GO:0007033

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Name vacuole organization
Categary Process
Go Slim No
Go Link GO:0007033
Unique Molecular Interactions 250
Total Molecular Interactions 305
Total Single Events 3559
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vacuole organization. They are ordered first by their pain relevance and then by number of times they were reported for vacuole organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
2 INT281383 FSCN1 Positive_regulation of Fig4 1 0.02 0.44 1.19
3 INT255335 Fig4 Regulation of Phosphorylation of Nav1 1 0.01 0 1.03
4 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
5 INT239638 Sst Regulation of Fig4 1 0.12 0.39 0.78
6 INT215630 Fig4 Regulation of Npy 1 0.01 0.26 0.76
7 INT202909 Binding of Tacr1 and Fig4 1 0.03 0.33 0.74
8 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
9 INT61798 Binding of NDP and POMC 2 0.22 0 0.66
10 INT211915 Fig4 Positive_regulation of Mapk3 1 0.12 0.25 0.66
11 INT211916 Fig4 Positive_regulation of Mapk1 1 0.13 0.25 0.66
12 INT246336 Fig4 Regulation of Localization of Nts 1 0.18 0 0.66
13 INT222253 Binding of Cxcl10 and Fig4 1 0.09 0.66 0.65
14 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
15 INT313703 Binding of Calca and Fig4 1 0.11 0 0.65
16 INT71110 Binding of MC1R and NDP 1 0.10 0 0.57
17 INT281378 FSCN1 Positive_regulation of Gene_expression of Fig4 1 0.02 0.22 0.56
18 INT281648 Negative_regulation of Binding of Trpv1 and Fig4 1 0.14 0.69 0.55
19 INT222252 Positive_regulation of Binding of Ccr2 and Fig4 1 0.16 0.67 0.55
20 INT281647 Binding of Trpv1 and Fig4 1 0.12 0.68 0.55
21 INT222245 Binding of Ccr2 and Fig4 1 0.12 0.67 0.55
22 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
23 INT147404 NDP Positive_regulation of MC1R 1 0.22 0.25 0.45
24 INT232293 Abat Regulation of Binding of Fig4 1 0.11 0 0.43
25 INT228323 PYCARD Positive_regulation of FIG4 1 0.17 0 0.42
26 INT61799 Negative_regulation of Binding of NDP and POMC 1 0.20 0 0.41
27 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4
28 INT232292 Abat Positive_regulation of Fig4 1 0.12 0 0.4
29 INT215629 Binding of Kcnj5 and Fig4 1 0.00 0.37 0.39
30 INT303444 Timp1 Regulation of Fig4 1 0.15 0.43 0.39
31 INT321292 Fig4 Negative_regulation of Pck1 1 0.10 0.33 0.39
32 INT321301 Fig4 Negative_regulation of G6pc 1 0.07 0.33 0.39
33 INT266553 Ppp2r1a Positive_regulation of Fig4 1 0.00 0 0.38
34 INT266530 Ppyr1 Positive_regulation of Fig4 1 0.01 0 0.38
35 INT215655 Fig4 Regulation of REG1A 1 0.00 0.13 0.38
36 INT177426 Izumo1 Positive_regulation of Positive_regulation of Fig4 1 0.16 0.59 0.34
37 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
38 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29
39 INT291383 Fig4 Regulation of Gene_expression of Cntf 1 0.10 0 0.28
40 INT179425 Fig4 Regulation of Creb1 1 0.02 0.32 0.28
41 INT179423 Fig4 Regulation of Mapk3 1 0.02 0.32 0.28
42 INT321288 Fig4 Positive_regulation of Nr0b2 1 0.15 0.47 0.27
43 INT231037 Fig4 Regulation of Gene_expression of Fos 1 0.03 0.31 0.27
44 INT290847 Regulation of Binding of Stx1a and Fig4 1 0.05 0.26 0.24
45 INT178720 NOVA2 Regulation of Fig4 1 0.01 0 0.23
46 INT177425 Binding of Fig4 and Izumo1 1 0.12 0.59 0.23
47 INT290846 Binding of Stx1a and Fig4 1 0.07 0.26 0.22
48 INT296172 Fig4 Positive_regulation of Gene_expression of NOVA2 1 0.04 0 0.22
49 INT290857 PPR Regulation of Fig4 1 0.02 0.45 0.21
50 INT261787 Positive_regulation of Bdnf Positive_regulation of Fig4 1 0.02 0.77 0.2
51 INT352945 Fig4 Regulation of Negative_regulation of Pik3cb 1 0.03 0.38 0.19
52 INT175073 Fig4 Regulation of Psmc1 1 0.05 0.07 0.18
53 INT268947 Fig4 Positive_regulation of Ros1 1 0.01 0.06 0.18
54 INT175078 Fig4 Regulation of Klk1c9 1 0.02 0.07 0.18
55 INT330798 Fig4 Negative_regulation of Gene_expression of Accn2 1 0.03 0 0.16
56 INT219913 Fig4 Positive_regulation of Trpv1 1 0.03 0 0.13
57 INT280618 Fig4 Regulation of Ucp3 1 0.09 0 0.13
58 INT280617 Fig4 Regulation of Pdk4 1 0.09 0 0.13
59 INT298548 Itgam Regulation of Fig4 1 0.08 0.05 0.12
60 INT303877 Binding of Nav1 and Fig4 1 0.09 0.07 0.12
61 INT229424 Atp6v0a2 Regulation of Fig4 1 0.00 1.14 0.1
62 INT251623 Car2 Regulation of Gene_expression of Fig4 1 0.02 0.31 0.08
63 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08
64 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08
65 INT293471 Binding of Map2 and Fig4 1 0.03 0 0.08
66 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08
67 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08
68 INT208989 Binding of CALM1 and Fig4 1 0.01 0 0.07
69 INT297230 Binding of Abcc8 and Fig4 1 0.10 0 0.07
70 INT281879 Cat Negative_regulation of Fig4 1 0.01 0.96 0.06
71 INT321295 Negative_regulation of Fig4 Positive_regulation of Nr0b2 1 0.09 0.13 0.06
72 INT321284 Regulation of Fig4 Positive_regulation of Nr0b2 1 0.06 0.13 0.06
73 INT292334 Binding of Sds and Fig4 1 0.02 0.07 0.05
74 INT303878 Fig4 Negative_regulation of Nav1 1 0.11 0.4 0.05
75 INT340271 Fig4 Positive_regulation of Localization of RELA 1 0.01 0.68 0.04
76 INT228679 Binding of Rps6kb1 and Fig4 1 0.08 0.08 0.04
77 INT296113 Fig4 Negative_regulation of Gene_expression of Csf2 1 0.01 0.91 0.04
78 INT249991 Agt Regulation of Fig4 1 0.12 0.57 0.04
79 INT216086 Binding of Nrtn and Fig4 1 0.03 0.23 0.04
80 INT340273 Fig4 Regulation of BGLAP 1 0.00 0.55 0.04
81 INT296115 Fig4 Negative_regulation of Csf2 1 0.01 0.91 0.04
82 INT182699 Binding of VEGFA and Fig4 2 0.04 0 0.03
83 INT295351 Egf Positive_regulation of Fig4 1 0.12 0.06 0.03
84 INT321287 Positive_regulation of Fig4 Positive_regulation of Nr0b2 1 0.10 0.07 0.03
85 INT217274 Avp Negative_regulation of Gene_expression of Fig4 1 0.02 0.06 0.03
86 INT351973 Agt Positive_regulation of Gene_expression of Fig4 1 0.07 1.33 0.03
87 INT268942 Binding of Crmp1 and Fig4 1 0.01 0.28 0.03
88 INT217270 Cpox Negative_regulation of Gene_expression of Fig4 1 0.01 0.06 0.03
89 INT283341 Binding of Ctbp1 and Fig4 1 0.06 0 0
90 INT242657 Fig4 Regulation of Ptger2 1 0.01 0.98 0
91 INT322126 Binding of Trpv4 and Fig4 1 0.02 0 0
92 INT182688 Binding of Vim and Fig4 1 0.08 0.07 0
93 INT349033 Binding of Cnp and Fig4 1 0.04 0.56 0
94 INT182686 Binding of Son and Fig4 1 0.12 0.07 0
95 INT256079 Serpina3k Negative_regulation of Fig4 1 0.07 0.16 0
96 INT256082 Serpina3k Negative_regulation of Positive_regulation of Fig4 1 0.07 0.16 0
97 INT280960 Binding of Cav3 and Fig4 1 0.08 0 0
98 INT280615 Fig4 Regulation of Gene_expression of Irs1 1 0.05 0 0
99 INT234145 Fig4 Negative_regulation of Gene_expression of Trib3 1 0.01 0.31 0
100 INT295340 Binding of Ptpn11 and Fig4 1 0.04 0 0
101 INT292330 Binding of Mb and Fig4 1 0.06 0 0
102 INT197910 Des Positive_regulation of Fig4 1 0.02 0 0
103 INT292326 Binding of Fig4 and LOC360919 1 0.00 0.08 0
104 INT184824 ALPP Regulation of Fig4 1 0.04 0 0
105 INT239401 FIG4 Regulation of NPPA 1 0.17 2.24 0
106 INT254747 Positive_regulation of Binding of Skil and Fig4 1 0.03 0.14 0
107 INT280613 Fig4 Regulation of Gene_expression of Mpl 1 0.03 0 0
108 INT280620 Fig4 Regulation of Gene_expression of Edn1 1 0.03 0 0
109 INT234141 Fig4 Negative_regulation of Trib3 1 0.01 0.13 0
110 INT283354 Binding of Ctbp2 and Fig4 1 0.04 0 0
111 INT227213 Binding of Fig4 and SCO 1 0.00 0 0
112 INT319042 Negative_regulation of Binding of Fgf7 and Fig4 1 0.07 0.2 0
113 INT209570 Fig4 Positive_regulation of Gene_expression of Gfap 1 0.40 0.17 0
114 INT283351 Binding of Srr and Fig4 1 0.04 0 0
115 INT295347 Egf Regulation of Fig4 1 0.11 0 0
116 INT293114 Fig4 Regulation of Gene_expression of Aqp2 1 0.08 1.53 0
117 INT254746 Binding of Skil and Fig4 1 0.02 0.14 0
118 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
119 INT352627 Binding of IGHG3 and MAN2A1 1 0.00 1.48 0
120 INT254748 Binding of Fig4 and Regulation of Skil 1 0.02 0.53 0
121 INT319043 Binding of Fgf7 and Fig4 1 0.06 0.26 0
122 INT241964 Acpt Negative_regulation of Gene_expression of Fig4 1 0.10 0 0
123 INT340238 Tnfsf11 Positive_regulation of Gene_expression of Fig4 1 0.02 0.4 0
124 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0
125 INT295355 Binding of Fig4 and She 1 0.01 0 0
126 INT286186 Binding of Blm and Fig4 1 0.09 0.34 0
127 INT349032 Negative_regulation of Binding of Cnp and Fig4 1 0.05 0.56 0
128 INT234144 Fig4 Negative_regulation of Transcription of Tyms 1 0.05 0.18 0
129 INT228588 Ppara Regulation of Gene_expression of Fig4 1 0.05 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vacuole organization. They are ordered first by their pain relevance and then by number of times they were reported in vacuole organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32
2 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81
3 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92
4 INT177581 Regulation of Fig4 113 0.41 39.26 27.75
5 INT171820 Localization of Fig4 144 0.65 27.38 20.88
6 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69
7 INT174844 Binding of Fig4 81 0.41 18.03 12.87
8 INT173272 Phosphorylation of Fig4 45 0.48 13.85 11.42
9 INT171146 Negative_regulation of Gene_expression of Fig4 38 0.37 11.41 7.42
10 INT195442 Gene_expression of FIG4 23 0.65 5.13 6.92
11 INT218698 Negative_regulation of Positive_regulation of Fig4 11 0.20 6.01 6.32
12 INT173273 Positive_regulation of Phosphorylation of Fig4 16 0.30 7.3 4.62
13 INT173751 Transcription of Fig4 31 0.46 8.28 3.7
14 INT187505 Positive_regulation of Localization of Fig4 16 0.24 1.21 3.17
15 INT187499 Positive_regulation of Positive_regulation of Fig4 9 0.21 3.28 2.69
16 INT174876 Regulation of Gene_expression of Fig4 18 0.39 7.83 2.44
17 INT61802 Binding of NDP 6 0.28 0 1.85
18 INT186022 Negative_regulation of Transcription of Fig4 6 0.28 2.09 1.5
19 INT61800 Negative_regulation of Binding of NDP 3 0.24 0 1.14
20 INT223133 Regulation of Localization of Fig4 5 0.39 0.5 0.88
21 INT176460 Protein_catabolism of Fig4 6 0.71 3.23 0.69
22 INT228327 Positive_regulation of Gene_expression of FIG4 1 0.22 0 0.64
23 INT71114 Regulation of NDP 1 0.12 0 0.61
24 INT171717 Regulation of Positive_regulation of Fig4 2 0.36 0.66 0.6
25 INT240718 Negative_regulation of Negative_regulation of Fig4 5 0.18 1.57 0.56
26 INT216271 Positive_regulation of Protein_catabolism of Fig4 2 0.13 1.21 0.54
27 INT249520 Negative_regulation of Phosphorylation of Fig4 3 0.15 0.52 0.52
28 INT251694 Regulation of Regulation of Fig4 3 0.06 0.05 0.52
29 INT147405 Positive_regulation of Transcription of NDP 1 0.20 0.27 0.45
30 INT147406 Transcription of NDP 1 0.28 0.26 0.44
31 INT61801 Negative_regulation of NDP 1 0.23 0 0.41
32 INT197774 Positive_regulation of Binding of Fig4 3 0.08 1.46 0.4
33 INT215889 Positive_regulation of Transcription of Fig4 3 0.29 0.15 0.39
34 INT336923 Localization of Fig4 1 0.20 0.69 0.38
35 INT331921 Positive_regulation of Fig4 1 0.27 1.43 0.38
36 INT200757 Gene_expression of Fig4 2 0.20 1.27 0.37
37 INT182690 Negative_regulation of Regulation of Fig4 1 0.15 0 0.36
38 INT178748 Regulation of FIG4 3 0.27 0.15 0.32
39 INT228330 Positive_regulation of Regulation of FIG4 1 0.22 0 0.32
40 INT200760 Positive_regulation of Gene_expression of Fig4 1 0.16 0.96 0.29
41 INT266566 Regulation of Transcription of Fig4 2 0.11 0.56 0.23
42 INT352629 Binding of MAN2A1 1 0.05 4.16 0.23
43 INT321354 Positive_regulation of Regulation of Fig4 1 0.16 0.23 0.21
44 INT228332 Localization of FIG4 3 0.33 1.03 0.2
45 INT292656 Regulation of Localization of FIG4 1 0.09 0.25 0.15
46 INT194253 Positive_regulation of FIG4 2 0.27 1.39 0.12
47 INT181573 Regulation of Phosphorylation of Fig4 1 0.02 1.26 0.12
48 INT179115 Negative_regulation of Localization of Fig4 5 0.33 1.94 0.11
49 INT225131 Negative_regulation of Binding of Fig4 5 0.19 1.43 0.08
50 INT185512 Positive_regulation of Negative_regulation of Fig4 2 0.20 0 0
51 INT254733 Regulation of Binding of Fig4 1 0.06 0.15 0
52 INT258449 Positive_regulation of NDP 1 0.00 0.81 0
53 INT352628 Negative_regulation of MAN2A1 1 0.05 1.52 0
54 INT178747 Negative_regulation of FIG4 1 0.20 0 0
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