GO:0007165

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Name signal transduction
Categary Process
Go Slim Yes
Go Link GO:0007165
Unique Molecular Interactions 15345
Total Molecular Interactions 21753
Total Single Events 168491
Pain Genes Associated 1043

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
3 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
4 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
5 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
6 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
7 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
8 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
9 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
10 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
11 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
12 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
13 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
14 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
15 INT69229 Ngf Positive_regulation of Gene_expression of Bdnf 6 0.76 8.19 6.66
16 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
17 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
18 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
19 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
20 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
21 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
22 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
23 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
24 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
25 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
26 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
27 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
28 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
29 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
30 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
31 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
32 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
33 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
34 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
35 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
36 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
37 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
38 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
39 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
40 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
41 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
42 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
43 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
44 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
45 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
46 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
47 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
48 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
49 INT240653 Ngf Positive_regulation of Positive_regulation of Bdnf 1 0.55 2.97 4.23
50 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
51 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
52 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
53 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
54 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
55 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
56 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
57 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
58 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
59 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
60 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
61 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
62 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92
63 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
64 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
65 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
66 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
67 INT180813 Ngf Positive_regulation of Sorbs1 1 0.04 2.09 3.79
68 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
69 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
70 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
71 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
72 INT132862 Ngf Positive_regulation of Bdnf 4 0.46 4.05 3.65
73 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
74 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
75 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
76 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
77 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
78 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
79 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
80 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
81 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
82 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
83 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
84 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
85 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
86 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
87 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
88 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
89 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
90 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
91 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
92 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
93 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
94 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
95 INT211694 Binding of Cntnap1 and Nav1 1 0.04 0 3.14
96 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
97 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
98 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
99 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08
100 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
101 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
102 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
103 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
104 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
105 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
106 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
107 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96
108 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
109 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
110 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
111 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
112 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
113 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
114 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
115 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
116 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
117 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
118 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
119 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
120 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
121 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
122 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
123 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
124 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
125 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
126 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
127 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
128 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
129 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
130 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
131 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
132 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
133 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
134 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
135 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
136 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
137 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
138 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
139 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
140 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
141 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
142 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
143 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
144 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
145 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
146 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
147 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
148 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
149 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
150 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
151 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
152 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
153 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
154 INT170037 Ngf Regulation of Gene_expression of DRGX 1 0.01 1.37 2.46
155 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
156 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
157 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
158 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
159 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
160 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
161 INT318998 IFNA1 Positive_regulation of Localization of CXCL10 1 0.15 2.09 2.39
162 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
163 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
164 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
165 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
166 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
167 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
168 INT108987 Ngf Regulation of Gene_expression of Sit1 1 0.00 1.46 2.32
169 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
170 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
171 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3
172 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
173 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
174 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
175 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
176 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
177 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
178 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
179 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
180 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
181 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
182 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
183 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
184 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
185 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
186 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
187 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
188 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
189 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
190 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
191 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
192 INT113451 Ngf Regulation of Gene_expression of ASIC3 1 0.07 1.35 2.18
193 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
194 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
195 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
196 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
197 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
198 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
199 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
200 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 1020 0.81 284.52 443.17
3 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
4 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
5 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
6 INT876 Localization of Gh1 843 0.80 67.75 340.82
7 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
8 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
9 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
10 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56
11 INT477 Localization of Avp 813 0.81 131.58 300.4
12 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
13 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
14 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
15 INT6852 Localization of TNF 883 0.81 705.95 270.84
16 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
18 INT1893 Localization of Gh 1041 0.79 340.23 256.58
19 INT738 Regulation of POMC 459 0.62 111.19 243.74
20 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238
21 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
22 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
23 INT1308 Localization of Pomc 457 0.81 66.83 217.5
24 INT6481 Binding of TNF 624 0.48 510.2 214.82
25 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
26 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
27 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
28 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
29 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
30 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
31 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71
32 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
33 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
34 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
35 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
36 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
37 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
38 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
39 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
40 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23
41 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
42 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
43 INT9660 Regulation of TNF 363 0.62 312.94 139.99
44 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
45 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
46 INT695 Binding of POMC 304 0.48 56.66 126.85
47 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73
48 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
49 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
50 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
51 INT7395 Localization of GNRH1 399 0.81 62.88 117.68
52 INT12339 Localization of IL8 437 0.81 251.87 117.39
53 INT1438 Localization of Pomc 360 0.81 101.26 116.47
54 INT4207 Regulation of Avp 267 0.62 63.72 115.33
55 INT1793 Localization of CGA 379 0.81 67.38 114.69
56 INT90 Localization of Gast 400 0.81 137.67 113
57 INT1530 Regulation of Gh 382 0.61 115.96 112.47
58 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
59 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
60 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06
61 INT114 Binding of Oprl1 139 0.48 23 103.35
62 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
63 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
64 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
65 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98
66 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
67 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
68 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
69 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
70 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
71 INT214 Localization of AVP 370 0.81 208.51 91.09
72 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
73 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
74 INT10166 Localization of Tnf 237 0.81 153.95 88.64
75 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
76 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27
77 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97
78 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
79 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08
80 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5
81 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
82 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
83 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
84 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49
85 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
86 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19
87 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
88 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
89 INT12001 Regulation of Ngf 97 0.62 54.64 76.25
90 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
91 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
92 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
93 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
94 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
95 INT3034 Localization of Ngf 126 0.81 50.81 72.84
96 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
97 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
98 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
99 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
100 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
101 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
102 INT6849 Localization of IL1B 229 0.81 112.56 69.63
103 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
104 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
105 INT462 Regulation of Pomc 157 0.62 41.67 67.27
106 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
107 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
108 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
109 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
110 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
111 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
112 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
113 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
114 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
115 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
116 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
117 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
118 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
119 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
120 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
121 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
122 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74
123 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
124 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
125 INT1463 Binding of Pomc 129 0.48 15.89 56.27
126 INT1782 Regulation of Gh1 125 0.62 22 55.74
127 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5
128 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
129 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
130 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
131 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
132 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
133 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
134 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
135 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
136 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
137 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
138 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96
139 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
140 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
141 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
142 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
143 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
144 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
145 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
146 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
147 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
148 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
149 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
150 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
151 INT2463 Localization of CCK 101 0.81 37.54 47.59
152 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
153 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75
154 INT2406 Gene_expression of CCK 85 0.78 28.04 46.67
155 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
156 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
157 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
158 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
159 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
160 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
161 INT19078 Binding of Ngf 78 0.48 31.03 44.33
162 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
163 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
164 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9
165 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
166 INT1295 Binding of Pomc 85 0.48 12.92 42.8
167 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
168 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
169 INT13354 Transcription of TNF 108 0.72 85.81 42.32
170 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
171 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08
172 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07
173 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
174 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
175 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
176 INT5454 Localization of CRH 124 0.79 79.18 41.53
177 INT30 Gene_expression of Gast 158 0.78 99 41.45
178 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
179 INT4862 Localization of PENK 62 0.81 11.57 40.28
180 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
181 INT685 Regulation of AVP 124 0.62 34.9 39.91
182 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
183 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
184 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
185 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
186 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
187 INT20210 Localization of Ngf 69 0.79 46.22 38.57
188 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
189 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
190 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
191 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
192 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
193 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
194 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
195 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
196 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76
197 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
198 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23
199 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
200 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
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