GO:0006983

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Name ER overload response
Categary Process
Go Slim No
Go Link GO:0006983
Unique Molecular Interactions 429
Total Molecular Interactions 504
Total Single Events 4965
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ER overload response. They are ordered first by their pain relevance and then by number of times they were reported for ER overload response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
3 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
4 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
5 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
6 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
7 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
8 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
9 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
10 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
11 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
12 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
13 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
14 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
15 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
16 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
17 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
18 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
19 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
20 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
21 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
22 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
23 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
24 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
25 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
26 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
27 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
28 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
29 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
30 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
31 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
32 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
33 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
34 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
35 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
36 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
37 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
38 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
39 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
40 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
41 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
42 INT350835 Binding of SELS and Sels 1 0.16 1.24 0.26
43 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
44 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
45 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
46 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
47 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
48 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
49 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
50 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
51 INT333927 GLUL Positive_regulation of HSPA5 1 0.17 0.78 0.24
52 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
53 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
54 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
55 INT192864 Binding of Hspa5 and Mela 1 0.25 1.06 0.22
56 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
57 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
58 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
59 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
60 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
61 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
62 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
63 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
64 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
65 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
66 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
67 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
68 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
69 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
70 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
71 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
72 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
73 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
74 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
75 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
76 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
77 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
78 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
79 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
80 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
81 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
82 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
83 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
84 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
85 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
86 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
87 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
88 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
89 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
90 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
91 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
92 INT350820 INS Regulation of SELS 1 0.13 1.11 0.1
93 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
94 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
95 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
96 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
97 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
98 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
99 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
100 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
101 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
102 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
103 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
104 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
105 INT215880 Car2 Regulation of Hspa5 1 0.09 0.66 0.08
106 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
107 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07
108 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
109 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
110 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
111 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
112 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
113 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
114 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
115 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
116 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
117 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
118 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
119 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
120 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
121 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
122 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
123 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
124 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
125 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
126 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
127 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
128 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
129 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
130 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
131 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
132 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
133 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
134 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
135 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
136 INT350823 Binding of SAA1 and SELS 1 0.17 2.75 0.05
137 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
138 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05
139 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
140 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
141 INT193788 ITIH4 Regulation of Phosphorylation of TP53 1 0.07 0.45 0.05
142 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
143 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
144 INT215876 Atf4 Regulation of Hspa5 1 0.22 0.43 0.04
145 INT348022 Binding of Jun and Trp53 1 0.07 0.46 0.04
146 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04
147 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
148 INT5608 Gnl3 Regulation of Eif2ak3 1 0.05 0 0.04
149 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04
150 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04
151 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04
152 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04
153 INT352619 Bcl2l12 Negative_regulation of Trp53 1 0.27 0.94 0.04
154 INT352613 Binding of Trp53 and Bcl2l12 1 0.23 0.94 0.04
155 INT170457 RASGRP1 Regulation of TP53 1 0.02 0.58 0.04
156 INT201726 Mapk8 Positive_regulation of Positive_regulation of Trp53 1 0.00 0.41 0.04
157 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
158 INT260267 Binding of TFAM and TP53 2 0.37 2.1 0.03
159 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
160 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
161 INT355036 CKAP4 Regulation of Positive_regulation of TP53 1 0.08 0.4 0.03
162 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03
163 INT211873 TP53 Positive_regulation of Transcription of CD40 1 0.03 1.44 0.03
164 INT257513 Regulation of Binding of Slc4a4 and H47 1 0.00 0.08 0.03
165 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03
166 INT352624 Trp53 Negative_regulation of CEL 1 0.01 1.01 0.03
167 INT257512 Binding of Slc4a4 and H47 1 0.00 0.08 0.03
168 INT265464 CSPG4 Regulation of Gene_expression of TP53 1 0.09 0.23 0.03
169 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03
170 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
171 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
172 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
173 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
174 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
175 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
176 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03
177 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
178 INT276389 Binding of Trp53 and KRT20 1 0.01 0.97 0.03
179 INT302134 TP53 Positive_regulation of Transcription of CDKN1A 1 0.04 0.28 0.03
180 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
181 INT314690 TP53 Regulation of Gene_expression of ZBTB7A 1 0.33 0.97 0.03
182 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
183 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
184 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
185 INT211872 TP53 Positive_regulation of CD40 1 0.03 1.44 0.03
186 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
187 INT352615 Binding of Mdm4 and Trp53 1 0.30 1.36 0
188 INT304029 Binding of PTEN and TP53 1 0.35 0.62 0
189 INT315395 Regulation of Binding of IFNA1 and Tp53 1 0.00 0.46 0
190 INT304020 AR Regulation of TP53 1 0.24 1.11 0
191 INT315221 Tpt1 Regulation of Positive_regulation of Trp53 1 0.33 1.04 0
192 INT204997 Ppp1r15b Regulation of Mavs 1 0.00 0.87 0
193 INT203901 HIVEP1 Positive_regulation of Gene_expression of TP53 1 0.04 0.86 0
194 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
195 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
196 INT232006 Binding of Trp53 and Tsp1 1 0.06 0.75 0
197 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0
198 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
199 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
200 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ER overload response. They are ordered first by their pain relevance and then by number of times they were reported in ER overload response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
2 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
3 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
4 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
5 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
6 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
7 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
8 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
9 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
10 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
11 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
12 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
13 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
14 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
15 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06
16 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
17 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
18 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
19 INT60585 Regulation of TP53 59 0.59 54.55 5.21
20 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
21 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
22 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
23 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
24 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
25 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
26 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
27 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
28 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
29 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
30 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
31 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
32 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
33 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31
34 INT250581 Gene_expression of SELS 4 0.78 47.37 3.27
35 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
36 INT8103 Binding of TP53 46 0.44 40.2 2.96
37 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81
38 INT130702 Positive_regulation of Gene_expression of HSPA5 7 0.59 7.53 2.68
39 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
40 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
41 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
42 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
43 INT55952 Transcription of TP53 16 0.61 12.14 2.36
44 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
45 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
46 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
47 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
48 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
49 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
50 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
51 INT65855 Localization of TP53 18 0.76 17.08 1.89
52 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
53 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
54 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
55 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
56 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
57 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
58 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
59 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
60 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45
61 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
62 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
63 INT172953 Binding of Trp53 33 0.37 20.76 1.41
64 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
65 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
66 INT145221 Binding of Tp53 10 0.37 8.59 1.37
67 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
68 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
69 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
70 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
71 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
72 INT174156 Localization of Trp53 16 0.72 13.52 1.18
73 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
74 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
75 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
76 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
77 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
78 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
79 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
80 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
81 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
82 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
83 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
84 INT159015 Positive_regulation of Localization of HSPA5 1 0.36 0.33 0.88
85 INT159013 Localization of HSPA5 2 0.42 0.32 0.87
86 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
87 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
88 INT99156 Binding of HSPA5 3 0.38 0.57 0.84
89 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
90 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
91 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
92 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
93 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
94 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
95 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
96 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
97 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
98 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
99 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
100 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
101 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
102 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
103 INT118564 Regulation of Gene_expression of Ddit3 1 0.55 0.89 0.68
104 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
105 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
106 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
107 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
108 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
109 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
110 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
111 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
112 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
113 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
114 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
115 INT15047 Negative_regulation of SELS 1 0.35 0.34 0.49
116 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
117 INT312821 Binding of Ins2 2 0.37 2.13 0.46
118 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44
119 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
120 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
121 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
122 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
123 INT130698 Negative_regulation of Positive_regulation of HSPA5 2 0.36 1.58 0.42
124 INT173418 Transcription of Ddit3 6 0.65 7.91 0.41
125 INT100254 Binding of SELS 6 0.36 4.54 0.4
126 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
127 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
128 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
129 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
130 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
131 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36
132 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
133 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
134 INT15697 Negative_regulation of EIF2AK3 1 0.41 0 0.33
135 INT26173 Regulation of SELS 3 0.52 3.4 0.32
136 INT15698 Transcription of EIF2AK3 1 0.52 0 0.32
137 INT350833 Positive_regulation of Gene_expression of SELS 1 0.61 6.07 0.32
138 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
139 INT127902 Negative_regulation of Gene_expression of EIF2AK3 1 0.42 0.47 0.3
140 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
141 INT202373 Transcription of Ddit3 6 0.62 5.52 0.29
142 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
143 INT333957 Regulation of HSPA5 3 0.52 0.61 0.27
144 INT154749 Negative_regulation of Gene_expression of Ddit3 2 0.41 1.15 0.27
145 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
146 INT215850 Regulation of Ddit3 5 0.50 6.15 0.25
147 INT252833 Positive_regulation of Gene_expression of Ddit3 4 0.67 7.58 0.25
148 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
149 INT350825 Gene_expression of Sels 1 0.34 1.07 0.25
150 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
151 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
152 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
153 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
154 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
155 INT142482 Positive_regulation of Positive_regulation of HSPA5 1 0.28 1.17 0.22
156 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
157 INT305975 Regulation of Gene_expression of SELS 2 0.60 3.19 0.21
158 INT172021 Localization of Hspa5 2 0.18 0.93 0.2
159 INT144676 Gene_expression of Hspa5 1 0.06 1.12 0.19
160 INT350827 Localization of SELS 1 0.62 1.24 0.19
161 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
162 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
163 INT305978 Protein_catabolism of SELS 1 0.86 0.88 0.17
164 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
165 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
166 INT192842 Binding of Hspa5 3 0.33 1.48 0.16
167 INT154746 Regulation of Positive_regulation of Hspa5 1 0.40 0.18 0.16
168 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
169 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
170 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
171 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
172 INT191137 Binding of H47 4 0.19 1.22 0.13
173 INT350834 Transcription of SELS 1 0.53 4.8 0.13
174 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
175 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
176 INT350832 Positive_regulation of Transcription of SELS 1 0.41 1 0.13
177 INT169910 Positive_regulation of H47 1 0.17 1.52 0.12
178 INT312828 Negative_regulation of Gene_expression of Ins2 1 0.37 0.8 0.12
179 INT143825 Regulation of Ddit3 3 0.58 2.03 0.11
180 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
181 INT250570 Negative_regulation of Gene_expression of SELS 2 0.43 2.85 0.1
182 INT144677 Positive_regulation of Gene_expression of Hspa5 1 0.04 0.59 0.1
183 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
184 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
185 INT169948 Gene_expression of H47 6 0.22 0.73 0.09
186 INT111139 Localization of Tp53 4 0.45 2.4 0.09
187 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
188 INT355099 Localization of Ins2 1 0.44 0.83 0.09
189 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09
190 INT144668 Positive_regulation of Hspa5 1 0.03 0.53 0.09
191 INT192840 Transcription of Hspa5 4 0.47 1.93 0.08
192 INT173416 Localization of Ddit3 2 0.71 0.98 0.08
193 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
194 INT173421 Positive_regulation of Transcription of Ddit3 2 0.47 0.7 0.08
195 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
196 INT327269 Regulation of Transcription of Ddit3 1 0.06 1.24 0.08
197 INT174717 Negative_regulation of Transcription of Ddit3 1 0.32 0.5 0.08
198 INT174709 Positive_regulation of Positive_regulation of Ddit3 1 0.38 0.85 0.08
199 INT263568 Negative_regulation of Positive_regulation of Ddit3 1 0.47 0.98 0.08
200 INT263572 Regulation of Hspa5 3 0.41 4.15 0.07
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