GO:0006978

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Name DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Categary Process
Go Slim No
Go Link GO:0006978
Unique Molecular Interactions 392
Total Molecular Interactions 472
Total Single Events 4140
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. They are ordered first by their pain relevance and then by number of times they were reported for DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
3 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
4 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
5 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
6 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
7 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
8 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
9 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
10 INT172982 Binding of MUC1 and MUC4 1 0.30 2.46 0.78
11 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
12 INT132154 PSG7 Positive_regulation of Localization of MUC1 1 0.00 0 0.65
13 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
14 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
15 INT138353 Foxm1 Positive_regulation of Phosphorylation of Trpv1 1 0.10 0.31 0.51
16 INT138352 Foxm1 Positive_regulation of Trpa1 1 0.05 0.33 0.51
17 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
18 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5
19 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 0.04 0 0.49
20 INT86089 Foxm1 Regulation of Binding of Crygs 1 0.02 0 0.49
21 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
22 INT58969 TNF Regulation of Regulation of RPS6KA6 1 0.35 0.34 0.38
23 INT58967 TNF Regulation of RPS6KA6 1 0.18 0.33 0.38
24 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
25 INT353454 Binding of BRCA1 and IL17A 1 0.00 2.55 0.36
26 INT132174 PSG7 Positive_regulation of Gene_expression of Muc1 1 0.00 0 0.34
27 INT353452 Binding of AGRP and BRCA1 1 0.00 3.89 0.34
28 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
29 INT132169 PSG7 Positive_regulation of Muc1 1 0.00 0 0.34
30 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
31 INT132155 PSG7 Positive_regulation of Gene_expression of MUC1 1 0.00 0 0.32
32 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
33 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
34 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
35 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
36 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
37 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29
38 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
39 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
40 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
41 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
42 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
43 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
44 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
45 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
46 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
47 INT353449 BRCA1 Positive_regulation of IL4 1 0.00 1.37 0.26
48 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
49 INT353455 BRCA1 Positive_regulation of IL13 1 0.00 1.37 0.26
50 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
51 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
52 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
53 INT220635 Binding of Lrp1 and Kat5 2 0.09 0.71 0.25
54 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
55 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
56 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
57 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
58 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
59 INT225118 Foxm1 Positive_regulation of Gene_expression of MMP2 1 0.01 0.34 0.23
60 INT147590 Binding of Muc1 and Mag 1 0.26 3.29 0.23
61 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
62 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22
63 INT225117 Foxm1 Regulation of Gene_expression of FN1 1 0.01 0.4 0.22
64 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
65 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
66 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
67 INT58968 TNF Positive_regulation of Gene_expression of RPS6KA6 1 0.36 0.2 0.21
68 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
69 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
70 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
71 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
72 INT318188 MUC5AC Positive_regulation of MUC1 1 0.16 1.12 0.17
73 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
74 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
75 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
76 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
77 INT244116 ELAVL3 Negative_regulation of MUC1 1 0.09 3.41 0.15
78 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
79 INT286769 Tusc2 Regulation of Foxm1 1 0.02 1.55 0.15
80 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
81 INT353451 Binding of BRCA1 and CRP 1 0.01 1.18 0.14
82 INT353453 Binding of BRCA1 and IL4 1 0.00 1.18 0.14
83 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
84 INT185455 MUC1 Negative_regulation of Timp1 1 0.06 0.84 0.13
85 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
86 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
87 INT185416 MUC1 Negative_regulation of TIMP1 1 0.18 0.84 0.13
88 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
89 INT220633 Binding of Kat5 and Ighd 1 0.09 0.32 0.12
90 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
91 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
92 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
93 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
94 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
95 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
96 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
97 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
98 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
99 INT147591 Binding of MAG and Muc1 1 0.46 0.83 0.09
100 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
101 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08
102 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
103 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
104 INT267592 IL6 Positive_regulation of Localization of MUC1 1 0.00 1.24 0.07
105 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
106 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
107 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
108 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
109 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
110 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
111 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
112 INT267593 IL8 Positive_regulation of Localization of MUC1 1 0.00 1.06 0.06
113 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
114 INT353450 Binding of BRCA1 and VEGFA 1 0.01 0.82 0.05
115 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
116 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
117 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
118 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
119 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
120 INT273068 Binding of P2RY2 and TFAP4 1 0.01 0.27 0.05
121 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
122 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
123 INT344747 ABAT Positive_regulation of Gene_expression of MUC1 1 0.04 0.6 0.05
124 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
125 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
126 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
127 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
128 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
129 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
130 INT176326 IL2 Positive_regulation of Gene_expression of MUC1 1 0.08 0.71 0.04
131 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
132 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
133 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
134 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
135 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03
136 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
137 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03
138 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
139 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
140 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
141 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
142 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
143 INT338900 MYC Positive_regulation of Gene_expression of TP73 1 0.05 0.27 0.03
144 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
145 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
146 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
147 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
148 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
149 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
150 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
151 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
152 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
153 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
154 INT347577 Binding of MUC1 and MUC16 1 0.25 0.42 0
155 INT348532 TP63 Positive_regulation of CASP3 1 0.04 0.55 0
156 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0
157 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
158 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
159 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
160 INT304020 AR Regulation of TP53 1 0.24 1.11 0
161 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0
162 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
163 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
164 INT235649 TP73 Regulation of EFNA1 1 0.09 0.97 0
165 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
166 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0
167 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0
168 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
169 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
170 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0
171 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
172 INT333690 Hr Negative_regulation of Transcription of Trp53 1 0.23 0.51 0
173 INT217776 TP53 Regulation of MITF 1 0.00 1.28 0
174 INT334322 Binding of RB1 and TP53 1 0.34 2 0
175 INT342007 Mta1 Regulation of Trp53 1 0.15 0.15 0
176 INT179095 Myc Positive_regulation of Gene_expression of Trp53 1 0.43 0.83 0
177 INT315397 Binding of IFNA1 and Tp53 1 0.00 0.43 0
178 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0
179 INT333689 Hr Positive_regulation of Protein_catabolism of Trp53 1 0.25 1.71 0
180 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
181 INT286044 Wwox Positive_regulation of Tp53 1 0.05 0.63 0
182 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
183 INT235645 TP53 Regulation of EPHA2 1 0.10 0.97 0
184 INT241256 TP53 Regulation of OPCML 1 0.12 1.31 0
185 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
186 INT352625 Trp53 Regulation of CEL 1 0.00 0.71 0
187 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
188 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
189 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
190 INT177793 EGR1 Positive_regulation of Negative_regulation of TP53 1 0.18 0.44 0
191 INT284232 Binding of TP53 and HNRNPUL1 1 0.26 0.88 0
192 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
193 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
194 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
195 INT337708 Naf1 Regulation of Gene_expression of Tp53 1 0.09 0.22 0
196 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0
197 INT348540 TP63 Positive_regulation of CASP8 1 0.03 0.55 0
198 INT345337 Binding of TP53 and BCC1 1 0.11 1.05 0
199 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
200 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. They are ordered first by their pain relevance and then by number of times they were reported in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19
3 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
4 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
5 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
6 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64
7 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
8 INT49802 Localization of MUC1 75 0.81 44.74 8.87
9 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
10 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
11 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48
12 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
13 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
14 INT55513 Binding of Foxm1 19 0.37 2.37 5.54
15 INT60585 Regulation of TP53 59 0.59 54.55 5.21
16 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07
17 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
18 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
19 INT49805 Positive_regulation of MUC1 56 0.70 44.5 4.56
20 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
21 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17
22 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75
23 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
24 INT12844 Binding of TP63 15 0.47 10.57 3.38
25 INT8103 Binding of TP53 46 0.44 40.2 2.96
26 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81
27 INT221269 Binding of BRCA1 14 0.40 31.77 2.7
28 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
29 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
30 INT9473 Binding of MUC1 66 0.48 46.77 2.36
31 INT55952 Transcription of TP53 16 0.61 12.14 2.36
32 INT113203 Regulation of Foxm1 8 0.34 7.5 2.36
33 INT173005 Transcription of MUC1 11 0.63 10.15 2.24
34 INT49803 Negative_regulation of MUC1 37 0.58 26.37 2.06
35 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
36 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
37 INT65855 Localization of TP53 18 0.76 17.08 1.89
38 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
39 INT113985 Positive_regulation of TP63 9 0.50 8.79 1.62
40 INT193823 Positive_regulation of Gene_expression of TP63 7 0.18 7.74 1.57
41 INT132163 Positive_regulation of Localization of MUC1 9 0.19 8.96 1.54
42 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
43 INT221422 Positive_regulation of BRCA1 5 0.23 12.63 1.53
44 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
45 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
46 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
47 INT172953 Binding of Trp53 33 0.37 20.76 1.41
48 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
49 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
50 INT145221 Binding of Tp53 10 0.37 8.59 1.37
51 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36
52 INT49804 Negative_regulation of Localization of MUC1 7 0.59 5.84 1.19
53 INT174156 Localization of Trp53 16 0.72 13.52 1.18
54 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
55 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
56 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13
57 INT138349 Phosphorylation of Foxm1 1 0.10 0.9 1.05
58 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
59 INT72710 Negative_regulation of Negative_regulation of Foxm1 3 0.10 0.55 0.84
60 INT6602 Gene_expression of RPS6KA6 3 0.56 1.75 0.82
61 INT89290 Regulation of MUC1 19 0.45 10.4 0.81
62 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
63 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79
64 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79
65 INT282916 Positive_regulation of Transcription of MUC1 2 0.45 0.47 0.79
66 INT44293 Regulation of TP63 6 0.24 2.88 0.76
67 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
68 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
69 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
70 INT132164 Gene_expression of Muc1 4 0.71 4.15 0.67
71 INT203749 Binding of FOXM1 10 0.31 6.1 0.64
72 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
73 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
74 INT249764 Regulation of Binding of Foxm1 1 0.39 0.19 0.58
75 INT206006 Negative_regulation of Gene_expression of Foxm1 4 0.43 2.63 0.56
76 INT221420 Positive_regulation of Gene_expression of BRCA1 2 0.24 2.17 0.55
77 INT154151 Positive_regulation of TP73 5 0.67 5.71 0.52
78 INT86087 Negative_regulation of Binding of Foxm1 1 0.28 0 0.52
79 INT206009 Transcription of Foxm1 2 0.68 1.49 0.51
80 INT343798 Negative_regulation of Transcription of MUC1 1 0.39 0.37 0.5
81 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
82 INT306741 Positive_regulation of Positive_regulation of TP63 2 0.05 1.16 0.49
83 INT278121 Negative_regulation of Negative_regulation of TP63 1 0.03 0 0.48
84 INT61813 Localization of TFAP4 1 0.73 0 0.47
85 INT61812 Gene_expression of TFAP4 1 0.65 0 0.45
86 INT173022 Regulation of Gene_expression of MUC1 9 0.60 7.59 0.44
87 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
88 INT58976 Positive_regulation of RPS6KA6 1 0.36 0.32 0.39
89 INT50336 Negative_regulation of Positive_regulation of Foxm1 1 0.30 0 0.38
90 INT58975 Regulation of RPS6KA6 1 0.33 0.33 0.37
91 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36
92 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
93 INT353457 Positive_regulation of Binding of BRCA1 1 0.09 1.69 0.34
94 INT221419 Regulation of BRCA1 5 0.35 6.18 0.31
95 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
96 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
97 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
98 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25
99 INT220604 Binding of Kat5 2 0.11 0.7 0.25
100 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
101 INT154150 Regulation of TP73 3 0.15 2.81 0.24
102 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
103 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
104 INT147586 Positive_regulation of Gene_expression of Muc1 1 0.43 2.54 0.22
105 INT58973 Positive_regulation of Gene_expression of RPS6KA6 1 0.36 0.2 0.21
106 INT348361 Localization of Muc1 1 0.27 0.58 0.2
107 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19
108 INT203750 Positive_regulation of FOXM1 8 0.39 2.72 0.19
109 INT154147 Gene_expression of TP73 7 0.34 3.97 0.19
110 INT19359 Binding of BRCA2 5 0.47 2.63 0.19
111 INT221268 Localization of BRCA1 7 0.63 4.83 0.18
112 INT119061 Negative_regulation of Gene_expression of BRCA1 4 0.51 0.85 0.18
113 INT89690 Binding of Brca2 2 0.37 1.8 0.18
114 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
115 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
116 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
117 INT139201 Localization of TP63 4 0.32 2.56 0.15
118 INT145147 Negative_regulation of Gene_expression of TP63 4 0.42 2.91 0.15
119 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
120 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
121 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
122 INT176329 Protein_catabolism of MUC1 4 0.72 2.14 0.14
123 INT154148 Negative_regulation of Gene_expression of TP73 3 0.21 1.89 0.14
124 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
125 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
126 INT147589 Binding of Muc1 1 0.41 2.48 0.13
127 INT203751 Negative_regulation of FOXM1 2 0.20 0.94 0.11
128 INT146072 Binding of TP73 2 0.12 0.58 0.1
129 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
130 INT111139 Localization of Tp53 4 0.45 2.4 0.09
131 INT176328 Positive_regulation of Protein_catabolism of MUC1 1 0.41 0.86 0.09
132 INT136890 Protein_catabolism of TP63 2 0.56 1.17 0.07
133 INT234186 Localization of BRCA2 2 0.69 1.48 0.07
134 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
135 INT282927 Regulation of Localization of MUC1 1 0.26 0.92 0.07
136 INT129204 Positive_regulation of Positive_regulation of MUC1 2 0.09 1.01 0.06
137 INT147587 Negative_regulation of Muc1 1 0.50 0.88 0.06
138 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
139 INT273080 Binding of TFAP4 1 0.01 0.27 0.05
140 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
141 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
142 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
143 INT249792 Regulation of Gene_expression of Foxm1 1 0.45 0.45 0.04
144 INT221856 Regulation of Positive_regulation of MUC1 1 0.25 0.85 0.04
145 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
146 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
147 INT344009 Negative_regulation of Localization of BRCA1 1 0.30 0.18 0.03
148 INT249769 Localization of Foxm1 6 0.74 1.13 0
149 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
150 INT154149 Positive_regulation of Gene_expression of TP73 3 0.18 0.67 0
151 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
152 INT209451 Regulation of Gene_expression of TP63 3 0.16 4.32 0
153 INT259116 Transcription of BRCA1 3 0.44 3.77 0
154 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
155 INT167536 Positive_regulation of BRCA2 2 0.49 0.29 0
156 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
157 INT172483 Positive_regulation of TFAP4 2 0.44 0.33 0
158 INT172481 Transcription of TFAP4 2 0.66 0.58 0
159 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
160 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
161 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0
162 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
163 INT282929 Negative_regulation of Binding of MUC1 1 0.57 0.34 0
164 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
165 INT154146 Regulation of Gene_expression of TP73 1 0.16 0.26 0
166 INT139622 Transcription of Muc1 1 0.21 0 0
167 INT314708 Gene_expression of Brca2 1 0.41 1.75 0
168 INT119064 Regulation of Gene_expression of BRCA1 1 0.53 0.05 0
169 INT282917 Negative_regulation of Protein_catabolism of MUC1 1 0.37 0.22 0
170 INT154152 Negative_regulation of TP73 1 0.13 0.21 0
171 INT207724 Transcription of FOXM1 1 0.58 0.85 0
172 INT314707 Regulation of Transcription of Brca2 1 0.27 0.56 0
173 INT139621 Regulation of Gene_expression of Muc1 1 0.56 0 0
174 INT282924 Regulation of Transcription of MUC1 1 0.26 0.12 0
175 INT333671 Regulation of Transcription of Trp53 1 0.24 0.83 0
176 INT249793 Regulation of Transcription of Foxm1 1 0.45 0 0
177 INT172478 Positive_regulation of Transcription of TFAP4 1 0.09 0.06 0
178 INT179076 Negative_regulation of Protein_catabolism of Trp53 1 0.32 0.43 0
179 INT249780 Positive_regulation of Binding of Foxm1 1 0.50 0.5 0
180 INT249768 Regulation of Localization of Foxm1 1 0.39 0 0
181 INT314705 Transcription of Brca2 1 0.42 0.56 0
182 INT221271 Negative_regulation of Binding of BRCA1 1 0.28 0.93 0
183 INT179957 Positive_regulation of Binding of Tp53 1 0.08 0.48 0
184 INT271772 Negative_regulation of Positive_regulation of MUC1 1 0.08 0 0
185 INT280555 Regulation of Binding of TP63 1 0.12 0.93 0
186 INT282920 Positive_regulation of Negative_regulation of MUC1 1 0.45 0.11 0
187 INT333663 Positive_regulation of Protein_catabolism of Trp53 1 0.45 0.84 0
188 INT173224 Regulation of BRCA2 1 0.21 1.3 0
189 INT333662 Negative_regulation of Transcription of Trp53 1 0.53 1.15 0
190 INT334189 Regulation of Binding of BRCA1 1 0.13 0.8 0
191 INT249776 Negative_regulation of Localization of Foxm1 1 0.37 0.46 0
192 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0
193 INT282915 Positive_regulation of Binding of MUC1 1 0.49 0.45 0
194 INT282926 Phosphorylation of MUC1 1 0.79 0.06 0
195 INT223765 Negative_regulation of Positive_regulation of Tp53 1 0.07 1.69 0
196 INT201567 Positive_regulation of Protein_catabolism of TP63 1 0.23 1.17 0
197 INT203752 Regulation of FOXM1 1 0.02 0 0
198 INT305295 Regulation of Binding of TP53 1 0.39 1.09 0
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