GO:0007089

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Name traversing start control point of mitotic cell cycle
Categary Process
Go Slim No
Go Link GO:0007089
Unique Molecular Interactions 42
Total Molecular Interactions 72
Total Single Events 330
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for traversing start control point of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported for traversing start control point of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
4 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
5 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
6 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
7 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
8 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
9 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
10 INT184953 Binding of CDC6 and PCNA 1 0.05 0.19 0.13
11 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
12 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
13 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
14 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
15 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
16 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
17 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
18 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
19 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
20 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
21 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
22 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
23 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
24 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
25 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
26 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
27 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
28 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
29 INT208152 Binding of CDK4 and MDM2 1 0.01 1.11 0
30 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
31 INT294523 Binding of MDM2 and PDB1 1 0.40 0.1 0
32 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
33 INT182400 E2F2 Regulation of CDC25C 1 0.00 0.09 0
34 INT352614 Negative_regulation of Binding of Mdm2 and Trp53 1 0.19 1.16 0
35 INT294527 Binding of MDM2 and p53 1 0.40 0.1 0
36 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
37 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
38 INT294524 Binding of MDM2 and TNF 1 0.03 0.1 0
39 INT294522 Binding of IL2 and MDM2 1 0.40 0.2 0
40 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0
41 INT214922 Binding of MDM2 and TP53 1 0.08 1.55 0
42 INT182401 NFYA Regulation of CDC25C 1 0.00 0.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for traversing start control point of mitotic cell cycle. They are ordered first by their pain relevance and then by number of times they were reported in traversing start control point of mitotic cell cycle. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
2 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
3 INT185879 Gene_expression of CDC6 9 0.39 5.18 6.46
4 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
5 INT306836 Negative_regulation of Gene_expression of CDC6 1 0.19 1.28 1.88
6 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
7 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
8 INT306875 Localization of CDC6 1 0.34 1.51 1.52
9 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
10 INT219492 Negative_regulation of CDC6 2 0.20 1.74 1.31
11 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
12 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
13 INT306847 Positive_regulation of Gene_expression of CDC6 1 0.23 0.16 0.99
14 INT184992 Positive_regulation of CDC6 2 0.28 0.7 0.96
15 INT306882 Transcription of CDC6 1 0.24 0.57 0.92
16 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
17 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
18 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
19 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
20 INT184987 Regulation of CDC6 2 0.12 0.27 0.25
21 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
22 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
23 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
24 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
25 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
26 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
27 INT113346 Binding of MDM2 10 0.35 5.73 0.15
28 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
29 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
30 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
31 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
32 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
33 INT185019 Binding of CDC6 2 0.21 0.31 0.13
34 INT184998 Negative_regulation of Binding of CDC6 1 0.11 0.19 0.13
35 INT201462 Binding of CDK2 12 0.39 5.2 0.12
36 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
37 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
38 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
39 INT302272 Localization of CDK2 2 0.30 1.09 0.09
40 INT287282 Regulation of Binding of MDM2 1 0.04 0.63 0.04
41 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
42 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
43 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
44 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0
45 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
46 INT169427 Transcription of CDK2 2 0.09 0.42 0
47 INT260276 Negative_regulation of MDM2 2 0.42 0.62 0
48 INT276357 Protein_catabolism of MDM2 2 0.32 1.18 0
49 INT276370 Phosphorylation of MDM2 2 0.50 1.99 0
50 INT294536 Localization of MDM2 1 0.73 0.09 0
51 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
52 INT121497 Transcription of MDM2 1 0.54 0.12 0
53 INT182436 Gene_expression of CDC25C 1 0.15 0.09 0
54 INT235473 Negative_regulation of Gene_expression of MDM2 1 0.18 0.99 0
55 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
56 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
57 INT276343 Regulation of Phosphorylation of MDM2 1 0.14 0.85 0
58 INT276359 Positive_regulation of Protein_catabolism of MDM2 1 0.15 1.79 0
59 INT329762 Positive_regulation of CDC25C 1 0.22 0.82 0
60 INT276366 Positive_regulation of Phosphorylation of MDM2 1 0.15 0.85 0
61 INT113347 Negative_regulation of Binding of MDM2 1 0.25 0.13 0
62 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
63 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
64 INT329772 Phosphorylation of CDC25C 1 0.28 0.81 0
65 INT276365 Negative_regulation of Protein_catabolism of MDM2 1 0.14 0.86 0
66 INT266009 Negative_regulation of Gene_expression of Mdm2 1 0.43 1.03 0
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