GO:0007167

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Name enzyme linked receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0007167
Unique Molecular Interactions 228
Total Molecular Interactions 327
Total Single Events 2893
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enzyme linked receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for enzyme linked receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
2 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
3 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
4 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
5 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
6 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
7 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
8 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
9 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
10 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
11 INT257745 SAGE1 Positive_regulation of AXL 1 0.07 1.96 0.69
12 INT231751 Binding of Il2rg and Jak3 1 0.03 1.56 0.67
13 INT231534 Binding of JAK1 and SOAT1 1 0.01 0.6 0.64
14 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
15 INT231750 LOC690550 Negative_regulation of Jak3 1 0.02 1.3 0.52
16 INT62299 Binding of CD4 and SGCG 1 0.39 1.23 0.51
17 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
18 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
19 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
20 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
21 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
22 INT251297 Binding of C2 and CD4 1 0.04 0.35 0.47
23 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
24 INT208461 Binding of CD4 and IL16 1 0.05 3.04 0.41
25 INT330515 TNFSF10 Regulation of Gene_expression of CD4 1 0.29 1.24 0.4
26 INT330518 TNFSF10 Regulation of CD4 1 0.29 1.24 0.4
27 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
28 INT184092 Il11ra1 Positive_regulation of Jak1 1 0.17 0.3 0.39
29 INT234607 Socs3 Negative_regulation of JAK1 1 0.01 0.54 0.39
30 INT237369 SOAT1 Negative_regulation of Phosphorylation of JAK1 1 0.00 0 0.38
31 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
32 INT328819 Binding of Il6 and Jak1 1 0.08 0 0.38
33 INT278957 JAK3 Positive_regulation of Gene_expression of IL8 1 0.28 0.67 0.38
34 INT328822 Binding of Jak1 and TYK2 1 0.11 0 0.38
35 INT328821 Binding of Il6st and Jak1 1 0.05 0 0.38
36 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
37 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
38 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
39 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
40 INT273172 Negative_regulation of PDE4A Negative_regulation of Localization of CD4 1 0.11 0.74 0.37
41 INT278955 JAK3 Positive_regulation of Gene_expression of PRKCA 1 0.12 0.65 0.37
42 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37
43 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37
44 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
45 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
46 INT27030 HERPUD1 Regulation of CD4 1 0.41 0 0.34
47 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34
48 INT27037 HERPUD1 Regulation of Gene_expression of CD4 1 0.55 0 0.34
49 INT254213 Binding of Jak1 and Tyk2 1 0.09 0.84 0.33
50 INT254209 Jak1 Positive_regulation of Stat3 1 0.18 0.84 0.33
51 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
52 INT184110 Jak1 Positive_regulation of Stat1 1 0.32 0.3 0.33
53 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
54 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31
55 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31
56 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
57 INT174499 Binding of CD4 and HLA-E 1 0.04 1.08 0.29
58 INT257740 SAGE1 Positive_regulation of Gene_expression of AXL 1 0.07 0.72 0.27
59 INT194670 CREB1 Regulation of Gene_expression of CD4 1 0.05 0.07 0.25
60 INT330521 Binding of CD4 and TNFSF10 1 0.20 0.73 0.24
61 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
62 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
63 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23
64 INT237748 Negative_regulation of Jak3 Negative_regulation of Positive_regulation of Stat3 1 0.25 1.01 0.22
65 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
66 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21
67 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
68 INT255516 Binding of COL5A2 and GP6 1 0.01 1.17 0.2
69 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
70 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
71 INT188570 Negative_regulation of IRF6 Positive_regulation of CD4 1 0.04 0.19 0.19
72 INT188573 IRF6 Positive_regulation of CD4 1 0.05 0.19 0.19
73 INT226346 Binding of IL21 and Positive_regulation of Positive_regulation of JAK3 1 0.08 0.48 0.18
74 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
75 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18
76 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
77 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
78 INT226339 Binding of IK and JAK1 1 0.00 0.46 0.16
79 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
80 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
81 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
82 INT226366 Binding of CISH and JAK1 1 0.00 0.46 0.15
83 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
84 INT10731 NEUROD1 Regulation of CD4 1 0.42 1.3 0.12
85 INT10730 CD9 Regulation of CD4 1 0.42 1.3 0.12
86 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
87 INT251295 Binding of CD4 and Regulation of ITIH4 1 0.11 0.24 0.11
88 INT241748 CCR5 Regulation of CD4 1 0.21 0.39 0.11
89 INT189144 MTNR1B Positive_regulation of Gene_expression of CD4 1 0.01 0.35 0.11
90 INT188358 Binding of Csf2 and Positive_regulation of Jak2 1 0.34 0.19 0.11
91 INT169340 Binding of UGT8 and Jak2 1 0.36 0.15 0.11
92 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
93 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
94 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
95 INT333099 Localization of IL2 Negative_regulation of Negative_regulation of CD4 1 0.14 0.8 0.09
96 INT292632 CD4 Positive_regulation of Gene_expression of IL9 1 0.24 0 0.09
97 INT333094 HIVEP1 Regulation of CD4 1 0.00 0.22 0.09
98 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
99 INT333089 CD4 Positive_regulation of ERVW-1 1 0.05 0.07 0.08
100 INT355019 Lif Positive_regulation of JAK1 1 0.00 0.69 0.08
101 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
102 INT355022 Cntf Positive_regulation of JAK1 1 0.00 0.69 0.08
103 INT342288 Binding of CD4 and HFE 1 0.01 1.26 0.08
104 INT15953 Binding of CD4 and IgG2a 1 0.54 0.38 0.08
105 INT183768 Csf2 Regulation of CD4 1 0.37 0.52 0.08
106 INT273374 Binding of JAK2 and STAT3 1 0.24 0 0.07
107 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
108 INT244289 Il6 Positive_regulation of Gene_expression of Jak1 1 0.38 0.09 0.07
109 INT273368 Negative_regulation of Binding of JAK2 and STAT3 1 0.28 0 0.07
110 INT333096 Binding of CD4 and IFN1@ 1 0.12 0.17 0.07
111 INT273369 SOCS3 Negative_regulation of JAK1 1 0.03 0 0.07
112 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
113 INT333092 Binding of CD4 and IL2 1 0.01 0.17 0.07
114 INT242480 Ciapin1 Positive_regulation of Gene_expression of Jak2 1 0.27 1.05 0.07
115 INT273371 JAK2 Regulation of Protein_catabolism of SOCS1 1 0.01 0 0.06
116 INT200807 Jak2 Positive_regulation of Mvd 1 0.18 3.46 0.06
117 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
118 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
119 INT325769 Binding of EPOR and Positive_regulation of Phosphorylation of JAK2 1 0.66 0 0.06
120 INT273365 JAK2 Regulation of SOCS1 1 0.01 0 0.06
121 INT335715 Binding of FASLG and CD4 1 0.22 0.9 0.06
122 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
123 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
124 INT335714 Binding of FAS and CD4 1 0.38 0.9 0.06
125 INT333091 Localization of IFN1@ Negative_regulation of Negative_regulation of CD4 1 0.14 0.4 0.05
126 INT238117 Positive_regulation of STAT3 Positive_regulation of Gene_expression of JAK2 1 0.11 0 0.05
127 INT238116 STAT3 Positive_regulation of Gene_expression of JAK2 1 0.16 0 0.05
128 INT233303 Binding of CD4 and SRY 1 0.07 0.34 0.05
129 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
130 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04
131 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04
132 INT283464 Binding of CD4 and DLAT 1 0.07 0.69 0.04
133 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
134 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
135 INT286968 Positive_regulation of STAT3 Regulation of Gene_expression of CD4 1 0.16 0.44 0.04
136 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
137 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04
138 INT286962 IL2 Regulation of Gene_expression of CD4 1 0.01 0.45 0.04
139 INT212584 IFNA1 Regulation of Gene_expression of CD4 1 0.21 0.98 0.03
140 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
141 INT253578 Csnk2a2 Negative_regulation of Jak2 1 0.09 0 0.03
142 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
143 INT200816 Jak2 Positive_regulation of Binding of Mvd 1 0.19 1.51 0.03
144 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
145 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03
146 INT308540 CD4 Regulation of Localization of AGRP 1 0.39 0.85 0.03
147 INT200810 Jak2 Positive_regulation of Src 1 0.29 1.46 0.03
148 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03
149 INT253575 Binding of Jak2 and Pik3r2 1 0.00 0 0.03
150 INT200815 Binding of Epo and Jak2 1 0.36 0.98 0.03
151 INT221262 Binding of BRCA1 and CD4 1 0.22 0.81 0.03
152 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
153 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0
154 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
155 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0
156 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0
157 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
158 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
159 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0
160 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
161 INT253366 Il6 Positive_regulation of Phosphorylation of Jak2 1 0.31 0.2 0
162 INT326167 Binding of CD4 and Tmed8 1 0.47 0.29 0
163 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0
164 INT186603 Binding of ERBB2 and Ednra 1 0.02 0.53 0
165 INT260127 Binding of CD4 and Trav6-3 1 0.03 0 0
166 INT339113 Binding of ASIP and ERBB2 1 0.00 0.64 0
167 INT339104 Binding of ERBB2 and GRB7 1 0.30 1.29 0
168 INT121649 Binding of CD4 and CXCL12 1 0.29 0.2 0
169 INT343501 CD4 Regulation of ERVW-1 1 0.09 0.16 0
170 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
171 INT240420 Myo5a Positive_regulation of CD4 1 0.06 0.27 0
172 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
173 INT186589 Binding of ERBB2 and SCFV 1 0.13 0.65 0
174 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
175 INT277809 Binding of CD4 and CD40LG 1 0.15 0 0
176 INT206088 IL6 Positive_regulation of JAK1 1 0.18 0.05 0
177 INT200819 Epo Positive_regulation of Gene_expression of Jak2 1 0.49 0.91 0
178 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
179 INT293807 Positive_regulation of Binding of ERBB2 and RORC 1 0.02 0.12 0
180 INT250667 KLF1 Regulation of ERBB2 1 0.00 1.16 0
181 INT293803 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of AR 1 0.10 0 0
182 INT329101 Binding of CD4 and INCENP 1 0.01 0.11 0
183 INT343499 CD4 Regulation of HIVEP1 1 0.02 0.16 0
184 INT300081 Binding of JAK2 and TYK2 1 0.09 1.13 0
185 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
186 INT250666 ERBB2 Positive_regulation of PIK3CB 1 0.15 0.69 0
187 INT293814 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of GOPC 1 0.02 0 0
188 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
189 INT278372 Binding of Syk and Pycard 1 0.06 0 0
190 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
191 INT205121 Binding of CD4 and CD7 1 0.05 0.51 0
192 INT277860 MUC4 Negative_regulation of ERBB2 1 0.19 0.29 0
193 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
194 INT223583 TXK Negative_regulation of ERBB2 1 0.07 0.18 0
195 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0
196 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0
197 INT339115 Binding of ERBB2 and PVT1 1 0.43 1.11 0
198 INT340516 CD4 Regulation of IL2 1 0.04 0.32 0
199 INT258911 Binding of CD4 and HLA-G 1 0.04 0.06 0
200 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enzyme linked receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in enzyme linked receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
2 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
3 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
4 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
5 INT36287 Binding of CD4 96 0.47 58.93 11.88
6 INT16404 Regulation of CD4 54 0.61 33.05 10.29
7 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
8 INT17049 Localization of CD4 57 0.75 35.33 6.89
9 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
10 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
11 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
12 INT158573 Negative_regulation of Jak3 3 0.43 8.2 3.99
13 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
14 INT15375 Gene_expression of AXL 21 0.65 18.5 3.74
15 INT328808 Negative_regulation of Jak1 1 0.42 7.01 3.64
16 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
17 INT118035 Positive_regulation of JAK1 23 0.67 10.57 3.29
18 INT145298 Gene_expression of Jak3 5 0.78 7.69 3.07
19 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
20 INT113339 Binding of JAK2 6 0.40 5.31 2.4
21 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
22 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37
23 INT153411 Positive_regulation of Jak1 3 0.49 1.24 2.25
24 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
25 INT145297 Positive_regulation of Jak3 3 0.50 5.52 2.14
26 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
27 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
28 INT100689 Negative_regulation of JAK1 8 0.57 5.36 1.87
29 INT189839 Gene_expression of Jak1 2 0.50 0.51 1.87
30 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
31 INT142477 Gene_expression of GP6 12 0.76 12.53 1.79
32 INT278981 Negative_regulation of JAK3 5 0.46 2.12 1.69
33 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
34 INT206144 Phosphorylation of JAK1 6 0.57 1.77 1.64
35 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
36 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59
37 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
38 INT106574 Phosphorylation of Jak1 2 0.60 0.35 1.5
39 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
40 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
41 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
42 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
43 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
44 INT155846 Transcription of JAK1 4 0.67 1.93 1.19
45 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
46 INT278975 Gene_expression of JAK3 3 0.52 1.03 0.97
47 INT198049 Positive_regulation of JAK2 16 0.58 5.35 0.96
48 INT226480 Positive_regulation of JAK3 4 0.45 0.96 0.95
49 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
50 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94
51 INT169336 Binding of Jak2 2 0.42 1.31 0.93
52 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
53 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
54 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
55 INT205906 Negative_regulation of Gene_expression of Jak1 1 0.32 0.47 0.87
56 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
57 INT134038 Positive_regulation of Phosphorylation of Jak1 1 0.50 0.25 0.86
58 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
59 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
60 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
61 INT238201 Gene_expression of JAK2 9 0.70 7.09 0.81
62 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79
63 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
64 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
65 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
66 INT142478 Positive_regulation of Gene_expression of GP6 6 0.68 4.5 0.73
67 INT113342 Positive_regulation of Phosphorylation of JAK2 2 0.66 2.58 0.72
68 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69
69 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68
70 INT186276 Phosphorylation of Jak1 4 0.58 0.65 0.68
71 INT184016 Negative_regulation of Jak1 4 0.32 0.68 0.68
72 INT328809 Binding of Jak1 1 0.35 0.32 0.65
73 INT106569 Regulation of Jak1 1 0.06 0.1 0.65
74 INT167712 Positive_regulation of Positive_regulation of Jak1 1 0.23 0.57 0.63
75 INT132324 Localization of SYK 2 0.78 1.9 0.59
76 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
77 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56
78 INT205901 Positive_regulation of Gene_expression of Jak1 1 0.35 0 0.56
79 INT184036 Positive_regulation of Jak1 5 0.45 2.25 0.55
80 INT264129 Protein_catabolism of JAK1 1 0.02 0.38 0.55
81 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
82 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
83 INT202426 Transcription of CD4 6 0.69 3.96 0.49
84 INT226580 Localization of JAK1 3 0.11 0.52 0.49
85 INT237738 Positive_regulation of Gene_expression of Jak3 1 0.32 1.98 0.49
86 INT237739 Gene_expression of Jak3 1 0.44 1.97 0.48
87 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
88 INT184062 Binding of Jak2 5 0.37 3.13 0.47
89 INT260119 Regulation of Localization of CD4 2 0.44 1.61 0.46
90 INT184025 Binding of Jak1 2 0.21 0.84 0.46
91 INT345936 Regulation of JAK3 1 0.02 0.41 0.46
92 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
93 INT231744 Negative_regulation of Gene_expression of Jak3 1 0.32 0.9 0.43
94 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
95 INT205895 Positive_regulation of Transcription of Jak1 1 0.35 0.22 0.43
96 INT205885 Transcription of Jak1 1 0.40 0.21 0.42
97 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
98 INT107462 Localization of Jak2 2 0.60 0.78 0.4
99 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4
100 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
101 INT279298 Gene_expression of JAK1 7 0.65 5.5 0.37
102 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
103 INT280551 Negative_regulation of Gene_expression of JAK1 2 0.41 1.02 0.37
104 INT278972 Regulation of Negative_regulation of JAK3 1 0.21 0.36 0.37
105 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
106 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
107 INT317742 Positive_regulation of Transcription of JAK1 1 0.49 0.57 0.35
108 INT154175 Regulation of SYK 2 0.62 1.48 0.34
109 INT181729 Binding of GP6 2 0.35 1.21 0.32
110 INT260110 Positive_regulation of Regulation of CD4 2 0.48 1.5 0.32
111 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
112 INT282775 Regulation of Positive_regulation of CD4 2 0.37 1.28 0.3
113 INT212592 Regulation of Binding of CD4 2 0.30 1.15 0.3
114 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
115 INT280561 Binding of JAK1 2 0.26 0.39 0.26
116 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
117 INT328812 Binding of Jak3 1 0.24 0.33 0.26
118 INT293346 Binding of JAK3 1 0.12 0.34 0.26
119 INT303972 Positive_regulation of Gene_expression of JAK2 2 0.63 1.3 0.24
120 INT328815 Regulation of Negative_regulation of Jak1 1 0.32 0.88 0.24
121 INT328816 Regulation of Negative_regulation of Jak3 1 0.30 0.88 0.24
122 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
123 INT204183 Negative_regulation of Negative_regulation of CD4 3 0.30 1.79 0.22
124 INT278154 Regulation of Syk 1 0.05 0.98 0.22
125 INT278139 Regulation of Jak3 1 0.06 0.97 0.22
126 INT278146 Localization of Jak3 1 0.35 0.97 0.22
127 INT278147 Localization of Syk 1 0.30 0.98 0.22
128 INT296064 Positive_regulation of Transcription of CD4 1 0.28 0.11 0.21
129 INT278142 Binding of Jak3 1 0.17 0.67 0.19
130 INT339167 Positive_regulation of Localization of ERBB2 2 0.49 1.49 0.17
131 INT63230 Positive_regulation of GP6 2 0.68 2.5 0.17
132 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
133 INT181787 Transcription of ERBB2 13 0.71 10.03 0.16
134 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
135 INT159685 Regulation of Gene_expression of GP6 1 0.60 1.86 0.16
136 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
137 INT328810 Positive_regulation of Negative_regulation of Jak1 1 0.36 0.16 0.15
138 INT278141 Negative_regulation of Negative_regulation of Jak3 1 0.20 0.66 0.15
139 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
140 INT242243 Regulation of GP6 2 0.26 0.06 0.13
141 INT70018 Localization of AXL 2 0.55 0.49 0.13
142 INT20433 Regulation of Phosphorylation of CD4 1 0.06 0 0.13
143 INT20434 Phosphorylation of CD4 2 0.61 0 0.12
144 INT237736 Positive_regulation of Jak3 1 0.37 0.33 0.12
145 INT203282 Negative_regulation of Binding of CD4 2 0.30 0.63 0.11
146 INT278143 Positive_regulation of Negative_regulation of Jak2 1 0.16 0.54 0.11
147 INT278140 Regulation of Negative_regulation of Jak3 1 0.21 0.43 0.11
148 INT278144 Positive_regulation of Negative_regulation of Jak3 1 0.23 0.55 0.11
149 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11
150 INT293340 Negative_regulation of Negative_regulation of JAK1 1 0.02 0.34 0.1
151 INT312354 Regulation of Gene_expression of JAK2 1 0.25 1.17 0.1
152 INT275411 Binding of Syk 1 0.09 0.12 0.1
153 INT200792 Regulation of Gene_expression of Jak2 5 0.61 5.69 0.09
154 INT228800 Regulation of Gene_expression of Jak3 1 0.13 0.29 0.09
155 INT159684 Negative_regulation of Gene_expression of GP6 1 0.36 0.96 0.09
156 INT184018 Negative_regulation of Protein_catabolism of Jak2 1 0.36 1.76 0.08
157 INT184023 Protein_catabolism of Jak2 1 0.61 1.75 0.08
158 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
159 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06
160 INT213915 Negative_regulation of Positive_regulation of ERBB2 2 0.41 1.09 0.05
161 INT310747 Regulation of JAK2 2 0.33 1.58 0.05
162 INT255541 Negative_regulation of Binding of GP6 1 0.24 0.15 0.05
163 INT238202 Negative_regulation of Localization of JAK2 1 0.09 0 0.05
164 INT244286 Gene_expression of Jak1 1 0.65 0.09 0.05
165 INT238200 Localization of JAK2 1 0.16 0 0.05
166 INT212270 Regulation of Localization of ERBB2 1 0.42 0.45 0.05
167 INT255530 Positive_regulation of Binding of GP6 1 0.32 0.16 0.05
168 INT278363 Binding of Syk 1 0.32 0.3 0.04
169 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
170 INT266927 Positive_regulation of Transcription of ERBB2 2 0.46 2.5 0.03
171 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
172 INT238199 Positive_regulation of Positive_regulation of JAK2 1 0.10 0 0.03
173 INT234210 Regulation of Negative_regulation of ERBB2 1 0.25 0.5 0.03
174 INT265512 Negative_regulation of Binding of ERBB2 4 0.40 1.43 0
175 INT234204 Protein_catabolism of ERBB2 3 0.82 1.6 0
176 INT286987 Positive_regulation of Phosphorylation of ERBB2 2 0.23 0.91 0
177 INT279213 Positive_regulation of Binding of ERBB2 2 0.46 2.29 0
178 INT217179 Negative_regulation of AXL 2 0.01 1.9 0
179 INT273759 Positive_regulation of Negative_regulation of CD4 2 0.45 2.05 0
180 INT217193 Negative_regulation of Negative_regulation of AXL 1 0.01 1.12 0
181 INT280557 Negative_regulation of Binding of JAK1 1 0.30 0.4 0
182 INT206164 Positive_regulation of Phosphorylation of JAK1 1 0.19 0.19 0
183 INT154178 Binding of SYK 1 0.37 0.46 0
184 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
185 INT238196 Negative_regulation of Binding of JAK2 1 0.09 0 0
186 INT280558 Positive_regulation of Binding of JAK1 1 0.35 0.39 0
187 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
188 INT277861 Positive_regulation of Positive_regulation of ERBB2 1 0.64 0.32 0
189 INT315883 Positive_regulation of Positive_regulation of JAK1 1 0.01 0.38 0
190 INT144040 Negative_regulation of Positive_regulation of JAK1 1 0.04 0.08 0
191 INT202420 Transcription of Jak2 1 0.56 0.91 0
192 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
193 INT350506 Protein_catabolism of JAK2 1 0.48 1.55 0
194 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
195 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
196 INT320539 Negative_regulation of Phosphorylation of JAK2 1 0.26 0.46 0
197 INT223291 Regulation of Transcription of ERBB2 1 0.25 0.21 0
198 INT341850 Positive_regulation of Protein_catabolism of ERBB2 1 0.42 0.97 0
199 INT175420 Positive_regulation of Positive_regulation of AXL 1 0.01 0.54 0
200 INT293781 Regulation of Phosphorylation of ERBB2 1 0.24 0.13 0
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