GO:0007095

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Name mitotic cell cycle G2/M transition DNA damage checkpoint
Categary Process
Go Slim No
Go Link GO:0007095
Unique Molecular Interactions 46
Total Molecular Interactions 62
Total Single Events 282
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for mitotic cell cycle G2/M transition DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported for mitotic cell cycle G2/M transition DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
2 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37
3 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
4 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
5 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
6 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
7 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
8 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
9 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
10 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
11 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03
12 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
13 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
14 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
15 INT219416 CCNA2 Regulation of HNF4A 1 0.00 0.11 0
16 INT219417 CCNA2 Regulation of PCNA 1 0.10 0.11 0
17 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
18 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
19 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
20 INT219425 CCNA2 Regulation of SKP2 1 0.11 0.11 0
21 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
22 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
23 INT273518 Binding of ALB and NBN 1 0.06 0.47 0
24 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
25 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
26 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
27 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
28 INT219408 CCNA2 Regulation of E2F2 1 0.11 0.11 0
29 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
30 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
31 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
32 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
33 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
34 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
35 INT281608 Foxo4 Positive_regulation of Transcription of Trim63 1 0.27 0 0
36 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
37 INT268315 Cdk1 Positive_regulation of Mcm5 1 0.33 0.25 0
38 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
39 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for mitotic cell cycle G2/M transition DNA damage checkpoint. They are ordered first by their pain relevance and then by number of times they were reported in mitotic cell cycle G2/M transition DNA damage checkpoint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT167446 Regulation of CCNA2 2 0.39 2.01 3.49
2 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
3 INT219458 Negative_regulation of CCNA2 9 0.38 1.23 2.21
4 INT177841 Gene_expression of CCNA2 2 0.50 0.64 1.97
5 INT241672 Positive_regulation of CCNA2 4 0.44 1.56 1.57
6 INT241668 Negative_regulation of Transcription of CCNA2 1 0.27 0.44 1.5
7 INT239028 Negative_regulation of Foxo4 1 0.42 2.75 1.16
8 INT241665 Transcription of CCNA2 1 0.44 0.38 0.98
9 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
10 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
11 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
12 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
13 INT201627 Gene_expression of Foxo4 3 0.65 1.92 0.63
14 INT56251 Binding of NBN 4 0.38 3.16 0.62
15 INT201640 Phosphorylation of Foxo4 4 0.80 3.55 0.61
16 INT239019 Negative_regulation of Phosphorylation of Foxo4 2 0.42 2.38 0.61
17 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
18 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
19 INT241675 Negative_regulation of Gene_expression of CCNA2 1 0.27 0.22 0.43
20 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
21 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
22 INT177858 Positive_regulation of Gene_expression of CCNA2 2 0.44 0.42 0.37
23 INT241667 Positive_regulation of Regulation of CCNA2 1 0.32 0 0.35
24 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
25 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
26 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
27 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
28 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
29 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
30 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
31 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
32 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
33 INT167436 Localization of CDK1 2 0.14 0.41 0.1
34 INT186055 Binding of CDK1 3 0.35 1.43 0.09
35 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
36 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
37 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07
38 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
39 INT167441 Localization of CCNA2 1 0.54 0.39 0.07
40 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
41 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
42 INT273525 Regulation of NBN 1 0.49 1.28 0.05
43 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
44 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
45 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
46 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
47 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
48 INT236691 Regulation of Cdk1 2 0.20 0.46 0
49 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
50 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
51 INT201630 Positive_regulation of Phosphorylation of Foxo4 1 0.49 0.46 0
52 INT222135 Binding of Foxo4 1 0.02 0 0
53 INT196923 Binding of Hmga2 1 0.47 2.5 0
54 INT260848 Transcription of NBN 1 0.57 0.54 0
55 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0
56 INT300344 Localization of HMGA2 1 0.42 1.75 0
57 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
58 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
59 INT260850 Regulation of Gene_expression of NBN 1 0.38 0.57 0
60 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
61 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
62 INT169276 Localization of NBN 1 0.08 0.08 0
63 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
64 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
65 INT201649 Localization of Foxo4 1 0.78 0.45 0
66 INT268581 Regulation of HMGA2 1 0.18 0.72 0
67 INT268284 Gene_expression of Cdk1 1 0.26 0.25 0
68 INT201647 Positive_regulation of Foxo4 1 0.49 0.46 0
69 INT281597 Localization of Foxo4 1 0.49 0 0
70 INT273522 Negative_regulation of Gene_expression of NBN 1 0.34 0.91 0
71 INT222129 Gene_expression of Foxo4 1 0.04 0 0
72 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
73 INT201633 Regulation of Gene_expression of Foxo4 1 0.44 0.52 0
74 INT196921 Localization of Hmga2 1 0.74 0.44 0
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