GO:0007166

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Name cell surface receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007166
Unique Molecular Interactions 2807
Total Molecular Interactions 4003
Total Single Events 32731
Pain Genes Associated 197

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell surface receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for cell surface receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
3 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
4 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
5 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
6 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
7 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
8 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
9 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
10 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
11 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
12 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
13 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
14 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
15 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96
16 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
17 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
18 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
19 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76
20 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
21 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
22 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
23 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
24 INT67905 Binding of Spn and Fosl1 1 0.24 2.1 2.54
25 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
26 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
27 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
28 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
29 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
30 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
31 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
32 INT318998 IFNA1 Positive_regulation of Localization of CXCL10 1 0.15 2.09 2.39
33 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
34 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
35 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
36 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
37 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
38 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
39 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
40 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
41 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
42 INT273120 NOVA2 Regulation of Gene_expression of MET 1 0.23 1.17 2.11
43 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
44 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
45 INT202963 Binding of STC2 and CPP 1 0.02 5.16 2.04
46 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
47 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
48 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
49 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
50 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
51 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
52 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
53 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
54 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
55 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
56 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
57 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
58 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
59 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
60 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76
61 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73
62 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
63 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
64 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
65 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
66 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
67 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
68 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
69 INT187175 Binding of BSG and PPIA 1 0.14 2.23 1.64
70 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
71 INT147654 DYT10 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.93 1.62
72 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
73 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
74 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
75 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
76 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
77 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
78 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
79 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
80 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54
81 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
82 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
83 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
84 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
85 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44
86 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
87 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
88 INT148451 Gene_expression of Inhbe Positive_regulation of Pik3cd 1 0.04 1.35 1.4
89 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
90 INT116827 Binding of UCHL1 and TRPV1 1 0.41 0.88 1.39
91 INT26812 SST Regulation of Localization of OXT 1 0.40 0.57 1.37
92 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
93 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
94 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
95 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
96 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
97 INT96707 Ntf3 Positive_regulation of Localization of SST 1 0.01 0 1.3
98 INT96708 Bdnf Positive_regulation of Localization of SST 1 0.01 0 1.3
99 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
100 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
101 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
102 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
103 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29
104 INT147653 TACR1 Positive_regulation of TRPV1 1 0.02 0.72 1.29
105 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
106 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
107 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
108 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
109 INT342990 TRPV1 Positive_regulation of Gene_expression of SFTPA1 1 0.06 1.44 1.26
110 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
111 INT30128 Binding of MET and Gast 1 0.06 0.18 1.25
112 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
113 INT116892 Binding of TRPV1 and Phax 4 0.00 0.1 1.24
114 INT199593 Binding of TRPV1 and Myoz1 1 0.10 1.7 1.23
115 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
116 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
117 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
118 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
119 INT342988 HCL1 Positive_regulation of TRPV1 1 0.04 1.15 1.21
120 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
121 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
122 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
123 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
124 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
125 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
126 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
127 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
128 INT105240 POMC Positive_regulation of Gene_expression of CXCL10 1 0.07 1.18 1.16
129 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
130 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
131 INT289659 Tnfrsf1b Negative_regulation of Mcpt3 1 0.02 0.82 1.13
132 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
133 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12
134 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
135 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
136 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
137 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
138 INT29874 OXTR Negative_regulation of POMC 1 0.22 0 1.1
139 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1
140 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
141 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
142 INT105690 Ngf Positive_regulation of TRPV1 1 0.05 1.43 1.08
143 INT187176 Binding of BSG and MMP1 1 0.09 1.18 1.08
144 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07
145 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06
146 INT218840 Cysltr1 Positive_regulation of Ltp 2 0.02 1.04 1.06
147 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
148 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
149 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06
150 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04
151 INT250777 Binding of Cxcl10 and Cxcr1 1 0.14 3.1 1.04
152 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
153 INT162250 Binding of TRPV1 and Grm5 1 0.01 0.8 1.03
154 INT144069 Positive_regulation of TRPV1 Positive_regulation of Gene_expression of MMP1 1 0.43 1.35 1.03
155 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
156 INT164281 Ltb4r Positive_regulation of Cysltr1 2 0.32 1.87 1.02
157 INT40715 Binding of SST and Penk 1 0.10 0 1.02
158 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
159 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
160 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
161 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
162 INT33135 Binding of NFKBIL1 and PRL 1 0.09 0.29 1.01
163 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
164 INT25155 TRH Positive_regulation of PRL 2 0.50 0.4 1
165 INT32327 POMC Positive_regulation of Localization of PRL 4 0.45 0 0.99
166 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
167 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
168 INT147506 Binding of Ncam1 and Gtf3a 1 0.03 0.88 0.99
169 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
170 INT106248 Binding of CCR5 and YY1 1 0.54 0.19 0.98
171 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98
172 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98
173 INT311143 IL8 Positive_regulation of Cxcr1 1 0.04 1.74 0.98
174 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
175 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
176 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
177 INT93306 Binding of TRPV1 and CAP1 2 0.18 0.07 0.97
178 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
179 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
180 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
181 INT93307 CAP1 Positive_regulation of TRPV1 1 0.15 0.07 0.96
182 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
183 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
184 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95
185 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95
186 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
187 INT166842 Binding of ANXA1 and Nfkb1 1 0.37 1.64 0.95
188 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
189 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
190 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
191 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
192 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94
193 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94
194 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94
195 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
196 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94
197 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
198 INT128652 ITIH4 Regulation of Gene_expression of CCR5 1 0.36 1.46 0.93
199 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92
200 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell surface receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in cell surface receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
2 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
3 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
4 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
5 INT425 Localization of PRL 455 0.81 189.64 144.8
6 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
7 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31
8 INT397 Localization of SST 232 0.81 58.05 101.19
9 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
10 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
11 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
12 INT253 Regulation of PRL 184 0.62 47.27 65.79
13 INT8347 Gene_expression of SST 181 0.78 104.59 65.45
14 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
15 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74
16 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
17 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41
18 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
19 INT5118 Regulation of SST 97 0.62 34.35 51.74
20 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
21 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
22 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
23 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
24 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3
25 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
26 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13
27 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
28 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
29 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
30 INT692 Negative_regulation of SST 72 0.59 28.68 34.52
31 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
32 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05
33 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
34 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
35 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13
36 INT16290 Gene_expression of BSG 60 0.68 38.73 32.86
37 INT65698 Localization of CCL2 118 0.81 77.54 32.69
38 INT691 Binding of SST 67 0.48 24.66 32.67
39 INT14823 Gene_expression of MET 103 0.75 51.92 32.48
40 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
41 INT1158 Regulation of Agt 106 0.61 29.4 30.29
42 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48
43 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
44 INT116737 Localization of Mif 63 0.81 52.97 28.11
45 INT20585 Gene_expression of Gfra1 39 0.77 26.94 26.69
46 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
47 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
48 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2
49 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
50 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47
51 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
52 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03
53 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
54 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
55 INT100026 Gene_expression of Tnfrsf1b 73 0.72 43.26 23.23
56 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09
57 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
58 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01
59 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23
60 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
61 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54
62 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
63 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75
64 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
65 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
66 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
67 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
68 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
69 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
70 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
71 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
72 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
73 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44
74 INT77902 Negative_regulation of Positive_regulation of TRPV1 30 0.59 9.36 19.2
75 INT5048 Binding of Edn1 55 0.47 18.86 19.16
76 INT18672 Gene_expression of Ncam1 54 0.78 36.64 18.79
77 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
78 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11
79 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
80 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
81 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
82 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46
83 INT101501 Phosphorylation of TRPV1 31 0.82 9.26 17.27
84 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18
85 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16
86 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
87 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
88 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53
89 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43
90 INT2066 Localization of Agt 56 0.80 9.95 16.25
91 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89
92 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
93 INT129 Localization of OXTR 51 0.80 11.08 15.36
94 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
95 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
96 INT9191 Localization of EDN1 94 0.81 57.01 14.78
97 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
98 INT8989 Binding of Npr1 25 0.36 5.52 14.58
99 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
100 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21
101 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94
102 INT83950 Gene_expression of Cxcr1 31 0.59 27.76 13.91
103 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
104 INT6365 Localization of Edn1 56 0.81 18.84 13.83
105 INT103828 Negative_regulation of Gene_expression of TRPV1 23 0.59 13.63 13.81
106 INT4931 Localization of IFNG 53 0.78 33.25 13.65
107 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65
108 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
109 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
110 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44
111 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4
112 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36
113 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
114 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15
115 INT12464 Binding of MET 38 0.47 10.3 13.15
116 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
117 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75
118 INT4199 Binding of Agt 76 0.48 21.06 12.66
119 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64
120 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63
121 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
122 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
123 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49
124 INT97237 Transcription of TRPV1 33 0.72 10.56 12.4
125 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3
126 INT120828 Localization of CXCL10 29 0.68 18.01 12.17
127 INT36287 Binding of CD4 96 0.47 58.93 11.88
128 INT72949 Binding of Mif 31 0.46 23.12 11.65
129 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64
130 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
131 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57
132 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
133 INT20603 Positive_regulation of TNFRSF10B 40 0.67 32.61 11.44
134 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36
135 INT204112 Gene_expression of GEM 43 0.75 38.74 11.23
136 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
137 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91
138 INT4498 Gene_expression of F2 83 0.65 57.4 10.8
139 INT1708 Gene_expression of OXTR 56 0.78 6.92 10.69
140 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68
141 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
142 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
143 INT16404 Regulation of CD4 54 0.61 33.05 10.29
144 INT10019 Binding of CD8A 57 0.36 31.49 10.08
145 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
146 INT73504 Binding of CD28 35 0.45 15.99 10.04
147 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
148 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
149 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98
150 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
151 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
152 INT62544 Gene_expression of Anxa1 21 0.47 13.56 9.71
153 INT6361 Localization of Edn1 30 0.81 19.09 9.7
154 INT12367 Binding of PRLR 17 0.03 2.05 9.69
155 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22
156 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97
157 INT100653 Negative_regulation of Gene_expression of Gfra1 6 0.58 8.26 8.95
158 INT34544 Gene_expression of L1cam 43 0.77 5.3 8.89
159 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
160 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81
161 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
162 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
163 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
164 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
165 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68
166 INT117553 Regulation of MIF 10 0.56 12.76 8.67
167 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
168 INT123382 Gene_expression of Cxcr2 12 0.69 4.62 8.62
169 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59
170 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51
171 INT77790 Positive_regulation of Gene_expression of Tnfrsf1a 16 0.67 15.88 8.5
172 INT10237 Binding of EDN1 40 0.48 16 8.48
173 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42
174 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
175 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09
176 INT2271 Gene_expression of F2 51 0.76 30.21 7.97
177 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81
178 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
179 INT9398 Localization of MET 15 0.78 2.34 7.69
180 INT117543 Regulation of Gene_expression of CD14 21 0.59 6.66 7.67
181 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
182 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65
183 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
184 INT131359 Positive_regulation of Gene_expression of Cd4 40 0.58 22.43 7.53
185 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51
186 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
187 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
188 INT18909 Positive_regulation of Cd8a 92 0.60 56.55 7.35
189 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
190 INT184281 Binding of AGER 25 0.37 23.06 7.32
191 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31
192 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24
193 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
194 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14
195 INT91758 Binding of CCR5 28 0.45 20.16 7.07
196 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
197 INT9397 Regulation of MET 17 0.60 8.36 7.04
198 INT717 Regulation of F2 29 0.61 17.46 6.99
199 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95
200 INT17049 Localization of CD4 57 0.75 35.33 6.89
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