GO:0006987

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Name activation of signaling protein activity involved in unfolded protein response
Categary Process
Go Slim No
Go Link GO:0006987
Unique Molecular Interactions 486
Total Molecular Interactions 681
Total Single Events 5617
Pain Genes Associated 32

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of signaling protein activity involved in unfolded protein response. They are ordered first by their pain relevance and then by number of times they were reported for activation of signaling protein activity involved in unfolded protein response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
2 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
3 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
4 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
5 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
6 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
7 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
8 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
9 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
10 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
11 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
12 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
13 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
14 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
15 INT149844 Negative_regulation of Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.26
16 INT149845 Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.24
17 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
18 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
19 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
20 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
21 INT235709 Binding of NA and SSR1 1 0.07 0.72 1.08
22 INT101381 POMC Regulation of Localization of IL8 1 0.28 1.49 1.02
23 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
24 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
25 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
26 INT311102 IL8 Positive_regulation of CXCR7 1 0.00 1.74 0.98
27 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
28 INT311143 IL8 Positive_regulation of Cxcr1 1 0.04 1.74 0.98
29 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96
30 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
31 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95
32 INT182190 Binding of IL8 and CXCR4 1 0.26 1.25 0.95
33 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
34 INT182206 Binding of CXCR5 and IL8 1 0.30 1.25 0.94
35 INT182196 Binding of IL8 and CXCL13 1 0.27 1.24 0.93
36 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91
37 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
38 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
39 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
40 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
41 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
42 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
43 INT87494 CALCA Positive_regulation of IL8 1 0.48 0.15 0.81
44 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
45 INT87492 CALCA Regulation of IL8 1 0.28 0.15 0.81
46 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
47 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77
48 INT87493 Binding of CALCA and Positive_regulation of Gene_expression of IL8 1 0.52 0.18 0.76
49 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
50 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
51 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
52 INT248244 Binding of IL8 and SDC2 1 0.02 1.57 0.72
53 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71
54 INT27034 HERPUD1 Regulation of Gene_expression of IL2 1 0.38 0 0.71
55 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
56 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
57 INT120035 CCL2 Positive_regulation of Prap1 1 0.00 0.99 0.7
58 INT120037 IL8 Positive_regulation of Prap1 1 0.00 0.99 0.7
59 INT120019 IL8 Positive_regulation of CCL3 1 0.02 0.99 0.7
60 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
61 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
62 INT194618 Il17a Positive_regulation of Gene_expression of IL8 2 0.01 1.94 0.67
63 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
64 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
65 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
66 INT153750 Binding of CCL2 and Crp 1 0.02 1.8 0.65
67 INT153751 Regulation of Binding of CCL2 and Crp 1 0.03 1.8 0.65
68 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
69 INT292893 TNF Regulation of IL8 2 0.27 1.3 0.63
70 INT66602 TFF2 Positive_regulation of Gene_expression of IL8 1 0.01 0 0.63
71 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
72 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
73 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
74 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
75 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
76 INT342989 IL8 Regulation of SFTPA1 1 0.02 0.38 0.6
77 INT272146 PTAFR Positive_regulation of Localization of IL8 3 0.38 0.28 0.59
78 INT169299 CNR1 Positive_regulation of Localization of IL8 1 0.20 0.11 0.59
79 INT202038 MMP9 Positive_regulation of IL8 1 0.05 0.29 0.59
80 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58
81 INT147201 Binding of CCL2 and Hsp70-2os 1 0.00 0.76 0.57
82 INT84067 IGFBP1 Regulation of GH1 1 0.02 1.18 0.54
83 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
84 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
85 INT283434 Lcn2 Positive_regulation of Localization of IL8 1 0.07 1.33 0.51
86 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
87 INT286352 IL6 Positive_regulation of Gene_expression of IL8 2 0.24 1.32 0.48
88 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48
89 INT135591 CSF2 Regulation of IL8 1 0.09 1.27 0.48
90 INT144110 PRSS1 Positive_regulation of Gene_expression of IL8 1 0.21 1.38 0.48
91 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
92 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
93 INT177784 PDCD2 Positive_regulation of ASNS 1 0.04 0.76 0.46
94 INT132445 TF Positive_regulation of IL8 1 0.11 2.23 0.46
95 INT177794 BUB1B Positive_regulation of Gene_expression of ASNS 1 0.11 0.77 0.46
96 INT177791 PDCD2 Positive_regulation of ATF4 1 0.06 0.76 0.46
97 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
98 INT177780 BUB1B Positive_regulation of ASNS 1 0.05 0.76 0.46
99 INT106243 Oprm1 Regulation of Gene_expression of IL8 1 0.00 0 0.45
100 INT186711 IK Positive_regulation of Localization of IL8 1 0.00 0.39 0.44
101 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
102 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
103 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44
104 INT352972 IL4 Negative_regulation of Gene_expression of IL8 1 0.07 1.01 0.43
105 INT112800 CASP1 Positive_regulation of Gene_expression of CCL2 1 0.04 0.48 0.43
106 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
107 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
108 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42
109 INT331799 IL8 Negative_regulation of Mapk14 1 0.01 1.6 0.42
110 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42
111 INT316063 Ps Positive_regulation of IL8 1 0.09 1.33 0.41
112 INT316065 Eif1 Positive_regulation of IL8 1 0.01 1.34 0.41
113 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
114 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41
115 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4
116 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
117 INT103131 Positive_regulation of NFKB1 Regulation of Gene_expression of IL8 1 0.27 0.68 0.4
118 INT55460 Binding of OPRM1 and HERPUD1 1 0.11 0 0.4
119 INT265465 CSPG4 Negative_regulation of Gene_expression of IL8 1 0.07 0.98 0.39
120 INT103130 DCSTAMP Positive_regulation of Gene_expression of IL8 1 0.09 0.65 0.39
121 INT292892 IL4 Regulation of IL8 1 0.01 0.25 0.39
122 INT292886 IL2 Regulation of IL8 1 0.03 0.25 0.39
123 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38
124 INT57219 Binding of ATF3 and JUND 1 0.31 0.39 0.38
125 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
126 INT278970 MAPK14 Positive_regulation of Gene_expression of IL8 1 0.11 0.66 0.37
127 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
128 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
129 INT171296 TNFSF12 Positive_regulation of IL8 1 0.01 0.87 0.37
130 INT27036 HERPUD1 Positive_regulation of Gene_expression of IL2 1 0.31 0 0.37
131 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
132 INT163909 CCL2 Positive_regulation of Positive_regulation of Ccr2 1 0.05 0.19 0.36
133 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
134 INT286347 IL8 Positive_regulation of Gene_expression of IL6 1 0.11 0.7 0.36
135 INT103386 Negative_regulation of SLC9A1 Negative_regulation of Gene_expression of IL8 1 0.02 0.97 0.36
136 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
137 INT54570 Positive_regulation of NFKB1 Positive_regulation of Gene_expression of IL8 1 0.24 0.77 0.35
138 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
139 INT163908 CCL2 Positive_regulation of Ccr2 1 0.05 0.2 0.35
140 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34
141 INT27029 HERPUD1 Regulation of Gene_expression of CD8A 1 0.41 0 0.34
142 INT27033 HERPUD1 Regulation of Gene_expression of CD2 1 0.34 0 0.34
143 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
144 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
145 INT27031 HERPUD1 Regulation of CD2 1 0.34 0 0.34
146 INT27035 HERPUD1 Regulation of CD8A 1 0.18 0 0.34
147 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
148 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
149 INT134888 Negative_regulation of TNFRSF11A Negative_regulation of Gene_expression of CCL2 1 0.24 0.38 0.33
150 INT311265 RENBP Regulation of IL8 1 0.03 1.59 0.33
151 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
152 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
153 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
154 INT259639 MAPK14 Regulation of Gene_expression of IL8 1 0.02 1.2 0.32
155 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
156 INT322964 Binding of IL8 and Cxcl12 1 0.30 0.2 0.32
157 INT170994 KNG1 Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.32
158 INT260893 CRH Positive_regulation of Gene_expression of IL8 1 0.28 0.05 0.31
159 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
160 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
161 INT304278 CCNE1 Positive_regulation of IL8 1 0.02 1.93 0.31
162 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
163 INT174657 IL8 Positive_regulation of Gene_expression of LTBR 1 0.01 1.53 0.3
164 INT130946 IL8 Positive_regulation of Il6 1 0.00 0.29 0.3
165 INT281734 MT1JP Positive_regulation of Localization of IL8 1 0.02 0.64 0.3
166 INT342985 IL8 Positive_regulation of PPBP 1 0.02 0.66 0.3
167 INT69378 Positive_regulation of Binding of FOS and MBTPS1 1 0.13 0.16 0.3
168 INT69382 Binding of FOS and MBTPS1 1 0.09 0.16 0.29
169 INT69391 Binding of JUN and MBTPS1 1 0.09 0.16 0.29
170 INT171257 TNFSF12 Positive_regulation of CCL2 1 0.01 0.3 0.29
171 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
172 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
173 INT126006 Binding of ALB and IL8 1 0.41 0.28 0.28
174 INT207436 IL8 Negative_regulation of Gene_expression of PLA2G7 1 0.10 0.9 0.28
175 INT306107 Binding of CCL2 and Ccr2 1 0.06 0 0.28
176 INT294709 IRF6 Positive_regulation of Gene_expression of CCL2 1 0.08 0.14 0.28
177 INT67193 IL8 Regulation of Localization of SST 1 0.00 0.66 0.28
178 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28
179 INT67199 Tgfa Regulation of Localization of IL8 1 0.00 0.66 0.28
180 INT275509 IL8 Positive_regulation of Gene_expression of TIMP1 1 0.00 0.85 0.28
181 INT156640 ATF4 Regulation of Gene_expression of S100P 1 0.44 0.88 0.28
182 INT301668 Ltb4r1 Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
183 INT252806 F2 Positive_regulation of Gene_expression of CCL2 1 0.01 0.8 0.27
184 INT322966 Binding of IL8 and Darc 1 0.02 0.45 0.27
185 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27
186 INT137166 IL8 Positive_regulation of CXCR2 1 0.24 0.28 0.27
187 INT306941 Tnfsf12 Positive_regulation of Gene_expression of CCL2 1 0.03 1.65 0.27
188 INT67198 IL8 Regulation of Tgfa 1 0.00 0.65 0.27
189 INT101508 PPARA Regulation of IL8 1 0.31 0.53 0.27
190 INT342458 CSF1 Positive_regulation of Gene_expression of CCL2 1 0.17 0.84 0.27
191 INT101509 PPARA Regulation of Gene_expression of IL8 1 0.31 0.53 0.27
192 INT282648 IL8 Positive_regulation of Gene_expression of F3 1 0.00 1.89 0.27
193 INT353448 BRCA1 Positive_regulation of CCL2 1 0.01 1.37 0.26
194 INT155530 IRF6 Regulation of Gene_expression of IL8 1 0.06 0.79 0.26
195 INT103280 PGR Negative_regulation of Positive_regulation of ATF4 1 0.02 0.31 0.26
196 INT120896 Binding of CCL2 and Il6 1 0.08 1.2 0.26
197 INT252794 Binding of IL8 and TNF 1 0.02 0.75 0.25
198 INT252795 IL8 Positive_regulation of Positive_regulation of FOS 1 0.01 0.75 0.25
199 INT252822 CCL2 Positive_regulation of Positive_regulation of FOS 1 0.04 0.75 0.25
200 INT278941 MST1 Regulation of Gene_expression of IL8 1 0.01 0.4 0.25

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of signaling protein activity involved in unfolded protein response. They are ordered first by their pain relevance and then by number of times they were reported in activation of signaling protein activity involved in unfolded protein response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
2 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
3 INT12339 Localization of IL8 437 0.81 251.87 117.39
4 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
5 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
6 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
7 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
8 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
9 INT65698 Localization of CCL2 118 0.81 77.54 32.69
10 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
11 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71
12 INT10835 Regulation of IL8 79 0.49 53.04 24.14
13 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8
14 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46
15 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
16 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
17 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
18 INT10834 Binding of IL8 65 0.48 41.66 16.53
19 INT52107 Transcription of IL8 63 0.72 41.66 16.06
20 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
21 INT244490 Gene_expression of HSP90B1 4 0.33 41.16 10.37
22 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
23 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
24 INT81493 Transcription of CCL2 20 0.65 13.63 6.78
25 INT120895 Binding of CCL2 22 0.37 15.86 6.55
26 INT117621 Positive_regulation of HSPA5 17 0.59 13.26 6.06
27 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05
28 INT74422 Regulation of Localization of IL8 21 0.62 10.19 5.99
29 INT75833 Negative_regulation of Positive_regulation of IL8 15 0.53 6.69 5.59
30 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
31 INT75831 Positive_regulation of Transcription of IL8 21 0.63 13.56 4.98
32 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57
33 INT124622 Positive_regulation of ATF3 26 0.70 21.6 4.03
34 INT68255 Regulation of Positive_regulation of IL8 12 0.41 5.71 3.91
35 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
36 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36
37 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31
38 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28
39 INT18571 Binding of HERPUD1 6 0.48 0 3.17
40 INT244512 Positive_regulation of Gene_expression of HSP90B1 2 0.30 12.08 3.12
41 INT130700 Gene_expression of HSPA5 16 0.75 11.55 2.81
42 INT115622 Positive_regulation of Binding of IL8 7 0.44 5.79 2.69
43 INT130702 Positive_regulation of Gene_expression of HSPA5 7 0.59 7.53 2.68
44 INT103282 Positive_regulation of ATF4 12 0.66 7.28 2.65
45 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
46 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
47 INT129191 Regulation of ATF3 8 0.61 17.04 2.54
48 INT16672 Negative_regulation of MBTPS1 6 0.26 1.45 2.46
49 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
50 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
51 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
52 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17
53 INT77651 Negative_regulation of Transcription of IL8 8 0.43 4.48 2.16
54 INT18570 Gene_expression of HERPUD1 3 0.57 0.45 2.15
55 INT124624 Positive_regulation of Gene_expression of ATF3 11 0.70 21.22 2.06
56 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05
57 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01
58 INT70526 Binding of CALR 11 0.35 7.09 1.97
59 INT21941 Regulation of CALR 7 0.53 3.88 1.96
60 INT100490 Negative_regulation of Positive_regulation of CCL2 6 0.23 1.48 1.96
61 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
62 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85
63 INT38343 Regulation of IGFBP1 8 0.35 3.6 1.75
64 INT235710 Binding of SSR1 2 0.36 0.86 1.75
65 INT44888 Phosphorylation of EIF2S1 12 0.80 5.7 1.7
66 INT78487 Localization of SSR1 2 0.73 0.95 1.7
67 INT30138 Binding of TPP1 1 0.16 0.74 1.69
68 INT91664 Positive_regulation of Negative_regulation of IL8 5 0.40 3.28 1.62
69 INT18572 Negative_regulation of Binding of HERPUD1 1 0.53 0 1.62
70 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56
71 INT308527 Regulation of Gene_expression of HSP90B1 2 0.26 5.31 1.46
72 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45
73 INT130704 Gene_expression of ATF4 9 0.78 5.29 1.45
74 INT34460 Binding of MBTPS1 6 0.24 0.95 1.37
75 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29
76 INT162467 Gene_expression of ERN1 10 0.56 5.11 1.26
77 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25
78 INT81497 Positive_regulation of Transcription of CCL2 4 0.63 2 1.25
79 INT149843 Negative_regulation of C19orf10 1 0.41 0.45 1.25
80 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
81 INT119757 Negative_regulation of SSR1 3 0.42 0.38 1.18
82 INT162471 Positive_regulation of ERN1 7 0.34 3.02 1.08
83 INT257750 Positive_regulation of Gene_expression of SHC1 1 0.60 3.1 1.04
84 INT149842 Positive_regulation of C19orf10 1 0.67 0.47 1.03
85 INT129186 Positive_regulation of Regulation of ATF3 3 0.50 3.01 1.02
86 INT152407 Negative_regulation of Gene_expression of DDIT3 3 0.40 0.87 1.02
87 INT117622 Positive_regulation of HSP90B1 3 0.43 4.84 1.02
88 INT220074 Localization of ATF3 1 0.18 1.17 1.01
89 INT152408 Binding of DDIT3 3 0.35 2.06 1
90 INT65589 Protein_catabolism of MBTPS1 5 0.58 1.22 0.99
91 INT162464 Positive_regulation of Gene_expression of ERN1 2 0.36 1.66 0.97
92 INT21940 Positive_regulation of CALR 15 0.40 17.42 0.95
93 INT156649 Positive_regulation of Gene_expression of ATF4 3 0.69 2.79 0.88
94 INT159015 Positive_regulation of Localization of HSPA5 1 0.36 0.33 0.88
95 INT159013 Localization of HSPA5 2 0.42 0.32 0.87
96 INT67339 Localization of IGFBP1 10 0.70 1.73 0.86
97 INT129192 Transcription of ATF3 5 0.53 1.81 0.86
98 INT103389 Negative_regulation of Negative_regulation of IL8 3 0.39 2.2 0.86
99 INT99156 Binding of HSPA5 3 0.38 0.57 0.84
100 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81
101 INT337008 Binding of HSP90B1 2 0.20 4.91 0.81
102 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
103 INT117552 Regulation of Regulation of CCL2 1 0.13 0.57 0.8
104 INT274171 Negative_regulation of Binding of IL8 3 0.38 1.2 0.79
105 INT16670 Positive_regulation of MBTPS1 5 0.29 1.9 0.77
106 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
107 INT120010 Negative_regulation of Transcription of CCL2 1 0.02 0.99 0.72
108 INT84068 Negative_regulation of Gene_expression of IGFBP1 3 0.42 2.74 0.69
109 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
110 INT342507 Regulation of HSP90B1 1 0.26 2.29 0.67
111 INT263993 Positive_regulation of Transcription of ATF3 1 0.30 1.01 0.65
112 INT179168 Regulation of Transcription of IL8 4 0.43 1.88 0.63
113 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61
114 INT115623 Regulation of Binding of IL8 2 0.40 0.08 0.61
115 INT162801 Localization of CALR 7 0.73 8.69 0.6
116 INT222998 Positive_regulation of Negative_regulation of CCL2 1 0.12 1.11 0.59
117 INT170057 Regulation of Negative_regulation of IL8 1 0.33 0.99 0.58
118 INT100065 Negative_regulation of LMNA 12 0.49 0.12 0.56
119 INT163272 Gene_expression of SSR1 2 0.65 0.23 0.56
120 INT102776 Phosphorylation of CCL2 1 0.65 1.55 0.56
121 INT130711 Positive_regulation of DNAJB11 2 0.16 0.79 0.55
122 INT43158 Regulation of TPP1 1 0.23 0 0.55
123 INT147577 Binding of ATF4 1 0.05 0.15 0.54
124 INT147578 Regulation of Binding of ATF4 1 0.07 0.15 0.54
125 INT128162 Negative_regulation of Positive_regulation of DDIT3 4 0.41 4.54 0.53
126 INT16671 Gene_expression of MBTPS1 7 0.30 4.8 0.52
127 INT9426 Negative_regulation of IGFBP1 5 0.37 1.35 0.51
128 INT44899 Positive_regulation of EIF2S1 3 0.45 1.67 0.51
129 INT127060 Negative_regulation of Gene_expression of ATF3 3 0.58 4.27 0.5
130 INT85659 Gene_expression of TPP1 2 0.53 1.84 0.48
131 INT157023 Positive_regulation of Phosphorylation of EIF2S1 1 0.67 3.91 0.48
132 INT290397 Positive_regulation of Binding of CCL2 1 0.22 0.99 0.46
133 INT157308 Regulation of Gene_expression of DDIT3 1 0.44 0.45 0.46
134 INT177822 Gene_expression of ASNS 1 0.30 1.32 0.46
135 INT177817 Positive_regulation of Gene_expression of ASNS 1 0.19 0.92 0.46
136 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44
137 INT130712 Negative_regulation of Gene_expression of ATF4 1 0.33 0.75 0.43
138 INT130698 Negative_regulation of Positive_regulation of HSPA5 2 0.36 1.58 0.42
139 INT244505 Regulation of Transcription of HSP90B1 2 0.19 1.47 0.41
140 INT257756 Regulation of Gene_expression of SHC1 1 0.39 1.13 0.41
141 INT244495 Transcription of HSP90B1 2 0.28 1.47 0.4
142 INT140612 Transcription of ATF4 3 0.58 1.73 0.39
143 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
144 INT102778 Phosphorylation of IL8 1 0.43 0.94 0.38
145 INT130709 Negative_regulation of Positive_regulation of ATF4 1 0.44 0.75 0.36
146 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36
147 INT140617 Positive_regulation of ATF6 4 0.64 4.11 0.35
148 INT129189 Negative_regulation of ATF3 2 0.58 16.51 0.33
149 INT244571 Positive_regulation of HERPUD1 2 0.32 0.39 0.33
150 INT15697 Negative_regulation of EIF2AK3 1 0.41 0 0.33
151 INT57223 Binding of ATF3 5 0.37 6.3 0.32
152 INT15698 Transcription of EIF2AK3 1 0.52 0 0.32
153 INT156648 Positive_regulation of Transcription of ATF4 1 0.42 0.79 0.32
154 INT214842 Positive_regulation of LMNA 14 0.45 2.98 0.31
155 INT44902 Localization of EIF2S1 1 0.28 0.61 0.31
156 INT140619 Gene_expression of ATF6 3 0.62 3.29 0.3
157 INT127902 Negative_regulation of Gene_expression of EIF2AK3 1 0.42 0.47 0.3
158 INT129193 Positive_regulation of Positive_regulation of ATF3 1 0.50 0.82 0.28
159 INT195871 Positive_regulation of Gene_expression of CALR 9 0.29 3 0.27
160 INT104588 Phosphorylation of IGFBP1 4 0.70 0.47 0.27
161 INT333957 Regulation of HSPA5 3 0.52 0.61 0.27
162 INT342508 Negative_regulation of Gene_expression of HSP90B1 1 0.25 1.81 0.26
163 INT244537 Regulation of ERN1 3 0.26 1.32 0.25
164 INT105891 Negative_regulation of Positive_regulation of IGFBP1 2 0.12 0.66 0.25
165 INT318982 Positive_regulation of Binding of CALR 1 0.09 0.32 0.24
166 INT157020 Negative_regulation of DDIT3 2 0.42 2.39 0.23
167 INT279230 Regulation of Gene_expression of LMNA 1 0.02 0.22 0.22
168 INT342506 Localization of HSP90B1 1 0.34 0.73 0.22
169 INT142482 Positive_regulation of Positive_regulation of HSPA5 1 0.28 1.17 0.22
170 INT120202 Gene_expression of Ern1 2 0.14 1.78 0.21
171 INT136488 Regulation of LMNA 13 0.60 3.53 0.2
172 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
173 INT172021 Localization of Hspa5 2 0.18 0.93 0.2
174 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
175 INT144676 Gene_expression of Hspa5 1 0.06 1.12 0.19
176 INT188239 Binding of LMNA 20 0.47 6.58 0.18
177 INT63535 Regulation of HERPUD1 2 0.35 0.16 0.17
178 INT65590 Negative_regulation of Binding of MBTPS1 1 0.17 0 0.17
179 INT58620 Positive_regulation of Gene_expression of MBTPS1 1 0.02 0.37 0.17
180 INT157022 Negative_regulation of Phosphorylation of EIF2S1 1 0.41 1.34 0.17
181 INT129188 Regulation of Regulation of ATF3 1 0.61 0.52 0.17
182 INT116783 Protein_catabolism of IL8 3 0.86 1.11 0.16
183 INT192842 Binding of Hspa5 3 0.33 1.48 0.16
184 INT157019 Regulation of Positive_regulation of DDIT3 2 0.26 2.1 0.16
185 INT157021 Positive_regulation of Positive_regulation of DDIT3 2 0.49 1.78 0.16
186 INT154746 Regulation of Positive_regulation of Hspa5 1 0.40 0.18 0.16
187 INT342503 Negative_regulation of HSP90B1 1 0.18 1.41 0.16
188 INT174652 Gene_expression of EXTL3 2 0.05 1.49 0.15
189 INT231317 Localization of ERN1 1 0.65 0.45 0.14
190 INT351894 Negative_regulation of SHC1 1 0.12 0.69 0.14
191 INT102402 Binding of TSPYL2 1 0.04 0.5 0.14
192 INT215885 Transcription of DDIT3 3 0.69 2.57 0.13
193 INT215886 Positive_regulation of Transcription of DDIT3 2 0.49 2.32 0.13
194 INT44889 Binding of EIF2S1 2 0.23 0.35 0.13
195 INT326316 Positive_regulation of SSR1 1 0.49 0.41 0.13
196 INT306938 Regulation of Transcription of CCL2 1 0.05 0.81 0.13
197 INT239550 Negative_regulation of Binding of CCL2 1 0.18 0 0.13
198 INT101932 Negative_regulation of Gene_expression of TPP1 1 0.40 0.53 0.12
199 INT280592 Negative_regulation of Gene_expression of MBTPS1 1 0.19 0.63 0.12
200 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
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