.00 0 0.04
27 INT263432 Trib3 Regulation of Abl1 1 0.00 0 0.04
28 INT263379 Abl1 Regulation of Bmx 1 0.04 0 0.04
29 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03
30 INT286767 Binding of Abl1 and Tusc2 1 0.54 1.04 0.03
31 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
32 INT292680 Negative_regulation of TXK Negative_regulation of ABL1 1 0.00 0.26 0
33 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
34 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
35 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
36 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
37 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
38 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
39 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
40 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
41 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
42 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
43 INT296164 Mcph1 Regulation of Chek1 1 0.25 0.19 0
44 INT285582 Binding of ABL1 and S100A8 1 0.02 0.2 0
45 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
46 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0
47 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
48 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
49 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0
50 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0
51 INT333459 TP53 Positive_regulation of CHEK1 1 0.09 0 0
52 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
53 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
54 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0
55 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
56 INT292726 ABL1 Positive_regulation of Mapk1 1 0.01 0.15 0
57 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
58 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0
59 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage induced protein phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage induced protein phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT85126 Negative_regulation of MAP2K6 19 0.39 12.12 4.39
2 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
3 INT119420 Phosphorylation of MAP2K6 8 0.79 4.89 3.52
4 INT102646 Positive_regulation of MAP2K6 3 0.63 4.37 2.44
5 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13
6 INT119422 Negative_regulation of Phosphorylation of MAP2K6 3 0.38 2.09 1.76
7 INT263398 Positive_regulation of Abl1 1 0.60 1.44 1.66
8 INT109916 Positive_regulation of Positive_regulation of MAP2K6 2 0.45 2.28 1.45
9 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
10 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17
11 INT102758 Negative_regulation of Abl1 2 0.51 1.13 1.1
12 INT150546 Positive_regulation of Phosphorylation of MAP2K6 3 0.49 1.14 0.93
13 INT263387 Binding of Abl1 8 0.42 0.86 0.91
14 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87
15 INT346246 Positive_regulation of Gene_expression of MAP2K6 1 0.45 1.74 0.78
16 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75
17 INT241499 Binding of Abl1 23 0.47 8.86 0.75
18 INT151468 Regulation of MAP2K6 2 0.11 0.68 0.74
19 INT28118 Binding of Atm 13 0.38 12.24 0.68
20 INT58742 Localization of MAP2K6 1 0.61 0.16 0.58
21 INT48212 Binding of ATM 5 0.47 3.89 0.57
22 INT160777 Transcription of CHEK2 1 0.52 1.03 0.57
23 INT160778 Transcription of ATM 1 0.40 1.03 0.57
24 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
25 INT263404 Regulation of Abl1 1 0.53 0.66 0.52
26 INT346258 Negative_regulation of Gene_expression of MAP2K6 1 0.38 1.08 0.45
27 INT346260 Regulation of Gene_expression of MAP2K6 1 0.41 1.09 0.45
28 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
29 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39
30 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
31 INT158641 Positive_regulation of CHEK2 5 0.35 4.15 0.37
32 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
33 INT73854 Transcription of ABL1 4 0.52 2.26 0.34
34 INT263408 Gene_expression of Abl1 4 0.58 0.28 0.33
35 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
36 INT167438 Localization of ATM 3 0.55 1.61 0.27
37 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
38 INT158642 Regulation of Positive_regulation of CHEK2 1 0.07 1.27 0.25
39 INT263399 Positive_regulation of Gene_expression of Abl1 1 0.43 0 0.25
40 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
41 INT241498 Regulation of Abl1 8 0.32 6.46 0.22
42 INT263396 Localization of Abl1 1 0.61 0 0.21
43 INT239412 Binding of ABL1 8 0.28 5.39 0.18
44 INT263405 Phosphorylation of Abl1 1 0.71 0.05 0.18
45 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16
46 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16
47 INT163461 Regulation of ABL1 8 0.32 5.98 0.14
48 INT263392 Positive_regulation of Phosphorylation of Abl1 1 0.60 0 0.13
49 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
50 INT263411 Negative_regulation of Positive_regulation of Abl1 1 0.37 0.42 0.13
51 INT167440 Regulation of ATM 2 0.20 0.68 0.12
52 INT211717 Gene_expression of CHEK2 13 0.37 2.13 0.1
53 INT263386 Negative_regulation of Binding of Abl1 1 0.51 0.05 0.1
54 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09
55 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09
56 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
57 INT252551 Phosphorylation of CHEK2 4 0.48 4.73 0.08
58 INT252552 Positive_regulation of Phosphorylation of CHEK2 1 0.23 0.26 0.08
59 INT263421 Regulation of Localization of Abl1 1 0.23 0 0.08
60 INT263389 Regulation of Regulation of Abl1 1 0.39 0.06 0.07
61 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
62 INT139362 Negative_regulation of CHEK2 2 0.35 1.66 0.06
63 INT139365 Negative_regulation of Negative_regulation of CHEK1 1 0.23 1.67 0.06
64 INT139364 Negative_regulation of Negative_regulation of CHEK2 1 0.26 1.67 0.06
65 INT163462 Negative_regulation of Regulation of ABL1 1 0.11 1.17 0.06
66 INT109594 Positive_regulation of ABL1 10 0.49 7.19 0.05
67 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05
68 INT273554 Positive_regulation of Binding of Abl1 2 0.40 2.05 0.05
69 INT315848 Positive_regulation of Negative_regulation of Abl1 1 0.20 0.61 0.05
70 INT263406 Protein_catabolism of Abl1 1 0.86 0 0.05
71 INT241506 Localization of Abl1 2 0.54 2.37 0.04
72 INT350897 Negative_regulation of Binding of ABL1 1 0.18 1.19 0.04
73 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
74 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03
75 INT207803 Regulation of Atm 3 0.41 1.15 0.03
76 INT315842 Regulation of Gene_expression of Abl1 1 0.11 0.94 0.03
77 INT207807 Localization of Atm 4 0.74 0.21 0
78 INT273548 Negative_regulation of Binding of Abl1 2 0.34 0.88 0
79 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
80 INT212461 Gene_expression of Chek1 2 0.65 0.11 0
81 INT292713 Phosphorylation of ABL1 2 0.44 1.04 0
82 INT252642 Transcription of Atm 1 0.53 0.18 0
83 INT296150 Negative_regulation of Gene_expression of Chek1 1 0.35 0.11 0
84 INT252942 Phosphorylation of Chek1 1 0.14 0.63 0
85 INT252553 Positive_regulation of Positive_regulation of CHEK2 1 0.17 0 0
86 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0
87 INT263393 Regulation of Binding of Abl1 1 0.39 0 0
88 INT350510 Localization of ABL1 1 0.40 2.51 0
89 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
90 INT292711 Regulation of Gene_expression of ABL1 1 0.06 1.02 0
91 INT350521 Negative_regulation of Negative_regulation of ABL1 1 0.23 0.55 0
92 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
93 INT329779 Positive_regulation of CHEK1 1 0.22 0.76 0
94 INT156466 Regulation of Negative_regulation of ABL1 1 0.44 0.63 0
95 INT350517 Negative_regulation of Gene_expression of ABL1 1 0.23 0.53 0
96 INT165179 Regulation of Positive_regulation of ABL1 1 0.15 0.95 0
97 INT283069 Negative_regulation of Gene_expression of Abl1 1 0.17 0.69 0
98 INT221708 Binding of CHEK2 1 0.01 0 0
99 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
100 INT273558 Transcription of Abl1 1 0.57 0.3 0
101 INT296140 Negative_regulation of Chek1 1 0.35 0.45 0
102 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
103 INT273546 Negative_regulation of Transcription of Abl1 1 0.46 0.3 0
104 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
105 INT329783 Phosphorylation of CHEK1 1 0.26 0.82 0
106 INT263391 Negative_regulation of Gene_expression of Abl1 1 0.37 0 0
107 INT350512 Positive_regulation of Phosphorylation of ABL1 1 0.27 0.75 0
108 INT351489 Regulation of Transcription of ABL1 1 0.28 0.08 0
109 INT350508 Protein_catabolism of ABL1 1 0.54 0.5 0
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