GO:0006977

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Name DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Categary Process
Go Slim No
Go Link GO:0006977
Unique Molecular Interactions 495
Total Molecular Interactions 651
Total Single Events 5166
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
3 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
4 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
5 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
6 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
7 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
8 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
9 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
10 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
11 INT172982 Binding of MUC1 and MUC4 1 0.30 2.46 0.78
12 INT144286 ACP1 Negative_regulation of Phosphorylation of PSMC6 1 0.45 0.39 0.78
13 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
14 INT132154 PSG7 Positive_regulation of Localization of MUC1 1 0.00 0 0.65
15 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
16 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
17 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
18 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
19 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
20 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
21 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
22 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
23 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
24 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
25 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
26 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
27 INT13879 Binding of PSMB9 and KCNAB2 1 0.03 0.19 0.41
28 INT121974 Lrdd Positive_regulation of Fos 1 0.04 0 0.39
29 INT132174 PSG7 Positive_regulation of Gene_expression of Muc1 1 0.00 0 0.34
30 INT132169 PSG7 Positive_regulation of Muc1 1 0.00 0 0.34
31 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
32 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
33 INT132155 PSG7 Positive_regulation of Gene_expression of MUC1 1 0.00 0 0.32
34 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
35 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
36 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
37 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
38 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
39 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
40 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
41 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
42 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29
43 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
44 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
45 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
46 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
47 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
48 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
49 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
50 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
51 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
52 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
53 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
54 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
55 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
56 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
57 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
58 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
59 INT35178 Binding of STT3A and PSME3 1 0.01 0.38 0.25
60 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
61 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
62 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
63 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
64 INT147590 Binding of Muc1 and Mag 1 0.26 3.29 0.23
65 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
66 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
67 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
68 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22
69 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
70 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
71 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
72 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
73 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
74 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
75 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
76 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
77 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
78 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
79 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
80 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
81 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
82 INT318188 MUC5AC Positive_regulation of MUC1 1 0.16 1.12 0.17
83 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
84 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
85 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
86 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
87 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
88 INT180503 Binding of SARS and PSMD6 1 0.22 2.44 0.16
89 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15
90 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
91 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
92 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
93 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
94 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
95 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
96 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
97 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
98 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13
99 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
100 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
101 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
102 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13
103 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
104 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
105 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
106 INT57014 PSMB1 Regulation of SCN5A 1 0.02 0 0.1
107 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
108 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
109 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
110 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
111 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
112 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
113 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
114 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
115 INT147591 Binding of MAG and Muc1 1 0.46 0.83 0.09
116 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
117 INT298351 PSMD1 Regulation of Gene_expression of HLA-DRA 1 0.01 0.42 0.08
118 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
119 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
120 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08
121 INT298356 PSMD1 Regulation of Gene_expression of Cd14 1 0.04 0.42 0.08
122 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
123 INT166784 Binding of PSMD1 and Nkx6-2 1 0.21 0.5 0.08
124 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
125 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07
126 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
127 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
128 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
129 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
130 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
131 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
132 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
133 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
134 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
135 INT174901 Binding of GSPT2 and GTSE1 1 0.01 1.28 0.07
136 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
137 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
138 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
139 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
140 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
141 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
142 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
143 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
144 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
145 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
146 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06
147 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
148 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
149 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
150 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
151 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
152 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
153 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05
154 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
155 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
156 INT302141 CDKN1C Regulation of CDKN1B 1 0.09 0.26 0.05
157 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
158 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
159 INT302163 IFI27 Regulation of CDKN1A 1 0.11 0.26 0.05
160 INT344747 ABAT Positive_regulation of Gene_expression of MUC1 1 0.04 0.6 0.05
161 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
162 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
163 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
164 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
165 INT231605 Binding of PSMD1 and SGCG 1 0.02 0.34 0.04
166 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
167 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
168 INT176326 IL2 Positive_regulation of Gene_expression of MUC1 1 0.08 0.71 0.04
169 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
170 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
171 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
172 INT176224 Binding of CDKN1A and PCNA 4 0.08 2.52 0.03
173 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
174 INT302159 TSC1 Positive_regulation of Transcription of CDKN1A 1 0.00 0.28 0.03
175 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
176 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
177 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
178 INT303091 Rorb Regulation of CDKN1A 1 0.00 0.52 0.03
179 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
180 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
181 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
182 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
183 INT283722 Id2 Negative_regulation of Transcription of CDKN1A 1 0.45 0.11 0.03
184 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
185 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
186 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
187 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
188 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
189 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
190 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
191 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
192 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
193 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
194 INT223066 CDKN1A Negative_regulation of CCND1 1 0.04 0.66 0.03
195 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
196 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
197 INT201771 CDKN1A Positive_regulation of Localization of Ccnd1 1 0.04 0 0
198 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
199 INT347577 Binding of MUC1 and MUC16 1 0.25 0.42 0
200 INT325154 CDKN1B Negative_regulation of CCNE2 1 0.07 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19
3 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98
4 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
5 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89
6 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
7 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
8 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
9 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
10 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
11 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
12 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
13 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
14 INT49802 Localization of MUC1 75 0.81 44.74 8.87
15 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
16 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
17 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
18 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
19 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
20 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
21 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86
22 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
23 INT151748 Positive_regulation of Positive_regulation of PSMD2 4 0.49 4.45 5.35
24 INT60585 Regulation of TP53 59 0.59 54.55 5.21
25 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
26 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
27 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69
28 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
29 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
30 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56
31 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
32 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
33 INT69591 Positive_regulation of Positive_regulation of PSMD1 2 0.50 3.06 3.99
34 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
35 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75
36 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
37 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
38 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33
39 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
40 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
41 INT8103 Binding of TP53 46 0.44 40.2 2.96
42 INT51993 Gene_expression of PSMA5 5 0.75 2.59 2.92
43 INT140547 Negative_regulation of PSMB10 3 0.02 2.33 2.92
44 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
45 INT24443 Gene_expression of PSMD2 20 0.54 7.29 2.77
46 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
47 INT60440 Localization of PSMD1 10 0.74 3.94 2.57
48 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
49 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
50 INT9473 Binding of MUC1 66 0.48 46.77 2.36
51 INT55952 Transcription of TP53 16 0.61 12.14 2.36
52 INT106616 Gene_expression of PSMB9 35 0.72 28.4 2.29
53 INT173005 Transcription of MUC1 11 0.63 10.15 2.24
54 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06
55 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
56 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
57 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
58 INT69027 Binding of PSMA5 4 0.47 1.08 1.93
59 INT65855 Localization of TP53 18 0.76 17.08 1.89
60 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
61 INT148721 Binding of PSMD1 13 0.31 4.78 1.76
62 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
63 INT97062 Binding of PML 10 0.41 11.63 1.65
64 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
65 INT159185 Positive_regulation of Gene_expression of PSMD2 3 0.40 1.4 1.63
66 INT164152 Negative_regulation of PSMD2 9 0.37 3.41 1.56
67 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
68 INT132163 Positive_regulation of Localization of MUC1 9 0.19 8.96 1.54
69 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
70 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
71 INT69513 Regulation of PSMA5 2 0.60 1.04 1.43
72 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
73 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
74 INT108587 Negative_regulation of PSMA5 1 0.57 1.73 1.42
75 INT172953 Binding of Trp53 33 0.37 20.76 1.41
76 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
77 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
78 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
79 INT145221 Binding of Tp53 10 0.37 8.59 1.37
80 INT6018 Positive_regulation of PSMB9 7 0.60 4.36 1.33
81 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
82 INT79660 Phosphorylation of PSMC6 3 0.80 0.45 1.28
83 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
84 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
85 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19
86 INT174156 Localization of Trp53 16 0.72 13.52 1.18
87 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
88 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
89 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
90 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
91 INT67638 Positive_regulation of PSMA5 1 0.21 1.15 1.05
92 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
93 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
94 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
95 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
96 INT13882 Binding of PSMB9 3 0.15 2.84 1
97 INT78322 Positive_regulation of PSME1 2 0.44 1.8 0.95
98 INT144289 Negative_regulation of Positive_regulation of PSMC6 1 0.41 0.56 0.92
99 INT144287 Positive_regulation of PSMC6 1 0.49 0.56 0.92
100 INT89290 Regulation of MUC1 19 0.45 10.4 0.81
101 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
102 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79
103 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
104 INT282916 Positive_regulation of Transcription of MUC1 2 0.45 0.47 0.79
105 INT78323 Negative_regulation of PSME1 1 0.37 0.5 0.78
106 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
107 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
108 INT108590 Negative_regulation of Negative_regulation of PSMA5 1 0.57 0.92 0.75
109 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
110 INT262726 Localization of PML 6 0.57 7.13 0.72
111 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
112 INT132164 Gene_expression of Muc1 4 0.71 4.15 0.67
113 INT235746 Positive_regulation of Casp2 2 0.04 2.67 0.67
114 INT108586 Positive_regulation of Negative_regulation of PSMA5 1 0.49 0.82 0.67
115 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
116 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
117 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
118 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
119 INT200797 Positive_regulation of Ptprv 4 0.14 3.19 0.58
120 INT17109 Regulation of Gene_expression of PSMD1 3 0.44 0.86 0.58
121 INT48212 Binding of ATM 5 0.47 3.89 0.57
122 INT160778 Transcription of ATM 1 0.40 1.03 0.57
123 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
124 INT16681 Positive_regulation of PSMC2 1 0.07 0 0.54
125 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
126 INT343798 Negative_regulation of Transcription of MUC1 1 0.39 0.37 0.5
127 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
128 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
129 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44
130 INT350879 Negative_regulation of Localization of PSMD1 1 0.05 0.43 0.43
131 INT202762 Gene_expression of PSMD3 8 0.47 1.44 0.42
132 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
133 INT280564 Negative_regulation of Gene_expression of PSMB9 5 0.54 5.99 0.41
134 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
135 INT78324 Regulation of PSME1 1 0.61 0.49 0.41
136 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
137 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
138 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
139 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
140 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
141 INT280560 Positive_regulation of Gene_expression of PSMB9 7 0.64 6.44 0.36
142 INT218901 Negative_regulation of Ptprv 1 0.02 1.73 0.36
143 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
144 INT296651 Negative_regulation of Casp2 2 0.21 1.75 0.35
145 INT335718 Regulation of Gene_expression of PSMD2 1 0.09 0.07 0.35
146 INT11689 Binding of PSMD2 16 0.36 2.77 0.34
147 INT57019 Gene_expression of PSMB1 1 0.38 0 0.34
148 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
149 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
150 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
151 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
152 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
153 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
154 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
155 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
156 INT11688 Binding of PSMD3 5 0.36 1.17 0.28
157 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
158 INT167438 Localization of ATM 3 0.55 1.61 0.27
159 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
160 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
161 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
162 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
163 INT131823 Negative_regulation of PSMB6 2 0.01 0.09 0.24
164 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
165 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
166 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
167 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
168 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
169 INT322282 Localization of PSMD2 2 0.20 1.42 0.22
170 INT147586 Positive_regulation of Gene_expression of Muc1 1 0.43 2.54 0.22
171 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
172 INT209076 Negative_regulation of PSME3 2 0.34 0.86 0.21
173 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
174 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
175 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
176 INT348361 Localization of Muc1 1 0.27 0.58 0.2
177 INT165973 Phosphorylation of PSMA5 1 0.79 0.07 0.2
178 INT165972 Positive_regulation of Phosphorylation of PSMA5 1 0.49 0.07 0.2
179 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
180 INT280553 Regulation of PSMB9 2 0.57 1.46 0.19
181 INT209077 Positive_regulation of Negative_regulation of PSME3 1 0.37 0.13 0.19
182 INT296650 Gene_expression of Casp2 2 0.30 1.49 0.17
183 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
184 INT296646 Transcription of Casp2 1 0.03 0.71 0.17
185 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
186 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
187 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
188 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
189 INT57020 Transcription of PSMB1 1 0.26 0 0.16
190 INT113346 Binding of MDM2 10 0.35 5.73 0.15
191 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
192 INT90493 Negative_regulation of PSMB9 3 0.54 0.88 0.15
193 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
194 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
195 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
196 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
197 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
198 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
199 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
200 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
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